Patents Assigned to The Board of Trustees of the Leland Stanford Junior University of Stanford
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Patent number: 11084858Abstract: Variant IL-13 polypeptides are provided, which are engineered to have one or more of the following properties: (a) altered affinity for IL-13R?2, relative to the native human IL-13 protein; (b) altered affinity for IL-13R?1 relative to the native human IL-13 protein; (c) a disruption in the binding site for IL-4R? relative to the native human IL-13 protein.Type: GrantFiled: January 25, 2019Date of Patent: August 10, 2021Assignee: The Board of Trustees of the Leland Stanford Junior University Stanford, CAInventors: Kenan Christopher Garcia, Ignacio Moraga Gonzalez
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Patent number: 11020345Abstract: Microdevices containing a chamber bound on one side by a nanoporous membrane are provided. The nanoporous membrane may contain hollow nanotubes that extend through the nanoporous membrane, from one surface to the other, and extend beyond the surface of the nanoporous membrane opposite the surface interfacing with the chamber. The nanotubes may provide a fluidic conduit between an environment external to the microdevice and the chamber, which is otherwise substantially fluid-tight. Also provided are methods of making a microdevice and methods of using the microdevices.Type: GrantFiled: March 14, 2017Date of Patent: June 1, 2021Assignee: The Regents of the University of California The Board of Trustees of the Leland Stanford Junior University StanfordInventors: Cade B. Fox, Hariharasudhan Chirra Dinakar, Nicholas A. Melosh, Tejal A. Desai
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Patent number: 10149860Abstract: Compounds, pharmaceutical compositions, and methods of using such compounds and compositions to treat or prevent Alzheimer's disease and related tauopathies through the inhibition of USP-9X and/or enhancement of SCF(?-TrCP).Type: GrantFiled: February 3, 2016Date of Patent: December 11, 2018Assignee: Board of Trustees of the Leland Stanford Junior University, Stanford University Office of Technology LicensingInventors: Bingwei Lu, Seongsoo Lee
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Publication number: 20140073568Abstract: The present invention provides methods for diagnosing mental disorders. The invention also provides methods of identifying modulators of mental disorders as well as methods of using these modulators to treat patients suffering from mental disorders.Type: ApplicationFiled: February 25, 2013Publication date: March 13, 2014Applicant: Board of Trustees of the Leland Stanford Junior University of StanfordInventor: Board of Trustees of the Leland Stanford Junior University of Stanford
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Patent number: 8415298Abstract: The present invention provides methods for diagnosing mental disorders. The invention also provides methods of identifying modulators of mental disorders as well as methods of using these modulators to treat patients suffering from mental disorders.Type: GrantFiled: June 21, 2005Date of Patent: April 9, 2013Assignee: The Board of Trustees of the Leland Stanford Junior University of StanfordInventors: Huda Akil, William E. Bunney, Jr., Prabhakara V. Choudary, Simon J. Evans, Edward G. Jones, Jun Li, Juan F. Lopez, David M. Lyons, Margherita Molnar, Richard M. Myers, Alan F. Schatzberg, Richard Stein, Robert C. Thompson, Hiroaki Tomita, Marquis P. Vawter, Stanley J. Watson
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Publication number: 20060051786Abstract: The present invention provides methods for diagnosing mental disorders. The invention also provides methods of identifying modulators of mental disorders as well as methods of using these modulators to treat patients suffering from mental disorders.Type: ApplicationFiled: June 21, 2005Publication date: March 9, 2006Applicant: The Board of Trustees of the Leland Stanford Junior University of StanfordInventors: Huda Akil, William Bunney, Prabhakara Choudary, Simon Evans, Edward Jones, Jun Li, Juan Lopez, David Lyons, Margherita Molnar, Richard Myers, Alan Schatzberg, Richard Stein, Robert Thompson, Hiroaki Tomita, Marquis Vawter, Stanley Watson
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Patent number: 5403919Abstract: Novel antibodies that recognize endothelial cell surface molecules and block leukocyte extravasation are provided. These antibodies recognize tissue-specific endothelial cell surface molecules and block lymphocyte migration from the blood into tissues such as mucosal lymphoid organs and peripheral lymph nodes. Novel endothelial cell surface proteins involved in leukocyte extravasation and having a molecular weight of approximately 58,000 to 69,000 daltons and express a tissue-specific determinant are also described. The antibodies are used in an immunotherapeutic method to treat individuals having a disease or inflammation-associated pathology in which leukocyte extravasation plays a role.Type: GrantFiled: March 3, 1993Date of Patent: April 4, 1995Assignee: Board of Trustees of the Leland Stanford Junior University Stanford UniversityInventor: Eugene C. Butcher
