Patents Assigned to The Board of Trustees of University of Illinois
  • Redox active colloidal particles for flow batteries
    Patent number: 10239978
    Abstract: The invention provides a redox flow battery comprising a microporous or nanoporous size-exclusion membrane, wherein one cell of the battery contains a redox-active colloidal particle dispersed in a non-aqueous solvent. The redox flow battery provides enhanced ionic conductivity across the electrolyte separator and reduced redox-active species crossover, thereby improving the performance and enabling widespread utilization of the battery. Redox active colloidal particles (RACs) were prepared, analyzed, and were found to be highly effective redox species for use in redox flow batteries.
    Type: Grant
    Filed: January 19, 2017
    Date of Patent: March 26, 2019
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Jeffrey S. Moore, Joaquin Rodriguez-Lopez, Nagarjuna Gavvalapalli, Elena Montoto, Jingshu Hui
  • Efficient dissociation of water vapor in arrays of microchannel plasma devices
    Patent number: 10240815
    Abstract: The invention provides methods and systems for water dissociation with microplasma generated in microchannel plasma arrays or chips. Preferred methods and systems introduce water vapor into a microchannel plasma array. Electrical power is applied to the microchannel plasma array to create a plasma chemical reaction of the water vapor in the microchannel plasma array. Dissociated hydrogen and/or oxygen gas is collected at an output of the microchannel plasma array. The water vapor can be entrained in a carrier gas, but is preferably introduced without carrier gas. Direct introduction of water vapor has been demonstrated to provide efficiencies at an above 60%. The use of carrier gas reduces efficiency, but still exceeds efficiencies of prior methods discussed in the background.
    Type: Grant
    Filed: May 9, 2016
    Date of Patent: March 26, 2019
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Zhen Dai, Thomas J. Houlahan, J. Gary Eden, Sung-Jin Park
  • SMALL MOLECULE-MEDIATED RESTORATION OF AIRWAY SURFACE PHYSIOLOGY IN HUMAN CYSTIC FIBROSIS LUNG EPITHELIA
    Publication number: 20190083517
    Abstract: Provided herein are complexes comprising amphotericin B (AmB) or derivatives and sterols. Also provided herein are methods of treating cystic fibrosis using AmB or complexes comprising AmB or derivatives and sterols.
    Type: Application
    Filed: April 10, 2017
    Publication date: March 21, 2019
    Applicant: The Board of Trustees of the University of Illinois
    Inventors: Martin D. BURKE, Katrina A. Muraglia
  • System and method for nano-opto-mechanical-fluidic sensing of particles
    Patent number: 10234444
    Abstract: A system and method includes nano opto-mechanical-fluidic resonators (nano-resonators), e.g., for identification of particles, e.g., single viruses and/or cells.
    Type: Grant
    Filed: September 28, 2016
    Date of Patent: March 19, 2019
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Gaurav Bahl, Kewen Han
  • Vertical hetero- and homo-junction tunnel field-effect transistors
    Patent number: 10236386
    Abstract: The present disclosure provides vertical hetero- and homo-junction tunnel FET (TFET) based on multi-layer black phosphorus (BP) and transition metal dichalcogenides.
    Type: Grant
    Filed: December 15, 2017
    Date of Patent: March 19, 2019
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Wenjuan Zhu, Shang-Chun Lu, Mohamed Mohamed
  • Selective histone deactylase 6 inhibitors
    Patent number: 10227295
    Abstract: Disclosed are selective histone deactylase inhibitors (HDACi) that having Formula I. Methods of making and using these inhibitors for the treatment of cancer, in particular melanoma are also disclosed.
    Type: Grant
    Filed: September 5, 2017
    Date of Patent: March 12, 2019
    Assignees: H. Lee Moffitt Cancer Center and Research Institute, Inc., Board of Trustees of The University of Illinois
    Inventors: Eduardo M. Sotomayor, Joel A. Bergman, Alan P. Kozikowski, Alejandro V. Villagra, Karrune V. Woan
  • L-ASPARAGINASE VARIANTS AND FUSION PROTEINS WITH REDUCED L-GLUTAMINASE ACTIVITY AND ENHANCED STABILITY
    Publication number: 20190070274
    Abstract: Variant Erwinia chrysanthemi L-asparaginases with reduced L-glutaminase activity and enhanced in vivo circulation are described as are fusion proteins containing an L-asparaginase and three tandem soluble domains of TRAIL for use in the treatment of cancers such as acute lymphoblastic leukemia and acute myeloid leukemia.
