Patents Assigned to The Chemo-Sero-Therapeutic Research Institute
-
Publication number: 20170044217Abstract: The present invention is intended to provide an egg drop syndrome (EDS) vaccine that is capable of effectively preventing EDS and can be stably supplied. The EDS vaccine provided to this end contains as an active ingredient fused protein in which a polypeptide having a coiled-coil forming unit is bound to the knob region in the fiber protein of EDS virus (EDSV).Type: ApplicationFiled: March 16, 2015Publication date: February 16, 2017Applicants: The Chemo-Sero-Therapeutic Research Institute, Jectas Innovators Company LimitedInventors: Kenichi YAMAZAKI, Kiyohiko ANDOH, Ryuichi SAKAMOTO, Kiyotaka SUENAGA, Takeshi ARAKAWA, Hirotaka UEFUJI, Tetsuya HARAKUNI, Takeshi MIYATA
-
Publication number: 20160347832Abstract: A humanized antibody which comprises a complementarity determining region of an H chain consisting of the amino acid sequence as shown in SEQ ID NOs: 1 to 3 and a complementarity determining region of an L chain consisting of the amino acid sequence as shown in SEQ ID NOs: 4 to 6. The humanized antibody of the present invention has the activity to specifically bind to transthyretin (TTR) with structural change and the activity to inhibit fibrillization of TTR and is a humanized antibody suitable for application to human body.Type: ApplicationFiled: January 23, 2015Publication date: December 1, 2016Applicants: THE CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTE, NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSIT YInventors: Akihiko HOSOI, Masaharu TORIKAI, Tomoyo TAKEO, Masayo UENO, Hirofumi HIGUCHI, Kenji SOEJIMA, Toshihiro NAKASHIMA, Yukio ANDO, Hirofumi JONO, Yu SU
-
Publication number: 20160340419Abstract: A human antibody which comprises a complementarity determining region of an H chain consisting of the amino acid sequence as shown in SEQ ID NOs: 1 to 3 and a complementarity determining region of an L chain consisting of the amino acid sequence as shown in SEQ ID NOs: 4 to 6. The human antibody of the present invention has the activity to specifically bind to transthyretin (TTR) with structural change and the activity to inhibit fibrillization of TTR and is a human antibody suitable for application to human body.Type: ApplicationFiled: January 23, 2015Publication date: November 24, 2016Applicant: THE CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTEInventors: Masaharu TORIKAI, Akihiko HOSOI, Tomoyo TAKEO, Masayo UENO, Kenji SOEJIMA, Toshihiro NAKASHIMA, Yukio ANDO, Hirofumi JONO, Yu SU, Mineyuki MIZUGUCHI
-
Publication number: 20160281066Abstract: This invention provides a vaccinia virus that grows specifically in a cancer cell and damages such cancer cell and the use of such virus for treatment of cancer. Such mitogen-activated protein kinase-dependent vaccinia virus strain lacks functions of vaccinia virus growth factor (VGF) and O1L, it does not grow in normal cells but grows specifically in cancer cells, and it has oncolytic properties that specifically damage cancer cells.Type: ApplicationFiled: November 20, 2014Publication date: September 29, 2016Applicants: National University Corporation Tottori University, The Chemo-Sero-Therapeutic Research InstituteInventor: Takafumi Nakamura
-
Publication number: 20160228526Abstract: A vaccine composition for birds comprising as an active ingredient a structure containing O-antigen derived from Gram-negative bacteria, provided that said structure does not contain a whole cell, and a process for preparing the same are provided. By using a structure containing O-antigen (e.g. lipopolysaccharide) derived from Gram-negative bacteria as an active ingredient in accordance with the present invention, alleviation of inoculation reaction and reduction in an amount of injection are attained as compared to the conventional whole-cells vaccine to thereby allow for the increase in the number of other antigens to be mixed therewith.Type: ApplicationFiled: April 14, 2016Publication date: August 11, 2016Applicant: THE CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTEInventors: Ryuichi SAKAMOTO, Masashi SAKAGUCHI
