Abstract: Devices, systems and methods for cleaning a surface of as elongated instrument held within a cavity. In particular embodiments of the device, a longitudinal wire member extends along an elongated instrument (e.g. a laparoscope) and a rotatable transverse member removes matter from a surface of the instrument (e.g. a lens).
Type:
Grant
Filed:
June 9, 2021
Date of Patent:
January 23, 2024
Assignees:
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, ASCENSION TEXAS
Inventors:
Christopher Rylander, Christopher Idelson, John Uecker
Abstract: Procedures for inhibiting hormone receptor activation include administering to a subject in need of hormone receptor inhibition a compound having a chemical structure of a molecule that, when docked in the PPIase pocket, could disrupt proline-rich loop conformation and interactions. Procedures for treating prostate cancer or breast cancer include administering to a subject having prostate cancer or breast cancer a compound having a chemical structure of a molecule that, when docked in the PPIase pocket, could disrupt proline-rich loop conformation and interactions.
Type:
Grant
Filed:
January 20, 2021
Date of Patent:
January 23, 2024
Assignees:
Board of Regents, The University of Texas System, The University of British Columbia
Abstract: A railway track defect detection system may include a mobile defect detection platform and a modal parameter analyzer. The platform may include an excitation mechanism (e.g., an excitation hammer or wheels that are in contact with a railway track) to apply multiple impact forces to the railway track while the platform travels along the railway track, and a laser Doppler vibrometer to capture, while the platform travels along the railway track, vibration data representing vibrations of the railway track caused by application of the multiple impact forces by the excitation mechanism. The modal parameter analyzer may be configured to detect, based on the vibration data captured by the laser Doppler vibrometer, a defect in the railway track. For example, changes in vibration amplitudes, mode shapes, damping ratios, or a natural frequency derived from the received vibration data may indicate the presence of a defect in the railway track.
Type:
Grant
Filed:
September 18, 2018
Date of Patent:
January 23, 2024
Assignee:
Board of Regents, The University of Texas System
Abstract: A method for fabricating a three-dimensional (3D) static random-access memory (SRAM) architecture using catalyst influenced chemical etching (CICE). Utilizing CICE, semiconductor fins can be etched with no etch taper, smooth sidewalls and no maximum height limitation. CICE enables stacking of as many nanosheet layers a desired and also enables a 3D stacked architecture for SRAM cells. Furthermore, CICE can be used to etch silicon waveguides thereby creating waveguides with smooth sidewalls to improve transmission efficiency and, for photon-based quantum circuits, to eliminate charge fluctuations that may affect photon indistinguishability.
Type:
Grant
Filed:
May 3, 2022
Date of Patent:
January 23, 2024
Assignee:
Board of Regents, The University of Texas System
Inventors:
Sidlgata V. Sreenivasan, Akhila Mallavarapu, Jaydeep Kulkarni, Michael Watts, Sanjay Banerjee
Abstract: The present disclosure provides compounds that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.
Type:
Grant
Filed:
September 3, 2021
Date of Patent:
January 16, 2024
Assignees:
IMMUNESENSOR THERAPEUTICS, INC., THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
Inventors:
Jian Qiu, Qi Wei, Matt Tschantz, Heping Shi, Youtong Wu, Hulling Tan, Lijun Sun, Chuo Chen, Zhijian Chen
Abstract: Disclosed herein are technological solutions that are configured to limit sub-optimal visualization of the surgical field during robotic and manual laparoscopic surgery. Such technological solutions are configured to systematically assess cleanliness of an imaging element of a laparoscope (or other type of similar imaging apparatus) and take action for enabling or causing the imaging element to be cleaned. In preferred embodiments, assessment of the cleanliness of the imaging element provides information that can be used for enabling or causing cleaning of the imaging element to be performed in-vivo in either a manual, semi-autonomous or autonomous manner. In this manner such technological solutions advantageously enable the surgical field during surgery to be more efficiently and consistently maintained in an optimal condition.
Type:
Grant
Filed:
July 22, 2021
Date of Patent:
January 16, 2024
Assignees:
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, CLEARCAM INC.
