Patents Assigned to The Board of Trustees of the University of Illinois
  • Publication number: 20220197276
    Abstract: The present disclosure provides a system for monitoring unstructured environments. A predetermined path can be determined according to an assignment of geolocations to one or more agronomically anomalous target areas, where the one or more agronomically anomalous target areas are determined according to an analysis of a plurality of first images that automatically identifies a target area that deviates from a determination of an average of the plurality of first images that represents an anomalous place within a predetermined area, where the plurality of first images of the predetermined area are captured by a camera during a flight over the predetermined area. A camera of an unmanned vehicle can capture at least one second image of the one or more agronomically anomalous target areas as the unmanned vehicle travels along the predetermined path.
    Type: Application
    Filed: November 9, 2021
    Publication date: June 23, 2022
    Applicant: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
    Inventors: Girish Chowdhary, Chinmay P. Soman, Beau David Barber
  • Publication number: 20220194917
    Abstract: This invention is benzothiophene-based estrogen receptor downregulators and their compositions and uses to treat estrogen-related medical disorders.
    Type: Application
    Filed: July 26, 2021
    Publication date: June 23, 2022
    Applicant: The Board of Trustees of the University of Illinois
    Inventors: Gregory R. Thatcher, Rui Xiong, Jiong Zhao, Debra A. Tonetti
  • Publication number: 20220186190
    Abstract: Genetically modified pigs having at least one cancer and/or at least one co-morbid condition are provided. Also provided are methods of using the pig and derived tumor cells to screen for therapeutic compounds, medical devices or procedures, and/or combinations thereof. Further provided are methods of producing personalized cancer models, including obtaining a tumor sample from a subject, identifying mutations in the tumor sample, and producing a genetically modified tumor or tumor cell line having the same mutations.
    Type: Application
    Filed: March 3, 2020
    Publication date: June 16, 2022
    Applicant: The Board of Trustees of the University of Illinois
    Inventors: Lawrence B. Schook, Ron C. Gaba, Regina M. Schwind, Kyle Schachtschneider
  • Patent number: 11350870
    Abstract: This disclosure provides methods, reagents, and diagnostic and prognostic markers useful for non-invasive identification, diagnosis, and therapeutic intervention in individuals with epilepsy. More particularly, the disclosure uses specific metabolites measured by magnetic resonance spectroscopy in brain tissue to detect epileptic brain regions.
    Type: Grant
    Filed: June 20, 2018
    Date of Patent: June 7, 2022
    Assignee: The Board of Trustees of the University of Illinois
    Inventor: Jeffrey A Loeb
  • Patent number: 11356235
    Abstract: An analog self-interference cancellation technique for In-Band Full-Duplex (IBFD) systems generates an inherent secondary self-interference (SI) signal of a circulator and uses that signal to cancel a primary SI signal leaked from a transmitter port within a communication device. The communication device manipulates the phase and angle of this secondary SI, using an adjustable Impedance Mismatch Terminal (IMT) circuit. The result is an efficient SI cancellation technique in the analog domain, which uses the circulator inherent SI signals.
    Type: Grant
    Filed: May 24, 2018
    Date of Patent: June 7, 2022
    Assignee: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
    Inventors: Besma Smida, Danilo Erricolo, Seiran Khaledian, Farhad Farzami
  • Publication number: 20220170072
    Abstract: Methods and compositions for specific cleavage of DNA molecules using single-stranded guides and Argonaute (Ago) proteins are described.
    Type: Application
    Filed: February 16, 2022
    Publication date: June 2, 2022
    Applicant: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
    Inventors: Huimin ZHAO, Benham Enghiad
  • Patent number: 11346829
    Abstract: The present disclosure provides methods for detection and quantification of trimethylamine (TMA) or trimethylamine oxide (TMAO) comprising passing a sample over a sensor comprising a substrate having a plurality of chemically responsive dyes selected from the following classes of chemically responsive dyes: metal-containing dyes, pH indicators, or solvatochromic/vapochromic dyes. The disclosure also provides devices and sensors for the detection and quantification of TMA, and methods of diagnosing a subject having trimethylaminuria (TMAU).
    Type: Grant
    Filed: May 17, 2017
    Date of Patent: May 31, 2022
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Kenneth S. Suslick, Zheng Li, Maria K. LaGasse
  • Publication number: 20220160703
    Abstract: The therapies described herein can be selectively lethal toward a variety of different cancer cell types and cancer conditions in a subject. The combination therapies described herein can be useful for the management, treatment, control, or adjunct treatment of diseases, where the selective lethality is beneficial in immunotherapy, particularly where the disease is accompanied by elevated levels of NQO1. In particular, embodiments where an immunotherapy, such as a heckpoint inhibitor, are combined with a NQO1 bioactivatable drug.
