Patents Assigned to The Board of Regents of the University of Texas System
  • Patent number: 11156818
    Abstract: A light sheet microscopy apparatus has a light source, a spatial light filter, a scanning device positioned between the light source and the spatial light filter, an imaging device, a computer readable medium, and a computer processor coupled to the light source, the scanning device, the imaging device, and the computer-readable medium. The computer processor is configured to operate the light source to generate a light beam, control the scanning device to scan the light beam across the spatial light filter to generate the light sheet, and utilize the imaging device to capture one or more images of light emitted by a sample illuminated by the one or more light sheets.
    Type: Grant
    Filed: August 13, 2019
    Date of Patent: October 26, 2021
    Assignees: The Board of Regents of The University of Texas System, Northwestern University
    Inventors: Reto Fiolka, Mark Kittisopikul, Bo-Jui Chang
  • Patent number: 11158091
    Abstract: The present disclosure includes systems and methods for color transfer. The method includes receiving a target image, and determining dominant source colors. The method further includes transforming the target image into a color model including a target luminance component and a target color information component. Additionally, the method includes segmenting the target image into a plurality of target segments based on the target color information component or the target luminance component and extracting dominant target colors from the target image by extracting information for at least one of the dominant target colors from each target segment of the plurality of target segments. Further, the method includes generating a color mapping relationship between the dominant target colors and the dominant source colors, and creating a recolored target image using the color mapping relationship.
    Type: Grant
    Filed: September 7, 2017
    Date of Patent: October 26, 2021
    Assignees: Trustees of Tufts College, THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Karen Panetta, Long Bao, Sos Agaian
  • Patent number: 11155812
    Abstract: Embodiments described herein are related to a one-step surface modification method with 3-aminopropyl trimethoxysilane (APTMS), which was developed and applied for DNA immobilization on a paper-based device via the ionic adsorption.
    Type: Grant
    Filed: November 29, 2017
    Date of Patent: October 26, 2021
    Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Xiujun Li, Wan Zhou
  • Patent number: 11155804
    Abstract: Composition comprising purified recombinant selenoproteins, such an antibodies and enzymes, are provided. Method of producing such recombinant polypeptides and bacterial strains for the same are likewise provided.
    Type: Grant
    Filed: July 10, 2017
    Date of Patent: October 26, 2021
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Andrew D. Ellington, Ross Thyer
  • Patent number: 11155599
    Abstract: The present invention is directed to adenoviruses for use in cancer therapy which comprise one or more heterologous nucleic acid sequences encoding a tumor antigen, whereby the adenovirus expresses the tumor antigen(s) on its surface.
    Type: Grant
    Filed: February 1, 2013
    Date of Patent: October 26, 2021
    Assignee: Board of Regents, The University of Texas System
    Inventors: Juan Fueyo-Margareto, Candelaria Gomez-Manzano, W. K. Alfred Yung, Victor Krasnykh, Hong Jiang
  • Patent number: 11154572
    Abstract: The present invention concerns methods of treating a disease such as leukemia in a subject by administering natural killer (NK) cells. In particular aspects, HLA-C1-licensed KIR2DL2/3 and KIR2DS2 NK cells are administered to a subject with an HLA-C genotype either homozygous or heterozygous for the C1 allele, or HLA-C2 licensed cells are administered to a subject with an HLA-C genotype homozygous for the C2 allele. In further aspects, the NK cells are genetically modified to express a chimeric antigen receptor and interleukin 15.
    Type: Grant
    Filed: June 6, 2016
    Date of Patent: October 26, 2021
    Assignee: Board of Regents, The University of Texas System
    Inventors: Katy Rezvani, Elizabeth Shpall, Enli Liu
  • Patent number: 11155670
    Abstract: An amorphous thermoset thiourethane polymer, comprising a sequential chain of a first type of monomer covalently bonded to a second type of monomer via thiourethane linkages, wherein the first type of monomer includes two or more thiol functional groups and the second type of monomer includes two or more isocyanate functional groups. Methods of synthesizing the polymer, bio-electronic devices comprising the polymer and methods of manufacturing such devices are disclosed.
