Patents Assigned to The Charles Stark Draper Laboratory
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Patent number: 11977613Abstract: A system including at least one processor programmed to translate a policy into policy code, wherein: the policy is provided in a policy language; the policy code is in a programming language that is different from the policy language; and the policy includes a statement that maps an entity name to one or more metadata symbols to be associated with an entity in a target system against which the policy is to be enforced.Type: GrantFiled: April 13, 2022Date of Patent: May 7, 2024Assignees: Dover Microsystems, Inc., The Charles Stark Draper Laboratory, Inc.Inventors: Eli Boling, Steven Milburn, Gregory T. Sullivan, Andrew Sutherland, Christopher J. Casinghino
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Publication number: 20240117286Abstract: Described herein are biofilm bioreactors for synthesis at the interface between two liquids, and methods of using such bioreactors for the biotransformation of feedstocks into chemical products. Also contemplated is the extraction of such products.Type: ApplicationFiled: October 17, 2023Publication date: April 11, 2024Applicants: US Department of the Navy, The Charles Stark Draper Laboratory, Inc.Inventors: Sarah Glaven, Elizabeth Onderko, Andrew Maygar, Matthew Yates
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Publication number: 20240115781Abstract: Systems and apparatuses for blood oxygenation are disclosed. A system includes a first layer defining a plurality of banks of first channels each extending in a first direction. The plurality of banks of first channels are configured to receive blood via a trunk channel. The system includes a second layer defining a bank of second channels extending in a second direction. The bank of second channels are configured to receive oxygen. The first direction is different from the second direction. The system includes a membrane disposed between the first layer and the second layer and configured to cause the oxygen to permeate from the second layer to the first layer to oxygenate the blood.Type: ApplicationFiled: October 3, 2023Publication date: April 11, 2024Applicant: The Charles Stark Draper Laboratory, Inc.Inventors: Brett Isenberg, Else Vedula, David Sutherland, Diana Lewis, Jose Santos, WeiXuan Lai, Ernie Kim, Beau Landis, Jeffrey Borenstein, Bryan Teece, Samuel Blumenstiel, Joseph Urban
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Patent number: 11953625Abstract: A LiDAR system includes a light source and an arrayed micro-optic configured to receive light from the light source so as to produce and project a two-dimensional array of light spots on a scene. The LiDAR system also includes receiver optics having an array of optical detection sites configured so as to be suitable for establishing a one-to-one correspondence between light spots in the two-dimensional array and optical detection sites in the receiver optics. The LiDAR system further includes a beamsplitter and a lens. The LiDAR system may also include a mask placed in the light path between the beamsplitter and the receiver optics. Alternatively, the LiDAR system may include a controller programmed to activate or deactivate each optical detection site.Type: GrantFiled: January 27, 2020Date of Patent: April 9, 2024Assignee: The Charles Stark Draper Laboratory, Inc.Inventors: Michael G. Moebius, Lucas D. Benney, Steven J. Spector, Steven J. Byrnes
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Patent number: 11947040Abstract: A LiDAR system includes a light source and an arrayed micro-optic configured to receive light from the light source so as to produce and project a two-dimensional array of light spots on a scene. The LiDAR system also includes receiver optics having an array of optical detection sites configured so as to be suitable for establishing a one-to-one correspondence between light spots in the two-dimensional array and optical detection sites in the receiver optics. The LiDAR system further includes a birefringent prism and a lens. The LiDAR system may also include a mask placed in the light path between the birefringent prism and the receiver optics. Alternatively, the LiDAR system may include a controller programmed to activate or deactivate each optical detection site.Type: GrantFiled: November 18, 2022Date of Patent: April 2, 2024Assignee: The Charles Stark Draper Laboratory, Inc.Inventors: Michael G. Moebius, Lucas D. Benney, Steven J. Spector, Steven J. Byrnes
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Patent number: 11938314Abstract: The present disclosure discusses a method of manufacturing an implantable neural electrode. The method includes cutting a metal layer to form a plurality of electrode sites, contact pads and metal traces connecting the electrode sites to the contact pads. A first silicone layer including a mesh is formed and coupled to the metal layer. A second silicone layer is formed and laminated to the first silicone layer coupled with the metal layer. Holes are formed in the first or second silicone layer exposing the contact pads and electrode sites. Wires are welded to the exposed contact pads and a third layer of silicone is overmolded over the contact pads and wires.Type: GrantFiled: July 6, 2020Date of Patent: March 26, 2024Assignee: The Charles Stark Draper Laboratory, Inc.Inventors: John Burns, IV, Julianne Grainger, Bryan McLaughlin, Tirunelveli S. Sriram, John Lachapelle
