Patents Assigned to The Brigham and Women's Hospital, Inc.
  • Publication number: 20200330553
    Abstract: Sortilin is a sorting receptor that directs target proteins to the secretary or endocytic compartments of cells that is found in both extracellular vesicles and cells. Provided herein are methods and compositions for decreasing or inhibiting trafficking of sortilin to an extracellular vesicle, for example by inhibiting the formation of intermolecular sortilin dimers.
    Type: Application
    Filed: October 23, 2018
    Publication date: October 22, 2020
    Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Shinsuke ITO, Elena AIKAWA, Masanori AIKAWA
  • Publication number: 20200333356
    Abstract: Provided herein are methods of detecting an antibody directed against a pathogen and uses thereof.
    Type: Application
    Filed: July 8, 2020
    Publication date: October 22, 2020
    Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Stephen J. Elledge, Harry B. Larman, Tomasz Kula, George Xu
  • Patent number: 10806761
    Abstract: Malignant tumors that are resistant to conventional therapies represent significant therapeutic challenges. An embodiment of the present invention provides a second generation oncolytic virus rQNestin34.5v2 with less toxicity that is more effective at selective killing target cells, such as tumor cells. In various embodiments presented herein, the oncolytic virus described herein is suitable for treatment of glioblastoma, as well as other cancers.
    Type: Grant
    Filed: May 4, 2016
    Date of Patent: October 20, 2020
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Hiroshi Nakashima, Ennio Antonio Chiocca
  • Publication number: 20200325482
    Abstract: The invention relates to compositions and methods for inhibiting macrophage activation via modulating PARP9 and/or PARP14 expression or activity, such as small molecules, RNAi and antibodies.
    Type: Application
    Filed: May 14, 2020
    Publication date: October 15, 2020
    Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Hiroshi IWATA, Masanori AIKAWA, Takuya HARA, Sasha SINGH, Piero RICCHIUTO, Hideo YOSHIDA, Iwao YAMADA
  • Publication number: 20200324095
    Abstract: Components with relatively high loading of active pharmaceutical ingredients are generally provided. In some embodiments, the component (e.g., a tissue interfacing component) comprises a solid therapeutic agent and a supporting material such that the solid therapeutic agent is present in the component in an amount of greater than or equal to 10 wt % versus the total weight of the tissue interfacing component. Such tissue-interfacing components may be useful for delivery of API doses e.g., to a subject. Advantageously, in some embodiments, the reduction of volume required to deliver the required API dose as compared to a liquid formulation permits the creation of solid needle delivery systems for a wide variety of drugs in a variety of places/tissues (e.g., tongue, GI mucosal tissue, skin) and/or reduces and/or eliminates the application of an external force in order to inject a drug solution through the small opening in the needle.
    Type: Application
    Filed: May 17, 2018
    Publication date: October 15, 2020
    Applicants: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.
    Inventors: Carlo Giovanni Traverso, Alex G. Abramson, Ester Caffarel Salvador, Niclas Roxhed, Minsoo Khang, Taylor Bensel, Robert S. Langer
  • Publication number: 20200323955
    Abstract: In some aspects, the invention teaches pharmaceutical compositions that include a TGF-? ligand trap, and methods of using a TGF-? ligand trap to treat, prevent, or reduce the progression rate of pulmonary hypertension (PH). The invention also provides methods of using a TGF-? ligand trap to treat, prevent, or reduce the progression rate of a variety of conditions including, but not limited to, pulmonary vascular remodeling, pulmonary fibrosis, right ventricular hypertrophy, diseases associated with excessive TGF-? signaling, diseases associated with excessive GDF15 signaling, and diseases associated with excessive PAI-1 signaling. The invention further provides methods of using a TGF-? ligand trap to reduce right ventricular systolic pressure in a subject.
    Type: Application
    Filed: April 17, 2020
    Publication date: October 15, 2020
    Applicants: THE BRIGHAM AND WOMEN'S HOSPITAL, INC., ACCELERON PHARMA INC.
    Inventors: Paul B. YU, Asya GRINBERG, Dianne S. SAKO, Roselyne CASTONGUAY, Rita STEEVES, Ravindra KUMAR
  • Patent number: 10799233
    Abstract: A suturing device includes an elongated body having an outer wall defining an interior space of the body, a shaft located in the interior space, and a needle mounted on a distal end of the shaft. The needle has a distal section transverse to a longitudinal axis of the shaft. The distal section of the needle terminates in a first jaw and a second jaw forming a forceps defining a piercing tip. The first jaw and second jaw have a grasping position wherein the first jaw and second jaw grasp a suturing material, and a release position wherein the first jaw and second jaw release the suturing material. After grasping the suturing material with the needle, the shaft rotates the needle to advance the needle and suturing material through tissue and mesh placed on the tissue. Spaced apart portions of the suturing material are then fused to create a suture.
