Abstract: The present invention relates to a Leukocyte-specific protein 1 (LSP1)-deficient T cell-based anticancer immunotherapy. According to the present invention, tumor growth, tumor volume and size were reduced by means of LSP1 knockout, and LSP1 deficiency in T cells increases the number, distribution frequency, migration, and invasion of T cells, and increases the production of an anti-tumor cytokine to inhibit tumor growth and enhance tumor-killing ability. Thus, the present invention can be used for T cell-based immunotherapy.

Abstract: The present invention relates to a novel feeder cell and a method for growing gamma delta T cells using the same. More specifically, a large amount of gamma delta T cells may be grown in vitro with high purity and without simulation of a T cell receptor by using a feeder cell into which costimulatory molecules are introduced and a low concentration of IL-2, differentiation into central memory cells may be possible when stimulated, activity by the feeder cell, and cytolytic against tumour cells is provided.

Abstract: The present invention relates to a HLA-A2 subtype-specific PLK1-derived epitope inducing an antigen-specific T cell immune response to a PLK1 protein. More specifically, a HLA-A2 subtype-specific PLK-1-derived epitope inducing an antigen-specific T cell immune response to a PLK1 protein according to the present invention can provide a CD8+ T cell immune response specific for tumor cells.

Abstract: Disclosed is a language area invasion determination apparatus including a memory unit including a language area invasion determination model, and a processor that controls an operation of the language area invasion determination model included in the memory unit. The processor trains the language area invasion determination model by using one or more training utterance data and outputs language area invasion determination data of an examiner by using test utterance data and the trained language area invasion determination model. The training utterance data and the test utterance data include utterance speech data of a speaker.

Abstract: The present disclosure relates to the preparation of citrullinated vimentin antigen-specific immune tolerogenic dendritic cells and a composition for preventing or treating heart failure after myocardial infarction comprising the same. According to the present disclosure, it is confirmed that immune tolerogenic dendritic cells differentiated by treating immature dendritic cells with citrullinated vimentin regulate the expression of immune-related factors and have an excellent therapeutic effect on heart failure caused by myocardial infarction.

Abstract: The present disclosure relates to a novel lipid compound and a lipid nanoparticle composition including the same and, more specifically, the lipid nanoparticle composition includes ionized lipid, helper lipid, PEG-lipid, and additives, and may mitigate changes and side effects in the delivery mechanism and enhance the protein expression efficiency by including a biofriendly vitamin-based novel lipid compound and helper lipids including neutral lipids.

Abstract: The inventive concept relates to an eyeball and eyelid protector including an eyeball cover that covers an eyeball, and an eyelid protection part that is bent and extends from one side of the eyeball cover to protect any one of an upper eyelid and a lower eyelid.

Abstract: A learning method for generating a multiphase collateral image comprises the steps of: receiving inputs of an MRI image of a head part and a multiphase collateral image generated on the basis of the MRI image; generating a brain mask by using the MRI image; generating an MRI image and a multiphase collateral image which are masked by the brain mask; and learning the masked multiphase collateral image for the masked MRI image by using a learning network.

Abstract: A blood vessel model simulation apparatus for conducting a test or a simulation surgery on a blood vessel model, including: a blood vessel model mounting unit on which a blood vessel model is mounted to allow a blood-mimicking liquid flow; a blood-mimicking liquid tank unit that is integrally attached to the blood vessel model mounting unit and stores a blood-mimicking liquid which is to be supplied to the blood vessel model mounted on the blood vessel model mounting unit; a pump unit that circulates the blood-mimicking liquid stored in the blood-mimicking liquid tank unit via the blood vessel model; and a pump control unit that controls drive of the pump unit. The units are configured to be integrally coupled to each other such that the blood vessel model simulation apparatus has a reduction in size and weight to be mobile.

Abstract: The present invention relates to a composition for preventing or treating transplantation rejection or a transplantation rejection disease, comprising a novel compound and a calcineurin inhibitor. A co-administration of the present invention 1) reduces the activity of pathogenic Th1 cells or Th17 cells, 2) increases the activity of Treg cells, 3) has an inhibitory effect against side effects, such as tissue damage, occurring in the sole administration thereof, 4) inhibits various pathogenic pathways, 5) inhibits the cell death of inflammatory cells, and 6) increases the activity of mitochondria, in an in vivo or in vitro allogenic model, a transplantation rejection disease model, a skin transplantation model, and a liver-transplanted patient, and thus inhibits transplantation rejection along with mitigating side effects possibly occurring in the administration of a conventional immunosuppressant alone.

