Patents Assigned to The Board of Regents of the University of Texas Systems
  • Palmerolides: methods of preparation and derivatives thereof
    Patent number: 7838691
    Abstract: Organic compounds having Formulas I and II are provided where the variables have the values described herein. Pharmaceutical formulations include the organic compounds or pharmaceutically acceptable salts thereof and a pharmaceutically acceptable carrier can be prepared. Methods of preparing the compounds includes deprotecting protected precursor compounds. Methods of treating cancer or inhibiting ATPase include administering the organic compounds to a subject in need thereof.
    Type: Grant
    Filed: April 4, 2008
    Date of Patent: November 23, 2010
    Assignee: Board of Regents, of the University of Texas System
    Inventors: Jef K. De Brabander, Xin Jiang, Bo Liu
  • USE OF FLUOROCARBON SURFACTANTS TO IMPROVE THE PRODUCTIVITY OF GAS AND GAS CONDENSATE WELLS
    Publication number: 20100292110
    Abstract: The present invention includes composition having a nonionic, fluorinated polymeric surfactant, water and solvent. Embodiments of compositions according to the present invention are useful, for example, for recovering hydrocarbons from subterranean clastic formations.
    Type: Application
    Filed: June 30, 2010
    Publication date: November 18, 2010
    Applicants: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, 3M INNOVATIVE PROPERTIES COMPANY
    Inventors: Gary A. Pope, Mukul M. Sharma, Viren Kumar, Jimmie R. Baran
  • NUCLEIC ACID MOLECULES AND PROTEINS FOR THE IDENTIFICATION, ASSESSMENT, PREVENTION, AND THERAPY OF OVARIAN CANCER
    Publication number: 20100291068
    Abstract: The invention relates to newly discovered nucleic acid molecules and proteins associated with ovarian cancer. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human ovarian cancers are provided.
    Type: Application
    Filed: March 8, 2010
    Publication date: November 18, 2010
    Applicants: MILLENNIUM PHARMACEUTICALS, INC., Board of Regents, The University of Texas System
    Inventors: Wilson O. Endege, Donna Ford, Manjula Gannavarapu, Karen Glatt, Sebastian Hoersch, Shubhangi Kamatkar, John E. Monahan, Robert Schlegel, Yong Yao Xu, Xumei Zhao, Robert C. Bast, JR., Gordon B. Mills, Karen Lu
  • TRYPHOSTIN-ANALOGS FOR THE TREATMENT OF CELL PROLIFERATIVE DISEASES
    Publication number: 20100292229
    Abstract: The present invention concerns compounds and their use to treat cell proliferative diseases such as cancer. In general aspects, compounds of the present invention are tyrphostin-like in structure. Compounds of the present invention, in certain embodiments, display significant potency by causing, for example, inhibition of Stat3 activation, reduction in c-myc protein levels and/or induction of apoptosis in tumor cells. In general aspects, compounds of the present invention induce one or more of these activities at nanomolar concentrations and typically function through a unique mechanism involving the induction of stress granules that bind specific signaling molecules and prevent them from participating in signal transduction and oncogenesis.
    Type: Application
    Filed: July 2, 2007
    Publication date: November 18, 2010
    Applicant: The Board of Regents of the University of Texas System
    Inventors: Nicholas J Donato, David Maxwell, Moshe Talpaz, William Bornmann, Zhenghong PENG, Ashutosh Pal, Dongmei Han, Shimei Wang, Geoffrey Bartholomeusz, Vaibhav Kapuria
  • SCREENING SYSTEM FOR DETECTING INHIBITORS OF HIV INTEGRASE-LEDGF/p-75 INTERACTION
    Publication number: 20100291606
    Abstract: The development and validation of a cell-based, homogeneous high throughput screening (HTS) assay for small compounds inhibiting the HIV integrase-LEDGF/p75 interaction is described herein. The HTS strategy has the potential to identify small-molecules interfering with the interaction of HIV integrase-LEDGF/p75. These small molecules represent starting scaffolds for therapeutic drug development.
