Patents Assigned to The Curators of the University of Missouri
  • WOUND CARE COMPOSITIONS
    Publication number: 20170014542
    Abstract: Glass-based particles of a biocompatible material which comprises 40 to about 80 wt % borate (B2O3) intermixed into a carrier which is an ointment, cream, or surgical glue.
    Type: Application
    Filed: September 29, 2016
    Publication date: January 19, 2017
    Applicant: The Curators of the University of Missouri
    Inventors: Steven B. Jung, Delbert E. Day
  • COMPOSITIONS AND METHODS FOR BORON NEUTRON CAPTURE THERAPY
    Publication number: 20170007700
    Abstract: Provided herein are compositions and methods for boron neutron capture therapy. In particular, the disclosure relates to therapy using liposomal Na3[1-(2?-B10H9)-2-NH3B10H8] and K[nido-7-CH3(CH2)15-7,8-C2B9H11] sources. A composition for boron neutron capture therapy, comprising a liposome having an aqueous core and an encapsulating bilayer, wherein the aqueous core comprises Na3[1-(2?-B10H9)-2-NH3B10H8] (TAC) and the encapsulating bilayer comprises K[nido-7-CH3(CH2)15-7,8-C2B9H11] (MAC) is also provided.
    Type: Application
    Filed: February 23, 2015
    Publication date: January 12, 2017
    Applicant: The Curators of the University of Missouri
    Inventors: Satish S. Jalisatgi, Marion Frederick Hawthorne
  • METHOD FOR ENHANCING AMIDOHYDROLASE ACTIVITY OF FATTY ACID AMIDE HYDROLASE
    Publication number: 20170000748
    Abstract: A method for enhancing amidohydrolase activity of Fatty Acid Amide Hydrolase (FAAH) is disclosed. The method comprising administering a phenoxyacyl-ethanolamide that causes the enhanced activity. The enhanced activity can have numerous effects on biological organisms including, for example, enhancing the growth of certain seedlings.
    Type: Application
    Filed: September 15, 2016
    Publication date: January 5, 2017
    Applicants: Research Foundation of the City University of New York, The Curators of the University of Missouri, University of North Texas
    Inventors: George John, Subbiah Nagarajan, Kent Chapman, Lionel Faure, Peter Koulen
  • METHODS AND COMPOSITIONS FOR TREATMENT OF NEURODEGENERATIVE DISEASES
    Publication number: 20170000729
    Abstract: The present invention provides methods and compositions for treating a neurodegeneration disease or retinal degenerative disease in a mammal comprising the use of mesenchymal stem cells expressing a therapeutic compound. The invention also provides cells and constructs for use in such methods. Also provided are kits for treatment of a neurodegeneration disease or retinal degenerative disease. The present invention relates in general to the field of retinal degenerative and neurodegenerative diseases. More specifically, the invention relates to methods for treatment of retinal degenerative and neurodegenerative disease.
    Type: Application
    Filed: March 11, 2015
    Publication date: January 5, 2017
    Applicant: THE CURATORS OF THE UNIVERSITY OF MISSOURI
    Inventors: Martin L. Katz, Joan R. Coates, Christopher J. Tracy, Rebecca E.H. Whiting, Jacqueline W. Pearce
  • Viscous sealing glass compositions for solid oxide fuel cells
    Patent number: 9530991
    Abstract: A sealant for forming a seal between at least two solid oxide fuel cell components wherein the sealant comprises a glass material comprising B2O3 as a principal glass former, BaO, and other components and wherein the glass material is substantially alkali-free and contains less than 30% crystalline material.
    Type: Grant
    Filed: July 23, 2013
    Date of Patent: December 27, 2016
    Assignees: MO-SCI Corporation, The Curators of the University of Missouri
    Inventors: Cheol Woon Kim, Richard K. Brow
  • Method for separation of chemically pure Os from metal mixtures
    Patent number: 9528169
    Abstract: A method for separating an amount of osmium from a mixture containing the osmium and at least one other additional metal is provided. In particular, method for forming and trapping OsO4 to separate the osmium from a mixture containing the osmium and at least one other additional metal is provided.
    Type: Grant
    Filed: July 21, 2014
    Date of Patent: December 27, 2016
    Assignee: The Curators of the University of Missouri
    Inventors: Hendrik P. Engelbrecht, Cathy S. Cutler, Leonard Manson, Stacy Lynn Wilder
  • RECOMBINATION ACTIVATING GENE 2 GENE TARGETING VECTOR, PRODUCTION OF SCID-LIKE MINIATURE PIGS BY TALEN-MEDIATED GENE TARGETING AND USE THEREOF
    Publication number: 20160366860
    Abstract: There are provided to a Rag-2 (Recombination activating gene 2) gene targeting vector, a method for producing SCID-like miniature pigs introduced with the vector, and a use thereof.
