Abstract: Compositions and methods for treatment and prevention of disorders and conditions characterized by reduced TGF-B signaling are described. In particular, the compositions and methods are useful for reducing or eliminating the pathologies associated with Alzheimer's disease. The compositions include urea derivatives containing a piperidine, piperidinium, or a piperidin-4-yl methyl; cycloalkyl, aryl, and fluorobenzyl moieties.
Type:
Application
Filed:
March 14, 2014
Publication date:
February 11, 2016
Applicant:
The Board of Trustees of the Leladn Stanford Junior University