Patents Assigned to The Brigham and Women's Hospital, Inc.
  • Publication number: 20220373537
    Abstract: Described herein are methods relating to the diagnosis, prognosis, and treatment of airway dysfunction, e.g., bronchiectasis by detecting gene expression in a sample obtained from a subject. Exemplary samples include a bronchial brushing, nasal brushing, sputum, or peripheral blood sample.
    Type: Application
    Filed: May 19, 2022
    Publication date: November 24, 2022
    Applicants: TRUSTEES OF BOSTON UNIVERSITY, THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Ke XU, Marc E. LENBURG, Ehab BILLATOS, Alejandro A. DIAZ
  • Patent number: 11504501
    Abstract: The disclosure of this application relates generally to medical devices and in particular to a steerable medical instrument applicable to guide interventional tools and instruments, such as percutaneous biopsy and ablations tools and endoscopes. The steerable medical instrument has an outer and an inner tube where the inner tube is movable at the proximal end and fixed at the distal end. At least one of the outer tube and inner tube has a plurality of openings, which creates deformable portions so that the outer and the inner tubes can bend by moving the inner tube at the proximal end.
    Type: Grant
    Filed: October 12, 2016
    Date of Patent: November 22, 2022
    Assignees: Canon U.S.A., Inc., The Brigham and Women's Hospital, Inc.
    Inventors: Takahisa Kato, Nobuhiko Hata
  • Patent number: 11504303
    Abstract: A dental tissue regenerative composition. The composition includes a combination of (1) human dental pulp stem cells and (2) at least one of human umbilical vein endothelial cells or vascular endothelial growth factor. The combination is encapsulated in a light-activated gelatin methacrylate hydrogel.
    Type: Grant
    Filed: December 21, 2021
    Date of Patent: November 22, 2022
    Assignees: TRUSTEES OF TUFTS COLLEGE, THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Pamela C. Yelick, Ali Khademhosseini
  • Publication number: 20220362228
    Abstract: The present invention features methods for increasing sensitivity and/or reversing resistance to chemotherapy, methods for treating or preventing a cancer in a subject, methods for treating clonal hematopoiesis of indeterminate potential in a subject, and methods of identifying resistance or sensitivity to chemotherapy in a subject. In some embodiments, the methods contain the step of administering an agent that inhibits the expression or activity of a Protein phosphatase 1D (PPM1D) polypeptide or polynucleotide. The present invention also features compositions for increasing sensitivity and/or reversing resistance to chemotherapy.
    Type: Application
    Filed: March 7, 2022
    Publication date: November 17, 2022
    Applicant: The Brigham And Women's Hospital, Inc.
    Inventors: Josephine KAHN, Siddhartha JAISWAL, Benjamin EBERT
  • Patent number: 11490886
    Abstract: A bone fixation system includes a length of suture, a screw, a tensioning tab, and an anchor. The length of suture has a first end and a second end. The screw comprises an elongated shaft having a threaded external surface, wherein the screw has a distal end, a proximal end, and an internal surface defining a passageway within the screw extending between the distal end and the proximal end, wherein the passageway is configured to receive the length of suture. The tensioning tab is affixed to a section of the length of suture. The anchor is configured to secure the first end of the length of suture adjacent to the proximal end of the screw.
    Type: Grant
    Filed: May 22, 2019
    Date of Patent: November 8, 2022
    Assignee: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventor: Charles S. Carrier
  • Patent number: 11484585
    Abstract: Provided herein are genetically engineered Vibrio cholerae bacterial strains, compositions including the bacterial strains, and methods of using the same for the prevention of Vibrio cholerae infection in a subject.
    Type: Grant
    Filed: July 12, 2018
    Date of Patent: November 1, 2022
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Matthew K. Waldor, Troy Hubbard, Gabriel Billings
  • Patent number: 11471367
    Abstract: A system and method for promoting angiogenesis and adipogenesis in soft tissue using a tissue enlargement apparatus. The tissue enlargement apparatus includes an interface configured for affixation to the soft tissue. A force generating device is coupled to the interface by a connecting tube for applying mechanical forces to the soft tissue. A processor is coupled to the force generating device and is configured to apply intermittent cyclical patterns of the mechanical forces to the soft tissue to promote angiogenesis and adipogenesis in soft tissue. The intermittent cyclical patterns are based on at least one of duration, frequency, and intensity of the mechanical forces.
