Patents Assigned to The Board of Trustee of the Leland Stanford Junior University
  • MRI reconstruction using deep learning, generative adversarial network and acquisition signal model
    Patent number: 10859657
    Abstract: A method for diagnostic imaging includes measuring undersampled data y with a diagnostic imaging apparatus; linearly transforming the undersampled data y to obtain an initial image estimate {tilde over (x)}; applying the initial image estimate {tilde over (x)} as input to a generator network to obtain an aliasing artifact-reduced image x? as output of the generator network, where the aliasing artifact-reduced image x? is a projection onto a manifold of realistic images of the initial image estimate {tilde over (x)}; and performing an acquisition signal model projection of the aliasing artifact-reduced x? onto a space of consistent images to obtain a reconstructed image {circumflex over (x)} having suppressed image artifacts.
    Type: Grant
    Filed: May 31, 2019
    Date of Patent: December 8, 2020
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Enhao Gong, Greg Zaharchuk, John M. Pauly, Morteza Mardani Korani
  • Electrically conductive hydrogels with tunable properties
    Patent number: 10858522
    Abstract: A manufacturing method includes: inducing gelation of an electrically conductive polymer to form a gel; infiltrating the gel with a solution including monomers; and polymerizing the monomers to form a secondary polymer network intermixed with the electrically conductive polymer.
    Type: Grant
    Filed: June 25, 2019
    Date of Patent: December 8, 2020
    Assignee: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Vivian R. Feig, Helen Tran, Zhenan Bao
  • Benzylisoquinoline alkaloids (BIA) producing microbes, and methods of making and using the same
    Patent number: 10858681
    Abstract: Aspects of the invention include host cells that are engineered to produce benzylisoquinoline alkaloids (BIAs). The host cells include heterologous coding sequences for a variety of enzymes involved in synthetic pathways from starting compounds to BIAs of the host cell. Also provided are methods of producing the BIAs of interest by culturing the host cells under culture conditions that promote expression of enzymes encoded by the heterologous coding sequences of the host cells. Aspects of the invention further include compositions, e.g., host cells, starting compounds and kits, etc., that find use in methods of the invention.
    Type: Grant
    Filed: May 11, 2018
    Date of Patent: December 8, 2020
    Assignee: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Christina D. Smolke, Catherine Thodey, Isis Trenchard, Stephanie Galanie
  • Methods of Predicting Disorder Progression for Control Arms Within an Experimental Trial
    Publication number: 20200381096
    Abstract: Methods of performing experimental treatments on a cohort of subjects are provided. A predictive model can be utilized to predict progression of a medical disorder or relevant imaging biomarker. The predicted medical disorder progression can be utilized as a control to determine whether an experimental treatment has an effect on the progression of the medical disorder. In some instances, the enrollment of subjects within a control group for clinical experiment is eliminated or reduced.
    Type: Application
    Filed: June 3, 2020
    Publication date: December 3, 2020
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventor: Greg Zaharchuk
  • Grabity: a virtual reality haptic controller for creating gravity and stiffness during grasping motions through asymmetric vibrations
    Patent number: 10852872
    Abstract: A device to simulate kinesthetic pad opposition grip forces and weight for grasping virtual objects in a virtual reality is provided. The device includes a base, a sliding part, a braking mechanism and a swinging part with linear resonant actuators (e.g. voice coil actuators). The sliding part is connected with the base through a first prismatic joint which allows for single degree of freedom pinching motions for grasping an object. The swinging part connected to the sliding part and the base through revolute joints. The brake mechanism is used to create a grasping force. The linear resonant actuators provide both touch sensation at initial contact and sensation of weight when lifting the object.