    Type: Application
    Filed: May 13, 2010
    Publication date: November 18, 2010
    Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Manuel Llano, Elisa Morales
  • RETICULATED MESH ARRAYS AND DISSIMILAR ARRAY MONOLITHS BY ADDITIVE LAYERED MANUFACTURING USING ELECTRON AND LASER BEAM MELTING
    Publication number: 20100291401
    Abstract: Compositions and methods for making a three dimensional structure comprising: designing a three-dimensional structure; melting the three-dimensional structure from two or more layers of a metal powder with a high energy electron or laser beam is described herein. The position where the metal is melted into the structure is formed along a layer of metal powder, wherein the location and intensity of the beam that strikes the metal layer is based on the three-dimensional structure and is controlled and directed by a processor. The instant invention comprises a novel dry state sonication step for removing metal powder that is not melted from the three dimensional structure.
    Type: Application
    Filed: May 14, 2010
    Publication date: November 18, 2010
    Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Frank Medina, Lawrence Murr, Ryan Wicker, Sara Gaytan
  • SYSTEMS AND METHODS INCLUDING SELF-CONTAINED CARTRIDGES WITH DETECTION SYSTEMS AND FLUID DELIVERY SYSTEMS
    Publication number: 20100291588
    Abstract: Methods, systems, and apparatus for detecting the presence of analytes are described. A fluid or gas sample may pass through a microsieve-based detection system and/or a particle-based detection system of a cartridge. Detection and analysis techniques may be applied to determine the identity and quantity of the captured analytes.
    Type: Application
    Filed: June 23, 2006
    Publication date: November 18, 2010
    Applicant: The Board of Regents of the University of Texas System
    Inventors: John T. McDevitt, Karri Ballard, Nicolaos J. Christodoulides, Pierre N. Floriano, Glennon W. Simmons
  • Plasmonic laser nanoablation methods
    Patent number: 7834331
    Abstract: A novel femtosecond laser nano-ablation technique called Plasmonic Laser Nano-Ablation (PLN). The technique takes advantage of surface-enhanced plasmonic scattering of ultrashort laser pulses by nanoparticles to vaporize sub-cellular structures in attoliter volumes. The use of nanoparticles may overcome problems associated with current FLMS techniques and does not rely on heating for nanodisruption. In PLN, the particle acts as a “nano-lens,” restricting laser light to the near-field of the particle, and only photodisrupting structures that are nanometers away. This eliminates the need for a tightly focused beam, while still achieving nanoscale ablation resolution. Moreover, the enhanced scattering around the particles reduces the amount of required laser fluence.
    Type: Grant
    Filed: August 1, 2008
    Date of Patent: November 16, 2010
    Assignee: Board of Regents, The University of Texas System
    Inventors: Adela Ben-Yakar, Daniel Eversole, Xun Guo
  • SYSTEMS, DEVICES AND METHODS FOR IMAGING AND SURGERY
    Publication number: 20100286674
    Abstract: Provided herein are devices, systems and methods for imaging of biological tissue. Also provided are devices, systems and methods for surgical manipulation of biological tissue. Further provided are devices, systems and methods for combined imaging and surgical manipulation of biological tissue.
    Type: Application
    Filed: January 22, 2009
    Publication date: November 11, 2010
    Applicants: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, BOARD OF TRUSSTESS OF THE LELAND STANFORD JUNIOR U
    Inventors: Adela Ben-Yakar, Christopher L. Hoy, Olav Solgaard
  • Peptides of CaV2.2 that inhibit pain
    Patent number: 7829688
    Abstract: The present invention relates to peptides of CaV2.2 and their use in the treatment of pain. The sequence of the peptides is derived from the C-terminus of CaV2.2. and is believed to inhibit the interaction of CaV2.2 with Mint1-PDZ1. The invention is related to use of this peptide to treat pain and to use of this peptide in binding reaction with int-PDZ to screen for small molecules that can inhibit pain.
