Abstract: Compositions and methods are provided for treating or inhibiting a bacterial infection involving at least one antibiotic and a compound that potentiates the antibiotic activity of the antibiotic. In certain embodiments the antibiotic is a beta lactam. In further embodiments, the antibiotic is oxacillin. In additional embodiments, the potentiating compound is an inhibitor of vraSR operon expression. In specific embodiments, the bacterial infection involves an antibiotic-resistant bacteria.
Type:
Application
Filed:
June 9, 2017
Publication date:
September 28, 2017
Applicants:
THE UNIVERSITY OF CHICAGO, THE BOARD OF REGENTS OF THE UNIVERSITY OF ILLINOIS
Inventors:
Robert S. Daum, Susan Boyle-Vavra, Michael E. Johnson
Abstract: Compositions and methods are provided for treating or inhibiting a bacterial infection involving at least one antibiotic and a compound that potentiates the antibiotic activity of the antibiotic. In certain embodiments the antibiotic is a beta lactam. In further embodiments, the antibiotic is oxacillin. In additional embodiments, the potentiating compound is an inhibitor of vraSR operon expression. In specific embodiments, the bacterial infection involves an antibiotic-resistant bacteria.
Type:
Grant
Filed:
March 14, 2014
Date of Patent:
June 13, 2017
Assignees:
The University of Chicago, The Board of Regents of the University of Illinois
Inventors:
Robert S. Daum, Susan Boyle-Vavra, Michael E. Johnson
Abstract: Compositions and methods are provided for treating or inhibiting a bacterial infection involving at least one antibiotic and a compound that potentiates the antibiotic activity of the antibiotic. In certain embodiments the antibiotic is a beta lactam. In further embodiments, the antibiotic is oxacillin. In additional embodiments, the potentiating compound is an inhibitor of vraSR operon expression. In specific embodiments, the bacterial infection involves an antibiotic-resistant bacteria.
Type:
Application
Filed:
March 14, 2014
Publication date:
May 5, 2016
Applicants:
THE BOARD OF REGENTS OF THE UNIVERSITY OF ILLINOIS, THE UNIVERSITY OF CHICAGO
Inventors:
Robert S. DAUM, Susan BOYLE-VAVRA, Michael E. JOHNSON