-
Patent number: 9345756Abstract: A vaccine composition for birds comprising as an active ingredient a structure containing O-antigen derived from Gram-negative bacteria, provided that said structure does not contain a whole cell, and a process for preparing the same are provided. By using a structure containing O-antigen (e.g. lipopolysaccharide) derived from Gram-negative bacteria as an active ingredient in accordance with the present invention, alleviation of inoculation reaction and reduction in an amount of injection are attained as compared to the conventional whole-cells vaccine to thereby allow for the increase in the number of other antigens to be mixed therewith.Type: GrantFiled: February 19, 2013Date of Patent: May 24, 2016Assignee: THE CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTEInventors: Ryuichi Sakamoto, Masashi Sakaguchi
-
Patent number: 9278133Abstract: A novel type A botulinum toxin preparation is provided. A neuromuscular transmission blocking agent comprising as an active ingredient a highly purified type A botulinum toxin from Clostridium botulinum as infant botulism pathogen and a medicament for treating a disease with a muscle overactivity comprising as an active ingredient said toxin. In particular, the medicament of the present invention, as compared to the conventional known botulinum toxin preparations, has rapid efficacy of potential and is less diffusive and thus, having a broader safety margin, may be used as therapeutic medicament for decreasing local, muscle overactivity in a disease with a muscle overactivity.Type: GrantFiled: October 26, 2007Date of Patent: March 8, 2016Assignees: THE CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTE, TOKUSHIMA UNIVERSITYInventors: Tetsuhiro Harakawa, Hirotoshi Nakano, Yasushi Torii, Yoshitaka Goto, Miho Shinmura, Sachio Okuda, Ryuji Kaji, Shunji Kosaki
-
Publication number: 20160051731Abstract: A hybrid gel comprising a particulate decellularized tissue (obtained by pulverizing animal-derived biological tissues that are decellularized (decellularized biological tissues)), fibrinogen and thrombin; a cell culture material comprising the hybrid gel; a method for preparing the hybrid gel; and a kit comprising a particulate decellularized tissue and a biological tissue adhesive are provided. The hybrid gel of the present invention exerts the effect to promote differentiation and gain of function of stem cells and the therapeutic effect to a variety of diseases.Type: ApplicationFiled: May 2, 2014Publication date: February 25, 2016Applicants: THE CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTE, NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY, SAPPORO MEDICAL UNIVERSITY, ADEKA CORPORATIONInventors: Junichi MATSUDA, Sumika MIYABASHIRA, Satomi HARANO, Akio KISHIDA, Tsuyoshi KIMURA, Jun NEGISHI, Tetsuya HIGAMI, Seiichi FUNAMOTO, Ken-ichiro HIWATARI, Akiko TASAKI
-
Publication number: 20150361142Abstract: A purpose is to provide a vaccine which can prevent porcine edema disease in farms where porcine edema disease is anticipated. Meeting this purpose is a vaccine that is a fusion protein in which Stx2eB and a polypeptide having a coiled-coil forming unit are joined or a multimer of the fusion protein, and by immunizing pigs with this vaccine, it is possible to induce potent neutralizing antibodies and to defend against the onset of porcine edema disease.Type: ApplicationFiled: October 18, 2013Publication date: December 17, 2015Applicants: The-Chemo-Sero-Therapeutic Research Institute, Jectas Innovators Company LimitedInventors: Kenji YOKOGAWA, Takashi WAKI, Yoko HONDA, Hirotaka UEFUJI, Tomomitsu SEWAKI, Takeshi ARAKAWA, Tetsuya HARAKUNI, Takeshi MIYATA
-
