Patents Assigned to The Board of Trustees of the University of Illinois
  • Patent number: 11041187
    Abstract: A digital assay for a micro RNA (miRNA) or other target analyte in a sample makes use of nanoparticles that absorb light at the resonant wavelength of a photonic crystal (PC). Such nanoparticles locally quench the resonant reflection of light from the PC when present on the surface of the PC. The nanoparticles are functionalized to specifically bind to the target analyte, and the PC surface is functionalized to specifically bind to the nanoparticles that have bound to the target analyte. The sample is exposed to the functionalized nanoparticles, and the individual nanoparticles bound to the PC surface can be identified and counted based on reduced intensity values in the reflected light from the PC. The number of bound nanoparticles that are counted in this way can be correlated to the abundance of the target analyte in the sample.
    Type: Grant
    Filed: October 25, 2018
    Date of Patent: June 22, 2021
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Brian T. Cunningham, Yue Zhuo, Brendan Harley, Ji Sun Choi, Thibault Marin, Yi Lu
  • Patent number: 11038318
    Abstract: This disclosure relates to semiconductor quantum cascade lasers (QCLs). A three-terminal QCL device is disclosed. The three-terminal QCL device includes a unipolar multi-period quantum cascade laser structure embedded in a bipolar structure having three terminals providing at least two independently controllable biases to the QCL device for adjusting the lasing intensity and for tuning the lasing wavelength of the QCL device. The three-terminal QCL device further includes a quantum impedance matching structure for achieving high efficiency carrier injection and lowering lasing threshold. In addition, the multi-period quantum cascade laser structure is selectively doped to provide near charge neutrality during operation. The three-terminal QCL may further be controlled to achieve simultaneous dual- or multi-color lasing.
    Type: Grant
    Filed: February 22, 2019
    Date of Patent: June 15, 2021
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Jean-Pierre Leburton, John Michael Dallesasse
  • Patent number: 11033199
    Abstract: Magnetic resonance elastography (MRE) is an imaging technique for estimating the stiffness of tissues non-invasively. Shear waves are generated via external mechanical actuation and the tissue imaged with a specially designed MR pulse sequence. The resulting images are used to calculate the underlying properties. The application provides methods for acquiring MRE data using a single shot, echo planar imaging readout. The purpose of the developed sequence is to acquire MRE data using a single-shot, echo-planar imaging readout, avoiding to need for off-line image processing.
    Type: Grant
    Filed: June 27, 2016
    Date of Patent: June 15, 2021
    Assignee: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
    Inventors: Curtis L. Johnson, Bradley Sutton
  • Patent number: 11038321
    Abstract: Vertical-cavity surface-emitting lasers (VCSELs) and methods for making such are provided. The VCSELs include stepped upper reflectors having respective differently-sized apertures. This allows the lower portion of the reflector to have formed therein a wider-diameter aperture to allow for increased current injection. The upper portion of the reflector has formed therein a narrower-diameter, mode-selecting aperture to allow higher-order modes to be reduced, leading to single-mode operation. The VCSELs are thus capable of higher-power emission in a single mode, allowing for longer-distance signaling over optical fiber, despite modal dispersion within the fiber and/or at the coupling between the VCSEL and the fiber. The two differently-sized apertures can be formed via respective lateral oxidation processes following etch-down to form the respective steps of the upper reflector.
    Type: Grant
    Filed: October 11, 2019
    Date of Patent: June 15, 2021
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Milton Feng, Xin Yu
  • Patent number: 11035800
    Abstract: A portable device for colorimetric or fluorometric analysis comprises a linear array of optically-responsive chemical sensing elements; an image sensor in optical communication with the linear array for determining a spectral response of the optically-responsive chemical sensing elements, where the image sensor comprises at least one light emission source; and electronics connected to the image sensor for analyzing spectral response data. A method of conducting colorimetric or fluorometric analysis comprises exposing a linear array of optically-responsive chemical sensing elements to a fluid comprising an analyte; impinging light on the linear array and detecting a spectral response of the chemical sensing elements; and determining an exposed color of each of the chemical sensing elements.