    Type: Grant
    Filed: February 17, 2016
    Date of Patent: October 18, 2022
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Dennis Paul Orgill, Luca Lancerotto, Giorgio Giatsidis
  • Patent number: 11471515
    Abstract: Compositions and methods for treating cancer that include administering a therapeutically effective amount of a tumor suppressor mRNA complexed with a delivery vehicle as described herein, e.g., a nanoparticle.
    Type: Grant
    Filed: November 9, 2017
    Date of Patent: October 18, 2022
    Assignees: The Brigham and Women's Hospital, Inc., Children's Medical Center Corporation
    Inventors: Jinjun Shi, Mohammad Ariful Islam, Yingjie Xu, Omid C. Farokhzad, Bruce Zetter
  • Patent number: 11458153
    Abstract: This invention discloses drug-delivery compositions, methods of making prodrugs, and methods of drug delivery using a self-assembled gelator. The backbone of the gelator can contain a drug or prodrug, such as acetaminophen or salicin. Additional drugs or agents can be encapsulated in the gelator. Enzymatic or hydrolytic cleavage can be used to release the drugs.
    Type: Grant
    Filed: July 18, 2016
    Date of Patent: October 4, 2022
    Assignees: The City University of New York, represented by The Research Foundation of the City University of New York, The Brigham and Women's Hospital Inc.
    Inventors: Jeffrey M. Karp, Praveen Kumar Vemula, George John, Greg Cruikshank
  • Patent number: 11459613
    Abstract: In one aspect, the present invention features method of identifying a cell resistant to a modulator of Cereblon (CRBN). In another aspect, the present invention features a method of characterizing sensitivity of a subject to a modulator of CRBN. In yet another aspect, the present invention features a method of monitoring sensitivity of a subject to a modulator of CRBN.
    Type: Grant
    Filed: September 9, 2016
    Date of Patent: October 4, 2022
    Assignee: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Benjamin Levine Ebert, Quinlan Sievers
  • Patent number: 11446331
    Abstract: The present invention is directed to wound healing scaffolds cografted with a population of stem cells, wherein the population of stem cells are ABCB5+ stem cells. The scaffolds are, for instance, collagen glycosaminoglycan scaffolds.
    Type: Grant
    Filed: May 9, 2014
    Date of Patent: September 20, 2022
    Assignees: The Brigham and Women's Hospital, Inc., Children's Medical Center Corporation, The United States Government as Represented by the Department of Veterans Affairs
    Inventors: Markus H. Frank, Natasha Y. Frank, Dennis P. Orgill, George F. Murphy
  • Publication number: 20220287983
    Abstract: The present disclosure provides branched poly(?-amino esters) (PBAEs) of Formula (I) made by reacting primary amines with diacrylates. Further provided herein are compositions comprising the polymers of Formula (I), and methods of using the compositions and polymers as described herein for the treatment of disease.
    Type: Application
    Filed: March 8, 2022
    Publication date: September 15, 2022
    Applicants: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.
    Inventors: Carlo Giovanni Traverso, Ameya R. Kirtane, Robert S. Langer, Hyunjoon KIM, Gary W. Liu, James Byrne, Daniel Reker, Yunhua Shi, Grace Junyue Zhong, Netra Rajesh
  • Publication number: 20220282341
    Abstract: Described herein are nucleic acid detection systems, devices, and kits having a CRISPR component comprising an effector protein and a guide RNA, and/or a polynucleotide encoding a guide RNA, that binds or hybridizes to a corresponding target molecule. Also described herein are methods that utilize these nucleic acid systems, devices, and kits.
    Type: Application
    Filed: August 5, 2020
    Publication date: September 8, 2022
    Applicants: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.
    Inventors: Leonardo V. Riella, James J. Collins, Michael M. Kaminski
  • Publication number: 20220280435
    Abstract: Components with relatively high loading of active pharmaceutical ingredients (e.g., drugs), are generally provided. In some embodiments, the component (e.g., a tissue interfacing component) comprises a solid therapeutic agent (e.g., a solid API) and a supporting material (e.g., a binder such as a polymer) such that the solid therapeutic agent is present in the component in an amount of greater than or equal to 10 wt % versus the total weight of the tissue interfacing component. Such tissue-interfacing components may be useful for delivery of API doses e.g., to a subject. Advantageously, in some embodiments, the reduction of volume required to deliver the required API dose as compared to a liquid formulation permits the creation of solid needle delivery systems for a wide variety of drugs in a variety of places/tissues (e.g., tongue, GI mucosal tissue, skin) and/or reduces and/or eliminates the application of an external force in order to inject a drug solution through the small opening in the needle.
