Patents Assigned to The Board of Regents of the University of Texas System
  • Publication number: 20200333350
    Abstract: Provided herein are block copolymers comprising a hydrophilic polymer segment and a hydrophobic polymer segment, wherein the hydrophilic polymer segment comprises a polymer selected from the group consisting of: poly(ethylene oxide) (PEO), poly(methacrylate phosphatidyl choline) (MPC), and polyvinylpyrrolidone (PVP), wherein the hydrophobic polymer segment comprises wherein R? is —H or —CH3, wherein R is —NR1R2, wherein R1 and R2 are alkyl groups, wherein R1 and R2 are the same or different, wherein R1 and R2 together have from 5 to 16 carbons, wherein R1 and R2 may optionally join to form a ring, wherein n is 1 to about 10, and wherein x is about 20 to about 200 in total. Also provided are pH-sensitive micelle compositions for therapeutic and diagnostic applications.
    Type: Application
    Filed: March 10, 2020
    Publication date: October 22, 2020
    Applicant: The Board of Regents of the University of Texas System
    Inventors: Jinming GAO, David BOOTHMAN, Kejin ZHOU, Xiaonan HUANG, Yiguang WANG
  • Publication number: 20200333357
    Abstract: The present disclosure is directed to a nanotechnology-enabled screening strategy to identify small molecule TFEB agonists that shift maturation of autophagosomes to degradative autolysosomes.
    Type: Application
    Filed: November 13, 2018
    Publication date: October 22, 2020
    Applicant: The Board of Regents of the University of Texas System
    Inventors: Jinming GAO, Michael A. WHITE, Chensu WANG, Yang LI, Bruce POSNER, Gang HUANG
  • Publication number: 20200330383
    Abstract: Provided herein are block copolymers comprising a hydrophilic polymer segment and a hydrophobic polymer segment, wherein the hydrophilic polymer segment comprises a polymer selected from the group consisting of: poly(ethylene oxide) (PEO), poly(methacrylate phosphatidyl choline) (MPC), and polyvinylpyrrolidone (PVP), wherein the hydrophobic polymer segment comprises wherein R? is —H or —CH3, wherein R is —NR1R2, wherein R1 and R2 are alkyl groups, wherein R1 and R2 are the same or different, wherein R1 and R2 together have from 5 to 16 carbons, wherein R1 and R2 may optionally join to form a ring, wherein n is 1 to about 10, and wherein x is about 20 to about 200 in total. Also provided are pH-sensitive micelle compositions for therapeutic and diagnostic applications.
    Type: Application
    Filed: March 10, 2020
    Publication date: October 22, 2020
    Applicant: The Board of Regents of the University of Texas System
    Inventors: Jinming GAO, David BOOTHMAN, Kejin ZHOU, Xiaonan HUANG, Yiguang WANG
  • Patent number: 10809678
    Abstract: Disclosed are systems and methods relating to managing and sharing resources within a spatially-distributed electrical power network in a fully distributed fashion. The electrical power network includes source nodes each having a power source and a local controller. The electrical power network includes a physical layer where the source nodes are connected to a power distribution network including one or more loads. The electrical power network also includes a communication layer for communicating power information between source nodes and neighbor source nodes of the electrical power network.
    Type: Grant
    Filed: March 15, 2016
    Date of Patent: October 20, 2020
    Assignee: Board of Regents, The University of Texas System
    Inventors: Vahidreza Nasirian, Ali Davoudi, Frank L. Lewis
  • Patent number: 10808230
    Abstract: In some aspects, isolated transgenic cells (e.g., transgenic T cells) are provided that comprise or express a transgene and DHFRFS and/or TYMSSS. Methods for selecting transgenic cells are also provided.
    Type: Grant
    Filed: February 24, 2016
    Date of Patent: October 20, 2020
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: David Rushworth, Laurence J. N. Cooper
  • Patent number: 10808499
    Abstract: Methods and systems that provide ways to detect the hydrocarbon flow while eliminating the hydrogen darkening effect in the downhole environment by separated strain and temperature measurement. The methods and systems use fiber optic sensing cables for real-time detection of hydrocarbon fluids (oil, gas, condensate or combination) in oil and gas wells, for example in cemented annuli between either a rock formation and a casing string, or between a larger diameter casing string and a smaller diameter casing string, or in a cement plug left in the well upon abandonment. Hydrogen darkening-resistant temperature and strain sensing fiber optic cables can be used in conjunction with hydrocarbon sensitive polymers to monitor hydrocarbon migration in the oil and gas well and/or to identify the zone(s) from which the hydrocarbons are flowing.
