Patents Assigned to The Board of Regents The University of Texas System
  • Publication number: 20220257792
    Abstract: Disclosed herein are methods for modulating an amount or activity of a gene or a gene product in a cell. The methods herein may comprise contacting a cell with a therapeutic agent assembled with a lipid composition, which lipid composition may comprise a dendrimer or dendron which may comprise one or more degradable diacyl group, in which may result in modulating the amount or activity of the gene or the gene product in the cell. The therapeutic agent modulating a gene or gene product in a cell may be sufficient to treat a disease or disorder in a subject. Further disclosed herein are pharmaceutical compositions, kits, and lipid compositions for modulating an amount or activity of a gene or a gene product in a cell.
    Type: Application
    Filed: December 30, 2021
    Publication date: August 18, 2022
    Applicant: The Board of Regents of The University of Texas System
    Inventors: Daniel J. SIEGWART, Kejin ZHOU
  • Publication number: 20220262561
    Abstract: In one aspect, described is a magnetic-core inductor design approach that leverages NiZn ferrites with low loss at RF, distributed gaps and field balancing to achieve improved performance eat tens of MHz and at hundreds of watts and above. Also described is an inductor design which achieves “self-shielding” in which the magnetic field generated by the element is wholly contained within the physical volume of the structure rather than extending into space as a conventional air-core inductor would. This approach enables significant reductions of system enclosure volume and improvements in overall system efficiency.
    Type: Application
    Filed: February 18, 2022
    Publication date: August 18, 2022
    Applicants: Massachusetts Institute of Technology, The Trustees of Dartmouth College, Board of Regents, The University of Texas System
    Inventors: Roderick S. BAYLISS, III, David J. PERREAULT, Charles SULLIVAN, Rachel S. YANG, Alex J. HANSON
  • Publication number: 20220257603
    Abstract: Provided herein are methods of treating patients with a combination of an anti-folate agent and an A2BR antagonist. Also provided are methods of treating patients with a combination of an anti-folate agent and an immune checkpoint inhibitor. The patients are selected for treatment based on having an MTAP-deficient cancer.
    Type: Application
    Filed: June 15, 2020
    Publication date: August 18, 2022
    Applicant: Board of Regents, The University of Texas System
    Inventor: Jianjun GAO
  • Publication number: 20220257601
    Abstract: Disclosed herein are compounds and methods for the inhibition of the RNF1 or RNF2 subunit of polycomb repressive complex 1 (PRC1) for the treatment of metastatic cancer, such as metastatic castration-resistant prostate cancer. The inhibitors can be combined with checkpoint inhibitors such as PD-1 inhibitors, PD-L 1 inhibitors, or CTLA-4 inhibitors.
    Type: Application
    Filed: June 26, 2020
    Publication date: August 18, 2022
    Applicants: Board of Regents, The University of Texas System, Memorial Sloan Kettering Cancer Center
    Inventors: Filippo Giancotti, Ouathek Ouerfelli, Wenjing Su, Guangli Yang, Howard Scher, Mohammad Marzabadi
  • Publication number: 20220260062
    Abstract: Actuators (artificial muscles) comprising twisted polymer fibers generate tensile actuation when powered thermally. In some embodiments, the thermally-powered polymer fiber tensile actuator can be incorporated into an article, such as a textile or garment.
    Type: Application
    Filed: October 18, 2021
    Publication date: August 18, 2022
    Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Na Li, Carter S. Haines, Marcio D. Lima, Monica Jung DeAndrade, Shaoli Fang, Jiyoung Oh, Mikhail E. Kozlov, Dongseok Suh, Ray H. Baughman
  • Publication number: 20220259774
    Abstract: Sheath-run artificial muscles (or SRAMs) are described in which the dimensional changes and/or modulus changes of a sheath on the surface of a twisted or coiled host yarn or fiber drives torsional and tensile actuation. The sheath-core artificial muscle includes a sheath on a coiled core yarn or fiber that has inserted twist, in which the sheath does not include a yarn, the coiled core yarn or fiber includes a core yarn or fiber, the sheath can change volume, modulus, or a combination thereof when actuated by an influence source to drive actuation, and the influence source is selected from a group consisting of absorption processes, desorption processes, changes in temperature, changes in external pressure, changes in a magnetic field, changes in an electric field, exposures to actinic radiation, electrochemical charge and discharge, chemical reactions, and combinations thereof.
