Patents Assigned to THE CURATORS OF THE UNIVERSITY MISSOURI
  • MODULATORS OF ALPHA-SYNUCLEIN TOXICITY
    Publication number: 20090099069
    Abstract: Disclosed are compositions and methods for modulating expression of genes that function at the step of ER of Golgi trafficking. Compounds that modulate expression of these genes of activity of the encoded proteins can be used to inhibit alpha-synuclein mediated toxicity and used to threat of prevent synucleinopathies such as Parkinson's disease. Also disclosed are methods of identifying inhibitors of alpha-synuclein mediated toxicity.
    Type: Application
    Filed: December 1, 2005
    Publication date: April 16, 2009
    Applicants: WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH, THE CURATORS OF THE UNIVERSITY MISSOURI
    Inventors: Susan L. Lindquist, Aaron D. Gitler, Anil Cashikar, Antony A. Cooper, Cole M. Haynes