    Type: Grant
    Filed: October 12, 2018
    Date of Patent: December 1, 2020
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Inrak Choi, Sean Follmer, Heather Culbertson
  • Antibody evolution immunogens
    Patent number: 10849970
    Abstract: The present invention relates, in general, to HIV-1 and, in particular, to broadly neutralizing HIV-1 antibodies, and to HIV-1 immunogens and to methods of using such immunogens to induce the production of broadly neutralizing HIV-1 antibodies in a subject (e.g., a human).
    Type: Grant
    Filed: January 8, 2018
    Date of Patent: December 1, 2020
    Assignees: Duke University, Triad National Security, LLC, The Trustees of The University of Pennsylvania, Trustees of Boston University, The Government of The United States of America as Represented by the Secretary of the Department of Health and Human Services, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Barton F. Haynes, Hua-Xin Liao, Rebecca M. Lynch, Tongqing Zhou, Feng Gao, Scott Boyd, George M. Shaw, Beatrice H. Hahn, Thomas B. Kepler, Bette T. Korber, Peter Kwong, John R. Mascola
  • 2-arylbenzimidazoles as PPARGC1A activators for treating neurodegenerative diseases
    Patent number: 10851066
    Abstract: The compound 2-(3-tert-Butylphenyl)-4,6-difluoro-1H-benzo[d]imidazole and its use are disclosed: The compound activates Ppargc1a and, as a consequence, is useful for treating neuroinflammation and for treating a variety of neurodegenerative diseases.
    Type: Grant
    Filed: May 29, 2020
    Date of Patent: December 1, 2020
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Samuel D. Banister, Edgar Engleman, Khoa D. Nguyen, Mark Smith
  • Isolated multi-level resonant topologies for wide-range power conversion and impedance matching
    Patent number: 10855186
    Abstract: Resonant power converters that replace the conventional impedance matching stage with series or parallel connections between resonant inverters and resonant rectifiers are provided. Two or more resonant rectifiers can be connected in series or in parallel to the resonant inverter to provide impedance matching. Similarly, two or more resonant inverters can be connected in series or in parallel to the resonant rectifier to provide impedance matching. Electrical isolation of DC voltage between input and output is provided using only capacitors.
    Type: Grant
    Filed: February 11, 2019
    Date of Patent: December 1, 2020
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Luke C. Raymond, Wei Liang, Juan M. Rivas Davila
  • METHODS UTILIZING SINGLE CELL GENETIC DATA FOR CELL POPULATION ANALYSIS AND APPLICATIONS THEREOF
    Publication number: 20200370112
    Abstract: Processes to infer stemness, cell lineage, and/or differentiation status are provided. In some instances, single cell RNA sequencing is used to infer a cell's stemness, cell lineage, and/or differentiation status. In some instances, a collection of cells is ordered based on each cell's differentiation status.
    Type: Application
    Filed: May 26, 2020
    Publication date: November 26, 2020
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Aaron M. Newman, Gunsagar S. Gulati, Michael F. Clarke, Shaheen Shabbir Sikandar
  • Fusion proteins comprising an engineered knottin peptide and uses thereof
    Patent number: 10844106
    Abstract: The present disclosure presents a general approach to engineering existing protein-protein interactions through domain addition and evolution. The disclosure teaches the creation of novel fusion proteins that include knottin peptides where a portion of the knottin peptide is replaced with a sequence that has been created for binding to a particular target. Such fusion proteins can also be bispecific or multi specific in that they can bind to and/or inhibit two or more receptors or receptor ligands. Knottins may be fused with an existing ligand (or receptor) as a general platform for increasing the affinity of a ligand-receptor interaction or for creating a multi specific protein. In addition, the fusion proteins may comprise a knottin peptide fused to another protein where the other protein facilitates proper expression and folding of the knottin.
