Abstract: A structural component for a vehicle includes a component including an interior surface defining a first hollow passage and a structural reinforcement contacting the interior surface of the component. The structural reinforcement and component define a cross-section and the structural reinforcement partially fills the cross-section. A process for forming the structural component including inserting a bladder into the first hollow passage defined by the interior surface of the component and inflating the bladder in the first hollow passage, forming a cavity between the bladder and the interior surface, filling the cavity with a polymer resin, and foaming the polymer resin. A system for forming a structural component for a vehicle includes a component including a first hollow passage defined by an interior surface of the component, a bladder insertable into the first hollow passage of the component, and a supply line connected to an interior of the bladder.

Abstract: The present application is directed to a method and system for restraining a patient before, during, or after surgery that increases efficiency of the surgical setup process and minimizes risk of musculoskeletal damage to the patient, particularly in surgeries requiring a patient to be in a Trendelenburg position (e.g., robotic or laparoscopic surgeries). One or more restraints can be worn by a patient prior to surgery', and may function to redistribute the patient's weight across the patient's torso to reduce strain on the patient's shoulders and back. The restraint(s) can be attached to a surgical table by way of an attachment mechanism coupled to the restraint(s) and the table. The attachment mechanism can secure the patient to the table by way of one or more straps, clips, and/or other intermediates. Optionally, the restraint(s) can fulfill other surgical needs, such as heat regulation and vascular compression.

Abstract: Provided herein are polymers having a polymer backbone including a zwitterionic precursor monomeric unit having a secondary or tertiary amine in the polymer backbone, as well as methods of making and using the same.

Abstract: The post-translational modification (PTM) and signaling molecule poly(ADP-ribose) (PAR) has an impact on diverse biological processes. PTM is regulated by a series of ADP-ribosyl glycohydrolases (PARG enzymes) that cleave polymers and/or liberate monomers from their protein targets. Disclosed herein is a substrate for monitoring PARG activity, TFMU-ADPr, which directly reports on total PAR hydrolase activity via release of a fluorophore; this substrate has excellent reactivity, generality, stability, and usability. A second substrate, TFMU-IDPr, selectively reports on PARG activity only from the enzyme ARH3. Use of these probes in whole-cell lysate experiments has revealed a mechanism by which ARH3 is inhibited by cholera toxin. TFMU-ADPr and TFMU-IDPr are versatile tools for assessing small-molecule inhibitors in vitro and probing the regulation of ADP-ribosyl catabolic enzymes.

Abstract: New synthetic methods to provide access to previously unexplored functionality at the C8 position of substituted imidazo[5,1-d][1,2,3,5]tetrazines of Formula I. Through synthesis and evaluation of a suite of compounds with a range of aqueous stabilities (from 0.5 to 40 hours), a predictive model for imidazotetrazine hydrolytic stability based on the Hammett constant of the C8 substituent was derived. Promising compounds were identified that possess activity against a panel of GBM cell lines, appropriate hydrolytic and metabolic stability, and brain-to-serum ratios dramatically elevated relative to TMZ, leading to lower hematological toxicity profiles and superior activity to TMZ in a mouse model of GBM.

Abstract: Embodiments are provided for determining simulated optical microscopy images of formalin-fixed paraffin embedded (FFPE) stained tissue samples from stimulated Raman scattering microscopy (SRSM) images of frozen tissue samples. These embodiments include applying the SRSM images to a first generative model to generate simulated optical microscopy images of thawed, stained tissue samples corresponding to the SRS imaged tissue samples. The simulated optical microscopy images are then applied to a second generative model to generate simulated FFPE microscopy images of the frozen tissue samples.

Abstract: Disclosed are broccoli plant extracts and nutraceuticals including the same that have increased levels of anti-inflammatory chemicals. Also provided are exosomal preparations containing the broccoli plant extracts and nutraceuticals as well as methods of using the broccoli plant extracts and nutraceuticals for treating inflammation and treating or reducing the risk of cancer recurrence in a subject.

Abstract: Embodiments described herein relate to training, by a computing system, a gamma mixture hurdle model. The model may characterize a functional relationship between: output data specifying food flows between zones, and input variables representing food production and food consumption in the zones. The training involves: (i) using binary logistic regression to estimate whether corresponding food flows exist between zone pairs, and (ii) for pairs in which corresponding food flows exist, using a gamma mixture model to estimate amounts of the corresponding food flows. Based on the gamma mixture hurdle model, the computing system can estimate, where each zone includes a respective set of regions: (i) whether corresponding food sub-flows exist between region pairs, and (ii) for pairs in which the corresponding food sub-flows are estimated to exist, potentials of the corresponding food sub-flows. The computing system can also determine, using a linear programming framework, values for the corresponding food sub-flows.