    Type: Grant
    Filed: November 18, 2016
    Date of Patent: October 20, 2020
    Assignee: Board of Regents, The University of Texas System
    Inventors: Eric van Oort, Qian Wu, Sriramya Duddukuri Nair, Michelle Shuck
  • Publication number: 20200325265
    Abstract: Provided herein are block copolymers comprising a hydrophilic polymer segment and a hydrophobic polymer segment, wherein the hydrophilic polymer segment comprises a polymer selected from the group consisting of: poly(ethylene oxide) (PEO), poly(methacrylate phosphatidyl choline) (MPC), and polyvinylpyrrolidone (PVP), wherein the hydrophobic polymer segment comprises wherein R? is —H or —CH3, wherein R is —NR1R2, wherein R1 and R2 are alkyl groups, wherein R1 and R2 are the same or different, wherein R1 and R2 together have from 5 to 16 carbons, wherein R1 and R2 may optionally join to form a ring, wherein n is 1 to about 10, and wherein x is about 20 to about 200 in total. Also provided are pH-sensitive micelle compositions for therapeutic and diagnostic applications.
    Type: Application
    Filed: March 10, 2020
    Publication date: October 15, 2020
    Applicant: The Board of Regents of the University of Texas System
    Inventors: Jinming GAO, David BOOTHMAN, Kejin ZHOU, Xiaonan HUANG, Yiguang WANG
  • Patent number: 10800769
    Abstract: The present disclosure relates to heterocyclic compounds and methods which may be useful as inhibitors of ATR kinase for the treatment or prevention of cancer.
    Type: Grant
    Filed: July 10, 2019
    Date of Patent: October 13, 2020
    Assignees: Board of Regents, The University of Texas System, ChemPartner Corporation
    Inventors: Maria Emilia Di Francesco, Philip Jones, Christopher Lawrence Carroll, Jason Bryant Cross, Suyambu Kesava Vijayan Ramaswamy, Michael Garrett Johnson, Sarah Lively, David Lapointe
  • Patent number: 10799466
    Abstract: The present invention provides methods for reducing pain in a subject in need of such pain reduction by delivering, e.g., intrathecally or epidurally, a volatile anesthetic such as a halogenated ether compound in an amount effective to reduce pain. Chronic or acute pain may be treated, or the anesthetic may be delivered to the subject to anesthetize the subject prior to a surgery. In certain embodiments, isoflurane, halothane, enflurane, sevoflurane, desflurane, methoxyflurane, xenon, and mixtures thereof may be used. Dosing regimens including a one-time administration, continuous and/or periodic administration are contemplated.
    Type: Grant
    Filed: June 7, 2019
    Date of Patent: October 13, 2020
    Assignee: The Board of Regents of the University of Texas System
    Inventors: Phillip C. Phan, Allen W. Burton
  • Patent number: 10800774
    Abstract: The present invention relates to heterocyclic compounds and methods which may be useful as inhibitors of ATR kinase for the treatment or prevention of cancer.
    Type: Grant
    Filed: August 17, 2018
    Date of Patent: October 13, 2020
    Assignees: Board of Regents, The University of Texas System, ChemPartner Corporation
    Inventors: Maria Emilia Di Francesco, Philip Jones, Christopher Lawrence Carroll, Jason Bryant Cross, Zhijun Kang, Michael Garrett Johnson, Sarah Lively
  • Patent number: 10804583
    Abstract: A magnet-free non-reciprocal device realized using modulated filters. The device includes one or more filters in one or more branches, where each branch connects two ports or a port and a central node. The poles and zeros of each of the first, second and third filters are modulated in time such that degenerate modes at each pole and zero is split thereby destructively interfering at one or more output ports and adding up at another output port allowing non-reciprocal transmission, isolation and/or non-reciprocal phase shift. The device is able to realize a magnet-free full-duplex communication scheme implementing a magnet-free circulator for radio frequency cancellation or a magnet-free isolator or gyrator.
    Type: Grant
    Filed: September 13, 2017
    Date of Patent: October 13, 2020
    Assignee: Board of Regents, The University of Texas System
    Inventors: Ahmed Kord, Andrea Alu, Dimitrios Sounas
  • Patent number: 10799246
    Abstract: Provided herein are methods, compositions, and devices for occluding cavities or passageways in a patient, in particular cavities or passageways in the cardiovascular system of a patient, such as the LAA of a patient's heart. The methods, compositions, and devices can be used to percutaneously occlude the LAA, decreasing the risk of thromboembolic events associated with AF.
    Type: Grant
    Filed: April 30, 2020
    Date of Patent: October 13, 2020
    Assignees: Board or Regents, The University of Texas System, Applied Cardiovascular Solutions, LLC
    Inventors: F. Javier Otero, Joseph J. Beaman, Krishnendu Roy, Andrew Zimbroff
  • Publication number: 20200316071
    Abstract: The present disclosure provides methods of treating cancer in a patient determined to have an EGFR and/or HER2 exon 20 mutation, such as an insertion mutation, by administering a third-generation tyrosine kinase inhibitor, such as poziotinib or afatinib.
