Patents Assigned to The Board of Trustees at the Leland Stanford Junior University
  • Methods for Preparing Nucleic Acid Libraries for Sequencing
    Publication number: 20220139497
    Abstract: Processes and materials to detect cancer from a biopsy are described. In some cases, cell-free nucleic acids can be sequenced, and the sequencing result can be utilized to detect sequences derived from a neoplasm. Detection of somatic variants occurring in phase can indicate the presence of cancer in a diagnostic scan and a clinical intervention can be performed.
    Type: Application
    Filed: November 16, 2021
    Publication date: May 5, 2022
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: David M. Kurtz, Maximilian Diehn, Arash Ash Alizadeh
  • Systems and Methods to Assess RNA Stability
    Publication number: 20220135964
    Abstract: Systems and methods for assessing mRNA in vivo and/or in vitro stability are disclosed. Some embodiments methods obtain RNA indexed or barcoded RNA molecules which are then tested against various conditions including stability inside of cells, stability in cell lysate, and stability in solution (e.g., for storage and/or transportation). Additional embodiments describe methods to determine degradation points with single base resolution.
    Type: Application
    Filed: November 12, 2021
    Publication date: May 5, 2022
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Maria Barna, Kathrin Leppek, Gun Woo Byeon
  • CO-FORMULATIONS OF AMYLIN ANALOGUES WITH INSULIN ANALOGUES FOR TREATMENT OF DIABETES
    Publication number: 20220125886
    Abstract: Compositions and methods for treating diabetes are disclosed. In particular, the invention relates to co-formulations of amylin analogues with insulin analogues for treatment of diabetes.
    Type: Application
    Filed: February 12, 2020
    Publication date: April 28, 2022
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Eric A. APPEL, Bruce A. BUCKINGHAM, David M. MAAHS, Caitlin MAIKAWA, Gillie Agmon ROTH
  • Inducible Ammonia Production from a Symbiotic Diazotroph, Methods of Creation and Uses Thereof
    Publication number: 20220127624
    Abstract: The present disclosure describes systems and methods capable of fixing atmospheric nitrogen into bio-available nitrogenous compounds, including ammonia. Embodiments of the present disclosure are directed to synthetic DNA constructs encoding genes to allow release of bio-available nitrogenous compounds in nitrogen fixing diazotrophic organisms. Many of these constructs encode these genes in inducible and constitutive means, such that inducible embodiments can be activated at select times. Additional embodiments are directed to genetically engineered diazotrophs utilizing these constructs to produce bio-available nitrogenous compounds. Further embodiments are directed to methods to create these constructs and organisms as well as to use these constructs and organisms.
    Type: Application
    Filed: February 5, 2020
    Publication date: April 28, 2022
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Tim Schnabel, Elizabeth Sattely
  • Diffusion-weighted MRI with magnitude-based locally low-rank regularization
    Patent number: 11313933
    Abstract: A diffusion-weighted magnetic resonance imaging (MRI) method acquires MRI scan data from a multi-direction, multi-shot, diffusion-weighted MRI scan, and jointly reconstructs from the MRI scan data 1) magnitude images for multiple diffusion-encoding directions and 2) phase images for multiple shots and multiple diffusion-encoding directions using an iterative reconstruction method. Each iteration of the iterative reconstruction method comprises a gradient calculation, a phase update to update the phase images, and a magnitude update to update the magnitude images. Each iteration minimizes a cost function comprising a locally low-rank (LLR) regularization constraint on the magnitude images from the multiple diffusion-encoding directions.
    Type: Grant
    Filed: March 19, 2020
    Date of Patent: April 26, 2022
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Brian A. Hargreaves, Yuxin Hu
  • Methods and systems to produce lignin-modifying enzymes and uses thereof
    Patent number: 11312753
    Abstract: Embodiments of the invention are generally directed to lignin-modifying enzymes and systems and methods of their manufacture. In many embodiments, the lignin-modifying enzymes are lignin-degrading enzymes capable of breaking down lignin into component parts that are usable for other purposes. Several embodiments are directed to systems for producing lignin-modifying enzymes in vivo, including in yeast and/or plant species, and certain embodiments are directed to methods of creating these systems, including transfecting the species to produce lignin-modifying enzymes.
    Type: Grant
    Filed: September 25, 2019
    Date of Patent: April 26, 2022
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Nikita A. Khlystov, Elizabeth Sattely
  • Efficient acoustic energy transfer through skull via excitation of Lamb waves
    Patent number: 11305133
    Abstract: We provide a novel technique for coupling focused ultrasound into the brain. The ultrasound beam can be used for therapy or neuro-modulation. We excite a selected Lamb wave mode in the skull that mode converts into longitudinal waves in the brain. The benefits of our approach is in improved efficiency, reduction in heating of the skull, and the ability to address regions in the brain that are close or far from the skull.