    Type: Grant
    Filed: November 7, 2011
    Date of Patent: November 24, 2020
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Jennifer R. Cochran, Douglas S. Jones, Mihalis S. Kariolis, Ping-Chuan Tsai
  • Acoustic biometric touch scanner
    Patent number: 10846501
    Abstract: An acoustic biometric touch scanner device and method is disclosed. In one aspect, an acoustic fingerprint sensing device includes an array of ultrasonic transducers configured to transmit an ultrasound signal having a frequency in a range from 50 megahertz (MHz) to 500 MHz. The acoustic fingerprint ultrasonic transducers include a piezoelectric film. The acoustic fingerprint sensing device further includes a receiving surface configured to receive a finger. The acoustic fingerprint sensing device further includes a processor configured to generate an image of at least a portion of a fingerprint of the finger based on a reflection of the ultrasound signal from the finger.
    Type: Grant
    Filed: March 30, 2018
    Date of Patent: November 24, 2020
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Morten Fischer Rasmussen, Gerard Touma, Butrus T. Khuri-Yakub
  • De novo design of potent and selective interleukin mimetics
    Patent number: 10844105
    Abstract: De novo designed polypeptides that bind to IL-2 receptor ?c heterodimer (IL-2R?c), IL-4 receptor ?c heterodimer (IL-4R?c), or IL-13 receptor ? subunit (IL-13R?) are disclosed, as are methods for using and designing the polypeptides.
    Type: Grant
    Filed: June 23, 2020
    Date of Patent: November 24, 2020
    Assignees: University of Washington, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Daniel Adriano Silva Manzano, Shawn Yu, Umut Ulge, David Baker, Kenan Christopher Garcia, Jamie Spangler, Carl Walkey
  • Method and apparatus for fabricating an energy transmitting device
    Patent number: 10843004
    Abstract: Implantable devices and/or sensors can be wirelessly powered by controlling and propagating electromagnetic waves in a patient's tissue. Such implantable devices/sensors can be implanted at target locations in a patient, to stimulate areas such as the heart, brain, spinal cord, or muscle tissue, and/or to sense biological physiological, chemical attributes of the blood, tissue, and other patient parameters. The propagating electromagnetic waves can be generated with sub-wavelength structures configured to manipulate evanescent fields outside of tissue to generate the propagating waves inside the tissue. Methods of use are also described.
    Type: Grant
    Filed: April 23, 2019
    Date of Patent: November 24, 2020
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Ada Shuk Yan Poon, Alexander Jueshyan Yeh, Yuji Tanabe, John Ho, Sanghoek Kim
  • Techniques for determining haplotype by population genotype and sequence data
    Patent number: 10847248
    Abstract: A novel phasing algorithm harnesses sequencing read information from next generation sequencing technologies to guide and improve local haplotype reconstruction from genotypes. Techniques include determining correlated occurrences of single nucleotide polymorphisms (SNPs) in genes of a population of individuals. A plurality of sequences of nucleotide bases in one or more individuals from the populations of individuals is determined based on ultra-high throughput sequencing of a sample from the one or more individuals. Haplotypes included in the population of individuals are determined based on both the correlated occurrences and the plurality of sequences. The inclusion of paired end read data is especially advantageous for the phasing of rare variants, including singletons.
    Type: Grant
    Filed: August 12, 2013
    Date of Patent: November 24, 2020
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Carlos D. Bustamante, Fouad Zakharia
  • Wireless midfield systems and methods
    Patent number: 10843003
    Abstract: Implantable devices and/or sensors can be wirelessly powered by controlling and propagating electromagnetic waves in a patient's tissue. Such implantable devices/sensors can be implanted at target locations in a patient, to stimulate areas such as the heart, brain, spinal cord, or muscle tissue, and/or to sense biological, physiological, chemical attributes of the blood, tissue, and other patient parameters. The propagating electromagnetic waves can be generated with sub-wavelength structures configured to manipulate evanescent fields outside of tissue to generate the propagating waves inside the tissue. Methods of use are also described.
