Abstract: The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid.

Abstract: Aspects of the disclosure encompass systems, methods, and compositions for producing exosomes from mesenchymal stem cells and, optionally, loading said exosomes with one or more therapeutic agents. The systems, methods, and compositions may occur in an automated cell expansion system that allows for controllable parameters and from which cells and exosomes may be harvested at one or more times as part of a particular regimen. The exosomes may be loaded with one or more therapeutic agents using electroporation. In specific aspects, the exosomes may be provided to an individual in need thereof, including in some cases where the individual in need thereof is an individual having a medical disorder for which the exosomes would be therapeutic.

Abstract: The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid.

Abstract: A method (of treating a patient who has tinnitus) includes: providing to the patient a series of tones including at least a single tone which is at least a half-octave outside a tinnitus frequency of the patient; and applying vagus nerve stimulation to the patient to induce a period of plasticity in a cortex of the patient that is transitory and that represents a transitory opportunity for learning to occur; and wherein the at least a single tone occurs during the transitory opportunity for learning.

Abstract: Embodiments disclosed herein provide a system, method, and computer program product for providing a patient dashboard system in a patient care setting. The patient dashboard system collects and stores patient data from a variety of sources. The collected patient data is filtered, analyzed, and displayed. The patient dashboard system displays patient data that is relevant to the treatment of the patient, including recommended medical actions and pertinent positives and pertinent negatives.

Abstract: The invention relates generally to the following novel fendiline derivatives, and the preparation and use thereof: Formula I (I) and Formula II (II)

Abstract: Methods and compositions for estimating one or more downhole qualities of a drilling apparatus by obtaining axial acceleration data. The axial acceleration data may be acquired by measuring an axial acceleration of a bottom hole assembly. The axial acceleration may then be used to estimate one or more of a downward weight on a drill bit of the drilling apparatus or a rate of penetration of the drill bit.

Abstract: Disclosures herein are directed to antibodies and epitope binding agents that specifically bind to the extracellular domain of Patched-1 and compositions thereof for use in clinical and non-clinical applications. Also provided are methods to treat and/or prevent Hedgehog pathway related disorders.

Abstract: Disclosed herein are methods and compositions for determining and improving the likelihood of response and/or determining and decreasing the likelihood of toxicity to a cellular therapy using metabolomics. Embodiments of the disclosure include methods for measuring certain metabolites in biological samples of an individual for determining whether the individual has a responder or non-responder phenotype to the cellular therapy or to a toxicity of the cellular therapy. Embodiments also include compositions for increasing the response to a cellular therapy or decreasing toxicities associated with a cellular therapy. Embodiments also show that plasma metabolomics correlate with efficacy and toxicities associated with CAR-T therapy towards a cancer. The present disclosure relates to compositions and methods for predicting a subject's response to a CAR T-cell therapy, by analyzing the plasma metabolomics of the subject.

Abstract: Aspects of the present disclosure are directed to liquid and substantially solid film compositions for storage, transport, and administration of parvovirus and parvovirus vectors, including adeno-associated vims (AAV) vectors, without the use of ultralow temperatures. Provided are compositions capable of long-term storage of AAV vectors at ambient temperatures. Also disclosed are injectable compositions comprising AAV vectors, as well as methods for formulation and administration of such compositions.

Abstract: Described herein are compositions, techniques, methods, and systems for sequestering carbon, for producing oil, for improved oil recovery, and for storing hydrogen by way of injecting aqueous mixtures into subterranean reservoirs. The aqueous mixtures include one or more carboxylates, which can represent a form of carbon dioxide and/or a form of hydrogen. The aqueous mixtures including carboxylates may also or alternatively be useful for increasing a viscosity of a fluid within the reservoir or modifying the wettability of rock within the reservoir to improve the availability and production of hydrocarbons contained within pores of the rock.

Abstract: Antibody antigen binding domains which specifically binds human leptin comprises VH or VL CDR1, CDR2 and CDR3 sequences of an hLept antibody. The antibody antigen binding domains and antibodies thereof are useful to treat obesity and diabetes.

Abstract: Methods and compositions relating to the engineering of an improved protein with homocyst(e)inase enzyme activity are described. For example, there are disclosed modified cystathionine-?-lyase (CGL) enzymes comprising one or more amino acid substitutions and capable of degrading homocyst(e)ine. Furthermore, provided are compositions and methods for the treatment of homocystinuria or hyperhomocysteinemia with homocyst(e)ine depletion using the disclosed enzymes or nucleic acids.

Abstract: Described herein are therapeutic pH responsive compositions useful for the treatment of cancer. The compositions involve combining a STING activating polymer micelle, such as PC7A, with a non-peptide STING agonist, such as cGAMP. Methods of administering these compositions in the treatment of cancer are also disclosed. These methods include administration of the pharmaceutical compositions by intratumoral injection in the treatment of solid tumors.

Abstract: The present disclosure relates to systems and methods for passive infrared sensing and detection of vehicular traffic. Vehicle parameters are detected using thermal detection states of pixels of an infrared array sensor. The vehicle parameters can include a velocity of a vehicle. A vehicle record that includes the vehicle parameters can be provided, for example, by a computing device in connection with the infrared array sensor.

Abstract: A method of measuring spectral emissivity of materials is provided. The method comprises placing material in a controlled chamber and exposing the material to an energy source to heat the material. At least one multi-wavelength pyrometer measures the spectral emissivity of the material produced by heating by the energy source, wherein the multi-wavelength pyrometer is positioned at a distal end of a tube extending from the chamber, wherein the tube provides a sacrificial surface for vapor condensation to prevent the vapor condensation from obscuring a view port used by the pyrometer.

Abstract: Disclosed herein are new cyclic dinucleotide compounds and compositions and their application as pharmaceuticals for the treatment of disease. Methods of modulation of immune response to disease, and induce Stimulator of Interferon Genes (STING) dependent type I interferon production and co-regulated genes in a human or animal subject are also provided for the treatment diseases such as cancer, particularly metastatic solid tumors and lymphomas, inflammation, allergic and autoimmune disease, infectious disease, and for use as anti-viral agents and vaccine adjuvants.

Abstract: Devices, systems and methods to directly quantify molecular entities and, compounds, inactive ingredients, compositions or formulations across and into specific layers of biological membranes, such as the skin. Exemplary methods enable the determination of the amount of drug into and across tissues as well as the measurement of the effect of chemicals/compounds on membranes, mainly the skin.

Abstract: Membrane materials and methods are disclosed for selectively separating or transporting ions in liquid media. In embodiments, the membranes comprise cellulose acetate polymer films having high cation, monovalent/divalent, and/or Li+/Mg2+ selectivity. Systems and methods for use of such membranes, including the direct extraction of lithium (DLE) from natural brines and other resources, also are disclosed.

Abstract: Provided herein are gene therapy methods, vectors and constructs for the treatment of Duchenne Muscular Dystrophy in a subject.