Abstract: A device for treatment of cells with particles is disclosed. The device includes a semi-permeable membrane positioned between two plates, the first plate defining a first flow chamber and comprising a port, a flow channel, a transverse port, and a transverse flow channel, the first flow chamber constructed and arranged to deliver fluid in a transverse direction along the first side of the semi-permeable membrane, the second plate defining a second flow chamber and comprising a port. A method for transducing cells is disclosed. The method includes introducing a fluid with cells and viral particles into a flow chamber adjacent a semi-permeable membrane such that the cells and the viral particles are substantially evenly distributed on the semi-permeable membrane. The method also includes introducing a recovery fluid to suspend the cells and the viral particles, and separating the cells from the viral particles. A method of activating cells is disclosed.

Abstract: A control circuit for an electrostatic machine includes a current source or sink, an inductor, a switching network coupled between the current source or sink and the electrostatic machine, and between the inductor and the electrostatic machine. A controller is configured to automatically cause the switching network to connect the current source or sink to the electrostatic machine each half-cycle of a periodically alternating polarity. At each polarity alternation, the electrostatic machine is isolated from the current source or sink for a first period of time. At each polarity alternation, the inductor is connected to the electrostatic machine for a second period of time while the electrostatic machine is isolated from the current source or sink, and then disconnect the inductor from the electrostatic machine.

Abstract: According to various aspects, a sensor system is provided comprising a first substrate configured to be coupled to a user, an electric field detector to detect a user electric field and comprising a second substrate, a proof mass positioned above the second substrate, one or more electrodes coupled to the second substrate, and a control circuit coupled to the one or more electrodes, the control circuit being configured to determine a change in capacitance between the proof mass and each electrode responsive to torsional movement of the proof mass responsive to the electric field, and a controller coupled to the first substrate and being configured to receive, from the detector, information indicative of each change in capacitance between the proof mass and each electrode, and determine, based on the information, characteristics of the electric field in at least two dimensions.

Abstract: Methods for fabricating MEMS tuning fork gyroscope sensor system using silicon wafers. This provides the possibly to avoid glass. The sense plates can be formed in a device layer of a silicon on insulator (SOI) wafer or in a deposited polysilicon layer in a few examples.

Abstract: A multi-band/multi-polarization reflective or catadioptric optical system yields differing effective focal lengths (EFLs) per band/polarization. This approach could be used to create an imaging system, for example. In such case, a sensor (imager, spectrometer, diode, etc.) is located at the one or more focal planes. On the other hand, it could also be used to create a projecting system or hybrid projecting and imaging system by locating an emitter such as an LED, laser, etc.) at the image or focal plane. The system employs polarizers and/or dichroic coatings nano patterns to create different focal lengths and/or fields of view using the same mirrors and/or lenses by, for example, including at least one dichroic coating optically in front of at least one additional mirror to separately reflect the different bands or polarizations.

Abstract: A device can include a first compliant optrode. The first compliant optrode can be introduced into a tissue sample and can include a stack of flexible waveguide materials providing a first optical interface. The stack of flexible waveguide materials can have a thickness of less than about 100 microns. The first compliant optrode can be linear and can be configured to bend at a turn radius of less than about 300 microns.

Abstract: A LiDAR system includes an array of optical emitters, an objective lens optically coupling each optical emitter to a respective unique portion of a field of view, an optical switching network coupled between a laser and the array of optical emitters and a controller coupled to the optical switching network and configured to cause the optical switching network to route light from the laser to a sequence of the optical emitters according to a dynamically varying temporal pattern and to vary the temporal pattern based at least in part on distance to an object within the field of view. The LiDAR system scans different portions of the field of view differently, such as with different laser power levels, different revisit rates and/or different scan patterns, for example based on likelihood of detecting objects of interest in the various portions or based on likely relative importance of objects likely to be found in the various portions.

Abstract: An antenna system has a two-dimensional field of view, yet can be implemented on a surface, such as on electronic or photonic integrated circuits. The antenna system includes an array of antennas disposed in a predetermined non-linear pattern and a two-dimensional beamforming network (BFN). The antenna system can be steered/selectively beamformed in two dimensions through beam port selection. The beamforming network is disposed entirely on a single first surface. The beamforming network has a one-dimensional array-side interface disposed on the first surface and a one-dimensional beam-side interface disposed on the first surface. The antennas of the array of antennas are individually communicably coupled to the array-side interface. Segments of the beam-side interface map to respective pixels in the two-dimensional field of view.

Abstract: A parallelized chain-synthesizing technique includes capillary tubes, where each tube provides multiple locations or addresses where a specific arbitrary sequence for polymeric chains can be synthesized. An optical addressing system selectively delivers light to the locations to mediate or control reactions in the tubes.

