Abstract: A method for maintaining and/or increasing body temperature of a patient may involve delivering heat to a first location on a limb of the patient, delivering heat to a second location on the limb, apart from the first location, and applying intermittent compression to a third location on the limb, located between the first location and the second location. A device for maintaining and/or increasing body temperature of a patient may include a sleeve for positioning over at least part of one of the patient's limbs, first and second heat delivery members coupled with the sleeve, and an intermittent compression member coupled with the sleeve between the first and second heat delivery members.

Abstract: Aspects are directed to a MEMS device configurable to receive signals from a first, a second, a third, and a fourth signal source operating at a first, a second, a third, and a fourth frequency, respectively. The MEMS device may be configured to combine the first signal with the second signal generating a first combined signal, and to combine the third signal with the fourth signal generating a second combined signal. The first combined signal may be coupled to the first terminal of the MEMS device while the second combined signal may be coupled to the second terminal of the MEMS device. The first common terminal may be configured to produce an output associated with the second and fourth frequencies. The MEMS device may be further configured to derive from the produced output a signal indicative of nonlinearities or of changes in capacitance related to the MEMS device.

Abstract: A method of forming a sulfur-based cathode material includes: 1) providing a sulfur-based nanostructure; 2) coating the nanostructure with an encapsulating material to form a shell surrounding the nanostructure; and 3) removing a portion of the nanostructure through the shell to form a void within the shell, with a remaining portion of the nanostructure disposed within the shell.

Abstract: An acid spearhead formulation for mineral scale reduction that includes a sulfuric acid solution having an acidity that is substantially equivalent to a hydrochloric acid solution in an acid spearhead formulation, a sodium citrate compound, where an acid spearhead formulation for mineral scale reduction is formed, the acid spearhead formulation is disposed in a well bore to stabilize mineral scales, the acid spearhead formulation is disposed in the well bore to chelate solubilized calcium in a rock bed of the well bore, and the well bore includes a temporal thermodynamic subsurface barite cycling having a subsurface barite dissolution temporal phase, a subsurface barite transport to fractures temporal phase, a subsurface barite precipitation to fracture temporal phase and a subsurface barite dissolution to fracture space temporal phase, where the acid spearhead formulation for mineral scale reduction reacts with the well bore within the subsurface barite dissolution temporal phase.

Abstract: Disclosed herein are methods of analyzing a biological sample comprising: separating components of the biological sample via reversed-phase (RP) chromatography to obtain an elute; subjecting the elute to separation via ion-exchange (IEX) chromatography or mixed-mode IEX chromatography; and detecting the separated compounds to determine the components of the biological sample. Also disclosed are devices comprising a reversed-phase (RP) chromatography column in communication with an ion-exchange (IEX) chromatography column or mixed-mode IEX chromatography column, wherein there is no switching valve between the columns.

Abstract: Processes and materials to detect cancer, transplant rejection, or fetal genetic abnormalities from a biopsy are described. In some cases, cell-free nucleic acids can be sequenced, and the sequencing result can be utilized to detect sequences indicative of a neoplasm, transplant rejection, or fetal genetic abnormality. Detection of somatic variants occurring in phase and/or insertions and deletions (indels) can indicate the presence of cancer, transplant rejection, or fetal genetic abnormalities in a diagnostic scan, and a clinical intervention can be performed.

Abstract: Example implementations include a sensor device with a superhydrophobic sensor panel having an abraded first planar surface and a second planar surface opposite to the first planar surface, and a metallic heating element adjacent to the second planar surface of the superhydrophobic sensor panel. Example implementations also include a method of detecting a concentration of heavy metal ions in a solution, by separating a target solute of a target microdroplet from the target micropdroplet, identifying a distribution area of at least one heavy metal ion in an image of the target solute, generating a heavy metal ion concentration quantity based on the distribution area, generating a composite image including an indication of the distribution area, and presenting an indication of at least one of the heavy metal ion concentration quantity and the composite heavy metal ion image.

Abstract: Functional in vitro assays are provided for determining patient specific responsiveness to immunotherapy agents within a clinically actionable time frame.

Abstract: Provided are ciliary neurotrophic factor receptor (CNTFR) ligands. In certain aspects, a CNTFR ligand of the present disclosure exhibits increased affinity for CNTFR relative to the corresponding wild-type CNTFR ligand. In certain aspects, a CNTFR ligand of the present disclosure results in reduced binding affinity of glycoprotein 130 (gp130), leukemia inhibitory factor receptor (LIFR), or both, for a complex including the CNTFR ligand and CNTFR, relative to the binding affinity for a complex including the corresponding wild-type CNTFR ligand and CNTFR. In certain aspects, a CNTFR ligand of the present disclosure has both of the aforementioned properties. Also provided are pharmaceutical compositions including the CNTFR ligands, as well as methods of using the CNTFR ligands.