    Type: Grant
    Filed: July 31, 2017
    Date of Patent: October 26, 2021
    Assignee: Board of Regents, The University of Texas System
    Inventors: Gregory T. Ellson, Walter Voit
  • Patent number: 11155538
    Abstract: Disclosed herein are novel cycloalka[b]heteroaryl compounds having CX3CR1/fractalkine receptor (CX3CR1) agonistic properties, pharmaceutical compositions comprising these compounds, chemical processes for preparing these compounds and their use in the treatment or prophylaxis of diseases associated with CX3CR1 receptor activity in animals, in particular humans.
    Type: Grant
    Filed: July 23, 2020
    Date of Patent: October 26, 2021
    Assignees: Board of Regents, The University of Texas System, Axxam S.p.A.
    Inventors: Paolo Pevarello, William J. Ray, Mary Hamby, Yaima Luzardo Lightfoot, Philip Jones, Russell Thomas, Chiara Liberati, Domenica Torino, Valentina Cusano, Francesco Piscitelli, Ali Munaim Yousif, Silvia Bovolenta
  • Publication number: 20210324411
    Abstract: The present disclosure provides methods and compositions for the treatment of diseases and/or disorders in a subject, including, but not limited to neurological disorders such as giant axonal neuropathy. The methods described herein include direct administration of a gene therapy (e.g. an rAAV viral vector) to a subject via injection into a vagus nerve (e.g. the left vagus nerve) of the subject.
    Type: Application
    Filed: April 14, 2021
    Publication date: October 21, 2021
    Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Rachel M. BAILEY, Steven J. GRAY
  • Patent number: 11149720
    Abstract: Actuators (artificial muscles) comprising twist-spun nanofiber twist-inserted polymer fibers generate tensile actuation when powered electrically, photonically, chemically, thermally, by absorption, or by other means. These artificial muscles utilize coiled polymer fibers and can be either neat or comprising a guest. In some embodiments, the coiled polymer fibers actuator can be incorporated into an article, such as a textile, braid, clothing, smart packaging, or a mechanical system, and the coiled polymer fiber in the coiled polymer fiber actuator can have a stroke amplification factor of 5 or greater.
    Type: Grant
    Filed: November 15, 2019
    Date of Patent: October 19, 2021
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Na Li, Carter S. Haines, Marcio D. Lima, Monica Jung DeAndrade, Shaoli Fang, Jiyoung Oh, Mikhail E. Kozlov, Dongseok Suh, Ray H. Baughman
  • Patent number: 11149053
    Abstract: The present invention includes a method and kit for cDNA synthesis of a 3?UTR/poly(A) tail junction of cellular RNA comprising: obtaining RNA comprising a 3?UTR/poly(A) junction and a poly(a) tail; combining the RNA with three terminating nucleotides of modified-deoxyGTP, modified-deoxyCTP and modified-deoxyATP, dNTPs, and adaptor sequence-oligo-dT; performing reverse transcription of the RNA with a reverse transcriptase primed with the adaptor sequence-oligo-dT to form terminated cDNA fragments that are stochastically terminated upstream of the 3?UTR/poly(A) junction, but not within the poly(A) tail; isolating the terminated cDNA fragments; chemically ligating a functionalized 5? adaptor to the terminated cDNA; and amplifying the chemically-ligated cDNA into an amplification product, wherein the cDNA is enriched for sequences at the 3?UTR/poly(A) tail junction without fragmentation or enzymatic ligation.