    Type: Grant
    Filed: December 12, 2019
    Date of Patent: June 15, 2021
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Kenneth S. Suslick, Jon R. Askim
  • Publication number: 20210170377
    Abstract: The invention provides methods for completely removing aluminum from existing zeolite frameworks that have been previously considered unalterable due to their small pore sizes and stable crystal structures. Consequently, new combinations of metal atoms and zeolite structures can now be made using the methods disclosed herein. Metal atoms that have useful properties for catalysis and adsorption have been integrated into zeolite structures that provide advantageous size selection or solvation properties to increase rates, conversions, and yields of catalytic processes. The disclosed catalysts and methods reduce the cost of synthesizing useful materials and zeolite structures with compositions of matter that have not been reported.
    Type: Application
    Filed: December 4, 2020
    Publication date: June 10, 2021
    Applicant: The Board of Trustees of the University of Illinois
    Inventors: David William Flaherty, Daniel T. Bregante
  • Patent number: 11031456
    Abstract: A rolled-up electromagnetic component for on-chip applications comprises: a multilayer sheet in a rolled configuration comprising at least one turn about a longitudinal axis; a core defined by a first turn of the rolled configuration; and a soft magnetic material disposed within the core, where the multilayer sheet comprises a conductive pattern layer on a strain-relieved layer. A method of making a rolled-up electromagnetic component for on-chip applications includes forming a rolled-up device comprising: a multilayer sheet in a rolled configuration having at least one turn about a longitudinal axis, where the multilayer sheet comprises a conductive pattern layer on a strain-relieved layer; and a core defined by a first turn of the rolled configuration. The method further includes introducing a soft magnetic material into the core.
    Type: Grant
    Filed: June 7, 2019
    Date of Patent: June 8, 2021
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Xiuling Li, Wen Huang, Zhendong Yang, Mark D. Kraman, Jimmy Ni, Zihao Ou, Qian Chen, J. Gary Eden
  • Patent number: 11029427
    Abstract: Measuring in a first semiconductor crystal two anode channels and two cathode channels and measuring in a second semiconductor crystal one anode channel and one cathode channel; responsive to an energy of a sum of the two anode channels being within an energy window and an energy of the one anode channel being within the energy window: separating the two anode channels and the two cathode channels into combinations of anode-cathode channel pairs; for each of the anode-cathode channel pairs, determining a respective direction difference angle, each respective direction difference angle being determined via use of the one anode channel and one cathode channel; determining a determined one of the direction difference angles that has a smallest value; and setting as an initial interaction position of a photon a selected one of the anode-cathode channel pairs that corresponds to the determined direction difference angle. Additional embodiments are disclosed.
    Type: Grant
    Filed: October 25, 2019
    Date of Patent: June 8, 2021
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Shiva Abbaszadeh, Garry Chinn, Craig Levin
  • Patent number: 11026918
    Abstract: A pharmaceutical composition for aerosol administration and method of preventing or treating a pulmonary disease or condition in a subject with a SphK1 inhibitor are provided.
    Type: Grant
    Filed: November 24, 2015
    Date of Patent: June 8, 2021
    Assignee: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
    Inventors: Anantha Harijith, Viswanathan Natarajan, Roberto F. Machado, Jeffrey Jacobson
  • Patent number: 11028114
    Abstract: Provided are certain derivatives of amphotericin B (AmB) characterized by reduced toxicity and retained anti-fungal activity. Certain of the derivatives are C16 urea derivatives of AmB. Certain of the derivatives are C3, C5, C8, C9, C11, C13, or C15 deoxy derivatives of AmB. Certain of the derivatives include C3? or C4? modifications of the mycosamine appendage of AmB. Also provided are methods of making AmB derivatives of the invention, pharmaceutical compositions comprising AmB derivatives of the invention, and methods of use of AmB derivatives of the invention.