    Type: Application
    Filed: March 18, 2020
    Publication date: May 26, 2022
    Applicants: The Board of Regents of The University of Texas System, Indiana University Research and Technology Corporation, The Board of Trustees of the University of Illinois
    Inventors: Yang-Xin FU, Xiumei HUANG, David BOOTHMAN, Paul J. HERGENROTHER, Xiaoguang LI, Lingxiang JIANG
  • Patent number: 11339175
    Abstract: Detection of nitroxyl (HNO), the transient one-electron reduced form of nitric oxide, is a significant challenge owing to its high reactivity with biological thiols (rate constants as high as 109M?1 s?1). Reported herein is a new thiol-based HNO-responsive trigger that can compete against reactive thiols for HNO. This process forms an N-hydroxysulfenamide intermediate which cyclizes to release a masked fluorophore leading to fluorescence enhancement. To ensure a rapid cyclization step, the disclosed design capitalizes on two established physical organic phenomena: the alpha-effect and the Thorpe-Ingold effect. Using this new trigger, NitroxylFluor was developed; a selective HNO-responsive fluorescent probe. Treatment of NitroxylFluor with an HNO donor results in a 16-fold turn-on. This probe also exhibits excellent selectivity over various reactive nitrogen, oxygen, and sulfur species and efficacy in the presence of thiols (e.g., glutathione in mM concentrations).
    Type: Grant
    Filed: November 6, 2019
    Date of Patent: May 24, 2022
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Jefferson Chan, Nicholas William Pino
  • Publication number: 20220153709
    Abstract: The present disclosure provides compounds represented by Formula I: and pharmaceutically acceptable salts, solvates, e.g., hydrates, and prodrugs thereof, wherein X and n are as defined as set forth in the specification. The present disclosure also provides compounds of Formula I for use to treat diseases and conditions, e.g., cancer, wherein inhibition of HDAC provides a benefit.
    Type: Application
    Filed: February 1, 2022
    Publication date: May 19, 2022
    Applicants: The George Washington University, A Congressionally Chartered Not-for-Profit Corporation, The Board of Trustees of the University of Illinois
    Inventors: Alejandro VILLAGRA, Alan P. KOZIKOWSKI, Sida SHEN
  • Patent number: 11332466
    Abstract: Described herein are pyridinone-based compounds, derivatives thereof, and pharmaceutical formulations thereof. In some aspects, the pyridinone-based compounds, derivatives thereof, and/or pharmaceutical formulations thereof can be administered to a subject in need thereof. In some aspects, pyridinone-based compounds, derivatives thereof, and/or pharmaceutical formulations thereof can modulate an activity and/or a function of a BRD protein and/or BET protein.
    Type: Grant
    Filed: December 1, 2018
    Date of Patent: May 17, 2022
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Gregory R. Thatcher, Rui Xiong, Jiong Zhao, Yangfeng Li
  • Patent number: 11333655
    Abstract: Aspects of the subject disclosure may include, for example, an apparatus comprising: a membrane having a first side and a second side, wherein the membrane has first and second pores disposed therein, a processing system; and a memory that stores executable instructions that, when executed by the processing system, facilitate performance of operations comprising: setting a first physical characteristic in a vicinity of the first pore to cause a first end of a molecule having the first end and a second end to be moved through the first pore; setting a second physical characteristic in a vicinity of the second pore to cause the second end of the molecule to be moved through the second pore; and adjusting the first physical characteristic to cause the molecule to be tightened, with a first given amount of force, between the first pore and the second pore. Additional embodiments are disclosed.
    Type: Grant
    Filed: September 6, 2017
    Date of Patent: May 17, 2022
    Assignees: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS, TECHNISCHE UNIVERSITEIT DELFT
    Inventors: Aleksei Aksimentiev, Cornelis Dekker
  • Publication number: 20220148284
    Abstract: A segmentation method and segmentation apparatus are provided, where the segmentation method includes receiving image frames comprising a current frame and an adjacent frame to the current frame, determining a feature map to aggregate the image frames based on temporal information between the current frame and the adjacent frame, extracting a feature of a region of interest (ROI) corresponding to instances included in the current frame from the feature map, predicting a class of an object corresponding to the ROI based on the feature of the ROI, and segmenting the instances by correcting an amodal mask predicted corresponding to the class of the object based on the feature of the ROI.
    Type: Application
    Filed: November 3, 2021
    Publication date: May 12, 2022
    Applicants: The Board of Trustees of the University of Illinois (Urbana, IL), SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Jihye KIM, Raymond Alexander Yeh, Alexander Gerhard Schwing, Yuan-Ting Hu
  • Patent number: 11329304
    Abstract: Intermittent energy sources, including solar and wind, require scalable, low-cost, multi-hour energy storage solutions to be effectively incorporated into the grid. Redox-flow batteries offer a solution, but suffer from rapid capacity fade and low Coulombic efficiency due to the high permeability of redox-active species across the battery's membrane. Here we show that active-species crossover can be arrested by scaling the membrane's pore size to molecular dimensions and in turn increasing the size of the active material to be above the membrane's pore-size exclusion limit. When oligomeric redox-active organic molecules were paired with microporous polymer membranes, the rate of active-material crossover was either completely blocked or slowed more than 9,000-fold compared to traditional separators at minimal cost to ionic conductivity. In the case of the latter, this corresponds to an absolute rate of ROM crossover of less than 3 ?mol cm?2 day?1 (for a 1.