    Type: Application
    Filed: March 1, 2017
    Publication date: March 7, 2019
    Applicant: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
    Inventors: Arnon LAVIE, Hien-Anh NGUYEN
  • Electrocatalyst for acidic media and method of making an electrocatalyst for acidic media
    Patent number: 10221492
    Abstract: An oxygen evolution reaction (OER) electrocatalyst for acidic media comprises a metal oxide structure comprising a pyrochlore phase of chemical formula A2B2On, wherein A comprises one or more A-site metals, B comprises one or more B-site metals, and 6.0?n?7.3. The metal oxide structure exhibits a mass current density of at least about 20 A/g at an over-potential of 0.22 V in 0.1 M HClO4. According to another embodiment, an electrocatalyst for acidic media comprises a porous metal oxide structure having particulate walls separating a plurality of pores, where each particulate wall comprises interconnected primary particles. The porous metal oxide structure comprises a pyrochlore phase of chemical formula A2B2On, wherein A comprises one or more A-site metals, B comprises one or more B-site metals, and 6.0?n?7.3.
    Type: Grant
    Filed: May 18, 2016
    Date of Patent: March 5, 2019
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Hong Yang, Jaemin Kim, Pei-Chieh Shih, Yao Qin
  • Substituted pyrazino[1?,2?:1 ,5]pyrrolo[2,3-b]indole-1,4-diones for cancer treatment
    Patent number: 10220099
    Abstract: The synthesis of various pyrazino[1?,2?:1,5]pyrrolo[2,3-b]-indole-1,4-dione analogs has been successfully implemented in the present application. From these efforts, compounds having the structure of Formula I-c: or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, wherein R1, R2, R4-R8, R3?, R6?, and n are as defined herein, are provided. These biologically active derivatives have been further used to prepare cell-specific drug conjugates effective in treating various diseases including cancer.
    Type: Grant
    Filed: May 10, 2016
    Date of Patent: March 5, 2019
    Assignees: Massachusetts Institute of Technology, The Board of Trustees of the University of Illinois
    Inventors: Mohammad Movassaghi, Justin Kim, Paul J. Hergenrother, Karen Morrison, Nicolas Boyer
  • Multi-metal films, alternating film multilayers, formation methods and deposition system
    Patent number: 10214817
    Abstract: A deposition system can conduct ALD or CVD deposition and can switch between the deposition modes. The system is capable of depositing multi-metal films and multi-layer films of alternating ALD and CVD films. Reactant supplies can be bypassed with carrier gas flow to maintain pressure in a reactor and in reactor supply lines and purge reactants.
    Type: Grant
    Filed: October 15, 2014
    Date of Patent: February 26, 2019
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Christos G. Takoudis, Manish Singh, Sathees Kannan Selvaraj
  • Method and system for near-eye three dimensional display
    Patent number: 10215983
    Abstract: A 3D near eye display device is provided, the display device comprising a display screen for displaying more than one 2D images, at least one focusing element for collimating the images to sub-images, a spatial multiplexing unit capable of remapping the sub-images to different depths while forcing their centers to align to form remapped sub-images, and an eye piece. The device and methods allow for a high quality, compact 3D display system that can be wearable and overcomes the vergence-accommodation conflict that leads to visual discomfort and fatigue caused by traditional 3D near eye display devices.
