Patents Assigned to The Board of Regents of the University of Washington
  • Patent number: 5714146
    Abstract: An in vivo assay for selecting a candidate therapeutic for treating osteoporosis. A candidate reagent is administered to an IL-4 transgenic mammal whose cells contain a recombinant IL-4 coding sequence operably lined to a promoter sequence which is transcriptionally active in bone marrow cells. At the time the candidate reagent is first administered the IL-4 transgenic mammal is either symptomatic of, or asymptomatic of, an osteoporotic phenotype. The candidate reagent is selected as a candidate therapeutic for treating osteoporosis if either amelioration of, or delay in the onset of, the osteoporotic phenotype is observed following administration of the candidate reagent to the IL-4 transgenic mammal.
    Type: Grant
    Filed: April 7, 1995
    Date of Patent: February 3, 1998
    Assignee: Board of Regents of the University of Washington
    Inventors: David B. Lewis, Roger M. Perlmutter
  • Patent number: 5706208
    Abstract: A method for predicting a property of a matter of biological origin, such as biological fluid, containing water, where the biological matter may be approximated to contain two compartments where one compartment has a proportionally larger or smaller amount of water than the other compartment having the property of interest. The method establishes a training set in the near-infrared (NIR) region with independent quantification of the property of the matter using known techniques. The training set is mathematically analyzed according to a correlation developed by regression analysis after employment of a ratio pre-processing technique. The result is a mathematical transformation equation which quantitatively relates spectral intensities at specific wavelengths to the property of interest. This transformation equation may be applied to unknown samples so as to predict their properties, thereby eliminating need for the reference method except for validation or recalibration.
    Type: Grant
    Filed: December 22, 1992
    Date of Patent: January 6, 1998
    Assignees: Minnesota Mining And Manufacturing Company, The Board of Regents of The University of Washington
    Inventors: David W. Osten, James B. Callis
  • Patent number: 5702936
    Abstract: The present invention provides novel purified and isolated nucleotide sequences encoding the cGMP-binding, cGMP-specific phosphodiesterase designated cGB-PDE. Also provided by the invention are methods and materials for the recombinant production of cGB-PDE polypeptide products and methods for identifying compounds which modulate the enzymatic activity of cGB-PDE polypeptides.
    Type: Grant
    Filed: May 27, 1994
    Date of Patent: December 30, 1997
    Assignees: ICOS Corporation, Vanderbilt University, Board of Regents of the University of Washington
    Inventors: Joseph A. Beavo, Jackie D. Corbin, Kenneth M. Ferguson, Sharron H. Francis, Ann Kadlecek, Kate Loughney, Linda M. McAllister-Lucas, William K. Sonnenburg, Melissa K. Thomas
  • Patent number: 5690635
    Abstract: A prosthesis template for aiding in the determination of a desired position of a prosthesis relative to a bone, the prosthesis having an exterior surface that simulates the exterior surface of the bone and an interior surface comprised of one or more contact surfaces to which the prepared bone must conform to provide an adequate fit of the prosthesis. The template comprises a template member having an interior surface which corresponds to an exterior surface of the prosthesis, whereby the template can be positioned adjacent to the bone and thereby provide means for evaluating a desired position of the prosthesis exterior surface.
    Type: Grant
    Filed: November 14, 1994
    Date of Patent: November 25, 1997
    Assignee: The Board of Regents of the University of Washington
    Inventors: Frederick A. Matsen, III, Joseph L. Garbini, John A. Sidles, Donald C. Baumgarten, Brian S. Pratt
  • Patent number: 5663314
    Abstract: An isolated nucleic acid molecule which hybridizes under stringent conditions with the nucleic acid shown in SEQ ID NO:32 or its complement or the nucleic acid shown in SEQ ID NO:34 or its complement, and which encodes mitogen activated protein kinase kinase protein.
