Abstract: Provided are a self voice training method for a patient with a voice disorder and a user terminal for self voice training. The user terminal for self voice training includes an input device configured to receive a training program selection command of a user, a storage configured to store voice training candidate programs for the user's voice training, a calculator configured to generate first guide content according to a first voice training program selected from among the voice training candidate programs by the user, an output device configured to output the first guide content, and a microphone configured to receive voice output by the user according to the first guide content output through the output device.

Abstract: Disclosed is an eyelid speculum including a frame, a first rotary arm coupled to one side of the frame to be rotatable, a second rotary arm coupled to an opposite side of the frame to be rotatable, a movement part configured to move the first rotary arm and the second rotary arm such that the first rotary arm and the second rotary arm are moved in a direction, in which they become closer to or more distant from each other, a first support arm coupled to the first rotary arm to be rotatable, and configured to support an upper eyelid, and a second support arm coupled to the second rotary arm, and configured to support a lower eyelid.

Abstract: The method comprises obtaining a document including a target infectious disease as a corpus for each of a plurality of time sections, converting a plurality of words included in the obtained corpus into embedding vectors, calculating similarities between the respective converted embedding vectors and an embedding vector indicating the target infectious disease, extracting an embedding vector of which the calculated similarity is higher than a predetermined first threshold value, for each time section, obtaining first time series data indicating a search volume, over time, of a word corresponding to the embedding vector extracted for each time section, calculating a correlation coefficient between the obtained first time series data and second time series data, and generating a word corresponding to the first time series data of which the calculated correlation coefficient is higher than a predetermined second threshold value as a keyword for each time section.

Abstract: Disclosed is a surgical pin guide. To this end, the present invention provides a surgical pin guide including a guide fixed to an outer circumferential surface of a femur and configured to allow a center pin and a central pressure reducer of a drill handpiece to approach a necrotic region of an expanded area, a guide main body including a handle provided on an upper surface of a block, a center pin-guide hole horizontally pierced at a center of a front surface of the block, and a plurality of side pin-guide holes pierced at predetermined inclination angles with respect to the center pin-guide hole, arranged radially in the front surface of the block, and configured to meet the center pin-guide hole in a rear surface of the block, and a leading body configured to allow the guide main body to be detached from the guide and approach the necrotic region of the femoral head in a rotationally folded state.

Abstract: An apparatus and a method for predicting re-rupture of a tendon based an artificial intelligence (AI) are provided. The apparatus includes a communication module to make communication with an external device, an acquiring module to acquire at least one arthroscopic image including a surgical portion of a patient experiencing a surgery, a storage module to store at least one process based on the AI, and a control module to perform an operation for predicting the re-rupture of the tendon based on the AI, through the at least one process. The control module performs a pre-processing operation for the at least one arthroscopic image, predicts a probability of the re-rupture of the tendon by inputting the at least one arthroscopic image, which is pre-processed, into a pre-trained model based on the AI, and generates prediction information for the patient based on a prediction result.

Abstract: Provided is an immunomodulatory treatment composition for a transplantation disease through combined administration of a microbiome and an immunosuppressant. According to the present disclosure, it was confirmed that in an allogeneic transplantation cell model, combined administration of FK506 and the microbiome suppressed alloresponse and regulated the activity of T cells and B cells. Further, it was confirmed that in an acute graft-versus-host disease animal model, the combined administration reduced the disease activity, increased the probability of survival, and protected the tissue damage. In addition, it was confirmed that the combined administration improved transplantation rejection diseases by reducing the activity of Th1 and Th17 and increasing the activity of Tregs, and thus can be usefully used as an immunomodulator for transplantation rejection.

Abstract: The present invention relates to a method for predicting survival of non-small cell lung cancer patients with brain metastasis. More specifically, it proposes a method that is useful for predicting the survival of the patients by comparing TMTrg of the patients with cut off value for predicting long term survival.

Abstract: A brain protection pad is disclosed. A brain protection pad, according to one embodiment of the present invention, comprises an artificial dura mater layer configured to cover the brain exposed to the outside after a craniotomy. The artificial dura mater layer comprises artificial dura mater having a predetermined area so as to cover the brain, and may comprise one or more from among incision portions formed by partially incising the artificial dura mater so as to enable the artificial dura mater to expand in a direction perpendicular to the incision direction, and corrugations formed by folding the artificial dura mater so as to enable the artificial dura mater to expand in an unfolding direction.

Abstract: The method for performing endoscopic examination according to an exemplary embodiment of the present invention may include the steps of obtaining an endoscopic image and a 3D model of a target organ; identifying location information of an endoscope on the 3D model in real time based on simultaneous localization and mapping (SLAM); classifying a plurality of areas constituting the 3D model into examination areas and unexamined areas by using the endoscopic image and the location information; and providing feedback information based on the examination areas and unexamined areas.

