Patents Assigned to The Brigham and Women's FHospital, Inc.
  • NOTCH inhibition in the treatment of atherosclerosis
    Patent number: 8133857
    Abstract: The present invention is directed to methods of treating or preventing atherosclerosis and other cardiovascular diseases by administering agents that inhibit or modulate the NOTCH signaling pathway. In addition, the invention encompasses methods for assaying compounds for their ability to treat atherosclerosis based upon their effects on NOTCH signaling, and for measuring levels of amount, function, or activity of NOTCH pathway components in biological samples.
    Type: Grant
    Filed: March 2, 2007
    Date of Patent: March 13, 2012
    Assignee: The Brigham and Women's FHospital, Inc.
    Inventor: Masanori Aikawa