    Type: Application
    Filed: November 13, 2014
    Publication date: December 22, 2016
    Applicant: THE CURATORS OF THE UNIVERSITY OF MISSOURI
    Inventors: Jin-Hoi KIM, Deug-Nam KWON, Randall S. PRATHER, Kiho LEE
  • FORMULATIONS FOR PHARMACEUTICAL AGENTS
    Publication number: 20160361327
    Abstract: Described herein are processes for improving the aqueous availability of poorly soluble bioactive materials and bioactive compounds and compositions formed by those processes.
    Type: Application
    Filed: June 10, 2016
    Publication date: December 15, 2016
    Applicant: The Curators of the University of Missouri
    Inventors: Albert N. Ngo, Bi-Botti C. Youan
  • System and method for linking a web-based resource with an electronic medical record
    Patent number: 9519885
    Abstract: A data processing system and method that, in some cases, include an EMR system and a web server. In some cases, the EMR system includes a plurality of electronic medical records for a plurality of patients. One or more of the electronic medical records may include a URL or HTTP Post message that defines a path to a web-based resource, such as a treatment algorithm or medical calculator. In some embodiments, the URL and/or HTTP Post message is constructed based on information in a patient's medical record.
    Type: Grant
    Filed: August 14, 2012
    Date of Patent: December 13, 2016
    Assignee: The Curators of the University of Missouri
    Inventors: Karl M. Kochendorfer, Jared S. Coberly
  • Identifying geographic areas based on change patterns detected from high-resolution, remotely sensed imagery
    Patent number: 9514386
    Abstract: A method, system, and medium are provided for identifying terrestrial objects that have changed in a certain manner. One embodiment of the method includes receiving a query that includes one or more inputs, which are related to 1) a first terrestrial object (“first object”) and 2) source change-detection information that describes change associated with the first object; applying the query to a dataset that includes indexed information that describes the imagery; based on the one or more inputs, receiving a query result by identifying a set of regions in the dataset that are respectively associated with change information that is similar to that of the source change-detection information; and presenting on a presentation device indications of at least a portion of the identified set of regions.
    Type: Grant
    Filed: August 28, 2015
    Date of Patent: December 6, 2016
    Assignee: The Curators of the University of Missouri
    Inventors: Grant Jason Scott, Chi-Ren Shyu, Matthew Nicholas Klaric, Curtis Herbert Davis, Brian Christopher Claywell
  • SYNTHESIS OF BORANE COMPOUNDS
    Publication number: 20160347621
    Abstract: The present invention is directed to a process for the synthesis of alkali metal tetrahydroborates-10B and amine borane-10B precursors, such as sodium tetrahydroborate-10B and triethylamine borane-10B.
    Type: Application
    Filed: February 3, 2015
    Publication date: December 1, 2016
    Applicant: THE CURATORS OF THE UNIVERSITY OF MISSOURI
    Inventors: ALEXANDER VALENTINOVICH SAFRONOV, SATISH SUBRAY JALISATGI, MARION FREDERICK HAWTHORNE
  • Method and system for dynamic stochastic optimal electric power flow control
    Patent number: 9507367
    Abstract: A dynamic stochastic optimal power flow (DSOPF) control system is described for performing multi-objective optimal control capability in complex electrical power systems. The DSOPF system and method replaces the traditional adaptive critic designs (ACDs) and secondary voltage control, and provides a coordinated AC power flow control solution to the smart grid operation in an environment with high short-term uncertainty and variability. The DSOPF system and method is used to provide nonlinear optimal control, where the control objective is explicitly formulated to incorporate power system economy, stability and security considerations. The system and method dynamically drives a power system to its optimal operating point by continuously adjusting the steady-state set points sent by a traditional optimal power flow algorithm.
    Type: Grant
    Filed: April 9, 2013
    Date of Patent: November 29, 2016
    Assignees: Clemson University, Georgia Tech Research Corporation, The Curators of the University of Missouri
    Inventors: Ganesh Kumar Venayagamoorthy, Jiaqi Liang, Ronald Gordon Harley
  • Method of predicting crop yield loss due to N-deficiency
    Patent number: 9508007
    Abstract: A method for determining the yield loss of a crop using remote sensor data is described. The yield loss is determined using the reflectivity of light by the crop canopy measured from remote sensor data such as an aerial photograph that is digitized and spatially referenced to the field's longitude and latitude. Pixel values from the aerial photograph, expressed relative to pixel values from well fertilized areas of the field, are transformed to yield losses using a linear transformation that was developed using empirical data. A similar method is described to determine recommended nitrogen fertilization rates for the crop fields. The yield loss data is useful for nitrogen fertilization management, as it allows a producer of crops to weigh the expense of fertilization against the loss of revenue due to yield loss.
    Type: Grant
    Filed: October 19, 2015
    Date of Patent: November 29, 2016
    Assignee: The Curators of the University of Missouri
    Inventors: Peter Clifton Scharf, Victoria Cacnio Hubbard
  • Methods and compositions for treating bacterial infection
    Patent number: 9504688
    Abstract: The present invention relates to chemical compounds, methods for their discovery, and their therapeutic and research use. In particular, the present invention provides compounds as therapeutic agents against bacterial infections (e.g., biofilms).
