Patents Assigned to THE CHILDEN'S HOSPITAL OF PHILADELPHIA
  • AAV vector compositions and methods for gene transfer to cells, organs and tissues
    Patent number: 11939590
    Abstract: The invention relates to adeno-associated virus (AAV) serotype AAV-Rh74 and related AAV vectors, and AAV-Rh74 and related AAV vector mediated gene transfer methods and uses. In particular, AAV-Rh74 targets polynucleotides to cells, tissues or organs for expression (transcription) of genes encoding therapeutic proteins and peptides, and polynucleotides that function as or are transcribed into inhibitory nucleic acid sequences.
    Type: Grant
    Filed: July 25, 2018
    Date of Patent: March 26, 2024
    Assignee: THE CHILDEN'S HOSPITAL OF PHILADELPHIA
    Inventors: Katherine A. High, Federico Mingozzi, Junwei Sun, Philip Johnson