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Patent number: 5235404Abstract: A method and apparatus for measuring nonreciprocal optical effects contemplates directing two circularly polarized optical beams having a known phase relation to each other at a sample, and detecting the difference in phase between the two beams after they have encountered the sample. In a transmission measurement the two circularly polarized beams have the same handedness, but pass through the sample in opposite directions. In a reflection measurement, the two circularly polarized beams have opposite handedness, but encounter the sample in the same direction. In a particular embodiment of the invention a linearly polarized beam is introduced into a Sagnac interferometer and split into two linearly polarized beams which are ultimately recombined.Type: GrantFiled: June 27, 1991Date of Patent: August 10, 1993Assignee: Board of Trustees, Leland Stanford Junior University, Stanford UniversityInventors: Martin M. Fejer, Aharon Kapitulnik, Kenneth A. Fesler
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Patent number: 4851206Abstract: Methods and compostions produced thereby are provided concerning the preparation and use of high specific surface area carbides and nitrides. The carbides and nitrides can be obtained by thermal reduction of oxides in the presence of a source of carbon and nitrogen respectively, with relatively slow progressive temperature increases prior to completion of the reaction, followed by quenching. Novel metastable carbides can be obtained by carburization of nitrides having high surface area, which nitrides can be prepared by the above-described process.Type: GrantFiled: October 5, 1987Date of Patent: July 25, 1989Assignee: The Board of Trustees of the Leland Stanford Junior University, Stanford UniversityInventors: Michel Boudart, Shigeo T. Oyama, Leo Volpe
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Patent number: 4851035Abstract: An ethylene biosynthesis inhibitor is provided comprising 2-cycloalkyl-1-aminocyclopropanecarboxylic acids or a derivative thereof. By applying the subject compound in an ethylene-production-inhibiting amount, ripening and senescence can be slowed. The compound finds use in conjunction with the inhibition of ripening and improved storage of fruits, vegetables and cut flowers.Type: GrantFiled: May 1, 1986Date of Patent: July 25, 1989Assignee: The Board of Trustees of the Leland Stanford Junior University, Stanford UniversityInventors: Michael C. Pirrung, Gerald M. McGeehan
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Patent number: 4837151Abstract: Live vaccines are provided and methods for preparing the live vaccines for protection of a host from a pathogenic microorganism. The vaccines are prepared by introducing at least one modification in a gene involved in at least one, normally at least two, biosynthetic pathways, involving the production of products which are unlikely to be found in the disease susceptible host. The modification results in a gene change which cannot be repaired by a single step e.g. polynucleotide deletions and inversions. Where the aro gene suffers such a change, the resultant auxotrophic mutants require aromatic amino acids, p-aminobenzoic acid and 2,3-dihydroxybenzoic acid or a highly concentrated source of absorbable iron. The auxotrophic mutations have substantially reduced or nonexistent virulence, while retaining the desired immunogenicity to initiate the immunogenic response. Various techniques can be employed for providing the desired change.Salmonella typhimurium strain SL1479 was deposited at the ATCC on Sept.Type: GrantFiled: November 14, 1985Date of Patent: June 6, 1989Assignee: The Board of Trustees of the Leland Stanford Junior University, Stanford UniversityInventor: Bruce A. D. Stocker
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Patent number: 4490363Abstract: A morphine-like amidated opioid octapeptide metorphamide having the struce Try-Gly-Gly-Phe-Met-Arg-Arg-Val-NH.sub.2 has been isolated from bovine caudate nucleus extracts and synthesized by solid phase peptide synthesis methods. Metorphamide is thus far the only natural opioid peptide having a high .mu.-binding activity.Type: GrantFiled: June 24, 1983Date of Patent: December 25, 1984Assignee: Board of Trustees of The Leland Stanford Junior University Stanford Univ.Inventors: Jack D. Barchas, Eckard Weber, Christopher J. Evans