Abstract: Compositions useful in treating immune modulated disease comprising an anticytokine antibody or immune active drug capable of modifying cytokine activity or modulating the immune system microencapsulated with a biodegradable nonantigenic material, such as albumin or PLGA. When the composition is introduced into a subject, it is phagocytosed by the target organ, the target organ digests the microsphere, releasing the drug or an active form or fragment thereof intracellularly. The drug then modifies the target organ function, thereby modulating it's activity. A method is disclosed for preparation of the microencapsulated composition.
Type:
Grant
Filed:
November 1, 1996
Date of Patent:
September 12, 2006
Assignee:
The Corporation of Mercer University
Inventors:
Martin J. D'Souza, William Carl Oettinger, James Cameron Oliver
Abstract: A system for locating electromagnetic signal sources via the rotational Doppler effect whereby a radar station generating electromagnetic signals, such as radar frequency signals, initially scans the sky for aircraft. An aircraft having the system operationally installed thereon and utilizing apparatus or navigational systems already present on the aircraft receives radar signals. The system is programmed to capture radar signal parameters and extract the rotational Doppler frequencies induced by the motion of the aircraft. The angular velocity of the host platform is often the dominant source of this frequency; however, lateral velocity is not detrimental to the process. The measurement of the rotational Doppler frequency is accomplished through antennas presently installed on large numbers of military aircraft with no requirement for phase calibration of the electrical paths between antennas and receiver.
Type:
Grant
Filed:
September 20, 2001
Date of Patent:
April 27, 2004
Assignee:
The Corporation of Mercer University
Inventors:
Charles David Bass, Jerome S. Finnigan, Peter Joseph Bryant
Abstract: Compositions useful in treating immune modulated disease comprising an anticytokine antibody or immune active drug capable of modifying cytokine activity or modulating the immune system microencapsulated with a biodegradable nonantigenic material, such as albumin or PLGA. When the composition is introduced into a subject, it is phagocytosed by the target organ, the target organ digests the microsphere, releasing the drug or an active form or fragment thereof intracellularly. The drug then modifies the target organ function, thereby modulating it's activity. A method is disclosed for preparation of the microencapsulated composition.
Abstract: A system and method for cleaning or removing coatings, such as paint, from a surface with a stream of particles. A carbon dioxide (CO.sub.2) pelletizer forms carbon dioxide pellets, which are delivered by a delivery system against a surface to be cleaned. The delivery system includes a hopper for containing the pellets and a high pressure air supply. A feeder introduces the pellets from the hopper into the high pressure air. The combined high pressure air and pellets are directed along a delivery hose to a nozzle, which directs the air and pellets against a surface to be cleaned. Temperature sensors are provided to monitor the temperature of the pressurized air at various points in the delivery system. Signals from the temperature sensor are provided in a feedback control manner to a control valve. The control valve controls the introduction of liquid nitrogen (N.sub.2) into the air stream at a mixing chamber in the delivery system.
Type:
Grant
Filed:
January 22, 1993
Date of Patent:
August 29, 1995
Assignee:
The Corporation of Mercer University
Inventors:
Michael A. Cryer, William D. Danielson, Robert A. Babb