Patents Assigned to The Board of Trustees of the Leland Sanford Junior University
  • Methods and systems for constraint of spinous processes with attachment
    Patent number: 9149304
    Abstract: Spinal implants for limiting flexion of the spine are implanted between a superior spinous process and an inferior spinous process or sacrum. The implants include upper straps which are placed over the upper spinous process, while the lower portions of the implant are attached to the adjacent vertebra or sacrum. The attachments may be fixed, for example using screws or other anchors, or may be non-fixed, for example by placing a loop strap through a hole in the spinous process or sacrum.
    Type: Grant
    Filed: August 2, 2013
    Date of Patent: October 6, 2015
    Assignees: The Board of Trustees of the Leland Sanford Junior University, Empirical Spine, Inc.
    Inventors: Todd Alamin, Ian Bennett, Louis Fielding, Colin Cahill
  • Humanized and chimeric monoclonal antibodies to CD47
    Patent number: 9017675
    Abstract: Humanized or chimeric anti-CD47 monoclonal antibodies are provided. The antibodies bind to and neutralize human CD47, and find use in various therapeutic methods. Preferred are non-activating antibodies. Embodiments of the invention include isolated antibodies and derivatives and fragments thereof, pharmaceutical formulations comprising one or more of the humanized or chimeric anti-CD47 monoclonal antibodies; and cell lines that produce these monoclonal antibodies. Also provided are amino acid sequences of the antibodies.
    Type: Grant
    Filed: November 13, 2012
    Date of Patent: April 28, 2015
    Assignee: The Board of Trustees of the Leland Sanford Junior University
    Inventors: Jie Liu, Irving L. Weissman, Ravindra Majeti
  • Purified human cytomegalovirus protein
    Patent number: 5194256
    Abstract: A purified human CMV virion protein that has a molecular weight of approximately 86,000 daltons by SDS-PAGE and exhibits in vivo immunizing activity and a murine monoclonal antibody that binds specifically to the protein and exhibits complement-independent human CMV neutralizing activity are described. The antibody is useful for isolating the protein by affinity chromatography and the protein is, in turn, useful for detecting CMV neutralizing antibody in sera and as a vaccine.
    Type: Grant
    Filed: October 2, 1987
    Date of Patent: March 16, 1993
    Assignee: The Board of Trustees of the Leland Sanford Junior University
    Inventors: Lucy E. Rasmussen, Thomas C. Merigan