    Type: Application
    Filed: May 7, 2020
    Publication date: August 18, 2022
    Applicant: Board of Regents, The University of Texas System
    Inventors: Ray H. Baughman, Jiuke Mu, Monica Jung De Andrade, Shaoli Fang, Na Li, Carter S. Haines
  • Patent number: 11413329
    Abstract: The present invention is directed to cancer cell traps and methods of using cancer cell traps to treat and detect metastatic cancer in subjects. The cancer cell traps are administered to subjects and induce the migration and accumulation of metastatic cancer cells in the cancer cell traps.
    Type: Grant
    Filed: October 19, 2013
    Date of Patent: August 16, 2022
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventor: Liping Tang
  • Patent number: 11415456
    Abstract: Certain embodiments are directed to an acoustograph or acoustic sensor configured as a thermometer or direct specific absorption rate (DSAR) sensor for the measurement of electromagnetic energy.
    Type: Grant
    Filed: September 15, 2016
    Date of Patent: August 16, 2022
    Assignee: The Board of Regents of The University of Texas System
    Inventors: Luisiana Cundin, Norman Barsalou, Shannon Voss, Saher Maswadi, Randolph D Glickman
  • Patent number: 11413336
    Abstract: The present invention concerns methods and compositions for treating or preventing a fungal infection, particularly infection by a Coccidioides species. The invention provides methods and compositions for stimulating an immune response against the fungus. In certain embodiments, the methods and compositions involve a recombinant vaccine.
    Type: Grant
    Filed: March 22, 2019
    Date of Patent: August 16, 2022
    Assignees: Board of Regents, The University of Texas System, The University of Massachusetts
    Inventors: Chiung-Yu Hung, Gary Ostroff, Natalia Castro-Lopez
  • Patent number: 11413613
    Abstract: A method and system for performing biomolecule extraction are provided that use liquid-to-liquid extraction (LLE) in combination with an electrowetting on dielectric (EWOD) device to provide a biomolecule extraction solution that has high extraction efficiency and that is less costly and easier to use than current state of the art methods and systems. The system and method are well suited for, but not limited to, extraction of DNA, RNA and protein molecules.
    Type: Grant
    Filed: January 15, 2020
    Date of Patent: August 16, 2022
    Assignee: Board of Regents, The University of Texas System
    Inventors: Hyejin Moon, Shubhodeep Paul
  • Patent number: 11413240
    Abstract: The present disclosure provides methods and compositions for the treatment of oral lesions in a subject comprising a methylene blue oral rinse.
    Type: Grant
    Filed: December 29, 2017
    Date of Patent: August 16, 2022
    Assignee: Board of Regents, The University of Texas System
    Inventor: Carlos Julio Roldan
  • Publication number: 20220249033
    Abstract: Apparatus and methods for imaging a region of a subject comprising an artifact. In certain embodiments, the apparatus and methods utilize computed tomography (CT) scans obtained at two different angles to image a region posterior to an artifact.
    Type: Application
    Filed: June 10, 2020
    Publication date: August 11, 2022
    Applicant: Board of Regents, The University of Texas System
    Inventors: David FOLLOWILL, Stephen KRY, Daniela BRANCO
  • Publication number: 20220249867
    Abstract: The present disclosure is directed towards a treatment planning system for use in a stereotactic radiotherapy system. In particular, the disclosed systems and methods may be used for generating a treatment plan and/or verifying an existing treatment plan. Moreover, the disclosed systems and methods may be suitable for use in a clinical setting. A method for verifying a treatment plan of a stereotactic radiotherapy device may include the steps of receiving a treatment plan, generating a second treatment plan by applying a modified monte-carlo method to regions of interest in the treatment plan, and identifying discrepancies between the received treatment plan and the generated second treatment plan.
