Patents Assigned to The Brigham and Womens's Hospital, Inc.
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Patent number: 11723972Abstract: The present invention is based, in part, on the discovery that galectin-1 (Gal1) plays a role in viral-associated PTLD, e.g., EBV-associated PTLD and hypoxia associated angiogenesis disorders. Accordingly, the invention relates to compositions, kits, and method for diagnosing, prognosing, monitoring, treating and modulating viral-associated PTLD, e.g., EBV-associated PTLD and hypoxia associated angiogenesis disorders.Type: GrantFiled: September 17, 2019Date of Patent: August 15, 2023Assignees: Dana-Farber Cancer Institute, Inc., The Brigham and Women's Hospital, Inc., Consejo Nacional De Investigaciones Científicas y Técnicas (CONICET), Fundacion SalesInventors: Margaret Shipp, Jing Ouyang, Kunihiko Takeyama, Jeffery L. Kutok, Scott J. Rodig, Gabriel Rabinovich, Diego Omar Croci Russo, Mariana Salatino
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Patent number: 11717283Abstract: A suturing device includes an elongated body having an outer wall defining an interior space of the body, a shaft located in the interior space, and a needle mounted on a distal end of the shaft. The needle has a distal section transverse to a longitudinal axis of the shaft. The distal section of the needle terminates in a first jaw and a second jaw forming a forceps defining a piercing tip. The first jaw and second jaw have a grasping position wherein the first jaw and second jaw grasp a suturing material, and a release position wherein the first jaw and second jaw release the suturing material. After grasping the suturing material with the needle, the shaft rotates the needle to advance the needle and suturing material through tissue and mesh placed on the tissue. Spaced apart portions of the suturing material are then fused to create a suture.Type: GrantFiled: July 24, 2020Date of Patent: August 8, 2023Assignee: The Brigham and Women's Hospital, Inc.Inventor: Jon Einarsson
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Patent number: 11712421Abstract: Self-actuating articles including, for example, self-actuating needles and/or self-actuating biopsy punches, are generally provided. Advantageously, the self-actuating articles described herein may be useful as a general platform for delivery of a wide variety of pharmaceutical drugs that are typically delivered via injection directly into tissue due to degradation in the GI tract. The self-actuating articles described herein may also be used to deliver sensors and/or take biopsies without the need for an endoscopy. In some embodiments, the article comprises a spring (e.g., a coil spring, a beam, a material having particular mechanical recovery characteristics).Type: GrantFiled: May 17, 2018Date of Patent: August 1, 2023Assignees: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.Inventors: Carlo Giovanni Traverso, Alex G. Abramson, Ester Caffarel Salvador, Niclas Roxhed, Minsoo Khang, Taylor Bensel, Robert S. Langer
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Publication number: 20230238146Abstract: The systems and methods described herein determine metrics of cardiac or vascular performance, such as cardiac output, and can use the metrics to determine appropriate levels of mechanical circulatory support to be provided to the patient. The systems and methods described determine cardiac performance by determining aortic pressure measurements (or other physiologic measurements) within a single heartbeat or across multiple heartbeats and using such measurements in conjunction with flow estimations or flow measurements made during the single heartbeat or multiple heartbeats to determine the cardiac performance, including determining the cardiac output. By utilizing a mechanical circulatory support system placed within the vasculature, the need to place a separate measurement device within a patient is reduced or eliminated. The system and methods described herein may characterize cardiac performance without altering the operation of the heart pump (e.g., without increasing or decreasing pump speed).Type: ApplicationFiled: December 23, 2022Publication date: July 27, 2023Applicants: ABIOMED, Inc., Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.Inventors: Qing Tan, Ahmad El Katerji, Noam Josephy, Elazer R. Edelman, Brian Yale Chang, Steven Keller, Sonya Sanat Bhavsar
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Patent number: 11709122Abstract: A system and method for sorting sperm is provided. The system includes a housing and a microfluidic system supported by the housing. The system also includes an inlet providing access to the microfluidic system to deliver sperm to the microfluidic system and an outlet providing access to the microfluidic system to harvest sorted sperm from the microfluidic system. The microfluidic system provides a flow path for sperm from the inlet to the outlet and includes at least one channel extending from the inlet to the outlet to allow sperm delivered to the microfluidic system through the inlet to progress along the flow path toward the outlet. The microfluidic system also includes a filter including a first plurality of micropores arranged in the flow path between the inlet and the outlet to cause sperm traveling along the flow path to move against through the filter and gravity to reach the outlet.Type: GrantFiled: May 17, 2021Date of Patent: July 25, 2023Assignee: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.Inventors: Utkan Demirci, Waseem Asghar