    Type: Grant
    Filed: February 21, 2019
    Date of Patent: October 19, 2021
    Assignee: Board of Regents, The University of Texas System
    Inventors: Andrew Routh, Eric Wagner, Ping Ji, Elizabeth Jaworski
  • Patent number: 11148958
    Abstract: Disclosed are a desalination device and processes of desalination using the device. The device is directly ocean-situated and fully nature-powered with on intake, no brine production, and no electricity consumption. The device contains a heating unit, configured to receive a dry air stream and heat the dry air stream with one or more renewable energy sources to produce a heated air stream; a humidifier, configured to receive the heated air stream, evaporate at least portion of water present in the humidifier and humidify the heated air stream to produce a wet air stream, a cooling unit, configured to receive the wet stream and cool the wet air stream resulting in condensation of at least a portion of the moisture to produce fresh water and a dehumidified air stream; and a fresh water collection tank, configured to collect at least a portion of the fresh water.
    Type: Grant
    Filed: December 12, 2019
    Date of Patent: October 19, 2021
    Assignee: Board of Regents, The University of Texas System
    Inventor: Yingchen Yang
  • Publication number: 20210320574
    Abstract: A novel high torque density double stator permanent magnet electric machine is provided. An outer stator is provided which has complex teeth and optionally can have windings every tooth or every other tooth. A rotor is provided having a plurality of magnet receivers, each with a complex topology. Magnets are provided in the rotor which are tangentially magnetized with alternating polarities and a complex topology to increase torque density. An inner stator is provided having a plurality of teeth with complex topologies. Windings are provided around every tooth or every other tooth, alternatively. Air-gaps are provided between the outer stator and the rotor and between the rotor and inner stator. The air-gap between the inner stator and the rotor is smaller than the air-gap between the outer stator and the rotor. A lower current density in certain windings improves thermal response without comprising average torque.
    Type: Application
    Filed: April 8, 2021
    Publication date: October 14, 2021
    Applicant: Board of Regents, The University of Texas System
    Inventors: Babak Fahimi, Amir Parsapour, Mehdi Moallem
  • Patent number: 11143169
    Abstract: Actuators (artificial muscles) comprising twist-spun nanofiber yarn or twist-inserted polymer fibers generate torsional actuation when powered electrically, photonically, chemically, thermally, by absorption, or by other means. These artificial muscles utilize coiled yarns/polymer fibers and can be either neat or comprising a guest. In some embodiments, the actuator system includes a twisted and coiled polymer fiber actuator, and at least one of (i) wire connections that enable electrical heating of the twisted and coiled polymer fiber actuator, (ii) a radiation source and radiation pathway that enables photothermal heating of the twisted and coiled polymer fiber actuator, and (iii) a delivery system for delivering chemicals whose reaction produces heating of the twisted and coiled polymer fiber actuator.
    Type: Grant
    Filed: October 9, 2019
    Date of Patent: October 12, 2021
    Assignee: Board of Regents, The University of Texas System
    Inventors: Na Li, Carter S. Haines, Marcio D. Lima, Monica Jung DeAndrade, Shaoli Fang, Jiyoung Oh, Mikhail E. Kozlov, Dongseok Suh, Ray H. Baughman
  • Patent number: 11142764
    Abstract: Provided are antisense oligomers targeted against bacterial mRNAs and other macromolecules associated with a biochemical pathway and/or cellular process, and related compositions and methods of using the oligomers and compositions to treat an infected mammalian subject, for example, as primary antimicrobials or as adjunctive therapies with classic antimicrobials.
    Type: Grant
    Filed: December 22, 2016
    Date of Patent: October 12, 2021
    Assignees: Board of Regents, The University of Texas System, Oregon State University
    Inventors: David Greenberg, Bruce L. Geller
  • Patent number: 11143661
    Abstract: An antibody and/or binding fragment thereof, wherein the antibody and/or binding fragment thereof comprises a light chain variable region and a heavy chain variable region, the light chain variable region comprising complementarity determining region (CDR) CDR-L3 and the heavy chain variable region comprising CDR-H1, CDR-H2 and CDR-H3, with the amino acid sequences of said CDRs comprising one or more of the sequences set forth below: CDR-L3; selected from any one of SEQ ID NOs: 123, 126-130, 142, 148 or 149; CDR-H1: SEQ ID NOs: 121 or 124; CDR-H2; SEQ ID NOs: 122 or 125; and/or CDR-H3: selected from any one of SEQ ID NOs: 196-226.
