Abstract: Methods and compositions related to molecules and formulations comprising antibiofilm materials are provide, including new formulations of Deep Eutectic Solvents (DES) that are chemically related to choline geranate. Specifically, geranic acid (a component of choline geranate DES) is a molecule from the isoprenoid/terpene family of compounds. Other members of this family as DES components include isoprenoid acids and chemical derivatives thereof.
Type:
Grant
Filed:
May 31, 2018
Date of Patent:
January 4, 2022
Assignees:
ARIZONA BOARD OF REGENTS ON BEHALF OF NORTHERN ARIZONA UNIVERSITY, TRIAD NATIONAL SECURITY, LLC, DIXIE STATE UNIVERSITY, THE COLLEGE OF NEW JERSEY
Inventors:
Andrew T. Koppisch, Gerrick E. Lindberg, David T. Fox, Joseph Baker, Alexanndra J. Heyert, Rico Del Sesto, Joshua R. Greene
Abstract: A protein-lipid vesicle that can be used to make an autogenous vaccine comprises patient-specific antigen, adjuvant or immunomodulator, and lipid carrier. In addition, a negatively charged lipid component is desirably included. The autogenous vaccine is useful to treat individuals with chronic diseases, including chronic infectious diseases and neoplasias. The chronic infectious diseases that can be treated include disease caused by infection with human immunodeficiency viruses.
Type:
Grant
Filed:
November 9, 1998
Date of Patent:
December 26, 2000
Assignees:
Albany Medical College, Medical College of New Jersey
Inventors:
James M. Oleske, Thomas N. Denny, Anthony J. Scolpino, Eleonora Feketeova, Susan Gould-Fogerite, Raphael J. Mannino