Publication number: 20150344529Abstract: A chimeric protein of HPV-L2 peptide and HBs protein wherein the HPV-L2 peptide is (1) a peptide consisting of the core sequence region of 20 amino acid residues, (2) a peptide inside the core sequence region comprising 6 amino acid residues Gly-Gly-Leu-Gly-Ile-Gly or (3) a peptide consisting of 70 or less amino acid residues obtained by adding an amino acid sequence derived from HPV L2 protein at the N-terminal and/or the C-terminal of the core sequence region; and a vaccine for HPV infection and/or hepatitis B comprising the chimeric protein as an active ingredient. A vaccine comprising the chimeric protein of the present invention is the one that has an increased expression level in a host, an enhanced immune ability (early antibody induction) and a broader spectrum effective for a number of HPV types.Type: ApplicationFiled: November 28, 2013Publication date: December 3, 2015Applicants: THE CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTE, JAPAN AS REPRESENTED BY DIRECTOR GENERAL OF NATIONAL INSTITUTE OF INFECTIOUS DISEASESInventors: Hiroshi YONEMURA, Masashi SAKAGUCHI, Takashi IMAMURA, Seiichiro MORI, Tadahito KANDA
-
Publication number: 20150313731Abstract: An artificial blood vessel that can be transplanted to blood vessels with a small diameter, can be adjusted to an arbitrary size of a diameter, improves in invasiveness when a graft is taken, and overcomes the problem on the provision of a graft is provided. An artificial blood vessel prepared from a decellularized tubular structure, which is prepared by processing a decellularized, sheet-like blood vessel (decellularized blood vessel sheet) into a roll structure, and a tissue adhesive, wherein a portion which is contacted with blood that flows within the artificial blood vessel consists of the tissue of the tunica intima lined with the tissue of the tunica media whereas a portion of the sheet that overlaps when the sheet is processed into a roll structure (overlap width) consists of the tissue of the tunica media and wherein a tissue adhesive is applied to the overlap width.Type: ApplicationFiled: December 17, 2013Publication date: November 5, 2015Applicant: THE CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTEInventors: Noriko SHINYA, Takanori UCHIDA, Akio KISHIDA, Tetsuya Higami
-
Patent number: 9175295Abstract: A modified transposon vector and a method for introducing a foreign gene into a cell are provided.Type: GrantFiled: July 4, 2006Date of Patent: November 3, 2015Assignee: THE CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTEInventors: Kazuyoshi Kaminaka, Hiroaki Maeda, Masaki Hirashima, Ryoichi Kawamura, Junichi Matsuda, Takashi Kuwana
-
Patent number: 9149557Abstract: A process for preparing a bioabsorbable sheet preparation holding thrombin is provided. A process for preparing a bioabsorbable sheet preparation holding thrombin which comprises immersing a bioabsorbable sheet consisting of polyglycolic acid in a thrombin solution containing thrombin as an active ingredient, glycerol as a softening agent, Tween 80 as a permeating agent, and optionally histidine and trehalose as a stabilizing agent followed by drying to hold thrombin on said bioabsorbable sheet, and a bioabsorbable sheet preparation holding thrombin prepared by said process.Type: GrantFiled: April 15, 2009Date of Patent: October 6, 2015Assignee: THE CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTEInventors: Ryoichi Kawamura, Takayuki Imamura, Hitomi Owaki
-
Patent number: 9114098Abstract: A method for using inactivated Japanese encephalitis virus particles as an adjuvant of a vaccine is provided. A method for using inactivated Japanese encephalitis virus (JEV) particles as an adjuvant of various vaccines or a mixed vaccine, said JEV particles being obtained by inoculating JEV Beijing-1 strain to Vero cells, culturing said JEV-infected cells to give cultured cells or culture supernatant, purifying JEV particles from said cultured cells or culture supernatant and inactivating said JEV particles with formalin, a method for preparing a (mixed) vaccine which comprises a step of letting inactivated Japanese encephalitis virus be contained, and a mixed vaccine prepared by said method.Type: GrantFiled: May 27, 2009Date of Patent: August 25, 2015Assignee: THE CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTEInventors: Makoto Moriyama, Kazuyoshi Kaminaka, Junichi Matsuda, Chikateru Nozaki
-
