Patents Assigned to The Board of Regents The University of Texas System
  • Publication number: 20200370042
    Abstract: The disclosure provides a method for treating or preventing Duchene Muscular Dystrophy (DMD) in a subject in need thereof, the method comprising administering to the subject a Cas9 nuclease or a sequence encoding a Cas9 nuclease, and a gRNA or a sequence encoding a gRNA, wherein the gRNA targets a splice donor or splice acceptor site of the dystrophin gene. The administering restores dystrophin expression in at least a subset of the subjects cardiomyocytes, and may at least partially or fully restore cardiac contractility.
    Type: Application
    Filed: January 31, 2019
    Publication date: November 26, 2020
    Applicant: The Board of Regents of the University of Texas System
    Inventors: Eric N. OLSON, Chengzu LONG
  • Patent number: 10842931
    Abstract: Occlusion of a vein during IV fluid treatment, in some embodiments, may be detecting by delivering predetermined flow patterns (e.g., flow frequencies and/or amplitudes) of fluid to the subject and monitoring the flow of the fluid downstream vein. A deviation of the flow pattern downstream from the vein from the predetermined flow pattern may be used to determine if an occlusion has occurred. A system for monitoring fluid delivery to a subject includes, in some embodiments, a pump system capable of delivering flow with predetermined flow rates and one or more flow detectors capable of detecting downstream peripheral venous flow.
    Type: Grant
    Filed: December 12, 2013
    Date of Patent: November 24, 2020
    Assignee: Board of Regents of the University of Texas System
    Inventors: Daniel T. DeArmond, John H. Calhoon
  • Patent number: 10842814
    Abstract: Methods and compositions are provided for inhibiting, preventing, ameliorating and/or reducing damage to DNA in non-cancerous cells in a subject undergoing chemotherapeutic treatment and/or radiation treatment of cancer cells in the subject, comprising administering to the subject one or more compounds of arsenic in a therapeutically effective amount prior to chemotherapeutic treatment and/or radiation treatment.
    Type: Grant
    Filed: August 16, 2017
    Date of Patent: November 24, 2020
    Assignees: Board of Regents of the University of Texas System, Baylor College of Medicine
    Inventors: Chul Soo Ha, Zhi-Min Yuan, Hang Su, Edward Paul Hasty, Alison A. Bertuch, Maria Monica Gramatges, Gregory P. Swanson
  • Patent number: 10845312
    Abstract: Certain embodiments are directed to systems and methods using surface enhanced Raman scattering (SERS) detection. More specifically, the present invention describes a system and method of use for SERS detection of sialic (N-acetylneuraminic acid) using citrate-reduced silver nanoparticles.
    Type: Grant
    Filed: July 22, 2016
    Date of Patent: November 24, 2020
    Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Ekaterina Vinogradova, Hugo Navarro-Contreras, Miguel Jose-Yacaman
  • Patent number: 10842384
    Abstract: In one embodiment, a temperature sensor includes an optical waveguide having a distal tip and a thermochromic sensing element mounted to the distal tip of the optical waveguide, wherein light transmitted through the optical waveguide to the distal tip is reflected back from the thermochromic sensing element and wherein the reflected light provides an indication of a local temperature at a location of the thermochromic sensing element.
    Type: Grant
    Filed: January 12, 2018
    Date of Patent: November 24, 2020
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Jing Yong Ye, Corinne Nawn
  • Publication number: 20200362693
    Abstract: Sensor systems for performing in-wellbore and/or in-fracture measurements of physical and/or chemical properties are injected into a wellbore (such as within a subterranean formation) or pipeline. The sensor systems each contain one or more sensors, which include a capability to communicate results of the measurements to an external device. Different sensor systems are injected into different isolated zones within the wellbore or pipeline to obtain measurements of the particular physical and/or chemical properties within each zone.
    Type: Application
    Filed: May 15, 2020
    Publication date: November 19, 2020
    Applicant: Board of Regents, The University of Texas System
    Inventor: Mohsen Ahmadian-Tehrani
  • Publication number: 20200362107
    Abstract: Described herein are water desalination membranes and methods of desalinating water. Sulfonated poly(arylene ether) polymers are also disclosed, including those comprising one or more sulfonate groups at various points along the polymer chain. The polymers may be used as at least a portion of a water desalination membrane. The polymers described herein are useful for preventing transport of aqueous ionic species (e.g., Na+ and Cl?) across a membrane made from the polymers while allowing water to pass. Chlorine-stable polymers are described, as well as polymers exhibiting good performance for rejecting monovalent cations in the presence of polyvalent cations.
    Type: Application
    Filed: July 31, 2020
    Publication date: November 19, 2020
    Applicants: Board of Regents, The University of Texas System, Virginia Tech Intellectual Properties, Inc.