    Type: Grant
    Filed: May 22, 2020
    Date of Patent: October 12, 2021
    Assignees: The Governing Council of the University of Toronto, Board of Regents, The University of Texas System
    Inventors: Sachdev S. Sidhu, Sarah L. Barker, Orson W. Moe, Makoto Kuro-o, Johanne Pastor
  • Patent number: 11141418
    Abstract: In one aspect, the disclosure relates to compounds that are inhibitors of KRAS, and the disclosed compounds are allosteric inhibitors of KRAS which render them extremely useful for therapeutic intervention in a variety of disorders and diseases in which inhibition of DHODH can be clinically useful, e.g., cancer. In various aspects, the disclosed compounds are substituted 7-(piperazin-1-yl)pyrazolo[1,5-a]pyrimidine analogs. In further aspects, the disclosed compounds can be used in methods of treating a cancer. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
    Type: Grant
    Filed: June 24, 2019
    Date of Patent: October 12, 2021
    Assignee: THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Alemayehu Gorfe Abebe, Michael J. McCarthy, Cynthia V. Pagba, Priyanka Prakash Srivastava
  • Patent number: 11143671
    Abstract: In the system and method disclosed, an ultrahigh vacuum (UHV) scanning tunneling microscope (STM) tip is used to selectively desorb hydrogen atoms from the Si(100)-2X1:H surface by injecting electrons at a negative sample bias voltage. A new lithography method is disclosed that allows the STM to operate under imaging conditions and simultaneously desorb H atoms as required. A high frequency signal is added to the negative sample bias voltage to deliver the required energy for hydrogen removal. The resulted current at this frequency and its harmonics are filtered to minimize their effect on the operation of the STM's feedback loop. This approach offers a significant potential for controlled and precise removal of hydrogen atoms from a hydrogen-terminated silicon surface and thus may be used for the fabrication of practical silicon-based atomic-scale devices.
    Type: Grant
    Filed: November 4, 2020
    Date of Patent: October 12, 2021
    Assignee: Board of Regents, The University of Texas System
    Inventors: Seyed Omid Reza Moheimani, Hamed Alemansour
  • Publication number: 20210312183
    Abstract: A system and method are provided for accurately recognizing actions and estimating action intensity. To enable the system to deal with the uncertainty and varied nature inherent in action recognition and intensity indexing, the system is a hybrid system that combines the concept of fuzzy logic and deep recurrent neural networks. The methodology is an attentive neuro-fuzzy system designed to recognize qualitative differences in human actions and to self-adapt to different intensities. The model of the system and method utilizes recurrent neural networks to detect actions from spatio-temporal patterns of human poses, in tandem with an adaptive fuzzy inference system to learn the various human motions used to perform actions with different intensities and then estimate the action's intensity. The integrated model can successfully learn the unique way a specific action with a certain intensity is performed and can estimate the intensity of the respective action.
    Type: Application
    Filed: April 5, 2021
    Publication date: October 7, 2021
    Applicant: Board of Regents, The University of Texas System
    Inventors: Nihar Shrikant Bendre, Nima Ebadi, Peyman Najafirad
  • Publication number: 20210308287
    Abstract: Disclosed herein are methods preparing a purified, carrier-free 68Ga solution. Tire present disclosure also provides systems for preparing a purified, carrier-free 68Ga solution. The present disclosure also provides compositions comprising the purified, carrier-free 68Ga solutions disclosed herein. Also provided are methods of administering compositions of the present disclosure to a patient in need thereof, for example, for imaging a disease or disorder, such as cancer.
    Type: Application
    Filed: August 2, 2019
    Publication date: October 7, 2021
    Applicant: Board of Regents, The University of Texas System
    Inventors: Mai LIN, Carlos E. GONZALEZ-LEPERA