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Patent number: 11701437Abstract: A method for the systemic delivery of a polypeptide within a subject is provided by creating genetically modified skin cells via topical introduction of a genetically engineered virus which delivers a nucleic acid encoding a therapeutic polypeptide for expression by the skin cells, wherein the expressed therapeutic polypeptide is secreted by the skin cells and is introduced into the circulatory system of the subject.Type: GrantFiled: May 14, 2018Date of Patent: July 18, 2023Assignees: President and Fellows of Harvard College, Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc., The General Hospital CorporationInventors: Denitsa M. Milanova, George M. Church, Noah Davidsohn, Carl Schoellhammer, Robert S. Langer, Anna I. Mandinova, Carlo Giovanni Traverso
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Publication number: 20230218535Abstract: Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface. In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent. In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component may comprise and/or be associated with the pharmaceutical agent.Type: ApplicationFiled: December 30, 2022Publication date: July 13, 2023Applicants: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.Inventors: Robert S. Langer, Carlo Giovanni Traverso, Alex G. Abramson, Michael Williams, Jacob Wainer
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Patent number: 11697850Abstract: This invention relates to nucleotide polymorphisms in the human Apo(a) gene and to the use of Apo(a) nucleotide polymorphisms in identifying whether a human subject will respond or not to treatment with acetylsalicylic acid.Type: GrantFiled: December 16, 2019Date of Patent: July 11, 2023Assignees: The Brigham and Women's Hospital, Inc., Celera CorporationInventors: Paul M. Ridker, Daniel Chasman, Dov Shiffman
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Publication number: 20230211045Abstract: An implantable, autonomously growing medical device is disclosed. The device may have an outer, braided outer element that holds an inner core. Degradation and/or softening of the inner core permits the outer element to elongate, allowing the device to grow with surrounding tissue. The growth profile of the medical device can be controlled by altering the shape/material/cure conditions of the inner core, as well as the geometry of the out element.Type: ApplicationFiled: September 1, 2022Publication date: July 6, 2023Applicants: Children's Medical Center Corporation, The Brigham and Women's Hospital, Inc.Inventors: Eric N. Feins, Pedro J. del Nido, Nikolay V. Vasilyev, Haruo Yamauchi, Douglas P. Perrin, Peter E. Hammer, Veaceslav Arabagi, Jeffrey M. Karp, Yuhan Lee, Eoin D. O'Cearbhaill
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Patent number: 11692212Abstract: Methods for diagnosing, treating, and monitoring the treatment of invasive aspergillosis (IA) are described. The methods can include detecting the presence of one or more volatile organic compounds (VOCs) in the breath of subjects suspected of having IA.Type: GrantFiled: April 12, 2021Date of Patent: July 4, 2023Assignee: The Brigham and Women's Hospital, Inc.Inventors: Sophia Koo, Horatio R. Thomas, Lindsey R. Baden, Francisco M. Marty
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Patent number: 11693311Abstract: Described are systems and methods for multi-material printing. The systems and methods can utilize a stereolithographic printing device, a moving stage, and a microfluidic device. The microfluidic device can include a plurality of reservoirs, each reservoir housing a different ink for printing, and a microfluidic chip. The microfluidic chip can include a chamber that comprises a plurality of inlets, a printing region, and one or more outlets as well as an elastic membrane.Type: GrantFiled: October 23, 2019Date of Patent: July 4, 2023Assignees: THE BRIGHAM AND WOMEN'S HOSPITAL, INC., PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Yu Shrike Zhang, Ali Khademhosseini
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Patent number: 11684583Abstract: Compositions, articles, and methods for targeted drug delivery, such as thermoresponsive hydrogel polymers, are generally provided. In one aspect, the compositions and articles comprise a thermoresponsive hydrogel polymer comprising a releasable therapeutic agent. In some cases, the compositions described herein have advantageous combinations of properties including mechanical strength, biocompatibility, tunable charge densities, thermal responsiveness, drug loading, and/or configurations for targeted drug delivery. In one embodiment, the composition comprises a solution comprising a thermoresponsive polymer including one or more ligands attached to the polymer, wherein the solution is configured to undergo a sol-to-gel transition under physiological conditions. In another embodiment, the composition comprises a plurality of nanoparticles e.g., associated with the thermoresponsive polymer. In yet another embodiment, the composition comprises a therapeutic agent e.g.Type: GrantFiled: December 8, 2017Date of Patent: June 27, 2023Assignees: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.Inventors: Carlo Giovanni Traverso, Ashok Kakkar, Joshua Korzenik, Robert S. Langer, Sufeng Zhang
