Abstract: Methods of preparing oligomers including heating a mixture of an amount of a functionalized cycloalkene, an amount of a chain transfer agent, a phosphite ester, and a catalyst, a degree of polymerization of the oligomers controllable by a molar ratio of the amount of the functionalized cycloalkene to the amount of the chain transfer agent, are provided herein. Methods of preparing polymers including heating the oligomers and a second amount of the functionalized cycloalkene, a phosphite ester, and a catalyst are further provided. Compositions of oligomers and functionalized cycloalkenes are further provided.
Type:
Application
Filed:
May 1, 2023
Publication date:
November 9, 2023
Applicant:
The Board of Trustees of the University of Illinois
Inventors:
Jeffrey S. Moore, Nancy R. Sottos, Benjamin A. Suslick, Diego M. Alzate-Sanchez, Nil A. Parikh
Abstract: Here we show that P. ananatis produces at least three phosphonates, two of which were purified and structurally characterized. The first, designated pantaphos, was shown to be 2-(hydroxy(phosphono)methyl)maleate; the second, a probable biosynthetic precursor, was shown to be 2-(phosphonomethyl)maleate. Purified pantaphos is both necessary and sufficient for the hallmark lesions of onion center rot. Moreover, when tested against mustard seedlings, the phytotoxic activity of pantaphos was comparable to the widely used herbicides glyphosate and phosphinothricin. Pantaphos was also active against a variety of human cell lines.
Type:
Application
Filed:
September 2, 2021
Publication date:
November 9, 2023
Applicant:
The Board of Trustees of the University of Illinois
Inventors:
William W. Metcalf, Alexander L. Polidore
Abstract: Staphylococcus nepalensis releases corisin, a peptide conserved in diverse Staphylococci, that induces apoptosis of lung epithelial cells. Therefore, methods and apparatus for detecting the presence of corisin in a biological sample of a patient are disclosed, as well as pharmaceutical compositions, such as antibodies, and methods for treating patents having or suspected of having fibrosis.
Type:
Application
Filed:
December 16, 2020
Publication date:
November 9, 2023
Applicants:
Mie University, The Board of Trustees of the University of Illinois
Inventors:
Esteban Gabazza, Corina D'Alessandro-Gabazza, Isaac Cann
Abstract: The present disclosure is generally directed to a plasma sheet source and methods of using same. The plasma sheet source includes a cylindrical electrode having a conductive cylindrical core surrounded by a dielectric material, a plurality of channels configured to direct gas from a gas inlet to the electrode, and a plasma outlet positioned below the electrode. Gas is introduced to the plasma sheet source and directed toward the electrode, which when powered by pulsed direct current, produces plasma as the gas ionizes. The produced plasma is then directed out of the plasma outlet to a specimen for treatment of the specimen. Notably, the plasma exiting the plasma outlet is in the form of a plasma sheet that is at approximately room temperature.
Type:
Grant
Filed:
September 25, 2020
Date of Patent:
November 7, 2023
Assignee:
Board of Trustees of the University of Alabama, for and on behalf of the University of Alabama in Huntsville
Abstract: A photoconductive switch that uses materials that support negative differential mobility, whose operation leverages the pulse compression of a charge could to generate the “on” time of the pulse in combination with the speed of light to generate the “off” time of the pulse, is described. In one example, a method of operating a photoconductive switch, which includes two electrodes and a light absorbing material positioned therebetween, includes selecting a value for one or more parameters comprising a voltage for generation of an electric field, a spot size of a laser pulse, a temporal pulse width of the laser pulse, or an intensity of the laser pulse, wherein the selected value(s) for the one or more parameters enable the switch to operate in a region where the light absorbing material exhibits negative differential mobility, and illuminating the light absorbing material with the laser pulse to generate a charge cloud within the light absorbing material.
Type:
Grant
Filed:
October 15, 2021
Date of Patent:
October 31, 2023
Assignees:
LAWRENCE LIVERMORE NATIONAL SECURITY, LLC, THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
Inventors:
Lars F. Voss, Adam Conway, Karen Marie Dowling, David Lawrence Hall, Shaloo Rakheja, Kexin Li
Abstract: A multiphase power converter for converting electrical energy. The multiphase power converter includes at least one transformer providing isolation in the multiphase power converter. The multiphase power converter further includes a series capacitor in a series capacitor configuration. The multiphase power converter additionally includes a plurality of switches connected within the series capacitor configuration. Furthermore, the multiphase power converter includes a controller in electrical communication with the series capacitor and the plurality of switches, where the controller is configured to control power output by causing the plurality of switches to be switched according to a plurality of switching intervals of a period.