    Inventors: Judy S. Riffle, Ozma R. Lane, Amin Daryaei, Shreya Roy-Choudhury, Benny D. Freeman, Eui Soung Jang, Gurtej S. Narang, John J. Lesko, Trevor Schumacher
  • Patent number: 10837130
    Abstract: The described incandescent tension annealing processes involve thermally annealing twisted or coiled carbon nanotube (CNT) yarns at high-temperatures (1000° C. to 3000° C.) while these yarns are under tensile loads. These processes can be used for increasing yarn modulus and strength and for stabilizing both twisted and coiled CNT yarns with respect to unwanted irreversible untwist, thereby avoiding the need to tether torsional and tensile artificial muscles, and increasing the mechanical loads that can be moved by these muscles.
    Type: Grant
    Filed: April 27, 2017
    Date of Patent: November 17, 2020
    Assignee: Board of Regents, The University of Texas System
    Inventors: Jiangtao Di, Shaoli Fang, Carter S. Haines, Na Li, Ray H. Baughman
  • Patent number: 10836949
    Abstract: Described herein are methods of cementing at least a portion of a well comprising feeding a magnetorheological cementitious slurry to a well and applying a magnetic field to the magnetorheological cementitious slurry concurrent with at least a portion of said feeding step to cause a mechanical response in said magnetorheological cementitious slurry in the well. Also disclosed herein are methods of temporarily blocking at least a portion of a well comprising providing a magnetorheological fluid in a well, applying a magnetic field to cause a mechanical response in said magnetorheological fluid thereby blocking at least a portion of the well, and removing the magnetic field to unblock the portion of the well. Also disclosed herein is a magnetorheological cement.
    Type: Grant
    Filed: July 11, 2014
    Date of Patent: November 17, 2020
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Eric van Oort, Kenneth M Cowan, Sriramya Duddukuri Nair, Raissa Ferron
  • Patent number: 10838971
    Abstract: Embodiments of an informatics platform where collected data can be normalized, integrated and mapped to a knowledge source, such as medical vocabulary systems are disclosed. One example of such a knowledge source is Unified Medical Language System (UMLS) which is a knowledge source for biomedical applications. Embodiments as depicted herein may provided a method to convert the desired information from UMLS into an ontology representation to allow for its use in conjunction with an informatics system.
    Type: Grant
    Filed: October 11, 2016
    Date of Patent: November 17, 2020
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventor: Parsa Mirhaji
  • Patent number: 10837961
    Abstract: Macromolecular imprinted silica particles (“MIP”) in the presence of polymer grafted carbon black are disclosed. The disclosed molecular imprinted beads can detect disease in body fluids. For the silica gel matrix, tetraethyl orthosilicate (TEOS) was used as the backbone monomer and 3-aminopropy/triethoxysilane (APS) as a functional monomer. Carbon black was added to the sol-gel process, yielding black silica particles. Furthermore, sodium dodecyl sulfate (SDS) was used as a structure-directing agent to increase network diffusion of the template. A total of 16 MIPs were synthetized in parallel with variables that evaluate the role of key reactants in the synthesis procedure. Agglomeration tests were performed with all 16 MIPs in the presence of their template, alongside their respective controls using only phosphate buffered saline (“PBS”). Each of the MIPs was evaluated using a novel device capable of simultaneously measuring up to four samples for near infrared transmission.
    Type: Grant
    Filed: August 6, 2014
    Date of Patent: November 17, 2020
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventor: Thomas Boland
  • Patent number: 10835759
    Abstract: Methods, apparatuses, systems, and implementations for creating a patient-specific soft bolus for radiotherapy treatment are disclosed. 2D and/or 3D images of a desired radiotherapy treatment site may be acquired, such as the head, neck, skin, breast, anus, and/or vulva. A user may interact with one or more representations of the images via an interactive user interface such as a graphical user interface (GUI). The images may include target/avoidance structures and radiation beam arrangement. The user may interact with the images to create a visualization of a patient-specific bolus. The visualization and properties of the bolus may be modified as the user manipulates aspects of the image. Data corresponding to the bolus models may be used to create 3D printed negative molds of the bolus model using 3D printing technology. A soft patient-specific bolus may be cast using the 3D printed model.
    Type: Grant
    Filed: February 22, 2018
    Date of Patent: November 17, 2020
    Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Tsuicheng D. Chiu, Xuejun Gu, Jun Tan, Bo Zhao, Troy Long, Weiguo Lu, Tobin Strom, Kenneth Westover, Steve B. Jiang
  • Patent number: 10836827
    Abstract: Antibodies that bind specifically to glycosylated PD-L1 relative to unglycosylated PD-L1 are provided. Antibodies that recognize specific epitopes of glycosylated PD-L1 protein and can block the binding of PD-L1 to PD-1 are provided. In some aspects, PD-L1 polypeptides comprising glycosylated amino acid residues at amino and carboxy terminal positions of the PD-L1 extracellular domain are also provided. Methods for making and using such antibodies and polypeptides (e.g., for the treatment of cancer) are also provided.
