Patents Assigned to The Broad Institute
  • Modified saponins for the treatment of fungal infections
    Patent number: 9629865
    Abstract: Methods of treating a fungal infection in a subject, the method comprising administering to the subject a modified saponin.
    Type: Grant
    Filed: April 21, 2016
    Date of Patent: April 25, 2017
    Assignees: The Broad Institute, Inc., The General Hospital Corporation
    Inventors: Eleftherios Mylonakis, Edward Holson, Frederick M. Ausubel
  • Signatures and determinants associated with cancer and methods of use thereof
    Patent number: 9593377
    Abstract: The present invention provides methods of detecting cancer using biomarkers.
    Type: Grant
    Filed: November 30, 2011
    Date of Patent: March 14, 2017
    Assignees: Dana-Farber Cancer Institute, Inc., The Broad Institute, Inc.
    Inventors: William C. Hahn, Pablo Tamayo, Jesse S. Boehm, Jill P. Mesirov
  • CANCER-RELATED EXTRACELLULAR MATRIX SIGNATURES AND RELATED METHODS AND PRODUCTS
    Publication number: 20170051073
    Abstract: Proteomic methods for identifying cancer related proteins and related products and kits are provided. The cancer specific proteins are extracellular matrix proteins that are associated with various aspects of cancer. Panels or signature sets of proteins useful in the detection, diagnosis and treatment of cancers as well as monitoring therapeutic progress in a cancer patient are provided herein along with methods for their detection and for their use in targeting imaging and/or therapeutic agents to the tumors via binding to the specified proteins. The proteins were identified using proteomics analyses of tissue samples taken from cancer patients. In certain aspects the proteins are particularly useful in colon cancer patients.
    Type: Application
    Filed: September 22, 2016
    Publication date: February 23, 2017
    Applicants: Massachusetts Institute of Technology, The General Hospital Corporation d/b/a Massachusettes General Hospital, The Broad Institute, Inc.
    Inventors: Richard O. Hynes, Alexandra Naba, Karl Clauser, Steven A. Carr, Kenneth Tanabe
  • METHOD FOR LABEL-FREE IMAGE CYTOMETRY
    Publication number: 20170052106
    Abstract: A computer-implemented method for the label-free classification of cells using image cytometry is provided. In some exemplary embodiments of the computer implemented method, the classification is the classification of the cells, such as individual cells, into a phase of the cell cycle or by cell type. A user computing device receives as an input one or more images of a cell obtained from a image cytometer. The user computing device extracts features form the one or more images, such as brightfield and/or darkfield images. The user computing device classifies the cell in the one or more images based on the extracted features using a cell classifier. The user computing device then outputs the class label of the cell, as defined by the classifier.
    Type: Application
    Filed: April 27, 2015
    Publication date: February 23, 2017
    Applicants: The Broad Institute, Inc., Swansea University, Helmholtz Zentrum Munchen
    Inventors: Holger HENNIG, Paul REES, Thomas BLASI, Anne CARPENTER VAN DYK
  • Modulators of hepatic lipoprotein metabolism
    Patent number: 9526720
    Abstract: The present invention relates to compounds that are useful for modulating hepatic cholesterol metabolism in an animal. The invention includes methods of making and using the compounds of the invention. The invention further provides methods of treating, preventing and/or alleviating a cholesterol related disorder, a cardiovascular disease and/or liver disease in an animal, such as a human, comprising administering compounds of the invention, or pharmaceutically acceptable salts or solvates thereof, to the animal.
    Type: Grant
    Filed: August 19, 2013
    Date of Patent: December 27, 2016
    Assignee: The Broad Institute, Inc.
    Inventors: Marek Maria Nagiec, Jose R. Perez, Michelle Palmer, Adam Skepner, Eamon Comer
  • Cancer-related extracellular matrix signatures and related methods and products
    Patent number: 9526800
    Abstract: Proteomic methods for identifying cancer related proteins and related products and kits are provided. The cancer specific proteins are extracellular matrix proteins that are associated with various aspects of cancer. Panels or signature sets of proteins useful in the detection, diagnosis and treatment of cancers as well as monitoring therapeutic progress in a cancer patient are provided herein along with methods for their detection and for their use in targeting imaging and/or therapeutic agents to the tumors via binding to the specified proteins. The proteins were identified using proteomics analyzes of tissue samples taken from cancer patients. In certain aspects the proteins are particularly useful in colon cancer patients.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: December 27, 2016
    Assignees: Massachusetts Institute of Technology, The General Hospital Corporation, The Broad Institute, Inc.
    Inventors: Richard O. Hynes, Alexandra Naba, Karl Clauser, Steven A. Carr, Kenneth Tanabe
  • Kynurenine Pathway Biomarkers Predictive of Anti-Immune Checkpoint Inhibitor Response
    Publication number: 20160299146
    Abstract: The present invention is based on the identification of novel biomarkers predictive of responsiveness to anti-immune checkpoint inhibitor therapies.