    Type: Grant
    Filed: April 18, 1995
    Date of Patent: September 2, 1997
    Assignee: The Board of Regents of the University of Washington
    Inventors: Rony Seger, Dalia Seger, Natalie G. Ahn, Edwin G. Krebs
  • Patent number: 5659327
    Abstract: A virtual retinal display utilizes photon generation and manipulation to create a panoramic, high resolution, color virtual image that is projected directly onto the retina of the eye without creating a real or an aerial image that is viewed via a mirror or optics. The virtual retinal display includes a source of photons, the photons being modulated with video information and scanned in a raster type of pattern directly onto the retina of the user's eye. The photon generator may utilize coherent or non-coherent light. Further, the photon generator may utilize color light generators so as to scan a colored virtual image directly onto the retina of the user's eye. The virtual retinal display may also include a depth accommodation cue to vary the focus of scanned photons rapidly so as to control the depth perceived by a user for each individual picture element of the virtual image.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: August 19, 1997
    Assignee: Board of Regents of the University of Washington
    Inventors: Thomas Adrian Furness, III, Joel S. Kollin
  • Patent number: 5652131
    Abstract: The present invention provides novel purified and isolated nucleotide sequences encoding the cGMP-binding, cGMP-specific phosphodiesterase designated cGB-PDE. Also provided by the invention are methods and materials for the recombinant production of cGB-PDE polypeptide products and methods for identifying compounds which modulate the enzymatic activity of cGB-PDE polypeptides.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: July 29, 1997
    Assignees: ICOS Corporation, Vanderbilt University, Board of Regents of the University of Washington
    Inventors: Joseph A. Beavo, Jackie D. Corbin, Kenneth M. Ferguson, Sharron H. Francis, Ann Kadlecek, Kate Loughney, Linda M. McAllister-Lucas, William K. Sonnenburg, Melissa K. Thomas
  • Patent number: 5648076
    Abstract: Methods for inhibiting vascular stenosis in a mammal, including restenosis following surgical removal of atherosclerotic plaques. Inhibition is achieved through the administration of anti-growth factor antibodies, including anti-FGF antibodies and anti-PDGF antibodies.
    Type: Grant
    Filed: July 26, 1994
    Date of Patent: July 15, 1997
    Assignee: Board of Regents of University of Washington
    Inventors: Russell Ross, Michael A. Reidy, Elaine W. Raines, Volkhard Lindner, Gordon A. A. Ferns
  • Patent number: 5602306
    Abstract: The present invention relates to the synthesis of functional human hemoglobin and other proteins in erythroid tissues of transgenic non-human animals and erythroid cell lines. It is based on the discovery that two of the five hypersensitivity sites of the .beta.-globin locus are sufficient to result in high level expression of human .alpha.- or .beta.-globin transgenes. The present invention also provides for novel recombinant nucleic acid vectors which may be used to produce .alpha.-globin as well as other proteins of interest in quantity in the red blood cells of transgenic animals or cell cultures of erythroid lineage. The vectors of the invention comprise at least one of the major DNase I hypersensitivity sites associated with the .beta.-globin locus together with a gene of interest. In a specific embodiment of the invention, a vector which comprises two DNase I hypersensitivity sites together with the human .alpha.-globin gene is used to create transgenic animals which produce human .alpha.
    Type: Grant
    Filed: July 13, 1994
    Date of Patent: February 11, 1997
    Assignees: The UAB Research Foundation, The Trustees of the University of Pennslyvania, Board of Regents of the University of Washington
    Inventors: Tim M. Townes, Thomas M. Ryan, Richard D. Palmiter, Ralph L. Brinster, Richard R. Behringer
  • Patent number: 5602019
    Abstract: The present invention relates to novel purified and isolated nucleotide sequences encoding mammalian Ca.sup.2+ /calmodulin stimulated phosphodiesterases (CaM-PDEs) and cyclic-GMP-stimulated phosphodiesterases (cGS-PDEs). Also provided are the corresponding recombinant expression products of said nucleotide sequences, immunological reagents specifically reactive therewith, and procedures for identifying compounds which modulate the enzymatic activity of such expression products.