Patent number: 9109217Abstract: An enhanced disintegrin-like domain, and metalloprotease, with an isolated human thrombospondin type 1 motif, member 13 (ADAMTS-13) that includes substitutions at one or more positions in the isolated human ADAMTS-13.Type: GrantFiled: October 30, 2014Date of Patent: August 18, 2015Assignee: THE CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTEInventor: Kenji Soejima
-
Publication number: 20150151020Abstract: A formed sheet product of a polymer composition comprising at least one protein selected from the group consisting of fibrinogen and thrombin and at least one polymer selected from the group consisting of an aliphatic polyester and a water-soluble polymer, and a laminated formed sheet product comprising a first polymer composition layer composed of fibrinogen and a water-soluble polymer and a second polymer composition layer composed of thrombin and an aliphatic polyester are provided. These formed products are applied onto a wound site and function as a hemostatic material.Type: ApplicationFiled: May 13, 2013Publication date: June 4, 2015Applicants: TEIJIN LIMITED, TEIJIN PHARMA LIMITED, THE CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTEInventors: Yukako Kageyama, Kentaro Fujinaga, Ayuko Yamaguchi, Yusuke Akiyama, Akitoshi Oono, Susumu Honda, Makoto Satake, Hiroaki Kaneko, Takayuki Imamura, Ryoichi Kawamura, Masaki Hirashima
-
Publication number: 20150132279Abstract: A protein composition which comprises a mixture of glycine, phenylalanine and histidine and/or a cellulose ether derivative as an additive and has resistance to radiation sterilization.Type: ApplicationFiled: May 13, 2013Publication date: May 14, 2015Applicants: TEIJIN LIMITED, THE CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTE, TEIJIN PHARMA LIMITEDInventors: Yukako Kageyama, Kentaro Fujinaga, Ayuko Yamaguchi, Yusuke Akiyama, Souichirou Katou, Yukiko Kimura, Susumu Honda, Makoto Satake, Hiroaki Kaneko, Ayumi Ishiwari, Masaki Hirashima
-
Patent number: 9028463Abstract: The present invention provides a method for enhancing the immunogenicity using a microneedle device capable of enhancing the immunogenicity of an influenza vaccine. According to the method for enhancing the immunogenicity using the present microneedle device, a microneedle device having microneedles made of polylactic acid, coated with an influenza vaccine composed of an antigen having type A strain (H1N1), type A strain (H3N2), and type B strain as active ingredients is brought into direct contact with the skin so as to transcutaneously administer the aforementioned influenza vaccine. After the transcutaneous administration, lauryl alcohol is applied to the site of the skin where the microneedle device has been brought into direct contact.Type: GrantFiled: May 22, 2009Date of Patent: May 12, 2015Assignees: Hisamitsu Pharmaceutical Co., Inc., The Chemo-Sero-Therapeutic Research InstituteInventors: Chikateru Nozaki, Kazuyoshi Kaminaka, Junichi Matsuda, Takaaki Terahara, Tetsuji Kuwahara, Seiji Tokumoto
-
Publication number: 20150125511Abstract: A sterile composition which comprises a protein and an aliphatic polyester containing the protein and is sterilized with radiation. In this sterile composition, the structure and function (activity) of the protein are retained.Type: ApplicationFiled: May 13, 2013Publication date: May 7, 2015Applicants: TEIJIN LIMITED, Teijin Pharma Limited, THE CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTEInventors: Yukako Kageyama, Kentaro Fujinaga, Ayuko Yamaguchi, Susumu Honda, Makoto Satake, Hiroaki Kaneko, Ayumi Ishiwari
-
Patent number: 9000136Abstract: Provided is a recombinant virus which is efficacious in preventing the onset of hepatitis C infection and has a high safety. Also provided is a vaccine for hepatitis C virus which contains the recombinant virus. A recombinant vaccinia virus which can express hepatitis C virus gene. The hepatitis C virus vaccine as described above contains the recombinant virus as described above.Type: GrantFiled: March 6, 2009Date of Patent: April 7, 2015Assignees: Tokyo Metropolitan Institute of Medical Science, The Chemo-Sero-Therapeutic Research InstituteInventors: Michinori Kohara, Fukashi Murai