    Type: Grant
    Filed: March 27, 2018
    Date of Patent: April 19, 2022
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Butrus T. Khuri-Yakub, Kamyar Firouzi
  • Chemically modified guide RNAs for CRISPR/CAS-mediated gene regulation
    Patent number: 11306309
    Abstract: Provided herein are methods for inducing CRISPR/Cas-based gene regulation (e.g., genome editing or gene expression) of a target nucleic acid (e.g., target DNA or target RNA) in a cell. The methods include using modified single guide RNAs (sgRNAs) that enhance gene regulation of the target nucleic acid in a primary cell for use in ex vivo therapy or in a cell in a subject for use in in vivo therapy. Additionally, provided herein are methods for preventing or treating a genetic disease in a subject by administering a sufficient amount of a modified sgRNA to correct a mutation in a target gene associated with the genetic disease.
    Type: Grant
    Filed: October 3, 2017
    Date of Patent: April 19, 2022
    Assignees: The Board of Trustees of the Leland Stanford Junior University, Agilent Technologies
    Inventors: Matthew H. Porteus, Ayal Hendel, Joe Clark, Rasmus O. Bak, Daniel E. Ryan, Douglas J. Dellinger, Robert Kaiser, Joel Myerson
  • Motion robust reconstruction of multi-shot diffusion-weighted images without phase estimation via locally low-rank regularization
    Patent number: 11308661
    Abstract: Multi-shot diffusion-weighted magnetic resonance imaging acquires multiple k-space segments of diffusion-weighted MRI data, estimates reconstructed multi-shot diffusion weighted images, and combines the estimated images to obtain a final reconstructed MRI image. The estimation of images iteratively calculates updated multi-shot images from the multiple k-space segments and current multi-shot images using a convex model without estimating motion-induced phase, constructs multiple locally low-rank spatial-shot matrices from the updated multi-shot images, and calculates current multi-shot images from spatial-shot matrices.
    Type: Grant
    Filed: May 20, 2019
    Date of Patent: April 19, 2022
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Bruce L. Daniel, Brian A. Hargreaves, Yuxin Hu, Evan G. Levine
  • Two-dimensional perovskite phosphor and method of formation
    Patent number: 11306244
    Abstract: Intrinsic broadband white-light emitting phosphors and a solution-state method for producing them are disclosed. Emitters in accordance with the present invention include layered perovskite-based phosphors that comprise metals and halides and have an emission spectrum that spans the entire visible-light spectrum.
    Type: Grant
    Filed: September 26, 2018
    Date of Patent: April 19, 2022
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Emma Rose Dohner, Hemamala Indivari Karunadasa
  • Apparatus and method for wide-range optical tracking during medical imaging
    Patent number: 11308645
    Abstract: Methods to quantify motion of a human or animal subject during a magnetic resonance imaging (MRI) exam are provided. In particular, these algorithms make it possible to track head motion over an extended range by processing data obtained from multiple cameras. These methods make current motion tracking methods more applicable to a wider patient population.
    Type: Grant
    Filed: May 11, 2018
    Date of Patent: April 19, 2022
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Jakob Ehrl, Julian Maclaren, Murat Aksoy, Roland Bammer
  • Systems and Methods for Targeted Neuromodulation
    Publication number: 20220110694
    Abstract: Systems and methods for neuronavigation in accordance with embodiments of the invention are illustrated. Targeting systems and methods as described herein can generate personalized stimulation targets for the treatment of mental conditions. In many embodiments, direct stimulation of a personalized the stimulation target indirectly impacts a brain structure that is more difficult to reach via the stimulation modality. In various embodiments, the mental condition is major depressive disorder. In a number of embodiments, the mental condition is suicidal ideation.
    Type: Application
    Filed: October 12, 2021
    Publication date: April 14, 2022
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Nolan R. Williams, Adi Maron-Katz
  • DYNAMICALLY-BONDED SUPRAMOLECULAR POLYMERS FOR STRETCHABLE BATTERIES
    Publication number: 20220115692
    Abstract: A battery includes: 1) an anode; 2) a cathode; and 3) a solid or gel electrolyte disposed between the anode and the cathode, wherein the electrolyte includes a supramolecular polymer formed of, or including, molecules crosslinked through dynamic bonds, and each of the molecules includes an ionic ally conductive domain.
    Type: Application
    Filed: January 17, 2020
    Publication date: April 14, 2022
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: David George Mackanic, Xuzhou Yan, Yi Cui, Zhenan Bao
  • IPSC-based vaccine as a prophylactic and therapeutic treatment for cancer
    Patent number: 11298380
    Abstract: In one embodiment, the application discloses a method for the treatment of cancer in a patient, the method comprises a vaccination of the patient with a vaccine, wherein the vaccine comprises an effective amount of mammalian pluripotent stem cells obtained from an embryonic source or obtained by reprogramming of somatic cells from the patient, wherein the vaccination comprising the step of administering a mammalian pluripotent stem cells to the patient in need thereof; and vaccine formulations for use in the treatment of cancer.
