Patents Assigned to The Finnish National Public Health Institute (KTL)
  • Patent number: 5780261
    Abstract: The invention provides a method and expression system for enhancing secretion of hyperproduced homologous and heterologous exoproteins in gram-positive bacteria such as Bacillus sp. The method and system comprise overproduction of PrsA protein in gram-positive bacterial host capable of also overproducing at least one exoprotein of interest. Use of the method and system of the invention results in greatly enhanced secretion of the synthesized exoproteins into the growth medium. Once in the growth medium these secreted exoproteins can be recovered and purified in a straightforward manner.
    Type: Grant
    Filed: July 8, 1996
    Date of Patent: July 14, 1998
    Assignee: The Finnish National Public Health Institute (KTL)
    Inventors: Vesa Kontinen, Matti Sarvas