    Type: Grant
    Filed: August 12, 2008
    Date of Patent: November 9, 2010
    Assignee: The Board of Regents of the University of Texas System
    Inventors: Mary Garry, Ilya Bezprozvanny
  • Artificial disulfide isomerases and uses thereof
    Patent number: 7829687
    Abstract: The present invention provides artificial enzymes comprising, e.g., an N-terminal domain derived from E. coli FkpA that allows for dimerization and provides a substrate binding region, and a C-terminal thioredoxin domain derived from E. coli DsbA. Similar to DsbC, such de novo designed chimeric (hybrid) FkpA-DsbA enzymes function, as disulfide reductases, oxidases, or isomerases, and chaperones in vivo and in vitro, despite lacking similarity to DsbC-related polypeptide sequence.
    Type: Grant
    Filed: April 5, 2007
    Date of Patent: November 9, 2010
    Assignee: The Board of Regents of the University of Texas System
    Inventors: George Georgiou, Laura Segatori
  • Method for providing fault tolerance to multiple servers
    Patent number: 7831859
    Abstract: A method for providing fault tolerance to multiple computer servers is disclosed. Basically, t backup computer servers are utilized to back up data from multiple active computer servers such that up to t faults can be tolerated. Data from the active computer servers are categorized under their respective data structure accordingly. In response to any access to data within one or more of the active computer servers, backup operations are performed on the accessed data in the t backup computer servers according to their data structures such that data with similar data structures are grouped under their respective fusible data structure within the t backup computer servers.
    Type: Grant
    Filed: June 17, 2008
    Date of Patent: November 9, 2010
    Assignee: The Board of Regents, University of Texas System
    Inventors: Vijay K. Garg, Vinit A. Ogale
  • Compositions and methods for modifying toxic effects of proteinaceous compounds
    Patent number: 7829668
    Abstract: The present invention provides methods to produce immunotoxins (ITs) and cytokines with a reduced ability to promote vascular leak syndrome (VLS). The invention also provides ITs and cytokines which have been mutated to lack amino acid sequences which induce VLS. Also disclosed are methods for producing peptides that inhibit the induction of VLS by ITs and cytokines. Also disclosed are peptides comprising the (x)D(y) sequence to promote the extravasation of other molecules. Toxins mutated in the (x)D(y) motif or active site residues are disclosed for used in vaccines.
    Type: Grant
    Filed: May 19, 2003
    Date of Patent: November 9, 2010
    Assignee: Board of Regents, The University of Texas System
    Inventors: Ellen S. Vitetta, Victor F. Ghetie, Joan Elizabeth Smallshaw, Roxana G. Baluna
  • DETECTION OF SALIVA PROTEINS MODULATED SECONDARY TO DUCTAL CARCINOMA IN SITU OF THE BREAST
    Publication number: 20100279419
    Abstract: A method of differentiating among the presence of ductal carcinoma in situ in the breast, benign fibroadenoma of the breast, and non-cancerous breast tissue in a subject is disclosed. The method comprises: measuring the concentration of at least one protein biomarker selected from a group of forty-nine differentially expressed proteins in the saliva of persons with DCIS, or benign fibroadenoma, or in persons who are cancer-free. The resulting test data is compared to a reference panel. From the comparison the presence in the subject of either ductal carcinoma in situ of the breast, or benign fibroadenoma of the breast is determined.