    Type: Application
    Filed: November 17, 2017
    Publication date: October 8, 2020
    Applicant: Board of Regents, The University of Texas System
    Inventors: Jacqulyne ROBICHAUX, Monique NILSSON, John V. HEYMACH
  • Patent number: 10792170
    Abstract: Systems and methods for prosthetic device control with a unified virtual constraint that controls an entire gait cycle of the prosthetic device.
    Type: Grant
    Filed: February 11, 2016
    Date of Patent: October 6, 2020
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEMS
    Inventors: Robert D. Gregg, David Quintero, Anne E. Martin, Darío J. Villarreal Suárez
  • Patent number: 10792044
    Abstract: Provided herein are methods, compositions, and devices for occluding cavities or passageways in a patient, in particular cavities or passageways in the cardiovascular system of a patient, such as the LAA of a patient's heart. The methods, compositions, and devices can be used to percutaneously occlude the LAA, decreasing the risk of thromboembolic events associated with AF.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: October 6, 2020
    Assignees: Applied Cardiovascular Solutions, LLC, Board of Regents, The University of Texas System
    Inventors: F. Javier Otero, Joseph J. Beaman, Krishnendu Roy, Andrew Zimbroff
  • Publication number: 20200308216
    Abstract: Cyclic-GMP-AMP synthase (cGAS) and cyclic-GMP-AMP (cGAMP), including 2?3-cGAMP, 2?2-cGAMP, 3?2?-cGAMP and 3?3?-GAMP, are used in pharmaceutical formulations (including vaccine adjuvants), drug screens, therapies, and diagnostics.
    Type: Application
    Filed: June 16, 2020
    Publication date: October 1, 2020
    Applicant: The Board of Regents of the University of Texas System
    Inventors: Zhijian CHEN, Lijun SUN, Jiaxi WU, Heping SHI, Chuo CHEN
  • Publication number: 20200306351
    Abstract: The present invention includes a composition and method of modulating a dysregulated gut-derived inflammation following a thermal injury comprising: identifying a mammal in need of treatment for the dysregulated gut-derived inflammation following the thermal injury; and providing the mammal with a recombinant Cystatin 9 (CST9) and Cystatin C (CSTC) in a synergistic amount sufficient to restrain or prevent a life-threatening, unrestrained systemic dysregulated gut-derived inflammation in the mammal caused by the thermal injury.
    Type: Application
    Filed: June 16, 2020
    Publication date: October 1, 2020
    Applicant: Board of Regents, The University of Texas System
    Inventors: Tonyia Eaves-Pyles, Richard B. Pyles
  • Patent number: 10786671
    Abstract: A spinal cord stimulator device, including an implantation paddle, a connection segment and an encapsulant. The implantation paddle includes at least one pair of electrode stimulation pads, each of the electrode stimulation pads connected to ends of separate thin film electrode leads, wherein the electrode stimulation pads and the thin film electrode leads are sandwiched between softening polymer layers. The connection segment includes insulated wire leads, one end of each of the wire leads can be connected to contact pads on opposite ends of each one of the thin film leads at separated coupling joints. The encapsulant encompasses portions of the implantation paddle, including encompassing portions of the softening polymer layers surrounding the contact pads, the coupling joints and portions of the connection segment including portions of the wire leads next to the coupling joints. Methods of manufacturing device and using the device for spinal cord stimulation are also described.
    Type: Grant
    Filed: October 27, 2017
    Date of Patent: September 29, 2020
    Assignees: Board of Regents, The University of Texas System, Cornell University
    Inventors: Walter E. Voit, Aldo Garcia-Sandoval, Jason Carmel
  • Patent number: 10786158
    Abstract: Embodiments of the invention are directed to a non-contact optical method using a probe beam deflection technique (PBDT) to detecting acoustic waves transiting an acoustic coupling medium.
    Type: Grant
    Filed: December 10, 2010
    Date of Patent: September 29, 2020
    Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventor: Saher Maswadi
  • Publication number: 20200297816
    Abstract: The present disclosure describes the C-type lectin CLEC11a as a bone growth factor. Clec11a-deficient mice showed reduced bone volume and mineralization, while bone resorption remained unchanged. Administration of recombinant Clec11a systemically promoted bone formation in mice at risk for osteoporosis.
    Type: Application
    Filed: May 1, 2020
    Publication date: September 24, 2020
    Applicant: The Board of Regents of the University of Texas System
    Inventors: Sean Morrison, Rui Yue