Patents Assigned to The Endowment For Research In Human Biology
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Patent number: 8158810Abstract: Disclosed are novel isoflavone derivatives having the structure of Formula I which are useful as ALDH-2 inhibitors for treating mammals for dependence upon drugs of addiction, for example addiction to dopamine-producing agent such as cocaine, morphine, amphetamines, nicotine, and alcohol.Type: GrantFiled: February 13, 2009Date of Patent: April 17, 2012Assignees: Gilead Sciences, Inc., The Endowment For Research in Human Biology, Inc.Inventors: Jeff Zablocki, Matthew Abelman, Michael Organ, Yaroslav Bilokin, Elfatih Elzein, Tetsuya Kobayashi, Rao Kalla, Thao Perry, Xiaofen Li, Robert Jiang, Ivan Diamond, Lina Yao, Peidong Fan, Maria Pia Arolfo, Zhan Jiang, Wing Ming Keung, Guoxin Tao
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Patent number: 7368434Abstract: The present invention provides novel antidipsotropic compounds. The invention further provides methods of inhibiting ALDH-2 using the compounds described herein. Methods for modulating alcohol consumption, alcohol dependence and/or alcohol abuse by administering the compounds of the invention to an individual are also provided. The present invention further provides a rationale for designing additional novel antidipsotropic compounds.Type: GrantFiled: June 27, 2003Date of Patent: May 6, 2008Assignee: The Endowment for Research in Human Biology, Inc.Inventors: Wing Ming Keung, Bert L. Vallee, Guangyao Gao
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Publication number: 20040068003Abstract: The present invention provides novel antidipsotropic compounds. The invention further provides methods of inhibiting ALDH-2 using the compounds described herein. Methods for modulating alcohol consumption, alcohol dependence and/or alcohol abuse by administering the compounds of the invention to an individual are also provided. The present invention further provides a rationale for designing additional novel antidipsotropic compounds.Type: ApplicationFiled: June 27, 2003Publication date: April 8, 2004Applicant: The Endowment for Research in Human Biology, Inc,Inventors: Wing Ming Keung, Bert L. Vallee, Guangyao Gao
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Patent number: 6482802Abstract: The present invention is directed to using neomycin or an analogue thereof as an therapeutic agent to treat angiogenesis-related diseases, which are characterized by excessive, undesired or inappropriate angiogenesis or proliferation of endothelial cells. The present invention is also directed to pharmaceutical compositions comprising (a) neomycin or an analogue and, optionally, (b) another anti-angiogenic agent or an anti-neoplastic agent. The present invention is further directed to a method for screening neomycin analogues having anti-angiogenic activity. A preferred embodiment of the invention relates to using neomycin to treat subjects having such diseases.Type: GrantFiled: November 9, 2000Date of Patent: November 19, 2002Assignee: Endowment for Research in Human Biology, Inc.Inventors: Guo-fu Hu, Bert L. Vallee
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Patent number: 6255497Abstract: Methods and compounds for inhibiting aldehyde dehydrogenase are disclosed. The compounds are useful as pharmaceutical compositions in methods for therapeutically treating alcohol consumption in a human.Type: GrantFiled: November 12, 1998Date of Patent: July 3, 2001Assignee: The Endowment for Research in Human Biology, Inc.Inventors: Bert L. Vallee, Wing-Ming Keung
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Patent number: 6121010Abstract: A method for the treatment of alcohol abuse using daidzin and compounds analogous to daidzin is disclosed. Also disclosed is a method for screening compounds having antidipsotropic activity.Type: GrantFiled: May 12, 1999Date of Patent: September 19, 2000Assignee: The Endowment for Research in Human BiologyInventors: Bert L. Vallee, Wing-Ming Keung
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Patent number: 5886028Abstract: Methods and compounds for inhibiting aldehyde dehydrogenase are disclosed. The compounds are useful as pharmaceutical compositions in methods for therapeutically treating alcohol consumption in a human.Type: GrantFiled: April 29, 1997Date of Patent: March 23, 1999Assignee: The Endowment for Research in Human Biology, Inc.Inventors: Bert L. Vallee, Wing-Ming Keung
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Patent number: 5852001Abstract: A method of inhibiting ribonucleases is disclosed wherein a nucleotide compound having a diphosphate group contacts a ribonuclease so as to inhibit the ribonuclease from effectively catalyzing the depolymerization of ribonucleic acid. Novel compounds useful in the method are also disclosed.Type: GrantFiled: December 23, 1996Date of Patent: December 22, 1998Assignee: The Endowment for Research in Human BiologyInventors: Bert L. Vallee, Aniello Russo
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Patent number: 5624910Abstract: Method for inhibiting aldehyde dehydrogenase activity using daidzin and/or daidzin analog and/or daidzin or daidzin analog in combination with a factor or factors which increase the bioavailability of the daidzin or daidzin analog, as ALDH-I inhibitory compounds or compositions. Such inhibitory compounds or compositions are useful as pharmaceutical compositions in methods for the treatment of alcohol dependence (i.e., alcoholism) or alcohol abuse, for alcohol sensitization, for extinguishing an alcohol-drinking response, for suppressing an urge for alcohol, for inducing alcohol intolerance, for preventing alcoholism in an individual with or without a susceptibility or predisposition to alcoholism or alcohol abuse, and for limiting alcohol consumption in an individual whether or not genetically predisposed.Type: GrantFiled: May 24, 1994Date of Patent: April 29, 1997Assignee: The Endowment for Research in Human Biology, Inc.Inventors: Bert L. Vallee, Wing-Ming Keung
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Patent number: 5204369Abstract: Method for inhibiting aldehyde dehydrogenase activity using daidzin as a selective inhibitor of ALDH-I activity. Because daidzin is a potent selective, yet reversible, inhibitor of ALDH-I activity, it is useful as a pharmaceutical composition in methods for the treatment of alcohol dependence (i.e., alcoholism) or alcohol abuse, for alcohol sensitization, for extinguishing an alcohol-drinking response, for suppressing an urge for alcohol, for inducing alcohol intolerance, for preventing alcoholism in an individual with or without a susceptibility or predisposition to alcoholism or alcohol abuse, and for limiting alcohol consumption in an individual whether or not genetically predisposed.Type: GrantFiled: July 1, 1991Date of Patent: April 20, 1993Assignee: The Endowment For Research In Human BiologyInventors: Bert L. Vallee, Wing M. Keung
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Patent number: 4908187Abstract: This invention relates to a diluting and mixing device which is capable of diluting a first solution to produce a second solution which is mixed with an undiluted third solution, to reproducibly produce a unique series of combined solutions. Each solution in said series of combined solutions may vary only in the concentration of a single (selected) reactant, and typically, each successive solution becomes increasingly more concentrated in the selected reactant. By employing a modification in procedure, each successive solution in said series may become decreasingly less concentrated in the selected reactant.This invention further relates to an automated system comprising the device connected to a stepping motor so as to rapidly and reproducibly produce said series of solutions, said device being further connected to an analyzer means for obtaining chemical, biochemical, or physical chemical data on said series of solutions.Type: GrantFiled: August 4, 1988Date of Patent: March 13, 1990Assignee: Endowment for Research in Human Biology, Inc.Inventors: Barton Holmquist, Robert K. Scopes