    Type: Grant
    Filed: August 2, 2019
    Date of Patent: June 8, 2021
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Martin D. Burke, Stephen Davis, Brice E. Uno, Justin Struble, Ian Dailey, Kaitlyn C. Gray, David M. Knapp, Pulin Wang, Nagarjuna Palyam
  • Patent number: 11029198
    Abstract: The invention provides systems and methods for wearable and tissue-mounted electronics for monitoring exposure of a subject or object to electromagnetic radiation, particularly electromagnetic radiation in the visible, ultraviolet and infrared portions of the electromagnetic spectrum. In some embodiments, the devices are purely passive devices where absorption of incident electromagnetic radiation by the device provides at least a portion of the power for the measurement of the radiant exposure or flux of the incident electromagnetic radiation. Devices of the invention may include near field communication components, for example, for enabling readout by an external device, such as a computer or mobile device.
    Type: Grant
    Filed: June 1, 2016
    Date of Patent: June 8, 2021
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: John A. Rogers, Anthony R. Banks, Xinying Wang, Gregory Brown
  • Publication number: 20210159146
    Abstract: A method of forming a textured surface layer along a substrate that includes disposing a plurality of polymer spheres on a surface of the metal substrate, and electroplating the metal substrate at a current density to deposit a metal layer along a body of each of the plurality of polymer spheres disposed on the surface of the metal substrate. The metal layer does not extend above a top surface of the plurality of polymer spheres. The method further includes removing the plurality of polymer spheres from the metal layer to form the textured surface defined by a size and shape of the plurality of polymer spheres.
    Type: Application
    Filed: November 26, 2019
    Publication date: May 27, 2021
    Applicants: Toyota Motor Engineering & Manufacturing North America, Inc., The Board of Trustees of the University of Illinois
    Inventors: Shailesh N. Joshi, Paul Braun, Julia Kohanek, Gaurav Singhal
  • Publication number: 20210159143
    Abstract: A method of forming an inverse opal structure along a substrate that includes depositing polymer spheres along the substrate and electroplating the substrate and spheres at a first current density to form a first solid metal layer such that the spheres are raised from the substrate. The method includes electroplating the substrate and the spheres at a second current density to diffuse metals from the substrate and deposit the metal about the spheres. The second current density is greater than the first current density. The method includes electroplating the substrate and spheres to form a second solid metal layer disposed over the spheres, and removing the spheres to form the inverse opal structure disposed between the first and second solid metal layers. The first and second solid metal layers define planar interface surfaces disposed over a porous structure of the inverse opal structure.
    Type: Application
    Filed: November 26, 2019
    Publication date: May 27, 2021
    Applicants: Toyota Motor Engineering & Manufacturing North America, Inc., The Board of Trustees of the University of Illinois
    Inventors: Shailesh N. Joshi, Paul Braun, Julia Kohanek, Gaurav Singhal
  • Publication number: 20210158041
    Abstract: Aspects of the subject disclosure may include, for example, obtaining video data from a single monocular camera, wherein the video data comprises a plurality of frames, wherein the camera is attached to a mobile robot that is travelling along a lane defined by a row of crops, wherein the row of crops comprises a first plant stem, and wherein the plurality of frames include a depiction of the first plant stem; obtaining robot velocity data from encoder(s), wherein the encoder(s) are attached to the robot; performing foreground extraction on each of the plurality of frames of the video data, wherein the foreground extraction results in a plurality of foreground images; and determining, based upon the plurality of foreground images and based upon the robot velocity data, an estimated width of the first plant stem. Additional embodiments are disclosed.
    Type: Application
    Filed: August 24, 2018
    Publication date: May 27, 2021
    Applicant: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
    Inventors: Girish Chowdhary, Chinmay P. Soman, Erkan Kayacan, Benjamin C. Thompson, Zhongzhong Zhang, Anwesa Choudhuri
  • Publication number: 20210161026
    Abstract: A method for forming an assembly is provided. The method includes depositing a colloidal template onto a substrate, wherein the colloidal template is porous, depositing a metal layer onto and within the colloidal template, depositing a cap structure onto the colloidal template opposite of the substrate, and removing the colloidal template from between the substrate and the cap structure to form a metal inverse opal structure disposed therebetween. The method continues by depositing an electrical isolation layer in contact with the cap structure opposite the metal inverse opal structure, and attaching the electrical isolation layer to a cooling device.