Abstract: The method for preventing or treating of cancer includes administering a pharmaceutical composition to a subject in need thereof comprising a compound represented by Chemical Formula 1 below or a pharmaceutically acceptable salt thereof as an active ingredient. wherein the composition inhibits the growth of cancer cells.

Abstract: A tumor classification method using multi-wavelength photoacoustic image and ultrasound image comprises the steps of: receiving, by an analysis device, an image set including photoacoustic frames and ultrasound frames collected over time for a predetermined period of time by each of a plurality of wavelength bands with respect to a subject; selecting, by the analysis device, photoacoustic frames and ultrasound frames to be analyzed, from the image set, on the basis of ultrasound image; performing, by the analysis device, spectral unmixing analysis on the selected photoacoustic frames; calculating, by the analysis device, at least one parameter for a tumor region by using the result of the spectral unmixing analysis; and classifying, by the analysis device, the subject's tumor by using the parameter.

Abstract: A simultaneous implementation method of 3D subtraction magnetic resonance (MR) arteriography, 3D subtraction MR venography, and color-coded 4D MR angiography through post-processing of image information of 4D MR angiography according to an embodiment of the present disclosure may reduce scan time required to individually obtain an MR arteriography and an MR venography. In addition, not only anatomical information of arteries but also more accurate anatomical information of veins and more detailed hemodynamic information may be obtained.

Abstract: A lung phantom unit for radiotherapy according to an embodiment of the present disclosure may arrange, at a location not affected by a magnetic field, a phantom driving cylinder and a driving device which may move a lung mimic and a tumor mimic in a lung simulation block. The lung phantom unit may be used for general purpose even as a phantom for MRI-based and CT image-based radiotherapy. Since lung and tumor motions are implemented by air injection, it may be possible to precisely measure the motion and volume change of a lung according to subtle changes in air pressure so that customized radiotherapy suitable for a patient having various breathing patterns is possible.

Abstract: An artificial bladder is provided, including: a main body which includes an inlet port, an outlet port, an inner wall that forms a first reservoir portion configured to store urine between the inlet port and the outlet port and that is expandable and contractible. An outer wall forms a second reservoir portion configured to surround at least a partial region of the inner wall. A sensor is attached to the inner wall, has a surface having a wrinkled structure, and is provided so that, when the volume of the first reservoir portion increases, the wrinkled structure stretches out and resistance of the sensor changes. A control unit is provided to discharge the urine in the first reservoir portion through the outlet port according to a result detected by the sensor.

Abstract: The present invention relates to a Leukocyte-specific protein 1 (LSP1)-deficient T cell-based anticancer immunotherapy. According to the present invention, tumor growth, tumor volume and size were reduced by means of LSP1 knockout, and LSP1 deficiency in T cells increases the number, distribution frequency, migration, and invasion of T cells, and increases the production of an anti-tumor cytokine to inhibit tumor growth and enhance tumor-killing ability. Thus, the present invention can be used for T cell-based immunotherapy.

Abstract: The present invention relates to a novel feeder cell and a method for growing gamma delta T cells using the same. More specifically, a large amount of gamma delta T cells may be grown in vitro with high purity and without simulation of a T cell receptor by using a feeder cell into which costimulatory molecules are introduced and a low concentration of IL-2, differentiation into central memory cells may be possible when stimulated, activity by the feeder cell, and cytolytic against tumour cells is provided.

Abstract: The present invention relates to a HLA-A2 subtype-specific PLK1-derived epitope inducing an antigen-specific T cell immune response to a PLK1 protein. More specifically, a HLA-A2 subtype-specific PLK-1-derived epitope inducing an antigen-specific T cell immune response to a PLK1 protein according to the present invention can provide a CD8+ T cell immune response specific for tumor cells.

Abstract: Disclosed is a language area invasion determination apparatus including a memory unit including a language area invasion determination model, and a processor that controls an operation of the language area invasion determination model included in the memory unit. The processor trains the language area invasion determination model by using one or more training utterance data and outputs language area invasion determination data of an examiner by using test utterance data and the trained language area invasion determination model. The training utterance data and the test utterance data include utterance speech data of a speaker.

Abstract: The present disclosure relates to a novel lipid compound and a lipid nanoparticle composition including the same and, more specifically, the lipid nanoparticle composition includes ionized lipid, helper lipid, PEG-lipid, and additives, and may mitigate changes and side effects in the delivery mechanism and enhance the protein expression efficiency by including a biofriendly vitamin-based novel lipid compound and helper lipids including neutral lipids.

Abstract: The present disclosure relates to the preparation of citrullinated vimentin antigen-specific immune tolerogenic dendritic cells and a composition for preventing or treating heart failure after myocardial infarction comprising the same. According to the present disclosure, it is confirmed that immune tolerogenic dendritic cells differentiated by treating immature dendritic cells with citrullinated vimentin regulate the expression of immune-related factors and have an excellent therapeutic effect on heart failure caused by myocardial infarction.