    Type: Application
    Filed: July 13, 2020
    Publication date: August 11, 2022
    Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Weigo LU, Xuejun GU, Mingli CHEN, Xun JIA, Steve Bin JIANG
  • Publication number: 20220249874
    Abstract: The present disclosures describes a remotely controlled stereotactic radiotherapy system. The system may include a gamma-ray irradiation system for radioablation of a target region of human tissue, the system having an irradiating unit configured to produce a radiation field, and a processor remote from the gamma-ray irradiation system configured to control the dosage and position of the radiation field applied to the target region.
    Type: Application
    Filed: July 13, 2020
    Publication date: August 11, 2022
    Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Xuejun GU, David PARSONS
  • Patent number: 11406722
    Abstract: Stable perfluorocarbon nanodroplet compositions with properties such as low-boiling points and small particle diameters are provided for improved performance in ultrasound imaging and therapeutic applications. Methods of producing stabilized nanodroplet compositions and methods of using the compositions are further provided to allow for improved performance in ultrasound imaging techniques and/or therapeutic applications.
    Type: Grant
    Filed: March 16, 2018
    Date of Patent: August 9, 2022
    Assignee: The Board of Regents of The University of Texas System
    Inventors: Caroline de Gracia Lux, Jacques Lux, Alexander M. Vezeridis, Robert F. Mattrey
  • Patent number: 11406643
    Abstract: Provided herein are methods for the treatment of brain metastasis by administering a kinase inhibitor targeted to a metastasis-promoting kinase identified by an in vivo kinase screen.
    Type: Grant
    Filed: August 10, 2018
    Date of Patent: August 9, 2022
    Assignee: Board of Regents, The University of Texas System
    Inventors: Dihua Yu, Frank Lowery, Chenyu Zhang, Sunil Acharya, Ping Li
  • Patent number: 11407105
    Abstract: A dielectric elastomer system (DES) variable stiffness actuator (VSA) is provided. In an embodiment, the DES VSA includes a variable stiffness module (VSM). The VSM includes a DES that softens when energized and stiffens when unpowered, an outer frame, and an inner frame member. The stiffness of the DES is variable. The outer frame supports the DES and the inner frame member, which is disposed within the DES. The inner frame member is configured to be displaceable with respect to the outer frame. The DES VSA also includes an actuation motor mechanically coupled to the inner frame member that is configured to cause a force to be applied to the inner frame member and the actuation motor is configured to control an equilibrium position of the DES VSA.
    Type: Grant
    Filed: December 15, 2020
    Date of Patent: August 9, 2022
    Assignee: Board of Regents, The University of Texas System
    Inventors: Robert D. Gregg, IV, Edgar A. Bolivar, David P. Allen, Walter E. Voit
  • Patent number: 11407752
    Abstract: A series of substituted 4,6-dihydrospiro[[1,2,3]triazolo[4,5-b]pyridine-7,3?-indoline]-2?,5(3H)-dione analogues, the use thereof and the preparation thereof.
    Type: Grant
    Filed: July 24, 2020
    Date of Patent: August 9, 2022
    Assignee: The Board of Regents of The University of Texas System
    Inventors: Jia Zhou, Pei-Yong Shi, Jimin Xu, Xuping Xie
  • Patent number: 11408096
    Abstract: Described herein is the application of centrifugal spinning to provide a flexible mechanoluminescent material composed of rare earth metal doped fibers. Rare earth metal doped fibers are formed, in one embodiment, by centrifugal spinning.
    Type: Grant
    Filed: September 7, 2018
    Date of Patent: August 9, 2022
    Assignee: The Board of Regents of the University of Texas System
    Inventors: Karen Lozano, Yuanbing Mao, Carlos Hernandez, Misael E. Martinez, Mark Anthony Ruiz, Jorge Ernesto Vidal, Jose Zuniga
  • Publication number: 20220242854
    Abstract: Small molecule disruptors of Beclin-1/Bc1-2 protein-protein interactions induce autophagy and hence are useful for treating a variety of indications where stimulation of autophagy is therapeutically useful, including cancer, infection immunity, neurodegeneration, longevity.
    Type: Application
    Filed: April 5, 2022
    Publication date: August 4, 2022
    Applicant: Board of Regents, The University of Texas System
    Inventors: Jef De Brabander, Qiren Liang, Beth Levine, Wei-Chung Chiang