Abstract: This invention provides compounds that have spirocyclic E3 Ubiquitin Ligase targeting moieties (Degrons), which can be used as is or linked to a targeting ligand for a protein that has been selected for in vivo degradation, and methods of use and compositions thereof as well as methods for their preparation.

Abstract: This invention provides heterocyclic compounds that bind to E3 Ubiquitin Ligase (typically through cereblon) (“Degrons”), which can be used as is or linked to a Targeting Ligand for a selected Target Protein for therapeutic purposes and methods of use and compositions thereof as well as methods for their preparation.

Abstract: This invention provides Degronimers that have E3 Ubiquitin Ligase targeting moieties (Degrons) that can be linked to a targeting ligand for a protein that has been selected for in vivo degradation, and methods of use and compositions thereof as well as methods for their preparation. The invention also provides Degrons that can be used to treat disorders mediated by cereblon or an Ikaros family protein, and methods of use and compositions thereof as well as methods for their preparation.

Abstract: A fin for swimming and underwater activities includes at least one foot pocket configured to accommodate the foot of a user and at least one blade associated rigidly with the foot pocket. The fin further includes a substantially spherical joint interposed between the blade and the foot pocket. An upper portion of the joint is rigidly coupled to the base of the foot pocket; and a lower portion of the joint is rigidly coupled to the blade in a portion that is proximate to a respective first end. The joint is lockable in a plurality of different configurations and introduces at least two degrees of rotational freedom.

Abstract: This invention provides compounds that have spirocyclic E3 Ubiquitin Ligase targeting moieties (Degrons), which can be used as is or linked to a targeting ligand for a protein that has been selected for in vivo degradation, and methods of use and compositions thereof as well as methods for their preparation.

Abstract: This invention provides Degronimers that have carbon-linked E3 Ubiquitin Ligase targeting moieties (Degrons), which can be linked to a targeting ligand for a protein that has been selected for in vivo degradation, and methods of use and compositions thereof as well as methods for their preparation.

Abstract: This invention provides heterocyclic compounds that bind to E3 Ubiquitin Ligase (typically through cereblon) (“Degrons”), which can be used as is or linked to a Targeting Ligand for a selected Target Protein for therapeutic purposes and methods of use and compositions thereof as well as methods for their preparation.

Abstract: This invention provides amine-linked C3-glutarimide Degronimers and Degrons for therapeutic applications as described further herein, and methods of use and compositions thereof as well as methods for their preparation.

Abstract: A packet data network gateway, P-GW, is located in a second network for supporting user plane data to terminal devices in a wireless communications system that additionally comprises a first network having a first packet data network gateway, P-GW operably couplable to the P-GW. The P-GW comprises a processor arranged to: check a destination address of received packets from the first P-GW to determine whether the received packets are destined for any of the terminal devices, and in response thereto: extract one or more properties of said received packets if they are destined for any of the terminal devices served with user plane data; or discard said received packets if they are not destined for the terminal device(s).

Abstract: A packet data network gateway, P-GW, is located in a second network for supporting user plane data to terminal devices in a wireless communications system that additionally comprises a first network having a first packet data network gateway, P-GW operably couplable to the P-GW. The P-GW comprises a processor arranged to: check a destination address of received packets from the first P-GW to determine whether the received packets are destined for any of the terminal devices, and in response thereto: extract one or more properties of said received packets if they are destined for any of the terminal devices served with user plane data; or discard said received packets if they are not destined for the terminal device(s).

Abstract: A method for increasing coverage in a wireless communication system is described. The method comprises, at the network element: transmitting a first portion of subframes comprising a number of resource blocks to a first wireless communication unit in a first mode of operation, wherein the number of resource blocks are transmitted at a first power level per resource block; and transmitting, a second portion of subframes to a second wireless communication unit in a second mode of operation at a second power level, wherein the second portion of subframes comprise a lower number of resource blocks than the first portion of subframes and the lower number of resource blocks is transmitted at a second power level per resource block that is higher than the first power level per resource block.

Abstract: A wireless communications system supporting user plane data comprises: a first network having a first packet data network gateway (P-GW); a second network having a second P-GW operably coupled to the first network via a backhaul link; a serving gateway (S-GW) a base station; and a terminal device, wherein a single packet data network connection is created for the terminal device that traverses through the first P-GW, second P-GW, S-GW and base station.

