Patents Assigned to The Council of Governors of the United Medical & Dental School of Guy's & St. Thomas's Hospitals
  • Polypeptide fragments capable of competition with Streptococcus mutans antigen I/II
    Patent number: 6500433
    Abstract: Defined peptide subunits of Streptococcus mutans antigen I/II (SAI/II) are useful as agents to prevent and treat dental caries either by eliciting an immunological response or by preventing adhesion of S. mutans to the tooth.
    Type: Grant
    Filed: December 9, 1999
    Date of Patent: December 31, 2002
    Assignee: The Council of Governors of the United Medical & Dental School of Guy's and St. Thomas's Hospitals
    Inventors: Thomas Lehner, Charles Kelly
  • Polypeptide fragments capable of competition with Streptococcus mutans antigen I/II
    Patent number: 6024958
    Abstract: Defined peptide subunits of Streptococcus mutans antigen I/II are useful as agents to prevent and treat dental caries either by eliciting an immunological response or by preventing adhesion of S. mutans to the tooth.
    Type: Grant
    Filed: October 20, 1997
    Date of Patent: February 15, 2000
    Assignee: The Council of Governors of the United Medical & Dental School of Guy's & St. Thomas's Hospitals
    Inventors: Thomas Lehner, Charles Kelly
  • Antibodies against Streptococcus
    Patent number: 5518721
    Abstract: Monoclonal antibodies which bind the surface antigen I/II of Streptococcus sobrinus serotype d and cross react with the surface antigen I/II of Streptococcus mutans serotypes c, e, f and g and method for producing the antibody. Compositions comprising the antibody used in a method to combat dental caries in a mammal.
    Type: Grant
    Filed: September 7, 1994
    Date of Patent: May 21, 1996
    Assignee: Council of Governors of the United Medical and Dental Schools of Guy's and St. Thomas Hospital
    Inventors: Thomas Lehner, Roberta Smith
  • Method of treating dental caries with monoclonal antibodies against the antigen I and antigen I/II of streptococcus mutans
    Patent number: 5352446
    Abstract: A method of combatting dental caries in a mammal comprises topical application to a surface of a tooth in the mammals mouth of a monoclonal antibody raised against antigen I or antigen I/II of Streptococcus mutans serotype c.
    Type: Grant
    Filed: November 30, 1992
    Date of Patent: October 4, 1994
    Assignee: Council of Governors of the United Medical and Dental Schools of Guy's and St. Thomas's Hospitals
    Inventor: Thomas Lehner
  • Antigenic materials
    Patent number: 4594244
    Abstract: An antigenic material having a molecular weight of 3800-4500, and useful in the preparation of an anticaries vaccine is produced from a known antigenic material, antigen I/II of molecular weight 185,000 daltons obtained from the culture supernatant of Streptococcus mutans. The smaller molecular weight fraction of the invention contains the same antigenic determinants as the known 185,000 dalton material but the lower molecular weight material can be used with less side effects. The antigenic material can be used for the production of vaccine preparations that could be administered parenterally or by topical application to the gums.
    Type: Grant
    Filed: February 10, 1984
    Date of Patent: June 10, 1986
    Assignee: Council of Governors of the United Medical and Dental Schools of Guy's and St. Thomas's Hospitals
    Inventors: Thomas Lehner, Abu S. M. Giasuddin