    Type: Grant
    Filed: March 29, 2016
    Date of Patent: November 17, 2020
    Assignees: STCUBE, INC., BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Stephen S. Yoo, Ezra M. Chung, Yong-Soo Kim, Mien-Chie Hung, Chia-Wei Li, Seung-Oe Lim
  • Patent number: 10835767
    Abstract: Apparatuses and methods for electrohydraulic generation of shockwaves at a rate of between 10 Hz and 5 MHz, and/or that permit a user to view a region of a patient comprising target cells during application of generated shockwaves to the region. Methods of applying electro-hydraulically generated shockwaves to target tissues (e.g., for reducing the appearance of tattoos, treatment or reduction of certain conditions and/or maladies).
    Type: Grant
    Filed: March 13, 2013
    Date of Patent: November 17, 2020
    Assignees: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, SOLITON, INC.
    Inventors: Christopher C. Capelli, Robert Crowley
  • Patent number: 10835609
    Abstract: In some aspects, methacrylate co-polymers crosslinked with an enzymatically cleavable peptide linker are provided and may be used for the oral delivery of a therapeutic. The peptide linker may be cleavable by an enzyme in the small intestine and may allow for the delivery of a therapeutic protein or nucleic acid to the small intestine. Also provided are methods of using the polymers for the treatment of a disease.
    Type: Grant
    Filed: February 27, 2018
    Date of Patent: November 17, 2020
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Jennifer M. Knipe, Laura E. Strong, Nicholas A. Peppas
  • Patent number: 10835716
    Abstract: A medical device includes at least one ionic electroactive polymer actuator, the actuator including at least one polymer electrolyte member defining at least a surface and a plurality of electrodes disposed about the surface of the at least one polymer electrolyte member, an elongate, flexible portion defining a proximal end and a distal end secured adjacent to the ionic electroactive polymer actuator and the elongate, flexible portion further comprising a core and a sleeve surrounding the core and a plurality of electrically-conductive wires, each having a proximal end and a distal end coupled to at least one of the plurality of electrodes, wherein the at least one polymer electrolyte member deforms asymmetrically in response to the application of an electrical potential supplied through at least one of the plurality of electrically-conductive wires to at least one of the plurality of electrodes.
    Type: Grant
    Filed: July 27, 2018
    Date of Patent: November 17, 2020
    Assignee: BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Daniel H. Kim, Dong Suk Shin, Viljar Palmre, Younghee Shim
  • Publication number: 20200353237
    Abstract: Certain aspects are directed to a housing and cap to provide protection of medical devices having one or more percutaneous connection (e.g., a three-way stopcock or catheter port).
    Type: Application
    Filed: November 13, 2018
    Publication date: November 12, 2020
    Applicant: The Board of Regents of The University of Texas System
    Inventors: Luiz MARACAJA, Edward SAKO
  • Patent number: 10829427
    Abstract: Provided herein are naphthoquinones compounds such as those with a hydrogen bond donating group of the formula (I): wherein: R1, R2, R3, R4, R5, and n are as defined herein. Also provided herein are pharmaceutical composition of the present compounds and methods of treatment using the compounds including their use in the treatment of cancer.
    Type: Grant
    Filed: December 16, 2016
    Date of Patent: November 10, 2020
    Assignee: The Board of Regents of the University of Texas System
    Inventors: Jinming Gao, Yuliang Liu, Qi Wei, Xinpeng Ma, Gang Huang
  • Patent number: 10830720
    Abstract: Embodiments of the present disclosure provide an interrogation device that is operable to apply one or more source signals to one or more coils surrounding a volume, where a material is disposed within the volume. Each of the one or more source signals may excite one of the one or more coils, and the behavior of each the one or more coils responsive to the exciting may be monitored. One or more parameters may be determined based on the behavior of each the one or more coils, and the one or more parameters may be utilized to generate a signature for the material within the volume. The signature may be compared to one or more signatures of known materials to identify the material within the volume.
    Type: Grant
    Filed: October 30, 2017
    Date of Patent: November 10, 2020
    Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventor: Jung-Chih Chiao
  • Patent number: D903110
    Type: Grant
    Filed: January 9, 2019
    Date of Patent: November 24, 2020
    Assignee: Board of Regents, The University of Texas System
    Inventors: Priya Bhosale, Sujaya H. Rao, Samer Harmoush