    Type: Application
    Filed: November 26, 2019
    Publication date: May 27, 2021
    Applicants: Toyota Motor Engineering & Manufacturing North America, Inc., The Board of Trustees of the University of Illinois
    Inventors: Shailesh N. Joshi, Paul Braun, Julia Kohanek, Gaurav Singhal
  • Patent number: 11014953
    Abstract: Disclosed are compounds for the selective labeling of cell-surface sugars in cancer cells. The compounds are activatable by triggers specific to cancer cells, and, when metabolized, label a cancer cell surface sugar with an azide chemical group. Facilitated by a click chemistry reaction, combination of the cell surface-expressed azide with a alkynyl-drug conjugate enables efficient targeted drug delivery to cancer cells with reduced toxicity. Also disclosed are compounds for delivering a drug to an azide-bearing cancer cell, and methods of treating cancer using the compounds of the invention.
    Type: Grant
    Filed: October 7, 2016
    Date of Patent: May 25, 2021
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Jianjun Cheng, Hua Wang
  • Patent number: 11014852
    Abstract: A method of using a flowable binder for construction or repair comprises providing a binder mixture including an alkali metal silicate, fly ash, slag, and added water, where a total water-to-solids mass ratio of the binder mixture is in a range from about 0.2 to 0.5. The binder mixture is mixed together with inert particles to form a flowable mortar. The flowable mortar is distributed over a bed of coarse aggregate, and the mortar seeps into interstices of the coarse aggregate. Upon curing, a composite comprising reinforcement material embedded in a cured binder is formed.
    Type: Grant
    Filed: January 23, 2019
    Date of Patent: May 25, 2021
    Assignees: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS, UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY
    Inventors: Waltraud M. Kriven, Kaushik Sankar, Ghassan K. Al-Chaar
  • Patent number: 11008353
    Abstract: Provided herein are metal-ligand complexes, and associated methods, characterized by formula MLxDy; wherein: M is a metal; x is equal to the oxidation state of M; each D is independently a neutral coordinating ligand; y is zero or an integer selected from the range of 1 to 4; and each L is independently a mono-anionic ligand. L may be a ?1,?2-?,?-disubstituted-?-alkenyl ligand.
    Type: Grant
    Filed: July 13, 2018
    Date of Patent: May 18, 2021
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Gregory S. Girolami, Sumeng Liu
  • Patent number: 11010881
    Abstract: The disclosure is directed to a method and apparatus for performing patterned microscopy. The method includes obtaining a microscopy image of an object based on optical signal from the object in response to a first incoming optical beam; and obtaining a contrast-enhancing image based on optical signal from the object in response to a second incoming optical beam. The method also includes generating a patterned mask based on the contrast-enhancing image. The method further includes applying the patterned mask on the microscopy image to obtain a patterned microscopy image. The microscopy image includes a polarization-analyzed reflection confocal microscopy image. The contrast-enhancing image includes a second-harmonic generation microscopy image. The patterned microscopy image includes a second-harmonic patterned polarization-analyzed reflection confocal microscopy image.
    Type: Grant
    Filed: May 14, 2019
    Date of Patent: May 18, 2021
    Assignee: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
    Inventors: Kimani C. Toussaint, Chukwuemeka O. Okoro
  • Publication number: 20210142550
    Abstract: Aspects of the subject disclosure may include, for example, a method comprising: receiving, by a processing system including a processor, an input three-dimensional dataset comprising a first plurality of two-dimensional images of all or a portion of a subject; applying, by the processing system, bias field correction to the input three-dimensional dataset to generate a corrected three-dimensional dataset comprising a second plurality of two-dimensional images; and generating, by the processing system, a labeled three-dimensional dataset comprising a third plurality of two-dimensional images, wherein the labeled three-dimensional dataset further comprises one or more labels indicating an anatomical structure, and wherein the labeled three-dimensional dataset is generated via a convolutional neural network based upon the corrected three-dimensional dataset and based upon a previously trained three-dimensional dataset. Additional embodiments are disclosed.
    Type: Application
    Filed: December 17, 2020
    Publication date: May 13, 2021
    Applicant: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
    Inventors: Bradley P. Sutton, Xi Peng, Matthew Bramlet, Kevin Urbain