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Patent number: 11684315Abstract: Gastric resident electronics, devices, systems, and related methods are generally provided. Some embodiments comprise administering (e.g., orally) an (electronic) resident structure to a subject (e.g., a patient) such that the (electronic) resident structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before exiting said location internal to the subject. In some embodiments, the resident structure is a gastric resident electronic. That is to say, in some embodiments, the resident structure is configured for relatively long gastric residence and comprises an electronic component. In some embodiments, the structures and components described herein may comprise one or more components configured for the delivery of an active substance(s) (e.g., a pharmaceutical agent) to the subject.Type: GrantFiled: November 28, 2018Date of Patent: June 27, 2023Assignees: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.Inventors: Robert S. Langer, Carlo Giovanni Traverso, Yong Lin Kong
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Publication number: 20230181463Abstract: The present disclosure provides oleogel and oleopaste compositions, as well as methods, kits, preparations, and methods of using the same. The oleogels and oleopastes presented herein include compositions comprising azithromycin, albendazole, lumefantrine, praziquantel, moxifloxacin, and ivermectin.Type: ApplicationFiled: May 14, 2021Publication date: June 15, 2023Applicants: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.Inventors: Robert S. Langer, Carlo Giovanni Traverso, Ameya R. Kirtane, Aniket Wahane, Christina Karavasili
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Patent number: 11674950Abstract: The present invention is based in part on the identification of DPH1 and other members of the diphthamide synthesis pathway as biomarkers of resistance to an ADP-ribosylating toxin in a cell, and methods for identification, assessment, and treatment of a condition that is resistant to an ADP-ribosylating toxin.Type: GrantFiled: October 30, 2018Date of Patent: June 13, 2023Assignees: Dana-Farber Cancer Institute, Inc., The Brigham and Women's Hospital, Inc.Inventors: Andrew Lane, Jon Aster
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Patent number: 11672795Abstract: Provided herein are compositions and methods for treating pulmonary vascular disease in a subject comprising administering to the subject a therapeutically effective amount of a YAP/TAZ inhibiting composition and/or a GLS1 inhibiting composition.Type: GrantFiled: January 14, 2021Date of Patent: June 13, 2023Assignees: UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, THE BRIGHAM AND WOMEN'S HOSPITAL INC.Inventors: Stephen Y. Chan, Thomas Bertero
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Patent number: 11672888Abstract: Methods for generating porous scaffolds may include tuning a porogen/crystallite's particle size to a desired range and mixing the crystallite particles with a polymer solution. The mixture is then cast to form films. The films are rolled and consolidated around another inner material to create a preform, which is then thermally drawn. The inner material and the porogen can be selectively removed to obtain porous constructs/fibers. The structures can be fuse-printed to produce complex tissue scaffolds with dimensions up to several centimeters and beyond.Type: GrantFiled: November 26, 2019Date of Patent: June 13, 2023Assignees: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.Inventors: Polina Olegovna Anikeeva, Dena Shahriari, Yoel Fink, Zi Jie Gabriel Loke, Ian James Tafel
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Patent number: 11672864Abstract: Self-assembled gel compositions including a gelator, e.g., an enzyme-cleavable gelator, e.g., having a molecular weight of 2500 or less, are described. The self-assembled gel compositions can encapsulate one or more agents. Methods of making the self-assembled gel compositions, and methods of drug delivery using the self-assembled gel compositions are also described.Type: GrantFiled: June 8, 2020Date of Patent: June 13, 2023Assignees: The Brigham And Women's Hospital, Inc., Massachusetts Institute Of TechnologyInventors: Jeffrey M. Karp, Praveen Kumar Vemula, Nathaniel R. Campbell, Abdullah M. Syed, Sufeng Zhang, Omid C. Farokhzad, Robert S. Langer
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Patent number: 11674951Abstract: The disclosure relates to biomarkers of rheumatoid arthritis, e.g., PTPN22, PFKFB3, ATM, IL-17A, and IL-17F, and methods of using these biomarkers for selecting an effective treatment for rheumatoid arthritis.Type: GrantFiled: July 17, 2018Date of Patent: June 13, 2023Assignee: The Brigham and Women's Hospital, Inc.Inventor: I-Cheng Ho
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Publication number: 20230174988Abstract: The compositions and methods provided herein are related, in part, to the discovery of cholic acid 7-sulfate as a treatment for diabetes. Selective transport of the microbial metabolite lithocholic acid (LCA) from the gut to the liver after bariatric surgery activates hepatic vitamin D receptor (VDR), thereby inducing expression of bile acid sulfotransferase SULT2A, which produces the antidiabetic molecule CA7S. Provided herein is a method for treating diabetes, obesity, or an inflammatory disease in a subject, the method comprises administering to a subject in need thereof a compound of Formula I-XV or Formula F-XV? or an agent that increases levels or activity or cholic acid 7-sulfate or upstream targets in a subject.Type: ApplicationFiled: May 7, 2021Publication date: June 8, 2023Applicants: President and Fellows of Harvard College, The Brigham and Women's Hospital, IncInventors: Abigail Sloan Devlin, Snehal N. Chaudhari, Eric Garland Sheu, David A. Harris