    Type: Grant
    Filed: July 17, 2017
    Date of Patent: February 26, 2019
    Assignee: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
    Inventors: Liang Gao, Wei Cui
  • Microfluidic devices
    Patent number: 10213782
    Abstract: In one representative embodiment, a device includes a main microchannel and at least two other microchannels. The main microchannel defines a main fluid flow path and has an opening, and first and second microchannels defining a first and second fluid flow paths, respectively. The first fluid flow path is in fluidic communication with the main fluid flow path via the opening and forms a first angle relative to the main microchannel less than 90 degrees. The second microchannel defines a second fluid flow path in fluidic communication with the main fluid flow path via the opening and in fluidic communication with the first fluid flow path. The second microchannel forms a second angle relative to the main microchannel less than 90 degrees. The first and second microchannels form a third angle relative to one another, with the third angle being between 60 and 135 degrees.
    Type: Grant
    Filed: March 2, 2016
    Date of Patent: February 26, 2019
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Ryan C. Bailey, Steven R. Doonan, Yi Xu
  • BENZOTHIOPHENE-BASED SELECTIVE ESTROGEN RECEPTOR DOWNREGULATORS
    Publication number: 20190055209
    Abstract: This invention is benzothiophene-based estrogen receptor downregulators and their compositions and uses to treat estrogen-related medical disorders.
    Type: Application
    Filed: October 24, 2018
    Publication date: February 21, 2019
    Applicant: The Board of Trustees of the University of Illinois
    Inventors: Gregory R. Thatcher, Rui Xiong, Jiong Zhao, Debra A. Tonetti
  • Real-Time Sensing of Flowing Nanoparticles with Electro-Opto-Mechanics
    Publication number: 20190056303
    Abstract: A system and method include a resonator device including walls forming a channel, where the walls are shaped to simultaneously confine light in an optical mode and to confine vibration in a mechanical mode, and where the mechanical mode is selected so that vibration in the mechanical mode can couple to the optical mode. A waveguide is coupled with the resonator device for guiding a probe light through the resonator device. An electro-mechanical actuation mechanism provides a mechanical drive force to the resonator device. A photodetector measure light outputted by the waveguide after passing through the resonator device, the outputted light including a modulated version of the probe light based on passing through the resonator device and interacting with a fluid, or a fluid containing a particle, contained by the channel of the resonator device.
    Type: Application
    Filed: August 21, 2018
    Publication date: February 21, 2019
    Applicant: The Board of Trustees of the University of Illinois
    Inventors: Gaurav Bahl, Jeewon Suh
  • Normally-off cubic phase GaN (c-GaN) HEMT having a gate electrode dielectrically insulated from a c-AlGaN capping layer
    Patent number: 10211328
    Abstract: A normally-off, heterojunction field effect transistor includes an intrinsic cubic-phase gallium nitride (c-GaN) substrate and an aluminum gallium nitride (AlGaN) capping layer disposed on the intrinsic c-GaN substrate. The AlGaN capping layer includes a first sublayer of intrinsic c-phase AlxGa1-xN disposed on the c-GaN substrate, wherein the first sublayer is of a first thickness; a second sublayer of doped c-phase AlxGa1-xN disposed on the first sublayer, and wherein the second sublayer is of a second thickness and is doped with a dopant. An insulating layer is disposed on the AlGaN capping layer, wherein the insulating layer is of a fourth thickness. A source electrode, a drain electrode, and a gate electrode are positioned adjacent to and on top of the insulating layer, respectively.
    Type: Grant
    Filed: September 13, 2017
    Date of Patent: February 19, 2019
    Assignee: Board of Trustees of the University of Illinois
    Inventors: Can Bayram, Ryan William Grady, Kihoon Park
  • Lipoprotein nanoplatelets: fluorescent, zwitterionic probes for molecular and cellular imaging
    Patent number: 10209258
    Abstract: Compositions are provided comprising water-stable semi-conductor nanoplatelets encapsulated in a hydrophilic coating further comprising lipids and lipoproteins. Uses include biomolecular imaging and sensing, and methods of making comprise: colloidal synthesis of CdSe core NPLs; layer-by-layer growth of a CdS shell; and encapsulation of CdSe/CdScore/shell NPLs in lipid and lipoprotein components through an evaporation-encapsulation using zwitterionic phospholipids, detergents, and amphipathic membrane scaffold proteins.
