Abstract: Described herein are quinoline compounds useful for, among other things, inhibition of the proteasome and for treatment of cancer and inflammation.

Abstract: A method of constructing an electrical contact including a contact element positioned between a first contact member and a second contact member. The method includes defining a transmission line model to represent operation of the electrical contact. The transmission line model indicates a contact resistance and a specific contact resistivity along a length of the contact element. The method includes determining a current flow profile of the contact element. The current flow profile is determined based on a current distribution using the transmission line model. The method includes determining one of: (i) a material, (ii) a thickness, and (iii) a geometry of the contact element based on the contact resistance and the current flow profile of the transmission line model. The method includes constructing the contact element positioned between the first contact member and the second contact member with the at least one of (i) the material, (ii) the thickness, and (iii) the geometry.

Abstract: Provided herein are vaccine composition comprising an antigen conjugated to a capsid, wherein the capsid comprises wild type or native sequence. Provided herein are also vaccine composition comprising an antigen conjugated to a capsid, wherein said capsid comprises at least one mutation, such as a non-natural mutation. Such compositions are useful in the treatment and prevention of pathogenic infections, inflammatory diseases, and neurodegenerative disease, and cancer, among others.

Abstract: A system and method for identifying a subject using imaging are provided. In some aspects, the method includes receiving an image depicting a subject to be identified, and applying a trained Disentangled Representation learning-Generative Adversarial Network (DR-GAN) to the image to generate an identity representation of the subject, wherein the DR-GAN comprises a discriminator and a generator having at least one of an encoder and a decoder. The method also includes identifying the subject using the identity representation, and generating a report indicative of the subject identified.

Abstract: A voltage conversion system including a source configured to supply a voltage and a switch capacitor circuit electrically coupled to the source. The switch capacitor circuit is configured to switch between a discharging state and a charging state. The switching between the discharging state and the charging state produces a boost to the supplied voltage. The voltage conversion system includes a capacitor in the switch capacitor circuit configured to store charge during the charging state and drain charge during the discharging state. The voltage conversion system includes a switching arrangement having a plurality of switch pairs configured to supply a converted voltage to a load. The switch capacitor circuit and the switching arrangement are interfaced to produce a unified circuit.

Abstract: Plants described herein have increased biomass and are more readily digested into fermentable sugars when the plants express increased levels of one or more types of CGR2 and/or CGR3 enzymes.

Abstract: The disclosure relates to the extraction and detection of pathogens using carbohydrate-functionalized biosensors. Immobilized carbohydrate moieties on the biosensor provide a means for non-specific binding of a plurality of target analytes. When a sample containing the target analyte is applied or otherwise transported to the biosensor detection surface, non-specific binding interactions between the carbohydrate moiety and the analyte immobilize/retain the analyte at the detection surface. The carbohydrate moiety is a stable binding pair member that allows on-sensor rinsing of a sample to enhance detection of an analyte in the sample. Specific analyte identification can be achieved with an analyte probe having a detection moiety and a binding pair member specific to the target analyte of interest.

Abstract: A method to convert at least a majority of native cellulose I? to cellulose IIII in pretreated or untreated densified biomass is disclosed. The densified biomass (cellulosic or lignocellulosic) is pretreated with anhydrous liquid ammonia or liquid ammonia comprising a solution of at least 80% ammonia. The pretreating can be performed at a temperature from about 4° C. to about 140° C. and a pressure from about 14.7 to about 200 psi. In one embodiment, the densified cellulosic converting pretreatment process is followed by lignin extraction (LE). The total moisture content of the densified biomass and the solution is 30% or less and a weight ratio of liquid ammonia to the densified biomass is from about 0.3:1 to about 2:1. Various products and systems are also disclosed.

Abstract: A method of exciting an organic salt in a cell is provided. The method includes contacting the cell with a composition including the organic salt, the organic salt having a photoactive ion and a counterion. The cell uptakes the organic salt, the organic salt is substantially free of a coating within the cell, and the organic salt is non-toxic to the cell in the dark. The method also includes exposing the cell to light having a first wavelength, wherein the organic salt absorbs the light having the first wavelength and the photoactive ion becomes excited.

Abstract: A system and method is provided that utilizes deep learning, including convolutional neural networks, to identify subject objects in unconstrained user images such as unknown pills. An image of, e.g., a pill, may be captured and subsequently processed using deep learning models to identify the pill. The deep learning models may be optimized to have a small footprint (in terms of computational and memory resources) suitable for a resource-limited device such as a smartphone while retaining a high object recognition accuracy. Each such model may also be run on modified versions of the unconstrained image, for example on color, greyscale, and gradient images, to focus the models on different distinguishing features of the object.