Type:
Application
Filed:
February 8, 2023
Publication date:
October 26, 2023
Applicant:
BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS
Abstract: Disclosed herein are methods of using spun synthetic fibers to model ligaments of a joint of an animal. Further disclosed are models of joints which comprise spun synthetic fibers used to model ligaments. In certain aspects, the models of joints can be used for instructional purposes, as phantom models for testing medical devices or as models for calibration of tools used in physiological and/or biomechanical measurement.
Type:
Grant
Filed:
February 4, 2021
Date of Patent:
October 24, 2023
Assignee:
The Board of Trustees of the University of Illinois
Inventors:
Mariana Elizabeth Kersh, Sam Walter Goldsmith, Sara Moshage, Roberto Alonso Pineda Guzman
Abstract: The disclosure provides various methods for separating and recovering free fatty acids crude oil containing free fatty acids using certain ion-exchange resins to reduce the amount of free fatty acids in the crude oil to 3% or less such that the resultant oil is useable in downstream chemical processes. After separation and removal of the free fatty acids form the crude oil, the ion-exchange resin is reusable in further free fatty acid separation reactions.
Type:
Grant
Filed:
May 31, 2022
Date of Patent:
October 24, 2023
Assignee:
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
Abstract: A soybean cultivar designated UA54i19GT is disclosed herein. The present invention provides seeds, plants, and plant parts derived from soybean cultivar UA54i19GT. Further, it provides methods for producing a soybean plant by crossing UA54i19GT with itself or another soybean variety. The invention also encompasses any soybean seeds, plants, and plant parts produced by the methods disclosed herein, including those in which additional traits have been transferred into UA54i19GT through the introduction of a transgene, through mutagenesis, or by breeding UA54i19GT with another soybean cultivar.
Type:
Grant
Filed:
February 1, 2021
Date of Patent:
October 24, 2023
Assignee:
The Board of Trustees of the University of Arkansas
Inventors:
Pengyin Chen, Leandro Mozzoni, Sandra L. Florez-Palacios
Abstract: Aspects of the subject disclosure may include, for example, obtaining video data from a single monocular camera, wherein the video data comprises a plurality of frames, wherein the camera is attached to a mobile robot that is travelling along a lane defined by a row of crops, wherein the row of crops comprises a first plant stem, and wherein the plurality of frames include a depiction of the first plant stem; obtaining robot velocity data from encoder(s), wherein the encoder(s) are attached to the robot; performing foreground extraction on each of the plurality of frames of the video data, wherein the foreground extraction results in a plurality of foreground images; and determining, based upon the plurality of foreground images and based upon the robot velocity data, an estimated width of the first plant stem. Additional embodiments are disclosed.
Type:
Grant
Filed:
August 24, 2018
Date of Patent:
October 17, 2023
Assignee:
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
Inventors:
Girish Chowdhary, Chinmay P. Soman, Erkan Kayacan, Benjamin C. Thompson, Zhongzhong Zhang, Anwesa Choudhuri
Abstract: A CRISPR/Cas system and method for editing or regulating transcription of a genome of a cell are provided, wherein the system includes a Cas endonuclease fused with one or more degron sequences and at least one activatable cognate single guide RNA harboring an inactivation sequence in a non-essential region of the cognate sgRNA, wherein said inactivation sequence comprises one or more endonuclease recognition sites of, e.g., a ribozyme.
Type:
Grant
Filed:
September 21, 2018
Date of Patent:
October 17, 2023
Assignee:
The Board of Trustees of the University of Illinois
Inventors:
Ryan E. Clarke, Bradley J. Merrill, Matthew S. MacDougall, Hannah M. Pennington, Brian R. Shy
Abstract: Vaccination is the most prevalent prophylactic means for controlling seasonal influenza infections. However, an effective vaccine usually takes at least 6 months to develop for the circulating strains. Therefore, new therapeutic options are needed for acute treatment of influenza infections to control this virus and prevent epidemic/pandemic situations from developing. Described herein are fast-acting, orally active acylated amino-substituted heterocyclyl compounds effective to control this virus. In one aspect, described herein is a method of treating an influenza infection in a subject comprising administering to the subject the compounds described herein.
Type:
Grant
Filed:
May 3, 2022
Date of Patent:
October 17, 2023
Assignees:
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS, CHICAGO BIOSOLUTIONS, INC.
