Patents Assigned to The Centre National de la Recherche Scientifique
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Patent number: 12055132Abstract: A magnetic circuit for creating a magnetic field in a main annular ionization and acceleration channel of a Hall-effect plasma thruster, having an open top end for emitting ions and a closed bottom end, includes outer magnets comprising a bottom annular outer magnet, and a top annular outer magnet disposed above the bottom outer magnet; inner magnets comprising a bottom inner magnet, of cylindrical form having a bottom part of a diameter less than the diameter of a top part, disposed below the top outer magnet, and a top annular inner magnet disposed above the bottom inner magnet; the outer magnets having a same pole (N, S) on their respective top face and an opposite same pole (S, N) on their bottom face; the inner magnets having an orientation of their poles that is the reverse of that of the outer magnets; and the outer magnets and the inner magnets being disposed above the closed bottom end of the annular channel.Type: GrantFiled: May 18, 2021Date of Patent: August 6, 2024Assignees: INSTITUT NATIONAL POLYTECHNIQUE DE TOULOUSE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Youness Rtimi, Frédéric Messine
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Patent number: 12054743Abstract: A method for obtaining a population of T cells from pluripotent stem cells, which includes a first step of obtaining hematopoietic stem cells and a second step of obtaining T cells. Also, the cell populations thus obtained according to this method and these cell populations for use as a medicament.Type: GrantFiled: March 22, 2019Date of Patent: August 6, 2024Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE, CENTRE HOSPITALIER UNIVERSITAIRE DE NANTES, UNIVERSITÉ DE NANTESInventors: Carole Guillonneau, Laurent David, Léa Flippe
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Patent number: 12054392Abstract: The invention concerns a method of forming a graphene device, the method comprising: forming a graphene film (100) over a substrate; depositing, by gas phase deposition, a polymer material covering a surface of the graphene film (100); and removing the substrate from the graphene film (100), wherein the polymer material forms a support (102) for the graphene film (100).Type: GrantFiled: December 14, 2022Date of Patent: August 6, 2024Assignees: Centre National de la Recherche Scientifique, UNIVERSITE GRENOBLE ALPESInventors: Dipankar Kalita, Vincent Bouchiat, Laetitia Marty, Nedjma Bendiab
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Patent number: 12052979Abstract: A transgenic non-human animal model for Neurofibromatosis type 1, wherein the Nf1 gene is specifically inactivated in BC cells and derivatives thereof. Also, an in vitro method of producing cutaneous and plexiform Neurofibromas (NFBs) and/or for studying the development and composition of plexiform NFBs, including culturing in vitro Prss56-expressing cells and-derivatives thereof obtained from the transgenic non-human animal model. Further, a method for screening a candidate compound for use as a drug to treat Neurofibromatosis type 1, cutaneous NFBs and/or plexiform NFBs including contacting the candidate compound Prss56-expressing cells and-derivatives thereof obtained from the transgenic non-human animal model or administering the candidate compound to the transgenic non-human animal model.Type: GrantFiled: June 29, 2018Date of Patent: August 6, 2024Assignees: 1. PARIS SCIENCES ET LETTRES—QUARTIER LATIN, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)Inventors: Piotr Topilko, Patrick Charnay, Fanny Coulpier, Aurélie Gresset, Katarzyna Radomska
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Patent number: 12055801Abstract: A device for modulating the amplitude of an incident laser radiation of wavelength ?i is provided.Type: GrantFiled: March 27, 2020Date of Patent: August 6, 2024Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE PARIS SACLAYInventors: Raffaele Colombelli, Stefano Pirotta, Ngoc Linh Tran
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Publication number: 20240252985Abstract: The method p1 for converting osmotic energy into hydraulic energy and the method p2 for desalination, include pressurisation/depressurisation and isochoric washing of an aqueous solution containing a salt in the presence of a selective hydrophobic nanoporous material of which the nanoporous volume within the material is only accessible to fresh water and which has a nanoporosity volume fraction ranging from 0.2 to 1 so as to convert osmotic energy into hydraulic energy or conversely to desalinate water, preferably sea water or brine.Type: ApplicationFiled: June 2, 2022Publication date: August 1, 2024Applicants: UNIVERSITE GRENOBLE ALPES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Cyril Picard, Elisabeth Charlaix, William Chèvremont