    Type: Application
    Filed: November 20, 2014
    Publication date: October 13, 2016
    Applicants: Dana-Farber Cancer Institute, Inc., The Broad Institute, Inc.
    Inventors: Levi Garraway, Marios Giannakis, Grigoriy V. Kryukov
  • Inhibitors of histone deacetylase
    Patent number: 9447030
    Abstract: The present invention relates to compounds of formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, or prodrug thereof, wherein U, J, V, X, R2a, R2b, R2c, R5 and t are as described herein. The present invention relates generally to inhibitors of histone deacetylase and to methods of making and using them. These compounds are useful for promoting cognitive function and enhancing learning and memory formation. In addition, these compounds are useful for treating, alleviating, and/or preventing various conditions, including for example, neurological disorders, memory and cognitive function disorders/impairments, extinction learning disorders, fungal diseases and infections, inflammatory diseases, hematological diseases, and neoplastic diseases in humans and animals.
    Type: Grant
    Filed: October 28, 2013
    Date of Patent: September 20, 2016
    Assignees: Massachusetts Institute of Technology, The General Hospital Corporation, The Broad Institute, Inc.
    Inventors: Edward Holson, Florence Fevrier Wagner, Michel Weiwer, Li-Huei Tsai, Stephen Haggarty, Yan-Ling Zhang
  • Compositions and methods for sensitizing a neoplastic cell to radiation
    Patent number: 9439909
    Abstract: The invention provides for the use of radiation sensitizing agents in combination with radiation for the treatment of neoplasia, methods for the identification of genotype-specific radiation sensitizing agents, and methods of identifying patients who could benefit from therapy with a genotype-specific radiation sensitizing agent.
    Type: Grant
    Filed: August 22, 2014
    Date of Patent: September 13, 2016
    Assignees: The Broad Institute, Inc., Dana-Farher Cancer Institute, Inc., President and Fellows of Harvard College
    Inventors: Mohamed Abazeed, Matthew Meyerson, Drew Adams
  • INHIBITORS OF HISTONE DEACETYLASE
    Publication number: 20160251351
    Abstract: The present invention relates to compounds of formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, or prodrug thereof, wherein U, J, V, X, R1a, R2b, R2c, R5 and t are as described herein. The present invention relates generally to inhibitors of histone deacetylase and to methods of making and using them. These compounds are useful for promoting cognitive function and enhancing learning and memory formation. In addition, these compounds are useful for treating, alleviating, and/or preventing various conditions, including for example, neurological disorders, memory and cognitive function disorders/impairments, extinction learning disorders, fungal diseases and infections, inflammatory diseases, hematological diseases, and neoplastic diseases in humans and animals.
    Type: Application
    Filed: May 5, 2016
    Publication date: September 1, 2016
    Applicants: The Broad Institute, Inc., The General Hospital Corporation d/b/a Massachusetts General Hospital, Massachusetts Institute of Technology
    Inventors: Edward Holson, Florence Fevrier Wagner, Michel Weiwer, Li-Huei Tsai, Stephen J. Haggarty, Yan-Ling Zhang
  • Compounds for the treatment of malaria
    Patent number: 9428507
    Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of malaria.
    Type: Grant
    Filed: June 20, 2014
    Date of Patent: August 30, 2016
    Assignees: The Broad Institute, Inc., President and Fellows of Harvard College
    Inventors: Eamon Comer, Benito Munoz, Jennifer A. Beaudoin, Sebastian T. Le Quement, Christina Scherer, Jeremy Duvall, Nobutaka Kato, Micah Maetani, Bertrand Braibant
  • Compounds and methods for treating diseases mediated by protease activated receptors
    Patent number: 9422262
    Abstract: The invention relates to the use of a compound of Formula I for the treatment of protease-activated receptor mediated diseases by the administration of a compound of Formula I or a prodrug or metabolite thereof.
    Type: Grant
    Filed: September 23, 2011
    Date of Patent: August 23, 2016
    Assignees: The Broad Institute, Inc., Beth Israel Deaconess Medical Center, Inc.
    Inventors: Chris Dockendorff, Robert Flaumenhaft
  • Compounds for the treatment of mycobacterial infections
    Patent number: 9416121
    Abstract: The invention relates to compounds of Formula I or a pharmaceutically acceptable salt, ester or prodrug thereof:
    Type: Grant
    Filed: March 27, 2014
    Date of Patent: August 16, 2016
    Assignees: The Broad Institute, Inc., Massachusetts General Hospital
    Inventors: Deborah Hung, Sarah Stanley, Tomohiko Kawate, Noriakie Iwase, Motohisa Shimizu
  • Compositions and methods of treating head and neck cancer
    Patent number: 9370551
    Abstract: The present invention provides methods related to the treatment of head and neck squamous cell carcinoma (HNSCC) and its associated premalignant lesions. In particular, the invention features methods which may specifically target HNSCC-associated genes and alter gene expression to treat or alleviate a symptom of HNSCC, or its related premalignant lesions. These methods may involve decreasing the function of an HNSCC-associated gene with aberrant gain-of-function; or increasing the function of an HNSCC-associated gene with aberrant loss-of-function.