Inventors:
Lijun Rong, Irina Gaisina, Gregory R. Thatcher, Norton Peet
Abstract: The invention provides a versatile sensing platform for sensing and analysis of biofluids, particularly well-suited for sensing and analysis of sweat. Systems of the invention allows for sensitive and selective detection of a range of analytes in sweat including metabolites, electrolytes and biomarkers. Systems of the invention provide a noninvasive and accurate means for quantitative characterization of important sweat characteristics including sweat volume, sweat loss and sweat rate. Systems of the invention are compatible with materials and device geometries for important class of conformal tissue mounted electronic devices, including epidermal electronic devices.
Type:
Grant
Filed:
June 1, 2018
Date of Patent:
October 17, 2023
Assignees:
NORTHWESTERN UNIVERSITY, THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
Inventors:
John A. Rogers, Johnathan T. Reeder, Amay J. Bandodkar, Sungbong Kim, Yurina Sekine, Jungil Choi, Tyler R. Ray, Aurelie Hourlier-Fargette, Philipp Gutruf, Kun Hyuck Lee, Milan Raj
Abstract: Embodiments of compositions and methods for the treatment of blood disorders and malignancies in a subject are described herein. In one embodiment, a composition for the treatment of a blood disorder or a malignancy in a subject comprises decitabine, tetrahydrouridine, and an excipient. In another embodiment, a method for the treatment of a blood disorder or a malignancy in a subject comprises the oral administration of a composition comprising decitabine and tetrahydrouridine. In some examples, the composition may be administered 1-3 times weekly.
Type:
Grant
Filed:
July 14, 2021
Date of Patent:
October 17, 2023
Assignee:
BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
Abstract: A method of fabricating a power semiconductor device includes forming a bi layer mask on a semiconductor substrate, where the bilayer mask comprises a first dielectric layer on the semiconductor substrate and a second dielectric layer on the first dielectric layer. The first and second dielectric layers are through-etched to define an exposed portion of the semiconductor substrate. The first dielectric layer is selectively etched to form an undercut region of the bi layer mask. A crystalline semiconductor material is epitaxially grown on the exposed portion of the semiconductor substrate, and a polycrystalline semiconductor material is deposited on the second dielectric layer of the bilayer mask. After the epitaxial growth, the bilayer mask and the polycrystalline semiconductor material are removed from the semiconductor substrate, leaving behind a mesa comprising the crystalline semiconductor material on the semiconductor substrate.
Type:
Application
Filed:
July 30, 2021
Publication date:
October 12, 2023
Applicant:
The Board of Trustees of the University of Illinois
Inventors:
Kyekyoon Kim, Palash Sarker, Frank P. Kelly
Abstract: A system for providing intraoperative feedback to a user during the course of surgery. A core imaging unit provides low-coherence optical radiation coupled to a sampling device and generates optical coherence tomography (OCT) data based on combining scattered light received from the sampling device together with a reference signal. The sampling device is adapted to receive the low-coherence optical radiation from the core imaging unit and to illuminate the tissue, and to collect light scattered by the tissue and to return said light to the core imaging unit. A core software unit receives the OCT data from the core imaging unit provides real-time feedback, such as an image, to the user via an indicator.
Type:
Grant
Filed:
December 20, 2018
Date of Patent:
October 10, 2023
Assignee:
The Board of Trustees of the University of Illinois
Inventors:
Stephen A. Boppart, Freddy T. Nguyen, Adam M. Zysk
Abstract: Certain aspects of the invention relate to a method of synthesizing a composite usably for oil-water separation comprising surface nanostructuring a pristine powder or porous material to form a nanostructured powder or porous material having surfaces with nanoscale features; and coating single or multilayers of one or more low surface energy oligomers, polymers, or their composites with other materials on the surfaces of the nanostructured powder or porous material.
Type:
Grant
Filed:
April 22, 2021
Date of Patent:
October 10, 2023
Assignee:
BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS
Abstract: Disclosed are methods of selective hydrodeoxygenation of aromatic compounds by using catalyst systems comprising N-heterocyclic carbene (NHC) and 4-pyridinol-derived pincer ligands and metal complexes containing these ligands.
Type:
Grant
Filed:
October 1, 2020
Date of Patent:
October 3, 2023
Assignees:
Board of Trustees of the University of Alabama, University of South Carolina
Abstract: Methods and systems are provided for measuring anatomical dimensions from a single two-dimensional (2D) digital image. The digital image is taken from the front/anterior view using a mobile, handheld communication device. The linear measurements are used to estimate the body volume of the individual. Total body density is calculated from estimated body volume and body weight. Body composition (fat mass and fat-free mass) of the individual is derived from density using known mathematical conversion formulas. A method for estimating body composition analysis is provided.
Type:
Grant
Filed:
April 7, 2020
Date of Patent:
September 19, 2023
Assignee:
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA
Inventors:
Michael Vernon Fedewa, Michael Randall Esco