    Type: Grant
    Filed: February 12, 2019
    Date of Patent: November 24, 2020
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Ada Shuk Yan Poon, Alexander Jueshyan Yeh, Yuji Tanabe, John Ho, Sanghoek Kim
  • Compounds and compositions that bind and stabilize transthyretin and their use for inhibiting transthyretin amyloidosis and protein-protein interactions
    Patent number: 10842777
    Abstract: Disclosed herein are compounds and compositions thereof which find use in increasing stability of proteins particularly proteins that tend to misfold and form aggregates. Also provided herein are methods for using these compounds and compositions for increasing stability of proteins and thereby decreasing aggregate formation by these proteins. Also disclosed herein are heterobifunctional compounds that include a TTR binding compound connected to a targeting moiety via a linker, for use in disrupting PPIs of a target protein.
    Type: Grant
    Filed: July 12, 2019
    Date of Patent: November 24, 2020
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Isabella A. Graef, Mamoun M. Alhamadsheh
  • Systems and methods for automated single cell cytological classification in flow
    Patent number: 10843196
    Abstract: Systems and methods in accordance with various embodiments of the invention are capable of rapid analysis and classification of cellular samples based on cytomorphological properties. In several embodiments, cells suspended in a fluid medium are passed through a microfluidic channel, where they are focused to a single stream line and imaged continuously. In a number of embodiments, the microfluidic channel establishes flow that enables individual cells to each be imaged at multiple angles in a short amount of time. A pattern recognition system can analyze the data captured from high-speed images of cells flowing through this system and classify target cells. In this way, the automated platform creates new possibilities for a wide range of research and clinical applications such as (but not limited to) point of care services.
    Type: Grant
    Filed: May 19, 2017
    Date of Patent: November 24, 2020
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Mahdokht Masaeli, Euan A. Ashley
  • RECEPTOR-BASED ANTAGONISTS OF THE PROGRAMMED CELL DEATH 1 (PD-1) PATHWAY
    Publication number: 20200360474
    Abstract: Provided herein are compositions and methods for alleviating cancer or infection in a subject by administering a therapeutically effective amount of a pharmaceutical composition comprising an isolated PD-1 variant polypeptide. The PD-1 variant polypeptide can inhibit the activity of PD-1 by, for example, competitive or non-competitive inhibition of the interaction between wild-type PD-1 and one or more of its ligands, PD-L1 and PD-L2.
    Type: Application
    Filed: February 7, 2020
    Publication date: November 19, 2020
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Amato J. Giaccia, Mihalis S. Kariolis, Todd A. Aguilera
  • SELECTIVE ACCRETION OF CYTOPROTECTANT IN RADIATION-SENSITIVE TISSUES AND USES THEREOF
    Publication number: 20200360406
    Abstract: The disclosure relates to the treatment of primary and metastatic cancer using radiation. Specifically, the disclosure relates to methods providing for the selective accretion of cytoprotective agent in tissues and/or organs, sensitive to radiation that are adjacent to malignant tumors prior to radiation of the tumors at a dose that otherwise would be toxic to the tissues and/or organs, but are necessary to achieve ablative outcome on the tumors.
    Type: Application
    Filed: November 19, 2018
    Publication date: November 19, 2020
    Applicants: WILLIAM MARSH RICE UNIVERSITY, THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY, BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM
    Inventors: James Tour, Cullen Taniguchi, Kathy Mason
  • TREATMENT OF HEART DISEASE BY DISRUPTION OF THE ANCHORING OF PP2A
    Publication number: 20200360536
    Abstract: The present invention provides a method of treating heart failure with reduced ejection fraction, by administering to a patient at risk of such damage, a pharmaceutically effective amount of a composition which inhibits the anchoring of PP2A to mAKAP?. This composition is preferably in the form of a viral based gene therapy vector that encodes a fragment of mAKAP? to which PP2A binds.
    Type: Application
    Filed: March 13, 2020
    Publication date: November 19, 2020
    Applicants: University of Miami, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Michael S. KAPILOFF, Jinliang LI