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Publication number: 20240253037Abstract: The present invention relates to a microfluidic chip capable of attracting and trapping a specific biological element, said chip comprising: a reservoir (1) consisting of a matrix comprising a chemoattractant compound capable of attracting the biological element, and at least one array of microchannels (2) arranged between the reservoir (1) and the external medium (3) of the chip and enabling the chemoattractant compound to pass towards said medium and the biological element present in said medium to pass towards the reservoir (1), characterized in that each microchannel is in the form of a harpoon comprising at least two arrows spaced apart longitudinally and directed towards the reservoir, in which each arrow comprises two branches each having a free end forming an acute angle of between 10° and 80°, and in which each arrow comprises two openings (7) communicating with a longitudinal part of the microchannel and having a width of between 5 ?m and 30 ?m.Type: ApplicationFiled: May 17, 2022Publication date: August 1, 2024Applicants: UNIVERSITE DE MONTPELLIER (UM), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), ECOLE NATIONALE SUPERIEURE DE CHIMIE DE MONTPELLIER (ENSCM)Inventors: Jean-Marie RAMIREZ, Benoît CHARLOT, Sébastien MEANCE, Xavier GARRIC, Coline PINESE, Isabelle GUIRAUD
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Publication number: 20240260478Abstract: A method for fabricating an asymmetric SOT-MRAM memory cell unit, the memory cell unit including a conductor track and a pad, arranged on the conductor track and including at least one first magnetic region with free magnetization. The method further includes producing a stack of a plurality of extended layers, including at least one first extended magnetic layer; depositing a mask on an upper surface of the stack; and defining the first magnetic region in the first extended magnetic layer though ion irradiation of the upper surface of the stack carrying the mask, the parameters of the ion irradiation being adapted so as to modify magnetic properties of the material forming the first magnetic layer.Type: ApplicationFiled: May 17, 2022Publication date: August 1, 2024Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE PARIS-SACLAY, COMMISSARIAT À L'ÉNERGIE ATOMIQUE ET AUX ÉNERGIES ALTERNATIVESInventors: Gilles GAUDIN, Ioan Mihai MIRON, Olivier BOULLE, Dafine RAVELOSONA
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Publication number: 20240254302Abstract: Organic solid three-dimensional polymeric foams, a process for preparing the same, and use thereof, the foams includes a solid continuous phase and pores, wherein the foams have a pore size ranging from 50 nm to 200 ?m and a volumetric fraction of the solid continuous phase is from 0.1 to 60%, with respect to the total volume of the foams, and a polydispersity index from 1 to 30%, the foams being ordered over a volume of at least 100 pores.Type: ApplicationFiled: February 29, 2024Publication date: August 1, 2024Applicants: PARIS SCIENCES ET LETTRES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLE DE LA VILLE DE PARISInventors: Ilham MAIMOUNI, Maria RUSSO, Janine COSSY, Patrick TABELING
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Patent number: 12049480Abstract: The present invention relates to a virus-derived particle comprising one or more Cas protein(s), as well as to kits and methods using the same for altering a target nucleic acid.Type: GrantFiled: November 22, 2023Date of Patent: July 30, 2024Assignees: Institut National De La Sante Et De La Recherche Medicale (INSERM) Paris, FRANCE, Centre National De La Recherche Scientifique (CNRS) Paris, FRANCEInventors: Théophile Ohlmann, Philippe Mangeot, Emiliano Ricci
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Patent number: 12051837Abstract: The present invention relates to a composite material comprising a porous solid matrix having interconnected channels, said matrix comprising sulfonate groups on at least a part of the surface of said channels, wherein a sulfonate group is in ionic interaction with a quaternary ammonium of a polymerizable molecule. The present invention also relates to a method for preparing such a composite material and applications thereof.Type: GrantFiled: October 28, 2020Date of Patent: July 30, 2024Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE FRANCHE-COMTEInventor: Bernard Gauthier-Manuel