    Type: Grant
    Filed: July 25, 2012
    Date of Patent: June 21, 2016
    Assignees: The Broad Institute, Inc., Massachusetts Institute of Technology, President and Fellows of Harvard College, Massachusetts Eye and Ear Infirmary, Dana-Farber Cancer Institute, Inc., University of Pittsburgh-Of The Commonwealth of Higher Education, Instituto Carlos Slim de la Salud, A.C.
    Inventors: Le Cong, Ann Marie Egloff, Levi A. Garraway, Jennifer Rubin Grandis, Eric S. Lander, Nicholas Stransky, Aaron D. Tward, Feng Zhang
  • Inhibitors of histone deacetylase
    Patent number: 9365498
    Abstract: The present invention relates to compounds of formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, or prodrug thereof, wherein U, J, V, X, R2a, R2b, R2c, R5 and t are as described herein. The present invention relates generally to inhibitors of histone deacetylase and to methods of making and using them. These compounds are useful for promoting cognitive function and enhancing learning and memory formation. In addition, these compounds are useful for treating, alleviating, and/or preventing various conditions, including for example, neurological disorders, memory and cognitive function disorders/impairments, extinction learning disorders, fungal diseases and infections, inflammatory diseases, hematological diseases, and neoplastic diseases in humans and animals.
    Type: Grant
    Filed: October 28, 2013
    Date of Patent: June 14, 2016
    Assignees: The Broad Institute, Inc., The General Hospital Corporation, Massachusetts Institute of Technology
    Inventors: Edward Holson, Florence Fevrier Wagner, Michel Weiwer, Li-Huei Tsai, Stephen Haggarty, Yan-Ling Zhang
  • Modified saponins for the treatment of fungal infections
    Patent number: 9320751
    Abstract: Methods of treating a fungal infection in a subject, the method comprising administering to the subject a modified saponin.
    Type: Grant
    Filed: February 12, 2015
    Date of Patent: April 26, 2016
    Assignees: The General Hospital Corporation, The Broad Institute, Inc., Massachusetts Institute of Technology
    Inventors: Eleftherios Mylonakis, Edward Holson, Frederick M. Ausubel
  • SLE AND SLE-RELATED DISEASE-ASSOCIATED RISK MARKERS AND USES THEREOF
    Publication number: 20160060699
    Abstract: Provided herein are methods and compositions for identifying subjects, including canine subjects, as having an elevated risk of developing systemic lupus erythematosus (SLE) or an SLE-related immune-mediated rheumatic disorder or having undiagnosed SLE or an SLE-related immune-mediated rheumatic disorder. These subjects are identified based on the presence of gem-line risk markers.
    Type: Application
    Filed: April 11, 2014
    Publication date: March 3, 2016
    Applicant: The Broad Institute, Inc.
    Inventors: Göran Andersson, Helene Hansson-Hamlin, Sergey Kozyrev, Kerstin Lindblad-Toh, Maria Wilbe
  • COMPOUNDS FOR INDUCING PROLIFERATION AND DIFFERENTIATION OF CELLS, AND METHODS OF USE THEREOF
    Publication number: 20160031837
    Abstract: The present invention provides methods of inducing proliferation of and/or differentiating cells comprising contacting cells with compounds within the methods of the invention. The present invention further provides cells obtainable by the methods of the invention. Liver disease affects more than 500 million people worldwide. Organ transplantation is the gold standard for treatment of liver failure, but organ shortages are acute.
    Type: Application
    Filed: March 14, 2014
    Publication date: February 4, 2016
    Applicants: The Broad Institute, Inc., Massachusetts institute of Technology
    Inventors: Sangeeta Bhatia, Jing Shan, Michelle Palmer, Nathan Ross
  • MAST CELL CANCER-ASSOCIATED GERM-LINE RISK MARKERS AND USES THEREOF
    Publication number: 20160032397
    Abstract: Provided herein are methods and compositions for identifying subjects, including canine subjects, as having an elevated risk of developing cancer or having an undiagnosed cancer. These subjects are identified based on the presence of germ-line risk markers.
    Type: Application
    Filed: March 13, 2014
    Publication date: February 4, 2016
    Applicants: The Broad Institute, Inc., Trustees of Tufts College, Animal Health Trust
    Inventor: Malin MELIN
  • METHODS OF IDENTIFYING RESPONSES TO MAP KINASE INHIBITION THERAPY
    Publication number: 20160024589
    Abstract: The invention provides methods and devices for determining molecular signatures in a cancer that predict response to a MARPK pathway inhibitor and methods of use of such signatures.
    Type: Application
    Filed: March 12, 2014
    Publication date: January 28, 2016
    Applicants: The Broad Institute, Inc., Dana-Farber Cancer Institute, Inc.
    Inventors: Cory M. Johannessen, David J. Konieczkowski, Levi A. Garraway