Abstract: The present disclosure relates to the preparation of citrullinated vimentin antigen-specific immune tolerogenic dendritic cells and a composition for preventing or treating heart failure after myocardial infarction comprising the same. According to the present disclosure, it is confirmed that immune tolerogenic dendritic cells differentiated by treating immature dendritic cells with citrullinated vimentin regulate the expression of immune-related factors and have an excellent therapeutic effect on heart failure caused by myocardial infarction.

Abstract: The inventive concept relates to an eyeball and eyelid protector including an eyeball cover that covers an eyeball, and an eyelid protection part that is bent and extends from one side of the eyeball cover to protect any one of an upper eyelid and a lower eyelid.

Abstract: The present invention relates to a pharmaceutical composition comprising a novel compound as an active ingredient for prevention or treatment of transplant rejection. The novel compound SD911 of the present invention was identified to repress the migration of immune cells, increase the engraftment and viability of a grafted tissue, and regulate immune cells. In addition, it was found in a kidney transplantation model that the compound restrained human PBMC from suppressing the engraftment and damaging renal tissues and downregulated the expression of the inflammatory cytokine IL-17, with the consequent effective prevention and treatment of transplant rejection.

Abstract: Disclosed is a portable model eye apparatus for intraocular lens evaluation that enables more accurate comparison of intraocular lenses by capturing the same image and situation for different intraocular lenses.

Abstract: Disclosed is a defocus curve measuring apparatus for a multifocal intraocular lens capable of automatically measuring an objective defocus curve. A defocus curve measuring apparatus for a multifocal intraocular lens according to an aspect of the present invention may include a light source passed through a target image for focusing; a first lens that infinitely refracts the focus as the light source passes through it; a beam splitter having a polarization function that passes p-polarized light of the light source that has passed through the first lens and reflects s-polarized light; an intraocular lens module that refracts the light source that has passed through the beam splitter as it passes, thereby determining the focus; and a camera that captures an image of s-polarized light reflected by the beam splitter after the light source reflected from a retina passes through the intraocular lens module.

Abstract: The present disclosure relates to an openable/closable vertebral endoscopic device. The openable/closable vertebral endoscopic device includes an endoscope body including a working channel for providing an access route of a surgical instrument to a diseased area of a human body, the working channel having an open channel formed by opening a portion of the working channel such that a portion of the surgical instrument inserted into the working channel is exposed to the outside; and a cover member provided on the endoscope body to selectively open or close the open channel of the endoscope body.

Abstract: Disclosed herein are a method and system for predicting an occurrence of acute kidney injury. A method of predicting an occurrence of acute kidney injury, according to some embodiments of the present disclosure, may train a model for predicting a risk of an occurrence of postoperative acute kidney injury using a dataset of a plurality of patients, and accurately and early predict the risk of an occurrence of postoperative acute kidney injury for a specific patient using the trained model.

Abstract: Provided is an intraocular lens exchanger for moving a foldable intraocular lens (IOL), the intraocular lens exchanger including: an outer tube having a first passage formed in a forward/rearward direction; an inner tube disposed to be movable along the first passage and having a second passage formed in the forward/rearward direction; and a variable tube extending from a front end of the inner tube to form a variable passage connected to the second passage, in which the variable tube has an extension part having a width that increases forward in an unconstrained state in which the variable tube is not positioned in the first passage, and the extension part is provided to be elastically deformed when the unconstrained state changes to a constrained state in which at least a part of the extension part is received in the first passage.

Abstract: A cervical spine endplate preparation apparatus is provided. To this end, the present invention comprises: a handle part having a handle to be held by hand and a leading rod extending from the handle in the length direction and for guiding to a space inside the spine of a part to be operated on; a rotating shaft part having an adjustment grip, which generates a driving force by means of rotation by hand, and a rotating shaft passing through the inside of the handle and leading rod; and a shaver part which has a case, provided on the leading rod and inserted into the space of the spine, and a shaver installed inside the case and mating with the rotating shaft to rotate by means of the driving force of the adjustment grip, and having a part of a blade exposed to the top of the case and rotating.

Abstract: The present invention relates to a novel antibody specifically binding to a specific epitope of GKN1 (gastrokine 1) protein, and a gastric cancer diagnostic use thereof. An antibody specific to GKN1 according to the present invention specifically binds to a new epitope, and can be used to confirm the level of GKN1 protein in serum and thereby detect (diagnose) gastric cancer with 100% sensitivity and specificity. Thus, the antibody can be useful for screening and diagnosing gastric cancer.