Abstract: A packet data network gateway, P-GW, is located in a second network for supporting control plane data in a wireless communications system that additionally comprises a first network having a first packet data network gateway, P-GW, operably couplable to the P-GW and a serving gateway, S-GW. The P-GW comprises a processor arranged to determine an operational status of at least one of: a backhaul link, first P-GW. In response to the processor determining that both of the backhaul link and the first P-GW are available, the processor is arranged to perform at least one of: trigger deferred signalling between the first network and at least one of a mobility management entity, MME, the S-GW; trigger user plane handling, monitor and build terminal device context information for a plurality of terminal devices being served with user plane data by the backhaul link of the second network.

Abstract: Systems and methods are described for managing channel selection among a plurality of mesh points in a wireless network. In one embodiment, a method includes receiving a first announcement that includes channel exclusion information from a first mesh point; managing a distributed channel exclusion list based on the announcement; and generating a second announcement to the first mesh point based on the channel exclusion list.

Abstract: A packet data network gateway, P-GW, is located in a second network for supporting control plane data in a wireless communications system that additionally comprises a first network having a first P-GW operably couplable to the P-GW, and a serving gateway, S-GW. The P-GW comprises a processor arranged to: monitor and build terminal device context information for a plurality of terminal devices being served with user plane data by the second network; and determine an operational status of at least one of: the backhaul link, first P-GW. In response to the processor determining that at least one of: the backhaul link, first P-GW, is unavailable, the processor is arranged to perform at least one of: terminate signalling between the first network and at least one of a mobility management entity, MME, the S-GW; defer signalling between the first network and at least one of the MME, the S-GW; perform at least some functionality of the first P-GW.

Abstract: A method for key generation at a terminal device supporting at least two communication modes of operation is described. The method comprises, at a terminal device comprising a key derivation function: receiving at least one input parameter from a first wireless communication system; generating a first key in the key derivation function using the received at least one input parameter and at least one first locally stored input parameter in order to transmit in a first mode of operation on the first wireless communication system; and generating a second key in the key derivation function solely using at least one second locally stored input parameter in order to transmit in a second mode of operation on a second wireless communication system; wherein the at least one second locally stored input parameter is arranged to enable the second key to be used as the first key.

Abstract: A phase shift device includes an input quadrature junction for receiving an input EM signal and extracting a first electromagnetic (EM) signal, a second EM signal, a third EM signal, and a fourth EM signal from the input EM signal. Four waveguide arms are operatively connected to the input quadrature junction for respectively conveying the first, second, third, and fourth EM signals therethrough. At least two of the waveguide arms shift the phase of EM signal conveyed therethrough such that two of the first, second, third, and fourth EM signals are phase shifted with respect to the other two of the first, second, third, and fourth EM signals. An output quadrature junction is operatively connected to the waveguide arms for combining the first, second, third, and fourth EM signals. Thus, polarization adjustment may be achieved through rotation of the phase shift device.

Abstract: A method for increasing coverage in a wireless communication system is described. The method comprises, at the network element: transmitting a first portion of subframes comprising a number of resource blocks to a first wireless communication unit in a first mode of operation, wherein the number of resource blocks are transmitted at a first power level per resource block; and transmitting, a second portion of subframes to a second wireless communication unit in a second mode of operation at a second power level, wherein the second portion of subframes comprise a lower number of resource blocks than the first portion of subframes and the lower number of resource blocks is transmitted at a second power level per resource block that is higher than the first power level per resource block.

Abstract: A method for a low bandwidth wireless communication unit to re-synchronize to a wireless communication system employing one or more virtual carrier(s) after the wireless communication unit has lost synchronization is described. The method comprises, at the wireless communication unit: entering a sleep mode of operation following communication on a first virtual carrier; waking up from the sleep mode of operation on a default virtual carrier that is not the first virtual carrier; and acquiring synchronization information using synchronization signals that occupy subcarrier resources that overlap with the subcarrier resources occupied by the default virtual carrier to re-synchronize with the wireless communication system.

Abstract: A network element for controlling a usage of at least one resource is described. The network element comprises: a transmitter for transmitting a signal identifying at least one uplink resource to at least one wireless communication unit; a signal processor operably coupled to the transmitter for generating the signal; and a receiver for receiving a transmission from the at least one wireless communication unit on the identified at least one uplink resource. The signal processor is arranged to allocate the uplink resource for the at least one wireless communication unit in a first portion of a first sub-frame on a first frequency and a first portion of a second sub-frame on a second frequency wherein a time gap is allocated between an end of the first portion of the first sub-frame and a beginning of the first portion of a second sub-frame.