Patents Assigned to The Board of Regents the Univeristy of Texas System
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Publication number: 20230172949Abstract: Compositions and methods for making a pharmaceutical dosage form include making a pharmaceutical composition that includes one or more active pharmaceutical ingredients (API) with one or more pharmaceutically acceptable excipients by thermokinetic compounding into a composite. Compositions and methods of preprocessing a composite comprising one or more APIs with one or more excipients include thermokinetic compounding, comprising thermokinetic processing the APIs with the excipients into a composite, wherein the composite can be further processed by conventional methods known in the art, such as hot melt extrusion, melt granulation, compression molding, tablet compression, capsule filling, film-coating, or injection molding.Type: ApplicationFiled: July 25, 2022Publication date: June 8, 2023Applicants: BOARD OF REGENTS, THE UNIVERISTY OF TEXAS SYSTEM, AustinPx, LLCInventors: Chris BROUGH, James W. MCGINITY, Dave A. MILLER, James C. DINUNZIO, Robert O. WILLIAMS, III
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Publication number: 20200261473Abstract: Compositions and methods for making a pharmaceutical dosage form include making a pharmaceutical composition that includes one or more active pharmaceutical ingredients (API) with one or more pharmaceutically acceptable excipients by thermokinetic compounding into a composite. Compositions and methods of preprocessing a composite comprising one or more APIs with one or more excipients include thermokinetic compounding, comprising thermokinetic processing the APIs with the excipients into a composite, wherein the composite can he further processed by conventional methods known in the art, such as hot melt extrusion, melt granulation, compression molding, tablet compression, capsule filling, film-coating, or injection molding.Type: ApplicationFiled: May 5, 2020Publication date: August 20, 2020Applicants: BOARD OF REGENTS, THE UNIVERISTY OF TEXAS SYSTEM, DISPERSOL TECHNOLOGIES, LLCInventors: Chris BROUGH, James W. MCGINITY, Dave A. MILLER, James C. DINUNZIO, Robert O. WILLIAMS, III
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Publication number: 20180360850Abstract: Compositions and methods for making a pharmaceutical dosage form include making a pharmaceutical composition that includes one or more active pharmaceutical ingredients (API) with one or more pharmaceutically acceptable excipients by thermokinetic compounding into a composite. Compositions and methods of preprocessing a composite comprising one or more APIs with one or more excipients include thermokinetic compounding, comprising thermokinetic processing the APIs with the excipients into a composite, wherein the composite can be further processed by conventional methods known in the art, such as hot melt extrusion, melt granulation, compression molding, tablet compression, capsule filling, film-coating, or injection molding.Type: ApplicationFiled: June 19, 2018Publication date: December 20, 2018Applicants: BOARD OF REGENTS, THE UNIVERISTY OF TEXAS SYSTEM, DISPERSOL TECHNOLOGIES, LLCInventors: Chris BROUGH, James W. MCGINITY, Dave A. MILLER, James C. DINUNZIO, Robert O. WILLIAMS, III
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Patent number: 9801863Abstract: A method of modulating hematopoietic stem cells and hematopoiesis includes administering to a subject in need thereof a 15-PGDH inhibitor.Type: GrantFiled: November 9, 2016Date of Patent: October 31, 2017Assignees: Case Western Reserve University, Board of Regents of the Univeristy of Texas SystemInventors: Sanford Markowitz, Amar Desai, Stanton Gerson, Joseph Ready
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Publication number: 20160250230Abstract: Compositions and methods for making a pharmaceutical dosage form include making a pharmaceutical composition that includes one or more active pharmaceutical ingredients (API) with one or more pharmaceutically acceptable excipients by thermokinetic compounding into a composite. Compositions and methods of preprocessing a composite comprising one or more APIs with one or more excipients include thermokinetic compounding, comprising thermokinetic processing the APIs with the excipients into a composite, wherein the composite can be further processed by conventional methods known in the art, such as hot melt extrusion, melt granulation, compression molding, tablet compression, capsule filling, film-coating, or injection molding.Type: ApplicationFiled: May 13, 2016Publication date: September 1, 2016Applicants: BOARD OF REGENTS, THE UNIVERISTY OF TEXAS SYSTEM, DISPERSOL TECHNOLOGIES, LLCInventors: Chris BROUGH, James W. MCGINITY, Dave A. MILLER, James C. DINUNZIO, Robert O. WILLIAMS, III
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Patent number: 8986737Abstract: A method of treating or preventing infection at a surgical site comprising a bony defect and an implanted metal device is disclosed. Biodegradable microspheres are placed at the site and are capable of near-linear controlled release of an antibiotic agent for a predetermined period of time. The microspheres are configured to be large enough to avoid being phagocytosed and removed from the body, and small enough in diameter to not physically inhibit bone growth at said bony defect site. The microspheres are formed of polylactic-co-glycolic acid (PLGA), with or without polyethylene glycol (PEG), and sufficient antibiotic agent to produce bactericidal levels in body tissues. The microspheres exhibit near-linear delivery of the antibiotic agent for at least 4 weeks at levels exceeding the minimum inhibitory concentration (MIC) for organisms commonly found to be the cause of infections, and facilitate bone ingrowth or regrowth at the site.Type: GrantFiled: December 10, 2008Date of Patent: March 24, 2015Assignees: Wm. Marsh Rice University, Board of Regents of the Univeristy of Texas SystemInventors: Catherine G. Ambrose, Terry A. Clyburn, Antonio G. Mikos