    Type: Grant
    Filed: August 29, 1994
    Date of Patent: February 11, 1997
    Assignee: The Board of Regents of The University of Washington
    Inventors: Joseph A. Beavo, Kelley J. Bentley, Harry Charbonneau, William K. Sonnenburg
  • Patent number: 5580771
    Abstract: The present invention relates to novel purified and isolated nucleotide sequences encoding mammalian Ca.sup.2+ /calmodulin stimulated phosphodiesterases (CaM-PDEs) and cyclic-GMP-stimulated phosphodiesterases (cGS-PDEs). Also provided are the corresponding recombinant expression products of said nucleotide sequences, immunological reagents specifically reactive therewith, and procedures for identifying compounds which modulate the enzymatic activity of such expression products.
    Type: Grant
    Filed: August 29, 1994
    Date of Patent: December 3, 1996
    Assignee: The Board of Regents of the University of Washington
    Inventors: Joseph A. Beavo, Harry Charbonneau, William K. Sonnenburg
  • Patent number: 5571110
    Abstract: An orthopedic saw guide for confining the blade of a surgical saw to movement in a single plane while allowing translational and rotational movement of the blade within the plane. A pair of elongated guideplates are secured together at either end to form a partially enclosed space. The distance between the inner surfaces of the guide plates is adjustable, and is preferably adjusted to be slightly greater than the thickness of the specific blade to be used. Mounting means is provided for rigidly securing the saw guide relative to the bone, so that the plane defined by the space between the inner surfaces corresponds to the cut plane. The inner surfaces of the guide plates include guide liners that are comprised of a low-friction material. The liners may be permanently secured to the guide plates or removable and disposable.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 5, 1996
    Assignee: Board of Regents of the University of Washington
    Inventors: Frederick A. Matsen, III, Joseph L. Garbini, John A. Sidles, Donald C. Baumgarten, Brian S. Pratt
  • Patent number: 5469403
    Abstract: A transponder of an active digital sonar system identifies a multifrequency underwater activating sonar signal received from a remote sonar transmitter. The transponder includes a transducer that receives acoustic waves, including the activating sonar signal, and generates an analog electrical receipt signal. The analog electrical receipt signal is converted to a digital receipt signal and cross-correlated with a digital transmission signal pattern corresponding to the activating sonar signal. A relative peak in the cross-correlation value is indicative of the activating sonar signal having been received by the transponder. In response to identifying the activating sonar signal, the transponder transmits a responding multifrequency sonar signal.
    Type: Grant
    Filed: August 11, 1992
    Date of Patent: November 21, 1995
    Assignee: Board of Regents of the University of Washington
    Inventors: Kenneth K. Young, R. Jeffrey Wilkes
  • Patent number: 5467104
    Abstract: A virtual retinal display utilizes photon generation and manipulation to create a panoramic, high resolution, color virtual image that is projected directly onto the retina of the eye without creating a real or an aerial image that is viewed via a mirror or optics. The virtual retinal display includes a source of photons, the photons being modulated with video information and scanned in a raster type of pattern directly onto the retina of the user's eye. The photon generator may utilize coherent or non-coherent light. Further, the photon generator may utilize color light generators so as to scan a colored virtual image directly onto the retina of the user's eye. The virtual retinal display may also include a depth accommodation cue to vary the focus of scanned photons rapidly so as to control the depth perceived by a user for each individual picture element of the virtual image.
    Type: Grant
    Filed: October 22, 1992
    Date of Patent: November 14, 1995
    Assignee: Board of Regents of the University of Washington
    Inventors: Thomas A. Furness, III, Joel S. Kollin
  • Patent number: 5467459
    Abstract: The present invention provides a unified image and graphics processing system that provides both image and graphics processing at high speeds. The system includes a parallel vector processing unit, a graphics subsystem, a shared memory and a set of high-speed data buses for connecting all of the other components. Generally, the parallel vector processing unit includes a series of vector processors. Each processor includes a vector address generator for efficient generation of memory addresses for regular address sequences. In order to synchronize and control the vector processors' accesses to shared memory, the parallel vector processing unit includes shared memory access logic. The logic is incorporated into each vector processor. The graphics subsystem includes a series of polygon processors in a pipelined configuration. Each processor is connected in the pipeline by a first-in-first-out (FIFO) buffer for passing data results.