Inventors:
Farshid Alambeigi, Alexander Cohen, Christopher R. Idelson, Christopher Rylander
Abstract: A tissue implantation device comprises a capsule; and a population of ultrasound-switchable fluorophores incorporated in the capsule. A method of imaging a tissue implantation device in a biological environment comprises disposing the tissue implantation device in a biological environment, the population of ultrasound-switchable fluorophores having a switching threshold in the biological environment; exposing the biological environment to an ultrasound beam to form an activation region within the biological environment; switching the ultrasound-switchable fluorophores in the activation region from an off state to an on state; exciting the ultrasound-switchable fluorophores in the activation region with a beam of electromagnetic radiation; and detecting light emitted by the ultrasound-switchable fluorophores.
Type:
Grant
Filed:
November 11, 2020
Date of Patent:
January 16, 2024
Assignee:
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
Abstract: Methods for the treatment of stroke, such as stroke of undetermined origin, by administration of xenon (Xe)-loaded liposome compositions are provided. In some aspects, Xe is encapsulated in echogenic liposomes and release of Xe can be enhanced by application of ultrasound stimulation. Compositions for use in treating stroke, such as liposomes loaded with Xe or Xe in combination with H2 or H2S, are also provided.
Type:
Grant
Filed:
April 13, 2021
Date of Patent:
January 16, 2024
Assignee:
THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEMS
Inventors:
Shao-Ling Huang, Melvin E. Klegerman, Yong-Jian Geng, Hyunggun Kim, David D. McPherson
Abstract: Autonomous wireless sensors in subsurface environments can be charged while present in the subsurface environment to allow the sensors to measure and wirelessly transmit measurements. The sensors rely upon a contrast agent to provide a power flow path to the sensors.
Type:
Grant
Filed:
March 2, 2020
Date of Patent:
January 16, 2024
Assignees:
National Technology & Engineering Solutions of Sandia, LLC, The Board of Regents of the University of Texas System, Wayne State University
Inventors:
Jason E. Heath, Gungor Didem Beskardes, Wallace McAliley, Chester J. Weiss, Mohsen Ahmadian-Tehrani, David T. Chapman, Leela Arava
Abstract: The present disclosure provide for methods of using 6-thio-2?-deoxyguanosine (6-thio-dG) to treat telomerase-positive cancers that exhibit (a) one or more TERT promoter mutations, and/or (b) enriched telomere transcriptional signature(s). In particular, melanomas, including those who are not sensitive or have become resistant to immune checkpoint inhibition and/or MAPKi therapy are targets for this therapy.
Type:
Application
Filed:
June 5, 2023
Publication date:
January 11, 2024
Applicants:
The Board of Regents of The University of Texas System, The Wistar Institute of Anatomy and Biology
Abstract: This disclosure provides for engineered T cell Receptors (TCRs), cells comprising the TCRs, and methods of making and using the TCRs. The current disclosure relates to TCRs that specifically recognize EGFR neoantigens comprising L858R mutations and restricted to HLA class I A11 allotype. Accordingly, aspects of the disclosure relate to a polypeptide comprising an antigen binding variable region comprising the amino acid sequence of a CDR3 of the disclosure or an amino acid sequence with at least 80% sequence identity to a CDR3 of the disclosure.
Type:
Application
Filed:
November 4, 2021
Publication date:
January 11, 2024
Applicant:
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
Abstract: This disclosure provides for engineered T cell Receptors (TCRs), cells comprising the TCRs, and methods of making and using the TCRs. The current disclosure relates to TCRs that specifically recognize EGFR neoantigens comprising L858R mutations and restricted to HLA class I A31 and A33 allotypes. Accordingly, aspects of the disclosure relate to a polypeptide comprising an antigen binding variable region comprising the amino acid sequence of a CDR3 of the disclosure or an amino acid sequence with at least 80% sequence identity to a CDR3 of the disclosure.
Type:
Application
Filed:
November 4, 2021
Publication date:
January 11, 2024
Applicant:
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
Inventors:
Patrick HWU, Cassian YEE, Geogory LIZEE
Abstract: Modular dendrimers with cationic groups and lipophilic groups are provided herein. In some aspects, the dendrimers provided herein may be formulated in compositions which contain a nucleic acid and one or more helper excipients. In some aspects, these compositions may also be used to treat diseases or disorders with a therapeutic nucleic acid.
Type:
Application
Filed:
June 15, 2023
Publication date:
January 11, 2024
Applicant:
The Board of Regents of The University of Texas System
Abstract: Provided herein are methods for determining a subtype of a small cell lung cancer in a patient based on the express status of ASCL1, NEUROD1, and POU2F3, which are expressed in a mutually exclusive fashion. The subtype of the cancer can be used to determine the sensitivity of the cancer to certain anti-cancer therapies. As such, also provided are methods of treating patients having small cell lung cancer based on the subtyping results.