    Type: Grant
    Filed: May 23, 2018
    Date of Patent: October 13, 2020
    Assignee: Brigham and Women's Hospital, Inc.
    Inventor: Jon Einarsson
  • Publication number: 20200317767
    Abstract: The methods and uses described herein relate to the treatment of age-related conditions, e.g. by administering an agent that inhibits the interaction of GDF11 and follistatin. In some embodiments, the agent can bind to an epitope of GDF11 as described herein.
    Type: Application
    Filed: May 26, 2020
    Publication date: October 8, 2020
    Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventor: Richard Theodore LEE
  • Patent number: 10793601
    Abstract: Isolated peptides and pharmaceutical compositions comprising isolated peptides that bind to retinoblastoma binding protein 4 (RBBp4) and block the Spalt-Like Transcription Factor 4 (SALL4)-RBBp4 interaction are described. Methods of inhibiting binding of SALL4 to RBBp4 and methods of treating a subject having a disorder mediated by a dysregulation of SALL4 are also described.
    Type: Grant
    Filed: April 28, 2017
    Date of Patent: October 6, 2020
    Assignees: National University of Singapore, The Brigham and Women's Hospital, Inc., Agency for Science, Technology and Research
    Inventors: Bee Hui Liu, Daniel Geoffrey Tenen, Li Chai, Cheng San Brian Chia, Anders Poulsen
  • Patent number: 10791933
    Abstract: A hand held spectrometer is used to illuminate the object and measure the one or more spectra. The spectral data of the object can be used to determine one or more attributes of the object. In many embodiments, the spectrometer is coupled to a database of spectral information that can be used to determine the attributes of the object. The spectrometer system may comprise a hand held communication device coupled to a spectrometer, in which the user can input and receive data related to the measured object with the hand held communication device. The embodiments disclosed herein allow many users to share object data with many people, in order to provide many people with actionable intelligence in response to spectral data.
    Type: Grant
    Filed: July 26, 2017
    Date of Patent: October 6, 2020
    Assignees: VERIFOOD, LTD., THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Damian Goldring, Menahem Kaplan, William B. Gormley
  • Publication number: 20200306515
    Abstract: Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject).
    Type: Application
    Filed: May 17, 2018
    Publication date: October 1, 2020
    Applicants: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc
    Inventors: Carlo Giovanni Traverso, Alex G. Abramson, Ester Caffarel Salvador, Niclas Roxhed, Minsoo Khang, Taylor Bensel, David Dellal, Robert S. Langer
  • Patent number: 10788500
    Abstract: This invention pertains to methods and compositions for the diagnosis and treatment of cardiovascular conditions. More specifically, the invention relates to isolated molecules that can be used to diagnose and/or treat cardiovascular conditions including cardiac hypertrophy, myocardial infarction, stroke, arteriosclerosis, and heart failure.
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: September 29, 2020
    Assignee: Brigham & Women's Hospital, Inc.
    Inventor: Richard T. Lee
  • Patent number: 10787433
    Abstract: Pyradizine derivatives that activity the excitatory amino acid transporter 2 (EAAT2) of the formula: and methods of use thereof for treating or preventing diseases, disorders, and conditions with glutamate toxicity.
    Type: Grant
    Filed: January 13, 2017
    Date of Patent: September 29, 2020
    Assignees: THE BRIGHAM AND WOMEN'S HOSPITAL, INC., OHIO STATE UNIVERSITY
    Inventors: Kevin Hodgetts, Chien-Liang Glenn Lin
  • Publication number: 20200288980
    Abstract: An automated system and method is provided for biotype extraction and biomarker discovery from task-based fMRI imaging data. The system and method may include automatically mapping a localizome, such as a task-condition/contrast/population-specific brain functional localizome, based on fMRI data and automatically selecting and sorting brain regions or brain nodes to produce a subset of functional brain regions or brain nodes. A report may then be generated indicating that the subject has a particular brain circuit pattern of activity and connectivity associated with one or more symptoms of the given mental disorder, treatments, or associated with normal brain functions, based upon the extracted biosignatures by searching for the optimal multivariate classifier with least dimensionality in the brain functional localizome.
