Abstract: The system and method described provides for the non-invasive detection and quantification of systolic and diastolic heart failure, including subclinical, not-yet symptomatic systolic and diastolic heart failure.

Abstract: A system and method for non-invasively monitoring the hemodynamic state of a patient by determining on a beat-by-beat basis the ratio of lusitropic function to inotropic function as an index of myocardial well-being or pathology for use by clinicians in the hospital or by the patient at home. In one embodiment of the system a smartphone running an application program that is connected through the internet to the cloud processes electronic signals, first, from an electrocardiogram device monitoring electrical cardiac activity, and second, from a seismocardiogram device monitoring mechanical cardiac activity in order to determine such ratio as an instantaneous measurement of the hemodynamic state of the patient, including such states as sepsis, myocardial ischemia, and heart failure.

Abstract: A body cavity irrigation and drainage system including a catheter apparatus that has a proximal end, a distal end, a longitudinal axis, a first flow channel extending from the proximal end to the distal end, and a second flow channel extending from the proximal end to the distal end and being fluidly isolated from the first flow channel. The catheter apparatus may alterable between: (1) a first state in which the first and second flow channels are linear and parallel to the longitudinal axis along an entire length of the first and second flow channels; and (2) a second state in which a distal portion of the first flow channel curls away from the longitudinal axis in a first direction and a distal portion of the second flow channel curls away from the longitudinal axis in a second direction that is different from the first direction.

Abstract: A body cavity irrigation and drainage system and a related method. The body cavity irrigation and drainage system may include two pigtail catheters that are coupled together so that when in a use state the tail portions of the two pigtail catheters curl in opposite directions. The two pigtail catheters may be coupled together so that they are maintained in a fixed relative orientation. The system may also include a sheath having a cavity within which both of the two pigtail catheters are positioned during an insertion process. The sheath may be a peel-away type sheath such that the sheath can be torn and removed from the body cavity while the two pigtail catheters remain in the body cavity.

Abstract: A system and method for non-invasively monitoring the hemodynamic state of a patient by determining on a beat-by-beat basis the ratio of lusitropic function to inotropic function as an index of myocardial well-being or pathology for use by clinicians in the hospital or by the patient at home. In one embodiment of the system a smartphone running an application program that is connected through the internet to the cloud processes electronic signals, first, from an electrocardiogram device monitoring electrical cardiac activity, and second, from a seismocardiogram device monitoring mechanical cardiac activity in order to determine such ratio as an instantaneous measurement of the hemodynamic state of the patient, including such states as sepsis, myocardial ischemia, and heart failure.

Abstract: A system and method for non-invasively monitoring the hemodynamic state of a patient by determining on a beat-by-beat basis the ratio of lusitropic function to inotropic function as an index of myocardial well-being or pathology for use by clinicians in the hospital or by the patient at home. In one embodiment of the system a smartphone running an application program that is connected through the internet to the cloud processes electronic signals, first, from an electrocardiogram device monitoring electrical cardiac activity, and second, from a seismocardiogram device monitoring mechanical cardiac activity in order to determine such ratio as an instantaneous measurement of the hemodynamic state of the patient, including such states as sepsis, myocardial ischemia, and heart failure.

Abstract: A system and method for non-invasively monitoring the hemodynamic state of a patient by determining on a beat-by-beat basis the ratio of lusitropic function to inotropic function as an index of myocardial well-being or pathology for use by clinicians in the hospital or by the patient at home. In one embodiment of the system a smartphone running an application program that is connected through the internet to the cloud processes electronic signals, first, from an electrocardiogram device monitoring electrical cardiac activity, and second, from a seismocardiogram device monitoring mechanical cardiac activity in order to determine such ratio as an instantaneous measurement of the hemodynamic state of the patient, including such states as sepsis, myocardial ischemia, and heart failure.

Abstract: The disclosure provides pharmaceutical preparations containing (2R,6R)-hydroxynorketamine, or (R)- or (S)-dehydronorketamine, or other stereoisomeric dehydro or hydroxylated ketamine metabolite. (2R,6R)-hydroxynorketamine The disclosure also provides novel ketamine metabolite prodrugs. The disclosure provides methods of treating, bipolar depression, major depressive disorder, neuropathic and chronic pain, including complex regional pain synthetic pain disorder (CRPD) by administering a purified ketamine metabolite or a ketamine metabolite prodrug directly to patients in need of such treatment.

