Patents Assigned to The Cleveland Clinic Foundation and National Institutes of Health
  • Method of cleaving specific strands of RNA
    Patent number: 5583032
    Abstract: A method of using a chimeric molecule made up of an antisense oligonucleotide attached to a 2',5'-oligoadenylate molecule to specifically cleave a sense strand of RNA, wherein the antisense oligonucleotide of the chimeric molecule is hybridized to the sense strand of RNA in the presence of 2',5'-dependent RNase.
    Type: Grant
    Filed: September 17, 1993
    Date of Patent: December 10, 1996
    Assignee: The Cleveland Clinic Foundation and National Institutes of Health
    Inventors: Paul Torrence, Robert Silverman, Ratan Maitra, Krystyna Lesiak