Abstract: Small molecule inhibitors of the localization of lipoprotein CDE (LolCDE) complex that is found in the membrane of bacteria. Searches for suitable candidates for the LolCDE complex led to the discovery of an inhibitor named lolamycin. Lolamycin specifically targets Gram-negative bacteria such as Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, and Salmonella typhimurium, and is selective over Gram-negative and Gram-positive commensal bacteria, thereby avoiding perturbation of the gut microbiome.

Abstract: A dry adhesive for attachment to a flexible adherend comprises a shape memory polymer having a glass transition temperature (Tg) above 25° C. and a compliant backing layer attached to the shape memory polymer. The shape memory polymer is configured to form a conformal and/or hermetic contact with a flexible adherend at temperatures at or above the Tg and to retain the conformal and/or hermetic contact during flexing of the flexible adherend at temperatures below the Tg.

Abstract: A structure for changing the attitude of a spacecraft is provided including an elongated member and a plurality of actuators coupled to the elongated member. The elongated member is coupled to the spacecraft. The elongated member has a length and an angular position relative to an axis. The plurality of actuators are configured to deflect the angular position of the elongated member relative to the axis and to alter the length of the elongated member.

Abstract: A computing device includes a host processor to execute a host driver to create a host-side interface, the host-side interface emulating a first Ethernet interface, assign the host-side interface a first medium access control (MAC) address and a first Internet Protocol (IP) address. Memory components are disposed on a substrate. A memory channel network (MCN) processor is disposed on the substrate and coupled between the memory components and the host processor. The MCN processor is to execute an MCN driver to create a MCN-side interface, the MCN-side interface emulating a second Ethernet interface. The MCN processor is to assign the MCN-side interface a second MAC address and a second IP address, which identify the MCN processor as a MCN network node to the host processor.

Abstract: Provided herein are compositions and methods for mechanochemical dynamic therapy.

Abstract: A segmentation method and segmentation apparatus are provided, where the segmentation method includes receiving image frames comprising a current frame and an adjacent frame to the current frame, determining a feature map to aggregate the image frames based on temporal information between the current frame and the adjacent frame, extracting a feature of a region of interest (ROI) corresponding to instances included in the current frame from the feature map, predicting a class of an object corresponding to the ROI based on the feature of the ROI, and segmenting the instances by correcting an amodal mask predicted corresponding to the class of the object based on the feature of the ROI.

Abstract: Provided herein are stimulus-responsive polymer microgelator particles that can activate fibrin fiber formation from their surfaces by actively ejecting thrombin to form an interconnected fibrin network with an increased elastic modulus and desirable microstructure. The use of the microgelators enables the decoupling of gelation rate and gel rigidity.

Abstract: Aspects of the subject disclosure may include, for example, an electrochemical apparatus, comprising a pair of electrodes each composed of an intercalation host compound (IHC), a separator disposed between the pair of electrodes, and a controller configured to control cycling of the electrochemical apparatus, wherein the pair of electrodes is configured to undergo, during the cycling, reduction-oxidation (redox) reactions in electrolyte solutions that facilitate capturing of carbon dioxide (CO2) and release of captured CO2. Additional embodiments are disclosed.

Abstract: The present invention provides compositions and methods for transferring phospholipids and other molecules between the leaflets of a cell membrane. The compositions comprise at least one nucleic acid or compound having a hydrophilic region, where the composition is able to form a nanostructure that forms a toroidal pore in a lipid membrane. The nucleic acid or hydrophilic region-containing compound further contains an attached molecule capable of inserting the nanostructure into the lipid membrane. The invention also provides methods for scrambling lipids and other molecules in a cell membrane, which can be used to alter the function of a selected cell or to facilitate the death of the cell. The scrambling activity of synthetic scramblases described herein outperforms previously known enzymatically active DNA nanostructures and naturally occurring scramblases, in some cases by several orders of magnitude.

Abstract: The disclosure provides example mass-sensing instruments and methods for use thereof. A mass-sensing instrument includes a mass sensor that includes a first terminal and a second terminal. The mass sensor has a natural oscillation frequency configured to correspond to a mass of a deposited material on the mass sensor. The mass-sensing instrument also includes a first driving circuit configured to control a first voltage of the first terminal and a second driving circuit configured to control a second voltage of the second terminal.

Abstract: Provided are compounds, or pharmaceutically acceptable salts thereof, which are useful for inhibiting FOXM1, inhibiting cancer growth, and/or treating cancer. In particular, these compounds and their corresponding quaternary ammonium salts may be used to treat various forms of breast cancer.

Abstract: An embodiment of the present disclosure takes the form of a sensor device including a base structure with a plurality of ports extending into the base structure, a plurality of cells within the base structure and fluidly coupled to the plurality of ports, and an electrically conductive material disposed within the cells. The sensor device also includes a sensorized lattice structure disposed on the base structure and an electrically conductive layer disposed on top of the sensorized lattice structure.