Abstract: The present invention relates to the preparation and use of liquid formulations of plasma proteins, particularly blood coagulation factors. More specifically, the present invention relates to stable liquid formulations of Factor VIII and Factor IX that can be administered by injection or infusion to provide a constant level of the coagulation factor in the blood.
Type:
Grant
Filed:
June 8, 1999
Date of Patent:
November 20, 2001
Assignees:
The American National Red Cross, Coalition for Hemophilia B, Inc.
Inventors:
Shirley I. Miekka, William N. Drohan, Thomas R. Jameson, John R. Taylor, Jr., Manish S. Singh
Abstract: This invention is directed to the preparation and utilization of supplemented chitin hydrogels, such as chitosan hydrogels. Further provided are biomaterials comprising same. The particular supplement delivered by the chitin hydrogel is selected as a function of its intended use. In one embodiment, this invention provides a composition of matter, comprising a chitin hydrogel or chitin-derived hydrogel, wherein the hydrogel does not inhibit full-thickness skin wound healing.
Type:
Grant
Filed:
October 13, 1997
Date of Patent:
September 26, 2000
Assignees:
Chitogenics, Inc., The American National Red Cross, Coalition for Hemophilia B
Inventors:
William N. Drohan, Martin J. MacPhee, Shirley I. Miekka, Manish S. Singh, Clive Elson, John R. Taylor, Jr.
Abstract: The present invention relates to the preparation and use of liquid formulations of plasma proteins, particularly blood coagulation factors. More specifically, the present invention relates to stable liquid formulations of Factor VIII and Factor IX that can be administered by injection or infusion to provide a constant level of the coagulation factor in the blood.
Type:
Grant
Filed:
November 29, 1996
Date of Patent:
July 20, 1999
Assignees:
The American National Red Cross, The Coalition for Hemophilia B
Inventors:
Shirley I. Miekka, William N. Drohan, Thomas R. Jameson, Manish P. Singh, John R. Taylor, Jr., Martin J. MacPhee
Abstract: The present invention relates to the preparation and use of liquid formulations of plasma proteins, particularly blood coagulation factors. More specifically, the present invention relates to stable liquid formulations of Factor VIII and Factor IX that can be administered by injection or infusion to provide a constant level of the coagulation factor in the blood.
Type:
Grant
Filed:
August 26, 2002
Date of Patent:
February 17, 2004
Assignees:
The American National Red Cross, The Coalition for Hemophilia B
Inventors:
Shirley I. Miekka, William N. Drohan, Thomas R. Jameson, John R. Taylor, Jr., Manish P. Singh, Martin J. MacPhee