Abstract: A laser apparatus includes an optic dispersion compensator. In another aspect, an optic (40, 45) uses phase wrapping to compress or stretch a laser pulse. A further aspect includes an apparatus and method for binary-phase compression of stretched laser pulses. In yet another aspect, a single monolithic transmissive or reflective optic (40, 45) provides compression or stretching of a laser pulse using a sinusoidal pattern for introducing binary steps. Another aspect provides a stretching or compressing optic (40, 45) for retarding a phase of multiple frequency regions of a laser pulse by a factor of 2? or less. Still another aspect employs a volume grating or multi-layer mirror including phase wrapping to obtain discontinuous phase jumps in a laser pulse compressor (45) or stretcher (40). Methods of using or making the laser apparatus are also provided.

Abstract: Disclosed are electrochemical devices, such as lithium ion battery electrodes, lithium ion conducting solid-state electrolytes, and solid-state lithium ion batteries including these electrodes and solid-state electrolytes. Also disclosed are methods for making such electrochemical devices.

Abstract: A diesel engine employs a turbulent jet ignition system and method. In another aspect, diesel fuel and air are premixed prior to introduction of the mixture into a main engine combustion chamber. A further aspect employs a turbocharger compressor to boost air pressure into a main piston combustion chamber and/or an ignition pre-chamber for missing with a heavy fuel, such as diesel.

Abstract: The disclosure relates to a surgical system and related methods to facilitate reduction and fixation of sacro-iliac luxations/fractures (SIL/F) in small animals, for example dogs and cats. In another aspect, the disclosure relates to an aiming device and related methods providing accurate, reliable, and safe fixation of SIL/F in such small animals. The surgical system includes a work surface, an articulatable and lockable reduction arm mounted to the work surface, a reduction handle mounted to the reduction arm; an articulatable and lockable fixation arm mounted to the work surface, a fixation drill guide mounted to the fixation arm, and an image acquisition unit directed toward the work surface. The surgical system provides enhanced safety to surgical personnel using the system in terms of reduced exposure to harmful radiation form the image acquisition unit.

Abstract: An electrochemical cell comprising an anode electrode, a cathode electrode and a reference electrode electronically connected to each other; a first biocatalyst comprising a consolidated bioprocessing organism (e.g., a cellulomonad or clostridium or related strains, such as Cellulomonas uda (C. uda), Clostridium lentocellum (C. lentocellum), Acetivibrio celluloyticus (A. cellulolyticus) Clostridium cellobioparum (C. cellobioparum), alcohol-tolerant C. cellobioparum, alcohol-tolerant C. uda, and combinations thereof) capable of fermenting biomass (e.g., cellulosic biomass or glycerin-containing biomass) to produce a fermentation byproduct; and a second biocatalyst comprising an electricigen (e.g., Geobacter sulfurreducens) capable of transferring substantially all the electrons in the fermentation byproduct (e.g., hydrogen, one or more organic acids, or a combination thereof) to the anode electrode to produce electricity is disclosed.

Abstract: An implantable device is provided. The implantable device includes a flexible polymeric substrate that extends through an aperture in an electrically conductive material to form an anchor that partially covers the electrically conductive material. Methods for fabricating the implantable device are also provided.

Abstract: A multiband sensing system includes an active multiband sensing unit configured to transmit a radio frequency (RF) signal in multiple bands and communicate with a network. The active multiband sensing unit includes at least one transmitting antenna configured to transmit the RF signal. The multiband sensing system includes a passive multiband sensing unit including at least one receiving antenna configured to receive the RF signal, an acoustic actuator powered by the received RF signal including an actuating sensor element configured to actuate in response to receiving extracted modulated information of the RF signal, and an acoustic detector. The acoustic detector includes a detector transmitting antenna configured to backscatter a new frequency band signal to the active multiband sensing unit and a detector sensor element configured to sense data. The sensed data is modulated over the received RF signal to produce the new frequency band signal.

Abstract: A technique is presented for correcting phase distortion in a digital wireless transmitter. The technique includes: receiving an RF signal in an analog domain by a digital-to-RF modulator; amplitude modulating, the RF signal in accordance with a digital input code; and introducing delay in a signal path traversed by the RF signal before the digital-to-RF modulator using a delay circuit. The duration of the delay depends upon the value of the digital input code and substantially cancels out the phase distortion introduced by the digital wireless transmitter.

Abstract: Disclosed herein are inhibitors of gene transcription mediated by myocardin-related transcription factor and serum response factor, or both myocardin-related transcription factor and serum response factor (“MRTF/SRF”), and methods for their use in treating or preventing cancer and fibrosis. In particular, disclosed herein are compounds of Formula (I) and Formula (II), and pharmaceutically acceptable salts thereof: wherein the substituents are as described.

Abstract: Thermoelectric materials based on tetrahedrite structures for thermoelectric devices and methods for producing thermoelectric materials and devices are disclosed.