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Patent number: 11921238Abstract: A method of lidar imaging pulses a scene with laser pulse sequences from a laser light source. Reflected light from the scene is measured for each laser pulse to form a sequence of time resolved light signals. Adjoining time bins in the time resolved light signals are combined to form super time bins. A three dimensional image of the scene is created from distances determined based on maximum intensity super time bins. One or more objects are located within the image. For each object, the time resolved light signals are combined to form a single object time resolved light signal from which to determine distance to the object.Type: GrantFiled: May 17, 2019Date of Patent: March 5, 2024Assignee: THE CHARLES STARK DRAPER LABORATORY, INC.Inventors: Joseph Hollmann, Zachary R. Hoffman
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Patent number: 11890620Abstract: Miniaturized DNA microarrays are described to be used in conjunction with microfluidic channels or microcentrifuge tubes and microcentrifuge filters to reduce sample size, incubation time and to increase overall binding efficiency.Type: GrantFiled: October 12, 2018Date of Patent: February 6, 2024Assignee: The Charles Stark Draper Laboratory, Inc.Inventors: Kirsty A. McFarland, Charles A. Lissandrello, Andrew P. Magyar, Erin Rosenberger
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Publication number: 20240036031Abstract: This disclosure describes microfluidic tissue biopsy and immune response drug evaluation devices and systems. A microfluidic device can include an inlet channel having a first end configured to receive a fluid sample optionally containing a tissue sample. The microfluidic device can also include a tissue trapping region at the second end of the inlet channel downstream from the first end. The tissue trapping region can include one or more tissue traps configured to catch a tissue sample flowing through the inlet channel such that the fluid sample contacts the tissue trap. The microfluidic device can also include one or more channels providing an outlet.Type: ApplicationFiled: October 16, 2023Publication date: February 1, 2024Applicant: The Charles Stark Draper Laboratory, Inc.Inventors: Ashley Lynne Beckwith, Jeffrey Borenstein, Nathan Moore, Daniel Doty, Luis Velasquez-Garcia
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Patent number: 11878300Abstract: A device, system and process involve conducting electroporation of microvesicles or exosomes or other target structures in a microfluidic arrangement at pressures that exceed atmospheric pressure. Single as well as multiple flow configurations can be employed. In some cases, the system and its operation are computer-controlled for partial or complete automation.Type: GrantFiled: September 4, 2019Date of Patent: January 23, 2024Assignee: THE CHARLES STARK DRAPER LABORATORY, INC.Inventors: Jonathan R. Coppeta, Timothy J. Biliouris, Daniel F. King, Vishal Tandon
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Patent number: 11872702Abstract: Embodiments provide functionality to prevent collisions between robots and objects. An example embodiment detects a type and a location of an object based on a camera image of the object, where the image has a reference frame. Motion of the object is then predicted based on at least one of: the detected type of the object, the detected location of the object, and a model of object motion. To continue, a motion plan for the robot is generated that avoids having the robot collide with the object based on the predicted motion of the object and a transformation between the reference frame of the image and a reference frame of the robot. The robot can be controlled to move in accordance with the motion plan or a signal can be generated that controls the robot to operate in accordance with the motion plan.Type: GrantFiled: September 13, 2019Date of Patent: January 16, 2024Assignee: The Charles Stark Draper Laboratory, Inc.Inventors: David M. S. Johnson, Syler Wagner, Steven Lines, Mitchell Hebert, Connor Lawson
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Patent number: 11874379Abstract: A system and method of LIDAR imaging to overcome scattering effects pulses a scene with light pulse sequences from a light source. Reflected light from the scene is measured for each light pulse to form a sequence of time-resolved signals. Time-resolved contrast is calculated for each location in a scene. A three-dimensional map or image of the scene is created from the time-resolved contrasts. The three-dimensional map is then utilized to affect operation of a vehicle.Type: GrantFiled: October 25, 2022Date of Patent: January 16, 2024Assignee: The Charles Stark Draper Laboratory, Inc.Inventor: Joseph Hollmann
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Publication number: 20240002919Abstract: A removable cartridge to be used in a system for extracting and detecting nucleic acids from heterogeneous samples includes a plurality of reservoirs defining at least a first wash buffer reservoir for holding a first wash buffer and a microfluidic assembly configured to attach to the plurality of reservoirs. The microfluidic assembly includes at least one sample reservoir and a nucleic acid extraction matrix in fluid communication to an automated sample preparation (ASP) reservoir through a first flow channel defined by the microfluidic assembly. An assay chamber is in fluid communication with a third flow channel and with the waste reservoir through a fourth flow channel such that a labeled nucleic acid-containing sample flows through the assay chamber and then to the waste reservoir, wherein vibration-driven mixing agitates fluids while present in the assay chamber. Finally, a nucleic acid-detecting microarray module is positioned in the assay chamber.Type: ApplicationFiled: May 1, 2023Publication date: January 4, 2024Applicant: The Charles Stark Draper Laboratory, Inc.Inventors: Charles A. LISSANDRELLO, Aditi R. NAIK, Diana J. LEWIS, Erin ROSENBERGER, Joseph Neil URBAN, Jason FIERING, Caleb R. Bell, Cait Ni Chleirigh, Ernest Kim