    Type: Application
    Filed: October 3, 2018
    Publication date: September 17, 2020
    Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Emily Stern, David Silbersweig, Hong Pan
  • Patent number: 10774124
    Abstract: The present invention is directed stromal cell derived factor-1 peptides that have been mutated to make them resistant to digestion by the proteases dipeptidyl peptidase IV (DPPIV) and matrix metalloproteinase-2 (MMP-2) but which maintain the ability of native SDF-1 to attract T cells. The mutants may be attached to membranes formed by self-assembling peptides and then implanted at sites of tissue damage to help promote repair.
    Type: Grant
    Filed: December 9, 2016
    Date of Patent: September 15, 2020
    Assignee: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Richard T. Lee, Vincent Segers
  • Patent number: 10768181
    Abstract: Provided herein are methods of detecting an antibody directed against a pathogen and uses thereof. One aspect provided herein relates to a method for detecting an antibody against a pathogen in a subject, the method comprising: (a) contacting a reaction sample comprising a display library with a biological sample comprising antibodies, wherein the display library comprises a plurality of peptides derived from a plurality of pathogens, and (b) detecting a peptide bound to at least one antibody, thereby detecting an antibody capable of binding the peptide.
    Type: Grant
    Filed: December 17, 2014
    Date of Patent: September 8, 2020
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Stephen J. Elledge, Harry B. Larman, Tomasz Kula, George Xu
  • Patent number: 10769765
    Abstract: Method and system for lensless, shadow optical imaging. Formation of a hologram shadow image having higher spatial resolution and lower noise level is accomplished by processing image information contained in multiple individual hologram shadow image frames acquired either under conditions of relative shift between point light source and the detector of the system or under stationary conditions, when system remains fixed in space and is devoid of any relative movement during the process of acquisition of individual image frames.
    Type: Grant
    Filed: May 13, 2019
    Date of Patent: September 8, 2020
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Antonio C. Sobieranski, Utkan Demirci, Huseyin C. Tekin, Fatih Inci
  • Patent number: 10765489
    Abstract: Exemplary relates to medical devices and in particular to a tool placement manipulator with multiple rotary guides and rotation bodies, the rotation bodies being free rotationally to the ring shaped rotary guides and rotational axis of the first rotary guide being slanted with respect to the rotational axis of the second rotary guide. The tool placement manipulator has at least one socket and at least one transmission element that transmits torques from the socket to rotation bodies.
    Type: Grant
    Filed: January 27, 2017
    Date of Patent: September 8, 2020
    Assignees: Canon U.S.A., Inc., The Brigham and Women's Hospital Inc.
    Inventors: Peter Denes Jakab, Nobuhiko Hata, Takahisa Kato, Peter Tia
  • Patent number: 10761173
    Abstract: A system and method for imaging a subject includes a first imaging pulse sequence having gradient blips along an x-direction and a y-direction to acquire calibration image data from multiple slices. The imaging pulse sequence also includes a plurality of Z-shimming gradient blips coincident in time with the gradient blips along the x- and y-directions and varied within each slice. A plurality of calibration images are reconstructed from the calibration image data and a comparison image is formed by selecting an image from the calibration images corresponding to at least one of the varied Z-shimming gradient blips for each slice to determine a desired value of the Z-shimming gradient blips. The desired values are used to perform a second pulse sequence to acquire clinical image data from the subject. The second pulse sequence is used to acquire clinical images having been compensated for magnetic susceptibility variations within the subject.
    Type: Grant
    Filed: April 8, 2019
    Date of Patent: September 1, 2020
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Emily Stern, David Silbersweig, Hong Pan, Yihong Yang, Hong Gu
  • Patent number: 10748451
    Abstract: Systems and methods for generating three-dimensional fluid flow simulations from two-dimensional (2D) image data are provided. Data is segmented from 2D images of a sample having a biological structure with fluid flow therethrough. Three-dimensional (3D) geometries are generated from the segmented data, and then a 3D reconstruction of the biological structure is generated from the 3D geometries. This 3D geometric computational analysis tool can be used to evaluate fluid dynamics and hemodynamics in the context of the structure anatomy and geometry.
    Type: Grant
    Filed: December 15, 2017
    Date of Patent: August 18, 2020
    Assignees: DUKE UNIVERSITY, THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Amanda Randles, Jane Leopold