    Type: Grant
    Filed: May 2, 2013
    Date of Patent: November 29, 2016
    Assignees: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, THE CURATORS OF THE UNIVERSITY OF MISSOURI
    Inventors: David Ginsburg, Scott D. Larsen, Bryan Yestrepsky, Hongmin Sun
  • Separation Method for Active Pharmaceutical Ingredients from Excipients
    Publication number: 20160340350
    Abstract: The present invention provides a method for physically separating the active pharmaceutical ingredient (API) from the excipients in a pharmaceutical formulation before the API is fully characterized by standard techniques. The presently disclosed method is based on making use of the difference in density of the API and that of the excipients. In the method, the API is not dissolved, nor is the crystal form of the API changed.
    Type: Application
    Filed: April 25, 2016
    Publication date: November 24, 2016
    Applicant: The Curators of the University of Missouri
    Inventor: Jerry L. Atwood
  • Combination of single-cell electroporation and electrical recording using the same electrode
    Patent number: 9488637
    Abstract: Methods for stimulating exocytosis from a cell are provided where the same electrochemical microelectrode is used to electroporate an adjacent cell and then measure quantal exocytosis from the adjacent cell. Also provided are methods for stimulating and measuring exocytosis from a select cell population arrayed on a chip comprising addressable electrodes. Calcium independent stimulation of exocytosis with inorganic anions such as chloride ions is also provided. These methods can provide for specific stimulation of a desired subset of cells without exposing other nearby cells to the stimulus.
    Type: Grant
    Filed: January 26, 2012
    Date of Patent: November 8, 2016
    Assignee: THE CURATORS OF THE UNIVERSITY OF MISSOURI
    Inventors: Kevin Gillis, Jaya Ghosh
  • Biomarkers of osteoarthritis
    Patent number: 9488646
    Abstract: Biomarkers, biomarker panels and methods for diagnosing osteoarthritis (OA) and determining treatment are disclosed, using measurement of the expression level of certain polypeptides in a test sample from a subject, including MCP1, IL8, KC, MMP2, MMP3, Apolipoprotein A1, and Apolipoprotein E. Related methods for monitoring OA treatment efficacy, diagnostic reagents, and kits are also described.
    Type: Grant
    Filed: February 7, 2014
    Date of Patent: November 8, 2016
    Assignee: The Curators of the University of Missouri
    Inventors: James L. Cook, Cristi R. Cook, Aaron M. Stoker, Keiichi Kuroki, Bridget Colleen Garner, Richard Evans, Brandon Lee Roller, Prakash Sidha Jayabalan
  • Nanocomposite membranes with advanced antifouling properties under visible light irradiation
    Patent number: 9486747
    Abstract: Nitrogen doped TiO2 (N—TiO2) is used to fabricate Poly(vinyledene fluoride) (PVDF)/N—TiO2 mixed matrix hollow fiber membranes (HFMs) through a phase inversion method to improve filtration efficiencies and antifouling properties. The membranes performances were evaluated based on the water permeability, humic acid (HA) rejection and antifouling properties. Resulting membranes showed brown color and improved hydrophilicity, especially under light irradiation. When compared to original PVDF and PVDF/P25 membrane, mixed matrix membranes containing N—TiO2 nanoparticles (NPs) showed clear photocatalytic activities under visible light irradiation. Also, membrane performance assessments indicated that PVDF/N—TiO2 membranes possessed enhanced water flux, similar HA rejection (e.g., above 96%) and improved fouling resistance with PVDF membranes as a control.
    Type: Grant
    Filed: August 7, 2015
    Date of Patent: November 8, 2016
    Assignee: The Curators of the University of Missouri
    Inventors: Baolin Deng, Jun Yin
  • Wound care compositions comprising borate (BO) glass-based particles
    Patent number: 9486554
    Abstract: Glass-based angiogenic particles of a biocompatible material which comprises 40 to about 80 wt% borate (B2O3) intermixed into a carrier which is an ointment, cream, or surgical glue.
    Type: Grant
    Filed: September 16, 2013
    Date of Patent: November 8, 2016
    Assignee: The Curators of the University of Missouri
    Inventors: Steven B. Jung, Delbert E. Day
  • Waveguide probe for nondestructive material characterization
    Patent number: 9482626
    Abstract: An open-ended waveguide probe including a finite flange extending outwardly and functioning as an infinite flange. A signal source provides a microwave signal to the waveguide, which in turn transmits microwave electromagnetic energy incident upon an object to be tested. The finite flange at the waveguide's aperture is shaped to reduce scattering of the electromagnetic field reflected from the object and received by the aperture. The probe is adapted for coupling to a receiver for sampling the reflected electromagnetic field received by the aperture and the receiver is adapted for coupling to a processor for determining at least one material characteristic of the object based on sampled electromagnetic field reflected from the object.
    Type: Grant
    Filed: September 13, 2013
    Date of Patent: November 1, 2016
    Assignee: The Curators of the University of Missouri
    Inventors: Mohammad Tayeb Ghasr, Matthew Kempin, Reza Zoughi