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Patent number: 12048693Abstract: The present invention relates to a compound of general formula (I), wherein R1 is OCH2CH2OCH3 or OCH3, R?1 is H or OH, R2 is Cl, F, Br or I, with the proviso that when: R1 is OCH2CH2OCH3 then R?1 is H, R1 is OCH3 then R?1 is OH, its pharmaceutically acceptable salts and/or optical isomers, tautomers, solvates or isotopic variations thereof. The invention also relates to said compounds for use in the treatment of cancer, namely solid tumor cancer, and preferably those selected from melanoma, colon, lung, pancreas, kidney, Merkel carcinoma, squamous cell carcinoma, prostate, breast and bladder. The invention also relates to a pharmaceutical composition comprising said compounds.Type: GrantFiled: January 4, 2019Date of Patent: July 30, 2024Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), UNIVERSITÉ CÔTE D'AZURInventors: Thierry Passeron, Rachid Benhida, Pascal Dao, Gian Marco De Donatis, Anthony Martin
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Publication number: 20240245058Abstract: A novel Trichoderma harzanium strain, filed on Jun. 12, 2018 with the CNCM (Collection Nationale de Cultures de Micro-organismes), 25-28 rue du Docteur Roux, 75724 Paris Cedex 15, under number CNCM I-5327. Also, the use of this Trichoderma harzanium strain to control fusarium head blight in cereals selected from wheat, Brachypodium distachyon, triticale, oats and rye, and more particularly to combat fusarium head blight in wheat.Type: ApplicationFiled: June 19, 2019Publication date: July 25, 2024Applicants: UNIVERSITE PARIS-SACLAY, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS -, B 2 BInventors: Marie DUFRESNE, Julie OBERT, Tracy PLAINCHAMP, Olivier BESNARD, Jean-Marc SENG
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Publication number: 20240251103Abstract: A computer-implemented method of machine-learning. The method includes obtaining a training dataset of 3D models of real-world objects. The method further includes learning, based on the training dataset and on a patch-decomposition of the 3D models of the training dataset, a finite codebook of quantized vectors and a neural network. The neural network comprises a rotation-invariant encoder. The rotation-invariant encoder is configured for rotation-invariant encoding of a patch of a 3D model into a quantized latent vector of the codebook. The neural network further includes a decoder. The decoder is configured for decoding a sequence of quantized latent vectors of the codebook into a 3D model. The sequence corresponds to a patch-decomposition. This constitutes an improved solution for 3D model generation.Type: ApplicationFiled: January 16, 2024Publication date: July 25, 2024Applicants: DASSAULT SYSTEMES, ECOLE POLYTECHNIQUE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Mariem MEZGHANNI, Kawtar ZAHER, Malika BOULKENAFED, Maks OVSJANIKOV
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Patent number: 12044620Abstract: A method for determining a set of physical parameters of a sample, comprising the steps of: —A Retrieving a measured sample temporal trace Es(t), —B retrieving a measured reference temporal trace Eref(t), —C determining an widened reference temporal trace, called Eref0(t), and determining a discrete Fourier transform {hacek over (E)}ref0(?) of the widened reference temporal trace—D determining a modeling of an impulse response of the sample in the frequency domain, depending on the set of physical parameters (pi), called sample frequency model {hacek over (E)}model{Pi}(?), from the Fourier Transform of the widened reference temporal trace {hacek over (E)}ref0(?) and a physical behavior model of the sample, —E applying an optimization algorithm on the set of physical parameters (pi) comprising the sub steps of: —E1 initializing physical parameters (pi), —realizing iteratively the sub steps of: —E2 calculating an inverse discrete Fourier transform of the sample frequency model {hacek over (E)}model{Pi}(?), callType: GrantFiled: February 11, 2021Date of Patent: July 23, 2024Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, CENTRALE LILLE INSTITUT, UNIVERSITE DE LILLE, UNIVERSITE POLYTECHNIQUE HAUTE-DE-FRANCE, JUNIAInventor: Romain Peretti
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Patent number: 12043683Abstract: Cumene hydroperoxide oligomer according to Formula (I): in which OLIGOMER is a homo- or copolymer chain, which is substituted n times by the group which is in brackets; Q is absent or is a divalent aromatic C6-C14 hydrocarbon radical or an aliphatic, linear or branched C1-C14 hydrocarbon radical, which can be interrupted by one or more S and/or O atoms and/or —O—CO—NR1— and which can be substituted by one or more substituents; X, Y independently of each other in each case are absent, —O—, —COO—; —CONR3— or —O—CO—NR4—, wherein X is absent if Q is absent, and wherein the substitution on the aromatic compound is effected in position 2, 3 or 4 relative to the cumene hydroperoxide group; and n is a value from 1 to 50.Type: GrantFiled: May 24, 2022Date of Patent: July 23, 2024Assignees: Ivoclar Vivadent AG, Université Montpellier, Centre National de la Recherche Scientifique, Ecole Nationale Supérieure de Chimie MontpellierInventors: Norbert Moszner, Yohann Catel, Jörg Angermann, Jean-Jacques Robin, Paul Morandi, Sophie Monge-Darcos