    Type: Grant
    Filed: May 26, 2017
    Date of Patent: May 10, 2022
    Assignees: The Regents of the University of California, The Board of Trustees of the University of Illinois
    Inventors: Brett A. Helms, Sean E. Doris, Ashleigh L. Ward, Peter D. Frischmann, Etienne Chenard, Nagarjuna Gavvalapalli, Jeffrey S. Moore
  • Patent number: 11327886
    Abstract: A memory device (or memory sub-system) includes one or more memory components having multiple blocks, the multiple blocks containing pages of data. A processing device is coupled to the one or more memory components. The processing device to execute firmware to: track write timestamps of the pages of data that have been marked as invalid; retain a storage state stored for each page marked as invalid, wherein invalid data of the marked pages remains accessible via the storage states; in response to a write timestamp of a page being beyond a retention time window, mark the page as expired, indicating that the page is an expired page; and reclaim the expired page for storage of new data during a garbage collection operation.
    Type: Grant
    Filed: July 9, 2020
    Date of Patent: May 10, 2022
    Assignee: Board of Trustees of the University of Illinois
    Inventor: Jian Huang
  • Publication number: 20220134337
    Abstract: Aspects of the subject disclosure may include, for example, an apparatus comprising: a membrane, wherein the membrane has a first side and a second side, wherein the membrane has a first pore disposed therein, wherein the first pore extends through the membrane from the first side of the membrane to the second side of the membrane, wherein the membrane has a second pore disposed therein, and wherein the second pore extends through the membrane from the first side of the membrane to the second side of the membrane; a first channel disposed on the first side of the membrane, wherein the first channel is along a first longitudinal axis; a second channel disposed on the first side of the membrane, wherein the second channel is along a second longitudinal axis, and wherein the first channel and the second channel are disposed side by side adjacent to each other; a third channel disposed on the second side of the membrane, wherein the third channel is along a third longitudinal axis, wherein the third channel is in
    Type: Application
    Filed: October 28, 2021
    Publication date: May 5, 2022
    Applicant: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
    Inventor: Aleksei Aksimentiev
  • Publication number: 20220125938
    Abstract: The present disclosure provides multivalent polymer-peptide conjugate compositions capable of breaking already formed amyloid fibrils. Also provided are methods of treating a subject having or suspected of having Alzheimer's disease by administering a therapeutically effective amount of these multivalent polymer-peptide conjugate compositions.
    Type: Application
    Filed: January 3, 2022
    Publication date: April 28, 2022
    Applicant: The Board of Trustees of the University of Illinois
    Inventors: Edwin G. MOORE, Jeffrey S. MOORE, Yang SONG
  • Patent number: 11314950
    Abstract: A computer-implemented method is provided for transferring a target text style using Reinforcement Learning (RL). The method includes pre-determining, by a Long Short-Term Memory (LSTM) Neural Network (NN), the target text style of a target-style natural language sentence. The method further includes transforming, by a hardware processor using the LSTM NN, a source-style natural language sentence into the target-style natural language sentence that maintains the target text style of the target-style natural language sentence. The method also includes calculating an accuracy rating of a transformation of the source-style natural language sentence into the target-style natural language sentence based upon rewards relating to at least the target text style of the source-style natural language sentence.
    Type: Grant
    Filed: March 25, 2020
    Date of Patent: April 26, 2022
    Assignees: INTERNATIONAL BUSINESS MACHINES CORPORATION, THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
    Inventors: Lingfei Wu, Jinjun Xiong, Hongyu Gong, Suma Bhat, Wen-Mei Hwu
  • Patent number: 11309305
    Abstract: Provided are optical devices and systems fabricated, at least in part, via printing-based assembly and integration of device components. In specific embodiments the present invention provides light emitting systems, light collecting systems, light sensing systems and photovoltaic systems comprising printable semiconductor elements, including large area, high performance macroelectronic devices. Optical systems of the present invention comprise semiconductor elements assembled, organized and/or integrated with other device components via printing techniques that exhibit performance characteristics and functionality comparable to single crystalline semiconductor based devices fabricated using conventional high temperature processing methods. Optical systems of the present invention have device geometries and configurations, such as form factors, component densities, and component positions, accessed by printing that provide a range of useful device functionalities.
    Type: Grant
    Filed: October 29, 2019
    Date of Patent: April 19, 2022
    Assignees: The Board of Trustees of the University of Illinois, X-Celeprint Limited
    Inventors: John A. Rogers, Ralph Nuzzo, Matthew Meitl, Etienne Menard, Alfred Baca, Michael Motala, Jong-Hyun Ahn, Sang-Il Park, Chang-Jae Yu, Heung Cho Ko, Mark Stoykovich, Jongseung Yoon
  • Publication number: 20220111068
    Abstract: Disclosed are recombinant extracellular vesicles (EVs), compositions including modified EVs encapsulated in a matrix, methods for controlling the release of EVs from an encapsulating matrix, and methods of using the same in the treatment of disease.
    Type: Application
    Filed: October 13, 2021
    Publication date: April 14, 2022
    Applicant: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
    Inventors: JAE-WON SHIN, STEPHEN LENZINI