    Type: Application
    Filed: March 15, 2022
    Publication date: September 8, 2022
    Applicants: Massachusetts Institute of Technology, The Brigham and Women's Hospital Inc.
    Inventors: Carlo Giovanni Traverso, Alex G. Abramson, Ester Caffarel Salvador, Niclas Roxhed, Minsoo Khang, Taylor Bensel, Robert S. Langer
  • Patent number: 11435360
    Abstract: The present disclosure provides a system comprising a communication interface and computer for assigning a label to the biomolecule fingerprint, wherein the label corresponds to a biological state. The present disclosure also provides a sensor arrays for detecting biomolecules and methods of use. In some embodiments, the sensor arrays are capable of determining a disease state in a subject.
    Type: Grant
    Filed: March 29, 2021
    Date of Patent: September 6, 2022
    Assignee: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Omid Farokhzad, Morteza Mahmoudi, Claudia Corbo
  • Patent number: 11435363
    Abstract: The invention involves, inter alia, the use of markers of systemic inflammation to determine whether or not an individual undergoing treatment with a cardiovascular agent to reduce the risk of a future cardiovascular event will benefit from continued treatment with the cardiovascular agent. Further, this invention describes the use of markers of systemic inflammation to evaluate the efficacy of treatment and to assist physicians in deciding on the course of a treatment in an individual at risk of future cardiovascular events.
    Type: Grant
    Filed: October 19, 2015
    Date of Patent: September 6, 2022
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventor: Paul M. Ridker
  • Patent number: 11433161
    Abstract: An implantable, autonomously growing medical device is disclosed. The device may have an outer, braided outer element that holds an inner core. Degradation and/or softening of the inner core permits the outer element to elongate, allowing the device to grow with surrounding tissue. The growth profile of the medical device can be controlled by altering the shape/material/cure conditions of the inner core, as well as the geometry of the out element.
    Type: Grant
    Filed: January 11, 2021
    Date of Patent: September 6, 2022
    Assignees: Children's Medical Center Corporation, The Brigham and Women's Hospital, Inc.
    Inventors: Eric N. Feins, Pedro J. del Nido, Nikolay V. Vasilyev, Haruo Yamauchi, Douglas P. Perrin, Peter E. Hammer, Veaceslav Arabagi, Jeffrey M. Karp, Yuhan Lee, Eoin D. O'Cearbhaill
  • Patent number: 11433094
    Abstract: This disclosure relates to compositions including formulated sucralfate or other aluminum-crosslinked sulfated agents for delivery of agents to biological surfaces and/or the modulation of nutrient absorption through the intestinal lining as well as methods for the manufacture of and the use of these compositions for treating disorders including diabetes type II and clinical obesity that require a modulation of certain nutrients to the body.
    Type: Grant
    Filed: April 12, 2021
    Date of Patent: September 6, 2022
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Jeffrey M. Karp, Yuhan Lee, Ali Tavakkoli, Tarawatie E. Deelman
  • Patent number: 11426450
    Abstract: This disclosure relates to methods of using shear-thinning compositions in the treatment of a vascular disorders, cancers, infections, abscesses, and fistulas.
    Type: Grant
    Filed: August 2, 2021
    Date of Patent: August 30, 2022
    Assignees: The Brigham and Women's Hospital, Inc., The General Hospital Corporation
    Inventors: Alireza Khademhosseini, Rahmi Oklu
  • Patent number: 11426405
    Abstract: The methods described herein include methods for the treatment of subjects who have Clonal Hematopoiesis of Indeterminate Potential (CHIP) or a Philadelphia-negative myeloproliferative neoplasm (MPN), e.g., polycythaemia vera (PV) or essential thrombocythaemia (ET), using inhibitors of JAK-STAT signaling.
    Type: Grant
    Filed: December 4, 2018
    Date of Patent: August 30, 2022
    Assignees: The Brigham and Women's Hospital, Inc., Children's Medical Center Corporation
    Inventors: Rob Sellar, Benjamin Ebert, Ofir Wolach, Kimberly Martinod, Denisa Wagner