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Patent number: 11859162Abstract: Transfer of genetic and other materials to cells is conducted in a hands-free, automated, high throughput, continuous process. A system using a microfluidic hydrodynamic sheath flow configuration includes arrangements for pushing cells from side streams containing a cell culture medium to a central stream containing an electroporation buffer. Electroporation can be conducted in an assembly in which two or more microfluidic channels are provided in a parallel configuration and in which various layers can be stacked together to form a laminate type structure.Type: GrantFiled: August 30, 2019Date of Patent: January 2, 2024Assignee: The Charles Stark Draper Laboratory, Inc.Inventors: Vishal Tandon, Charles A. Lissandrello, Jenna L. Balestrini, Jonathan R. Coppeta, Patricia A. Swierk
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Patent number: 11863086Abstract: An electrostatic motor includes a cylindrical rotor and a stator. Electrodes are disposed on an inside cylindrical surface of the stator. Electrets and/or electrically conductive electrodes are disposed on the cylindrical rotor and a dielectric fluid fills space between the rotor and the stator to prevent discharge of the electrets. A mask is used to charge portions of an electret cylinder or other curved surface.Type: GrantFiled: February 26, 2021Date of Patent: January 2, 2024Assignee: The Charles Stark Draper Laboratory, Inc.Inventors: Louis Beryl Kratchman, James A. Bickford
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Patent number: 11852626Abstract: This disclosure describes microfluidic tissue biopsy and immune response drug evaluation devices and systems. A microfluidic device can include an inlet channel having a first end configured to receive a fluid sample optionally containing a tissue sample. The microfluidic device can also include a tissue trapping region at the second end of the inlet channel downstream from the first end. The tissue trapping region can include one or more tissue traps configured to catch a tissue sample flowing through the inlet channel such that the fluid sample contacts the tissue trap. The microfluidic device can also include one or more channels providing an outlet.Type: GrantFiled: May 28, 2021Date of Patent: December 26, 2023Assignee: The Charles Stark Draper Laboratory, Inc.Inventors: Ashley Lynne Beckwith, Jeffrey Borenstein, Nathan Moore, Daniel Doty, Luis Velasquez-Garcia
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Patent number: 11835513Abstract: A method for separating particles in a biofluid includes pretreating the biofluid by introducing an additive, flowing the pretreated biofluid through a microfluidic separation channel, and applying acoustic energy to the microfluidic separation channel. A system for microfluidic separation, capable of separating target particles from non-target particles in a biofluid includes at least one microfluidic separation channel, a source of biofluid, a source of additive, and at least one acoustic transducer coupled to the microfluidic separation channel. A kit for microfluidic particle separation includes a microfluidic separation channel connected to an acoustic transducer, a source of an additive, and instructions for use.Type: GrantFiled: February 9, 2021Date of Patent: December 5, 2023Assignee: The Charles Stark Draper Laboratory, Inc.Inventors: Jason O. Fiering, Kenneth T. Kotz
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Publication number: 20230383286Abstract: The present disclosure provides methods of generating recombinant bacteriophage genomes. Specifically, the present technology provides methods of integrating a heterologous nucleic acid sequence into a linear bacteriophage DNA genome, and isolating recombinant bacteriophages that express the heterologous nucleic acid sequence.Type: ApplicationFiled: November 14, 2022Publication date: November 30, 2023Applicant: The Charles Stark Draper Laboratory, Inc.Inventors: Connor McBrine, Jason Holder
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Patent number: 11815668Abstract: A method of fabricating a visible spectrum optical component includes: providing a substrate; forming a resist layer over a surface of the substrate; patterning the resist layer to form a patterned resist layer defining openings exposing portions of the surface of the substrate; performing deposition to form a dielectric film over the patterned resist layer and over the exposed portions of the surface of the substrate, wherein a top surface of the dielectric film is above a top surface of the patterned resist layer; removing a top portion of the dielectric film to expose the top surface of the patterned resist layer and top surfaces of dielectric units within the openings of the patterned resist layer; and removing the patterned resist layer to retain the dielectric units over the substrate.Type: GrantFiled: May 25, 2022Date of Patent: November 14, 2023Assignees: PRESIDENT AND FELLOWS OF HARVARD COLLEGE, THE CHARLES STARK DRAPER LABORATORY, INC.Inventors: Robert C. Devlin, Mohammadreza Khorasaninejad, Federico Capasso, Hongkun Park, Alexander Arthur High
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Patent number: 11802306Abstract: Methods of detecting unknown genetic modifications in a DNA sample from an organism are disclosed.Type: GrantFiled: October 12, 2018Date of Patent: October 31, 2023Assignee: The Charles Stark Draper Laboratory, Inc.Inventors: Kirsty A. McFarland, Andrew P. Magyar, Ting Pang, Michael Springer