    Type: Grant
    Filed: August 2, 1993
    Date of Patent: November 14, 1995
    Assignees: Board of Regents of the University of Washington, Samsung Electronics
    Inventors: Thomas Alexander, Yongmin Kim, Hyunwook Park, Kil-Su Eo, Jing-Ming Jong
  • Patent number: 5459677
    Abstract: A technique for transferring a multivariant calibration model from a reference analytical instrument to a target analytical instrument that may be a different instrument, or the same instrument at a later time. In a "direct" approach, a plurality of transfer samples are selected, and a plurality of measurements are made for each transfer sample using the reference instrument, producing a reference instrument response for each sample. These measurements are repeated for the target instrument, to produce a target instrument response for each transfer sample. One then generates transfer coefficients capable of performing a multivariate estimation of the reference instrument responses for the transfer samples from the target instrument responses for those samples. The transfer coefficients may then be used to convert a target instrument response for an unknown sample into the equivalent response for the reference instrument.
    Type: Grant
    Filed: June 24, 1991
    Date of Patent: October 17, 1995
    Assignee: Board of Regents of the University of Washington
    Inventors: Bruce R. Kowalski, David J. Veltkamp, Yong D. Wang
  • Patent number: 5434084
    Abstract: There is disclosed a device capable of continuously measuring the presence and concentration of an analyte or analytes and a method for using said device in a liquid and/or a gas phase reaction volume. The inventive device comprises a sensor probe, a reservoir, and a detector. The inventive device delivers reagent to the sensor probe in a flow method to directly and continuously renew reagent, thereby allowing the continuous measurement of the presence and the concentration of an analyte or analytes.
    Type: Grant
    Filed: September 6, 1989
    Date of Patent: July 18, 1995
    Assignees: The Washington Research Foundation, The Board of Regents of the University of Washington
    Inventor: Lloyd W. Burgess, Jr.
  • Patent number: 5424187
    Abstract: Method of diagnosing arterial chlamydial granuloma by detecting in a biological sample both a first marker associated with Chlamydia pneumoniae and a second marker associated with arterial granuloma. Therapeutic composition for treating arterial chlamydial granulomatous disease, including an anti-Chlamydia pneumoniae agent and a granuloma inhibitor.
    Type: Grant
    Filed: June 12, 1992
    Date of Patent: June 13, 1995
    Assignees: Board of Regents of the University of Washington, Allan Shor
    Inventors: Allan Shor, Cho-chou Kuo
  • Patent number: 5409010
    Abstract: An ultrasonic pulse-echo medical device for determining the angular heading and magnitude of the velocity of blood flowing through a blood vessel by transmitting a pulsed ultrasonic beam from a single transmitting transducer and receiving echoes from sample volumes along such beam by a plurality of ultrasound receiving transducers. Independent motions in the same sample volume, such as those of a moving vessel wall and the motion of blood flowing through the blood vessel, can be separately analyzed and displayed.
    Type: Grant
    Filed: May 19, 1992
    Date of Patent: April 25, 1995
    Assignee: Board of Regents of the University of Washington
    Inventors: Kirk Beach, John Overbeck
  • Patent number: 5403319
    Abstract: A system and method for positioning a tool relative to a patient's bone to facilitate the performance of a surgical bone alteration task. The system comprises a bone immobilization device for supporting the bone in a fixed position with respect to a reference structure, and a robot that includes a base fixed in position with respect to the reference structure. The bone imobilization device includes two semicircular frame pieces having a plurality of radial apertures through which bone gripping components adjustably extend in order to contact the bone. The bone gripping components include a shaft with a point inserted through a shaft bore of a serrated bone contact element. A support attaches to the frame to adjustably secure and position the frame relative to the reference structure.
    Type: Grant
    Filed: June 4, 1993
    Date of Patent: April 4, 1995
    Assignee: Board of Regents of the University of Washington
    Inventors: Frederick A. Matsen, III, Joseph L. Garbini, John A. Sidles, Donald C. Baumgarten, Brian S. Pratt