Abstract: This invention relates to methods of treating and ameliorating congenital and neonatal hyperinsulinism and post-prandial hypoglycemia, comprising the step of administering an antagonist of the Glucagon-Like Peptide-1 (GLP-1) receptor, e.g. a GLP-1 fragment or analogue thereof.
Type:
Application
Filed:
February 14, 2023
Publication date:
March 14, 2024
Applicants:
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, The Children's Hospital of Philadelphia
Inventors:
Doris STOFFERS, Diva D. DE LEON, Charles STANLEY
Abstract: A nucleic acid sequence encoding a variant CYP3A4 gene is provided. Also provided are methods and kits for identifying individuals carrying a variant CYP3A4 gene with a heightened risk of developing or having prostate cancer or a decreased risk for developing treatment-related leukemias and identifying more effective and safer treatment regimes for individuals based upon their CYP3A4 genotype.
Type:
Grant
Filed:
August 11, 1999
Date of Patent:
January 16, 2001
Assignees:
Trustees of the University of Pennsylvania, Childrens Hospital of Pennsylvania
Abstract: A composition comprising a magainin peptide or an analogue or derivative thereof, and at least one member selected from the group consisting of a PGLa peptide or analogue or derivative thereof, and an XPF peptide or analogue or derivative thereof. The composition is employed as a pharmaceutical.
Abstract: A composition comprising at least one biologically active amphiphilic peptide, said peptide being an ion channel-forming peptide, and an antibiotic selected from the class consiting of bacitracins, aminoglycosides, penicillins, monobactams, hydrophobic antibiotics, 50-S ribosome inhibitors, antibiotics having a large lipid like lactone ring, and derivatives or analogues thereof. The biologically active amphiphilic peptide and the antibiotic may be administered in amounts effective to inhibit growth of a target cell. The biologically active amphiphilic peptide and antibiotic may potentiate each other.
Abstract: An aminosterol antibiotic, (3.beta.(N-[3-aminopropyl]-1,4-butanediamine)-7.alpha.,24.zeta.-dihydroxy- 5.alpha.-cholestane 24-sulfate), which can be isolated from the stomach of the common dogfish shark, Squalus acanthias, is disclosed.
Type:
Grant
Filed:
March 18, 1992
Date of Patent:
March 9, 1993
Assignee:
The Children's Hospital of Pennsylvania
Inventors:
Michael Zasloff, Karen Moore, Suzanne Wehrli