    Type: Grant
    Filed: August 23, 2016
    Date of Patent: February 19, 2019
    Assignee: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
    Inventors: Andrew Smith, Sung Jun Lim, Aditi Das
  • Antithrombotic compounds, methods and uses thereof
    Patent number: 10202507
    Abstract: Provided herein are polymers and methods for their use in binding a phosphate containing biological macromolecules. Specifically, the methods and uses provided herein may be used to inhibit thrombin binding to polyphosphate or as an antithrombotic agent for the treatment of stroke, acute coronary syndrome, pulmonary embolism, atrial fibrillation, venous and arterial thromboembolism, disseminated intravascular coagulation (DIC), deep-vein thrombosis (DVT), peripheral artery disease, trauma-induced coagulopathy, extracorporeal circulation, cancer-associated thrombosis, sepsis, septic shock, Systemic Inflammatory Response Syndrome (SIRS), or inflammation.
    Type: Grant
    Filed: May 29, 2015
    Date of Patent: February 12, 2019
    Assignees: The University of British Columbia, The Board of Trustees of the University of Illinois
    Inventors: Jayachandran Kizhakkedathu, James H. Morrissey, Richard J. Travers, Rajesh Shenoi, Manu Thomas Kalathottukaren
  • Stretchable form of single crystal silicon for high performance electronics on rubber substrates
    Patent number: 10204864
    Abstract: The present invention provides stretchable, and optionally printable, semiconductors and electronic circuits capable of providing good performance when stretched, compressed, flexed or otherwise deformed. Stretchable semiconductors and electronic circuits of the present invention preferred for some applications are flexible, in addition to being stretchable, and thus are capable of significant elongation, flexing, bending or other deformation along one or more axes. Further, stretchable semiconductors and electronic circuits of the present invention may be adapted to a wide range of device configurations to provide fully flexible electronic and optoelectronic devices.
    Type: Grant
    Filed: October 31, 2016
    Date of Patent: February 12, 2019
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: John A. Rogers, Dahl-Young Khang, Yugang Sun, Etienne Menard
  • Self-similar and fractal design for stretchable electronics
    Patent number: 10192830
    Abstract: The present invention provides electronic circuits, devices and device components including one or more stretchable components, such as stretchable electrical interconnects, electrodes and/or semiconductor components. Stretchability of some of the present systems is achieved via a materials level integration of stretchable metallic or semiconducting structures with soft, elastomeric materials in a configuration allowing for elastic deformations to occur in a repeatable and well-defined way. The stretchable device geometries and hard-soft materials integration approaches of the invention provide a combination of advance electronic function and compliant mechanics supporting a broad range of device applications including sensing, actuation, power storage and communications.
    Type: Grant
    Filed: April 3, 2017
    Date of Patent: January 29, 2019
    Assignees: The Board of Trustees of the University of Illinois, Northwestern University
    Inventors: John A. Rogers, Jonathan Fan, Woon-Hong Yeo, Yewang Su, Yonggang Huang, Yihui Zhang
  • Two-dimensional J-resolved laser and semi-laser spectroscopy
    Patent number: 10180477
    Abstract: J-resolved LASER and semi-LASER sequences for localized two-dimensional magnetic resonance spectroscopy are disclosed. After a delay time ?1 from application of an excitation RF pulse, a first pair of slice-selective adiabatic full-passage (AFP) pulses, separated by an inter-pulse interval ?2, is applied. At the end of the sequence a final pair of slice-selective AFP pulses, separated by a time of ?2/2+?1+t1/2 is applied, where t1 is the duration of an incremental evolution period corresponding to the indirect dimension of a 2D J-resolved spectrum. In the case of J-resolved LASER, an additional intermediate pair of slice-selective AFP pulses, separated by an inter-pulse interval ?2, is applied prior to the final pair of AFP pulses. An echo signal is acquired at time t1/2 from the application of the last AFP pulse.
    Type: Grant
    Filed: January 31, 2014
    Date of Patent: January 15, 2019
    Assignee: The Board of Trustees of the University of Illinois
    Inventor: Shaolin Yang