Patents Assigned to The Board of Supervisors of Louisiana State University and Mechanical College
  • Gene regulation in transgenic animals using a transposon-based vector
    Patent number: 7608451
    Abstract: Administration of modified transposon-based vectors has been used to achieve stable incorporation of exogenous genes into animals. These transgenic animals produce transgenic progeny. Further, these transgenic animals produce large quantities of desired molecules encoded by the transgene. Transgenic egg-laying animals produce large quantities of desired molecules encoded by the transgene and deposit these molecules in the egg.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: October 27, 2009
    Assignees: Transgen Rx, Inc., The Board of Supervisors of Louisiana State University and Mechanical College
    Inventors: Richard K. Cooper, Gary G. Cadd, William C. Fioretti, Kenneth F. De Boer
  • Vaccines for infections
    Patent number: 7279171
    Abstract: Vaccine compositions protective against Chlamydia psittaci infections in animals, including but not limited to humans and avian species, comprising an immunogenic amount of a C. psittaci major outer membrane protein (MOMP) polypeptide lacking regions VD1 and VD2 are provided. Nucleic acid vectors for the expression of MOMP polypeptides and MOMP polypeptide fusion proteins are disclosed. Nucleic acid vectors encoding a C. psittaci major outer membrane protein (MOMP) polypeptide lacking regions VD1 and VD2 useful for genetic, or “naked nucleic acid” vaccination are disclosed. Methods for preventing a Chlamydia psittaci infection in a subject using MOMP polypeptides, MOMP polypeptide-fusion proteins, or nucleic acid expression vectors are also provided.
    Type: Grant
    Filed: August 11, 2003
    Date of Patent: October 9, 2007
    Assignee: Board of Supervisors of Louisiana State University and Mechanical College
    Inventors: Konstantin G. Kousoulas, Vladimir N. Chouljenko, Abolgasem Baghian, Thomas N. Tully, Jr.
  • Synthesis of anti-inflammatory compounds and novel trisaccharides useful in the synthesis of anti-inflammatory compounds
    Patent number: 5618705
    Abstract: Anti-inflammatory compounds are useful, for example, in treating arthritis and heart attack patients. Novel oligosaccharides useful in the rapid synthesis of certain anti-inflammatory compounds are disclosed, as is a rapid method of synthesizing the oligosaccharides. Low pH can loosen the acceptor specificity of galactosyltransferase (lactose synthase: EC 2.4.1.22), allowing the rapid synthesis of novel oligosaccharides. The disaccharides cellobiose (.beta.1.fwdarw.4), laminaribiose (.beta.1.fwdarw.3), gentiobiose (.beta.1.fwdarw.6) and maltose (.alpha.1.fwdarw.4) acted as acceptors for lactose synthase under low pH conditions. From these four acceptors, the following four novel trisaccharides were synthesized: Gal.sub.p (.beta.1.fwdarw.4)Glc.sub.p (.beta.1.fwdarw.3)-Glc, Gal.sub.p (.beta.1.fwdarw.4)Glc.sub.p (.beta.1.fwdarw.4)-Glc, Gal.sub.p (.beta.1.fwdarw.4)Glc.sub.p (.beta.1.fwdarw.6)-Glc and Gal.sub.p (.beta.1.fwdarw.4)Glc.sub.p (.alpha.1.fwdarw.4) Glc.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: April 8, 1997
    Assignee: Board of Supervisors of Louisiana State University Mechanical College
    Inventors: Roger A. Laine, Eunsun Yoon