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Patent number: 12046398Abstract: A method for producing a permanent or soft magnet including the following steps: a) providing: a solution containing a solvent in which are dispersed a set of objects which possess a permanent magnetic moment; a substrate on which are fixed to the surface or within a cavity that it may have, a 1st pad and a 2nd pad, said 1st pad includes a face facing and parallel to a face that the 2nd pad includes; b) the solution is deposited on the surface of the substrate or, as the case may be, within its cavity; c) the substrate is placed in a magnetic field so that the set of objects are grouped together between the face of the 1st pad and the face of the 2nd pad so as to form a permanent magnet.Type: GrantFiled: December 12, 2019Date of Patent: July 23, 2024Assignees: INSTITUT NATIONAL DES SCIENCES APPLIQUÉES, UNIVERSITE PAUL SABATIER (TOULOUSE III), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Lise-Marie Lacroix, Guillaume Viau, Thierry Leichle, Pierre Moritz
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Patent number: 12043894Abstract: A chemical vapor deposition head, suitable in particular for spatial atomic layer deposition at ambient pressure, is provided. The chemical vapor deposition head is produced in a single piece by additive manufacturing, with a network of distribution ducts being formed by cavities formed in the piece. A method for depositing at least one thin layer by such a chemical vapor deposition head is also provided. A vapor deposition system is further provided. The vapor deposition system includes the chemical vapor deposition head and a carriage bearing the chemical vapor deposition head and allowing it to be moved over a substrate. The carriage may also include one or more reservoirs of precursors also produced by additive manufacturing.Type: GrantFiled: July 30, 2019Date of Patent: July 23, 2024Assignee: Centre National De La Recherche ScientifiqueInventor: David Munoz-Rojas
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Patent number: 12046867Abstract: An active laser medium for emitting a light beam by laser effect includes an X—F2-doped crystal, wherein X is a chemical element from the alkaline-earth family and F is fluorine. The crystal is doped with trivalent ions including: a first category of optically active dopant ions, in which each dopant ion is an ion of a first rare earth; and a second category of optically inactive dopant ions, referred to as buffer ions, in which each dopant ion is an ion of a rare earth different from the first rare earth. The second category of dopant ions has at least ions of a second rare earth and ions of a third rare earth, different from one another. The invention provides an active laser medium that can be used to obtain both a desired emission spectrum shape and a high thermal conductivity.Type: GrantFiled: October 30, 2019Date of Patent: July 23, 2024Assignees: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, UNIVERSITE DE CAEN NORMANDIE, ENSICAEN, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Patrice Camy, Alain Braud, Jean-Louis Doualan, Abdel Benayad, Jean-Paul Goossens
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Patent number: 12046268Abstract: A cryogenic magnetic device includes a free layer having a free magnetisation and a magnetic anisotropy favouring the orientation of the free magnetisation according to a first orientation or a second orientation, the magnetic anisotropy being defined by an energy barrier separating the first orientation and the second orientation, the amplitude of the energy barrier being less than 6300 kB, the free layer having a Gilbert damping factor comprised between 0.02 and 0.4; a tunnel barrier extending in contact with the free layer; and a system configured to apply a voltage pulse through the tunnel barrier so as to reduce the amplitude of the energy barrier and switch the free magnetisation.Type: GrantFiled: February 11, 2022Date of Patent: July 23, 2024Assignees: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, UNIVERSITE GRENOBLE ALPES, INSTITUT NATIONAL POLYTECHNIQUE DE GRENOBLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Bernard Dieny, Pedro Brandao Veiga, Ricardo Sousa, Liliana Buda-Prejbeanu, Hélène Bea, Cécile Grezes