Abstract: The described invention comprises a method for detecting the onset or monitoring the recurrence of chronic graft versus host disease (cGVHD) in a transplantation patient. The method comprises isolating peripheral blood mononuclear cells (PBMCs) from the transplantation patient and analyzing the isolated PBMCs to detect a biomarker specific for a donor cell. The detection of the biomarker is indicative of the onset or recurrence of cGVHD in the transplantation patient.
Type:
Grant
Filed:
March 12, 2013
Date of Patent:
May 23, 2017
Assignee:
The Board of Trustees of the Leland University Junior University
Inventors:
David B. Miklos, Bita Sahaf, Leonore A. Herzenberg