    Type: Application
    Filed: September 11, 2008
    Publication date: November 4, 2010
    Applicant: BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Charles F. Streckfus, William P. Dubinsky, Lenora R. Bigler
  • PHARMACEUTICAL TREATMENT EFFECTIVENESS ANALYSIS COMPUTER SYSTEM AND METHODS
    Publication number: 20100280846
    Abstract: Computer-implemented systems, program code, and related methods are provided. The systems, program code, and methods can be employed to analyze the effectiveness of pharmaceutical treatments for medical conditions utilizing real time prescription compliance records. Information related to medical history of a patient can be reviewed while simultaneously reviewing prescription compliance records for the same patient. Trends in target and non-target medical parameters can be identified and correlated with the prescription compliance records to determine the effectiveness of a pharmaceutical treatment on target and non-target medical parameters that various compliance and prescription levels.
    Type: Application
    Filed: July 16, 2010
    Publication date: November 4, 2010
    Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Leon M. Clements, Glenn G. Hammack
  • High concentration baclofen preparations
    Patent number: 7824697
    Abstract: Stable aqueous solutions comprising concentrations of baclofen in the range of greater than 2.0 mg/mL up to about 10 mg/mL are disclosed. These solutions can be used as pharmaceuticals for parenteral or oral administration. The invention also provides methods of preparing said stable aqueous baclofen solutions.
    Type: Grant
    Filed: June 17, 2005
    Date of Patent: November 2, 2010
    Assignee: Board of Regents, The University of Texas System
    Inventors: Lawrence A. Trissel, Yanping Zhang
  • Ligands for nematode nuclear receptors and uses thereof
    Patent number: 7825269
    Abstract: Anti-nematode compounds, compositions, and methods for identifying such compounds are disclosed, where the compounds have the formula I: where Q, Q?, R1, R2, and n are defined herein.
    Type: Grant
    Filed: March 8, 2007
    Date of Patent: November 2, 2010
    Assignee: Board of Regents, University of Texas System
    Inventors: David J. Mangelsdorf, Richard J. Auchus, Daniel L. Motola, Carolyn L. Cummins, Kamalesh K. Sharma
  • METHOD OF OBTAINING A TREATMENT COMPOSITION FOR IMPROVING THE PRODUCTIVITY OF HYDROCARBON PRODUCING WELLS
    Publication number: 20100270019
    Abstract: A method of obtaining a treatment composition for treating a hydrocarbon-bearing clastic formation having brine therein to enhance recovery of hydrocarbon from the formation.
    Type: Application
    Filed: August 22, 2007
    Publication date: October 28, 2010
    Applicants: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, 3M INNOVATIVE PROPERTIES COMPANY
    Inventors: Gary A. Pope, Jimmie R. Baran, JR.
  • Electronic textiles with electronic devices on ribbons
    Patent number: 7820497
    Abstract: Ribbons containing e.g. inorganic NMOS devices are assembled in electrical contact with ribbons containing e.g. PMOS devices (preferably organic) to enable flexible electronic textile circuits to be inexpensive and practical for a wide variety of functions. The use of ribbons provides flexibility, reduces costs, and allows testing during assembly and different processes to be efficiently used for different components. This is apparently the first time that ribbons (especially inorganic-device-containing ribbons) have been interconnected to form a flexible CMOS electronic textile.
    Type: Grant
    Filed: January 29, 2008
    Date of Patent: October 26, 2010
    Assignee: Board of Regents, The University of Texas System
    Inventor: Bruce Gnade
  • Composition and method for the treatment of diseases affected by a peptide receptor
    Patent number: 7816324
    Abstract: The present invention includes peptidomimetic compound compositions and methods of making and using peptidomimetic compounds to modulate the activity of a peptide receptor for the treatment of one or more of hyperglycemia, insulin resistance, hyperinsulinemia, obesity, hyperlipidemia, hyperlipoproteinemia or other symptoms that relate to the function of the targeted receptor. The peptidomimetic includes an oligo-benzamide compound having at least three optionally substituted benzamides.
    Type: Grant
    Filed: March 13, 2008
    Date of Patent: October 19, 2010
    Assignee: Board of Regents, The University of Texas System
    Inventors: Jung-Mo Ahn, Martin Beinborn