    Type: Grant
    Filed: January 1, 2019
    Date of Patent: April 12, 2022
    Assignees: Khloris Biosciences, Inc., THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Nigel G. Kooreman, Joseph C. Wu, Lynne A. Bui
  • On-slide staining by primer extension
    Patent number: 11299770
    Abstract: A method for analyzing planar sample is provided. In some cases the method comprises: (a) incubating the planar sample with a capture agent that is linked to an oligonucleotide, wherein the capture agent specifically binds to complementary sites in the planar sample; (b) reading a fluorescent signal caused by extension of a primer that is hybridized to the oligonucleotide, using fluorescence microscopy. Several implementations of the method, and multiplexed versions of the same, are also provided.
    Type: Grant
    Filed: January 4, 2019
    Date of Patent: April 12, 2022
    Assignee: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Nikolay Samusik, Garry P. Nolan, Yury Goltsev
  • System and Method Implementing a Distributed Audit Trail
    Publication number: 20220107929
    Abstract: Various disclosed embodiments pertain to a distributed audit trail system for use in a connected system including: a master unit to control a first aspect of the connected system and to create a blockchain light client and a distributed hash table (DHT); a first node to control a second aspect of the connected system; a second node to control a third aspect of the connected system; and one or more remote servers to form a blockchain full node, where the master unit, the first node, and the second node electronically communicate with each other through the DHT in order to form a combined audit trail, where the master unit creates a meta-hash of the software version of the software in the master unit, the first node, and the second node, system identification data, system sensor data, and system hardware configuration.
    Type: Application
    Filed: October 5, 2021
    Publication date: April 7, 2022
    Applicants: The Board of Trustees of the Leland Stanford Junior University, Board of Trustees of Michigan State University
    Inventors: Gregory Falco, Joshua Siegel
  • Solar cell comprising a metal-oxide buffer layer and method of fabrication
    Patent number: 11296244
    Abstract: A perovskite-based solar cell comprising a transparent electrode disposed on a buffer layer that protects the perovskite from damage during the deposition of the electrode is disclosed. The buffer material is deposited using either low-temperature atomic-layer deposition, chemical-vapor deposition, or pulsed chemical-vapor deposition. In some embodiments, the perovskite material is operative as an absorption layer in a multi-cell solar-cell structure. In some embodiments, the perovskite material is operative as an absorption layer in a single junction solar cell structure.
    Type: Grant
    Filed: September 15, 2017
    Date of Patent: April 5, 2022
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Kevin Alexander Bush, Axel F Palmstrom, Michael David McGehee, Stacey F Bent
  • Dynamic glass and method of formation
    Patent number: 11292029
    Abstract: The present disclosure enables high contrast, fast, uniform, and color-neutral dynamic-glass elements based on uniform and reversible electrodeposition of metals a surface of the element. Elements in accordance with the present disclosure include a surface-modified transparent-conductor-based window electrode, wherein the surface modification of the window electrode includes a nucleation layer that is anchored to the transparent conductor via a non-metallic adhesion layer. In some embodiments, a plurality of traces is disposed on and electrically connected to the window electrode to reduce the voltage drop across the total area of the element, where the traces have a core made of a low-resistivity material.
    Type: Grant
    Filed: July 19, 2018
    Date of Patent: April 5, 2022
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Christopher J. Barile, Daniel J. Slotcavage, Michael David McGehee, Tyler S. Hernandez, Michael T. Strand
  • Modular, electro-optical device for increasing the imaging field of view using time-sequential capture
    Patent number: 11294165
    Abstract: The present disclosure provides optical image acquisition methods and devices for microscopy systems that enhance the field-of-view during image acquisition. According to aspects of the present disclosure, the methods and devices for enhancing the field-of-view of a sample during image acquisition in an optical imaging system include directing an incident electromagnetic field through a plurality of polarization-selective gratings, where each of the polarization-selective gratings is configured to apply a discrete amount of angular displacement to the incident electromagnetic field in a direction transverse or axial to the optical system's electromagnetic axis, resulting in an enhanced field-of-view during image acquisition.
    Type: Grant
    Filed: March 28, 2018
    Date of Patent: April 5, 2022
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Karl A. Deisseroth, Sean Quirin
  • Broadband light emitting device with grating-structured electrode
    Patent number: RE49016
    Abstract: A light emitting device includes a substrate layer, a first electrode layer, a light emitting layer, and a patterned second electrode layer. The patterned second electrode layer includes a periodic grating structure having a grating period ?g less than or equal to 200 nm and the patterned second electrode layer and the light emitting layer are separated by at most 100 nm.
    Type: Grant
    Filed: November 26, 2018
    Date of Patent: April 5, 2022
    Assignees: KONICA MINOLTA BUSINESS SOLUTIONS U.S.A., INC., THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Leiming Wang, Mark Brongersma, Majid Esfandyarpour, Jun Amano