Abstract: A method for optimization of photonic devices is disclosed. The method includes receiving a set of unconstrained latent variables; mapping the set of unconstrained latent variables to a constrained space to generate a constrained device; calculating the permittivity across each element of the constrained device; determining a permittivity-constrained width gradient based at least partially on the permittivity across each element; and optimizing the set of unconstrained latent variables by at least partially using the permittivity-constrained width gradient.

Abstract: Systems and methods for active transfer learning in accordance with embodiments of the invention are illustrated. One embodiment includes a method for training a deep featurizer, wherein the method comprises training a master model and a set of one or more secondary models, wherein the master model includes a set of one or more layers, freezing weights of the master model, generating a set of one or more outputs from the master model, and training a set of one or more orthogonal models on the generated set of outputs.

Abstract: Aspects of this disclosure relate to driving a capacitive micromachined ultrasonic transducer (CMUT) with a pulse train of unipolar pulses. The CMUT may be electrically excited with a pulse train of unipolar pulses such that the CMUT operates in a continuous wave mode. In some embodiments, the CMUT may have a contoured electrode.

Abstract: Provided herein are small-molecules for use in modulating chloride ion channel (CLC) activity, particularly the activity of CLC-2, to elucidate the role of CLC-2 in disorders associated with CLC-2 malfunction, and to identify therapeutic leads for their treatment. Compositions and methods for modulating CLC activity are also provided. In certain aspects, the subject compounds and compositions are useful for imaging or channel pull-down studies.

Abstract: Adrenergic receptor modulating compounds and methods of using the same are provided. Also provided are methods of treating a subject for a disease or condition associated with an adrenergic receptor including administering a therapeutically effective amount of the subject compound. Aspects of the disclosure include a method of modulating an inflammatory pathway in a cell, such as the production of TNF-alpha in the cell. The method can include contacting a cell with ?1-selective adrenergic receptor modulating compound to selectively activate a cAMP pathway over a beta-arrestin pathway in the cell. Pharmaceutical compositions and kits which include the subject compounds are provided.

Abstract: A method for displaying proteins and peptides is disclosed in which individual proteins or peptides remain associated with the DNA encoding them. Proteins or peptides can be generated by in vitro translation of DNA templates, either free in solution or arrayed on a solid support, such that the proteins or peptides remain immobilized on their DNA templates. In particular, high throughput sequencing can be combined with high throughput functional characterization of encoded proteins and peptides, wherein the identity of each protein or peptide is determined by DNA sequencing, and functional studies are carried out directly on each protein or peptide while immobilized on the DNA template encoding it. The methods of the invention should find numerous applications, for example, in high throughput genetic or pharmacological screening, epitope mapping, and protein engineering and directed evolution.

Abstract: A method of magnetic resonance imaging acquires undersampled MRI data and generates by an adversarially trained generative neural network MRI data having higher quality without using any fully-sampled data as a ground truth. The generative neural network is adversarially trained using a discriminative neural network that distinguishes between undersampled MRI training data and candidate undersampled MRI training data produced by applying an MRI measurement function containing an undersampling mask to generated MRI training data produced by the generative neural network from the undersampled MRI training data.

Abstract: Provided herein is a method and system for analyzing a sample. In some embodiments the method makes use of a plurality of capture agents that are each linked to a different oligonucleotide and a corresponding plurality of labeled nucleic acid probes, wherein each of the labeled nucleic acid probes specifically hybridizes with only one of the oligonucleotides. The sample is labeled with the capture agents en masse, and sub-sets of the capture agents are detected using iterative cycles using corresponding subsets of the labeled nucleic acid probes.

Abstract: Improved electrochemical production of hydrogen peroxide is provided with a surface-oxidized carbon catalyst. The carbon can be, for example, carbon black or carbon nanotubes. The oxidation of the carbon can be performed, for example, by heating the carbon in nitric acid, or by heating the carbon in a base. The resulting carbon catalyst can have a distinctive oxygen is peak in its X-ray photoelectron spectrum.

Abstract: Improved temperature measurement and correction is provided for magnetoresistive sensor arrays. A linear coefficient of resistance vs. temperature is determined from one or more reference sensors in the array by measuring resistance of the reference sensors at known temperatures, which enables resistance measurements to be used to determine unknown temperatures in all sensors of the array. Double modulation leads to MR sensor outputs having center tones which can be used to correct temperature dependence in side tone MR signals. This correction can be according to a linear fit or a polynomial fit. Applications include biological assays requiring accurate temperature data, such as accurate determination of DNA melting curves.

Abstract: An immunomodulatory delivery system includes a hydrogel, a first immunomodulatory cargo encapsulated in the cargo, and a second immunomodulatory cargo encapsulated in the hydrogel. The hydrogel includes a polymer non-covalently crossed-linked with a plurality of nanoparticles. The first immunomodulatory cargo is smaller than the second immunomodulatory cargo. A ratio of a diffusivity of the first immunomodulatory cargo through the hydrogel to a diffusivity of the second immunomodulatory cargo through the hydrogel is less than 3.