Abstract: A system including at least one processor programmed to translate a policy into policy code, wherein: the policy is provided in a policy language; the policy code is in a programming language that is different from the policy language; and the policy includes a statement that maps an entity name to one or more metadata symbols to be associated with an entity in a target system against which the policy is to be enforced.

Abstract: Systems and apparatuses for blood oxygenation are disclosed. A system includes a first layer defining a plurality of banks of first channels each extending in a first direction. The plurality of banks of first channels are configured to receive blood via a trunk channel. The system includes a second layer defining a bank of second channels extending in a second direction. The bank of second channels are configured to receive oxygen. The first direction is different from the second direction. The system includes a membrane disposed between the first layer and the second layer and configured to cause the oxygen to permeate from the second layer to the first layer to oxygenate the blood.

Abstract: Described herein are biofilm bioreactors for synthesis at the interface between two liquids, and methods of using such bioreactors for the biotransformation of feedstocks into chemical products. Also contemplated is the extraction of such products.

Abstract: A LiDAR system includes a light source and an arrayed micro-optic configured to receive light from the light source so as to produce and project a two-dimensional array of light spots on a scene. The LiDAR system also includes receiver optics having an array of optical detection sites configured so as to be suitable for establishing a one-to-one correspondence between light spots in the two-dimensional array and optical detection sites in the receiver optics. The LiDAR system further includes a beamsplitter and a lens. The LiDAR system may also include a mask placed in the light path between the beamsplitter and the receiver optics. Alternatively, the LiDAR system may include a controller programmed to activate or deactivate each optical detection site.

Abstract: A LiDAR system includes a light source and an arrayed micro-optic configured to receive light from the light source so as to produce and project a two-dimensional array of light spots on a scene. The LiDAR system also includes receiver optics having an array of optical detection sites configured so as to be suitable for establishing a one-to-one correspondence between light spots in the two-dimensional array and optical detection sites in the receiver optics. The LiDAR system further includes a birefringent prism and a lens. The LiDAR system may also include a mask placed in the light path between the birefringent prism and the receiver optics. Alternatively, the LiDAR system may include a controller programmed to activate or deactivate each optical detection site.

Abstract: The present disclosure discusses a method of manufacturing an implantable neural electrode. The method includes cutting a metal layer to form a plurality of electrode sites, contact pads and metal traces connecting the electrode sites to the contact pads. A first silicone layer including a mesh is formed and coupled to the metal layer. A second silicone layer is formed and laminated to the first silicone layer coupled with the metal layer. Holes are formed in the first or second silicone layer exposing the contact pads and electrode sites. Wires are welded to the exposed contact pads and a third layer of silicone is overmolded over the contact pads and wires.

Abstract: A method of lidar imaging pulses a scene with laser pulse sequences from a laser light source. Reflected light from the scene is measured for each laser pulse to form a sequence of time resolved light signals. Adjoining time bins in the time resolved light signals are combined to form super time bins. A three dimensional image of the scene is created from distances determined based on maximum intensity super time bins. One or more objects are located within the image. For each object, the time resolved light signals are combined to form a single object time resolved light signal from which to determine distance to the object.

Abstract: Miniaturized DNA microarrays are described to be used in conjunction with microfluidic channels or microcentrifuge tubes and microcentrifuge filters to reduce sample size, incubation time and to increase overall binding efficiency.

Abstract: This disclosure describes microfluidic tissue biopsy and immune response drug evaluation devices and systems. A microfluidic device can include an inlet channel having a first end configured to receive a fluid sample optionally containing a tissue sample. The microfluidic device can also include a tissue trapping region at the second end of the inlet channel downstream from the first end. The tissue trapping region can include one or more tissue traps configured to catch a tissue sample flowing through the inlet channel such that the fluid sample contacts the tissue trap. The microfluidic device can also include one or more channels providing an outlet.

Abstract: A device, system and process involve conducting electroporation of microvesicles or exosomes or other target structures in a microfluidic arrangement at pressures that exceed atmospheric pressure. Single as well as multiple flow configurations can be employed. In some cases, the system and its operation are computer-controlled for partial or complete automation.

Abstract: A system and method of LIDAR imaging to overcome scattering effects pulses a scene with light pulse sequences from a light source. Reflected light from the scene is measured for each light pulse to form a sequence of time-resolved signals. Time-resolved contrast is calculated for each location in a scene. A three-dimensional map or image of the scene is created from the time-resolved contrasts. The three-dimensional map is then utilized to affect operation of a vehicle.