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Publication number: 20130296598Abstract: Alkylthioperoxydiphosphates having an alkyl group between about 4 and 18 carbons, a decomposition temperature between about 150 and 300° C. and a wear volume between about 0.0025 and 0.0015 mm3 in HFRB testing, and methods of making same. Lubricant additives that includes the alkylthioperoxydiphosphates.Type: ApplicationFiled: May 6, 2013Publication date: November 7, 2013Applicant: Board of Regents, The Univeristy of Texas SystemInventors: Pranesh Aswath, Xin Chen, BoHoon Kim, Ronald L. Elsenbaumer
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Publication number: 20130030035Abstract: The present invention relates to the identification of miRNAs that are involved in the process of neuromuscular synaptic maintenance and regeneration following injury or disease. Modulation of these miRNAs is proposed as treatment for spinal cord injury and neurodegenerative disease.Type: ApplicationFiled: June 18, 2012Publication date: January 31, 2013Applicant: Board of Regents, The Univeristy of Texas SystemInventors: Andrew Williams, Eric Olson
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Patent number: 7627938Abstract: The present invention includes device, system, method of using and making a microneedle array including the steps of forming one or more pins on a substrate, depositing one or more layers on the one or more pins and the substrate, exposing a portion of the one or more pins, and separating the one or more pins from the one or more layers to form the hollow microneedle array.Type: GrantFiled: October 15, 2004Date of Patent: December 8, 2009Assignee: Board of Regents, The Univeristy of Texas SystemInventors: Kabseog Kim, Jeong-Bong Lee
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Publication number: 20090290840Abstract: Embodiments herein provide an optical apparatus for focusing and guiding optical energy. An optical apparatus may include a dielectric fiber, a group of metallic wires embedded within the dielectric fiber, and a layer of metal covering an outer surface of the dielectric fiber. The metallic wires may be organized in a converging/diverging manner to guide optical waves. Other embodiments may be disclosed and claimed.Type: ApplicationFiled: September 25, 2008Publication date: November 26, 2009Applicant: The Board of Regents, The Univeristy of Texas SystemInventor: Gennady Shvets
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Publication number: 20080191265Abstract: A method for fabricating a flash memory device where the flash memory device includes a substantially uniform size and spatial distribution of nanoparticles on a tunnel oxide layer to form a floating gate. The flash memory device may be fabricated by defining active areas in a substrate and forming an oxide layer on the substrate. A self-assembled protein lattice may be formed on top of the oxide layer where the self-assembled protein lattice includes a plurality of molecular chaperones. The cavities of the chaperones may provide confined spaces where nanocrystals can be trapped thereby forming an ordered nanocrystal lattice. A substantially uniform distribution of nanocrystals may be formed on the oxide layer upon removal of the self-assembled protein lattice such as through high temperature annealing.Type: ApplicationFiled: May 22, 2006Publication date: August 14, 2008Applicant: Board of Regents, The Univeristy of Texas SystemInventors: Chuanbin Mao, Shan Tang, Sanjay Banerjee
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Patent number: 7223388Abstract: The present invention relates to hyperproliferative diseases. Specifically, the present invention encompasses pharmaceutical compositions comprising a modified Reoviridae virus, wherein the Reoviridae virus is conjugated to a hydroxylated hydrocarbon or a polycationic polymer to reduce the clearance of the composition and reduce the immunogenicity of the composition. Yet further, the invention relates to methods of treating a hyperproliferative disease by administering to a patient an effective amount of the modified Reoviridae virus.Type: GrantFiled: August 2, 2002Date of Patent: May 29, 2007Assignee: Board of Regents, The Univeristy of Texas SystemInventors: Jeffrey Tarrand, Xiang-Yang Han
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Patent number: 6627731Abstract: Thrombin is now known to mediate a number of potent biological effects on cells bearing high-affinity thrombin receptors. These effects depend, at least in part, upon receptor occupancy signals generated by thrombin's interaction with the high affinity thrombin receptor. The present inventors have formulated synthetic thrombin derivatives capable of selectively stimulating or inhibiting thrombin receptor occupancy signals. The stimulatory thrombin derivatives to bind to cell surface thrombin receptors and stimulate DNA synthesis in cells treated with non-mitogenic concentrations of alpha-thrombin or phorbol myristate acetate. Thus, these peptides, which have both a thrombin receptor binding domain and a segment of amino acids with a sequence common to a number of serine proteases, appear to generate receptor-occupancy dependent mitogenic signals.Type: GrantFiled: September 29, 1995Date of Patent: September 30, 2003Assignees: Pharmacia Corporation, The Board of Regents, Univeristy of Texas SystemInventors: Darrell H. Carney, Kevin C. Glenn
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Patent number: 5529914Abstract: This invention provides novel methods for the formation of biocompatible membranes around biological materials using photopolymerization of water soluble molecules. The membranes can be used as a covering to encapsulate biological materials or biomedical devices, as a "glue" to cause more than one biological substance to adhere together, or as carriers for biologically active species. Several methods for forming these membranes are provided. Each of these methods utilizes a polymerization system containing water-soluble macromers, species which are at once polymers and macromolecules capable of further polymerization. The macromers are polymerized using a photoinitiator (such as a dye), optionally a cocatalyst, optionally an accelerator, and radiation in the form of visible or long wavelength UV light. The reaction occurs either by suspension polymerization or by interfacial polymerization.Type: GrantFiled: October 7, 1992Date of Patent: June 25, 1996Assignee: The Board of Regents the Univeristy of Texas SystemInventors: Jeffrey A. Hubbell, Chandrashekhar P. Pathak, Amarpreet S. Sawhney, Neil P. Desai, Syed F. A. Hossainy