Type:
Application
Filed:
June 29, 2023
Publication date:
January 11, 2024
Applicant:
Board of Regents, The University of Texas System
Inventors:
Carl M. GAY, Lauren A. BYERS, John V. HEYMACH
Abstract: A method can include receiving, at a computer system, characteristic values of a pregnancy of a subject. As an example, the characteristic values can include a numerical value for a live birth order of the pregnancy for the subject. The computer system can store a machine learning model that receives a first set of input features and provides a second set of one or more output values. In some embodiments, the first set of input features can correspond to the characteristic values of the pregnancy of the subject. The second set of one or more output values can include a probability of a Cesarean delivery. The characteristic values can be input into the machine learning model to obtain the probability of the Cesarean delivery being required for the subject during an attempt of a vaginal delivery. The Cesarean delivery can be performed based on the probability.
Type:
Application
Filed:
November 4, 2021
Publication date:
January 11, 2024
Applicant:
Board of Regents, The University of Texas System
Abstract: Methods are provided for identifying tumor-specific antibodies and/or T-cell receptors by paired mRNA sequencing from individual immune cells in sentinel lymph nodes and comparison of these sequences with corresponding mass spectroscopy data from a subject having a cancer. Novel tumor-specific antibodies (e.g., NY-ESO-1-binding antibodies) are also provided.
Type:
Grant
Filed:
October 29, 2018
Date of Patent:
January 9, 2024
Assignee:
Board of Regents, The University of Texas System
Inventors:
Gregory C. Ippolito, Jonathan R. Mcdaniel, William N. Voss, George Georgiou
Abstract: In one embodiment, a system for evacuating subdural hematomas includes an inlet configured to be placed in fluid communication with a subdural space, an irrigation reservoir in fluid communication with the inlet and configured to supply irrigation fluid to the inlet and the subdural space, an outlet separate from the inlet and also configured to be placed in fluid communication with the subdural space, and a pump in fluid communication with the outlet and configured to create negative pressure within the subdural space and evacuate fluid from the subdural space.
Type:
Grant
Filed:
December 14, 2018
Date of Patent:
January 9, 2024
Assignee:
The Board of Regents, The University of Texas System
Abstract: A method for determining a radiotherapy treatment plan can include: receiving anatomical data for a patient; generating, via a neural network analyzing the anatomical data, a plurality of fitness values for a plurality of candidate beam orientations; determining a selected beam orientation based on the plurality of fitness values; performing a fluence map optimization (FMO) process on the selected beam orientation; and determining a dose distribution for the patient based on the FMO process.
Type:
Grant
Filed:
April 30, 2020
Date of Patent:
January 9, 2024
Assignee:
The Board of Regents of University
of Texas System
Inventors:
Dan Nguyen, Azar Sadeghnejad Barkousaraie, Steve Jiang
Abstract: Described herein are pharmaceutical compositions containing peptoids of general formula (I), (II), or (III) capable of reducing proliferation of cancer stem cells in a subject and methods of treatment or prophylactic administration of these pharmaceutical compositions to treat cancer. Also provided herein are method of detecting and treating cancerous cell masses by use of peptoids of general formula (I), (II), or (III).
Type:
Grant
Filed:
January 20, 2023
Date of Patent:
January 9, 2024
Assignees:
University of Houston System, The Board of Regents of the University of Texas System
Inventors:
Damith Gomika Udugamasooriya, Aaron Raymond, John Minna
Abstract: The disclosure provides for eRNA-targeted transcriptional reprogramming through targeted reduction of eRNAs for a clinically relevant gene, TNFSF10, resulting in a selective control of interferon-induced apoptosis. A method of inhibiting a TNFSF10 gene expression in a human cell is disclosed. The methods described herein comprise contacting the human cell with a single-stranded antisense compound consisting of the sequence selected from a set of SEQ ID NOs: disclosed herein, wherein the antisense compound targets an enhancer RNA (eRNA) transcribed from a genomic enhancer sequence or region. The eRNA is an TNFSF10 eRNA sequence comprising the nucleic acid sequence selected from the SEQ ID NOs disclosed herein which inhibits expression of the TNFSF10 gene in the human cell.
Type:
Grant
Filed:
October 21, 2020
Date of Patent:
January 9, 2024
Assignee:
Board of Regents, The University of Texas System