Abstract: The disclosure provides pharmaceutical preparations containing (2R,6R)-hydroxynorketamine, or (R)- or (S)-dehydronorketamine, or other stereoisomeric dehydro or hydroxylated ketamine metabolite. (2R,6R)-hydroxynorketamine The disclosure also provides novel ketamine metabolite prodrugs. The disclosure provides methods of treating, bipolar depression, major depressive disorder, neuropathic and chronic pain, including complex regional pain disorder (CRPS) by administering a purified ketamine metabolite or a ketamine metabolite prodrug directly to patients in need of such treatment.

Abstract: A system and method for endotracheal intubation of airways are disclosed. A malleable stylet having a distal end and a proximal end, a charged coupled device (CCD) at the distal end and a transmitter, at or near the proximal end or connected to the proximal end of the stylet with connectors, transmits video to a visualization device comprising a receiver means, a display means, and a display support adapted to be worn on an operator in a position so that the operator can view the display with one eye while simultaneously viewing the airway directly. The display support is typically worn on the head of a physician. A second display can be worn by a student or observer. In some instances, the transmitter means and receiver means are wireless.

Abstract: A system and method for regional anesthesia using ultrasound to assist in locating the anesthetic needle are disclosed. One or more piezo-electric crystal transducers is placed either at the tip of the needle or near the tip of the needle on a stylet which is inserted into the lumen of the needle. The transducer(s) are pulsed with ultrasonic frequency, the reflected ultrasonic signals from structures are detected and converted into a digital signal and may be displayed in an oscilloscopic format to indicate anatomical structures forward to the needle and allow the medical professional to avoid errors and/or increase efficiency and accuracy. An array of transducers can be pulsed in a phased array fashion to generate a 2D image, or a single transducer can be pulsed to generate a 1D image. A 2D image can also be obtained by mechanically sweeping a single transducer, for example by means of a miniature motor in or at the base of a needle or stylet.

Abstract: A system and method for regional anesthesia using ultrasound to assist in locating the anesthetic needle are disclosed. One or more piezo-electric crystal transducers is placed either at the tip of the needle or near the tip of the needle on a stylet which is inserted into the lumen of the needle. The transducer(s) are pulsed with ultrasonic frequency, the reflected ultrasonic signals from structures are detected and converted into a digital signal and may be displayed in an oscilloscopic format to indicate anatomical structures forward to the needle and allow the medical professional to avoid errors and/or increase efficiency and accuracy. An array of transducers can be pulsed in a phased array fashion to generate a 2D image, or a single transducer can be pulsed to generate a 1D image.

Abstract: A wearable blood chemistry monitoring device is disclosed which comprises a wearable automated blood chemistry monitoring device comprising (A) a mini pump which can be, for example a peristaltic pump or syringe pump; (B) a portable form factor mechanical apparatus which preferably includes a rotatable disc with a hole which fits over the pump; (C) at least one measurement element for measuring at least one blood parameter, preferably on the disc, and preferably a series of glucose strips arranged radially in a spoke-like pattern on the disc; (D) a catheter connected to the pump via a tube; (E) a computerized device adapted to automatically measure blood analytes and blood parameters; (F) a belt adapted to hold the housing, a waste bag, and a flush solution bag; wherein the pump and disk are arranged in the housing so that a hole in a disk fits over the pump.

Abstract: A method and system for determining a hyper or hypoglycemic state in a diabetic patient using acetone concentration in exhaled breath by means of a nasal device containing an acetone sensor. When a hyper or hypoglycemic state is detected, an alarm is issued. The alarm can be audible and/or can be sent wirelessly to a local or remote computer system.

Abstract: Compositions and methods for improving recovery following general anesthesia are provided. The composition comprises an effective dose of modafinil. Modafinil has been shown to reduce the symptoms associated with post-operative general anesthesia, improving the recovery form anesthesia.

Abstract: A system and method for regional anesthesia using ultrasound to assist in locating the anesthetic needle are disclosed. One or more piezo-electric crystal transducers is placed either at the tip of the needle or near the tip of the needle on a stylet which is inserted into the lumen of the needle. The transducer(s) are pulsed with ultrasonic frequency, the reflected ultrasonic signals from structures are detected and converted into a digital signal and may be displayed in an oscilloscopic format to indicate anatomical structures forward to the needle and allow the medical professional to avoid errors and/or increase efficiency and accuracy. An array of transducers can be pulsed in a phased array fashion to generate a 2D image, or a single transducer can be pulsed to generate a 1D image. A 2D image can also be obtained by mechanically sweeping a single transducer, for example by means of a miniature motor in or at the base of a needle or stylet.