Patents Assigned to The Florey Institute
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Patent number: 11713463Abstract: Described herein are compositions and methods that are used to increase the expression of SCN2A, which may be used to treat neurological or psychiatric disorders. Antisense oligonucleotides that target upstream open reading frames (uORFs) may be administered to prevent translation initiation from a uORF to increase expression from a primary ORF (pORF), thus increasing the levels of SCN2A protein.Type: GrantFiled: January 17, 2019Date of Patent: August 1, 2023Assignee: The Florey Institute of Neuroscience and Mental HealthInventors: Steven Petrou, Eric G. Marcusson
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Patent number: 11124550Abstract: This invention relates to peptides and their use for modulating sodium channels. More particularly, the present invention relates to peptides and their use in methods of enhancing Nav1.1 activity and for treating or preventing conditions associated with Nav1.1 activity.Type: GrantFiled: December 9, 2016Date of Patent: September 21, 2021Assignees: THE UNIVERSITY OF QUEENSLAND, THE JOHNS HOPKINS UNIVERSITY, THE FLOREY INSTITUTE OF NEUROSCIENCE AND MENTAL HEALTH, THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Steven Petrou, Glenn King, Frank Bosmans, David Julius, Jeremiah Osteen, Chuchu Zhang
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Patent number: 10577308Abstract: The present disclosure relates generally to compounds having activity as voltage-gated sodium channel blockers and their use in the field of therapeutic treatment, including the therapy or management of conditions associated with excessive, unwanted, inadequate or otherwise undesirable sodium ion passage through cellular membranes via voltage-gated sodium channels. In some embodiments, the disclosure relates to aryloxy-substituted amines for use as sodium channel blockers or modulators. Methods for their manufacture and compositions containing the compounds are also disclosed.Type: GrantFiled: March 24, 2016Date of Patent: March 3, 2020Assignees: The Florey Institute, The University of MelbourneInventors: Spencer John Williams, Bevyn Jarrott
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Patent number: 10251856Abstract: The present invention relates generally to methods for the treatment and/or prophylaxis of neurological diseases and disorders involving administration of trans 10-HDA. In particular, the methods of the present invention are useful in the treatment and/or prophylaxis of acquired or progressive neurodevelopmental disorders and conditions in mammals. More particularly, methods are taught herein for the treatment and/or prophylaxis of diseases and disorders such as autism spectrum disorders.Type: GrantFiled: February 8, 2018Date of Patent: April 9, 2019Assignees: DEAKIN UNIVERSITY, THE FLOREY INSTITUTE OF NEUROSCIENCE AND MENTAL HEALTHInventors: Steve Cheung, Wah Chin Boon
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Patent number: 10081662Abstract: Provided herein are biologically active single chain relaxin peptides. In particular the present invention relates to single chain relaxin peptides comprising a B chain derived from relaxin-2, the peptide being truncated by one or more amino acid residues at the N-terminus with respect to the sequence of the B chain of native relaxin-2. Typically the single chain relaxin peptides selectively bind to the RXFP1 receptor.Type: GrantFiled: April 17, 2015Date of Patent: September 25, 2018Assignee: THE FLOREY INSTITUTE OF NEUROSCIENCE AND MENTAL HEALTHInventors: Ross Alexander David Bathgate, Mohammed Akhter Hossain, John Desmond Wade
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Publication number: 20180177839Abstract: The present invention relates generally to a method of modulating glutathione metabolism in the central nervous system of mammals and to agents for use therein. More particularly, the present invention relates to a method of up-regulating glutathione metabolism in the central nervous system by up-regulating levels of glutathione precursor molecules. The method of the present invention is particularly useful, inter alia, in the treatment and/or prophylaxis of conditions characterised by aberrant, unwanted or otherwise inappropriate central nervous system oxidation homeostasis including, but not limited to, schizophrenia.Type: ApplicationFiled: February 23, 2018Publication date: June 28, 2018Applicant: The Florey Institute of Neuroscience & Mental HealthInventors: Ashley I. Bush, David L. Copolov, Michael Berk
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Publication number: 20180170891Abstract: The present disclosure relates generally, but not exclusively, to compounds and their use in therapy, to compositions and agents comprising said compounds, to methods of treatment using said compounds, and their use in the manufacture of medicaments. The disclosure further relates to inhibitors of IRAP and their use in the treatment or prevention of Alzheimer's disease and the treatment and prevention of memory and cognitive disorders.Type: ApplicationFiled: May 6, 2016Publication date: June 21, 2018Applicants: Monash University, The Florey Institute of Neuroscience and Mental Health, St. Vincent's Institute of Medical ResearchInventors: Siew Yeen CHAI, Philip THOMPSON, Simon MOUNTFORD, Michael W. PARKER
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Patent number: 9925163Abstract: The present invention relates generally to methods for the treatment and/or prophylaxis of neurological diseases and disorders involving administration of trans 10-HDA. In particular, the methods of the present invention are useful in the treatment and/or prophylaxis of acquired or progressive neurodevelopmental disorders and conditions in mammals. More particularly, methods are taught herein for the treatment and/or prophylaxis of diseases and disorders such as autism spectrum disorders.Type: GrantFiled: June 5, 2015Date of Patent: March 27, 2018Assignees: DEAKIN UNIVERSITY, THE FLOREY INSTITUTE OF NEUROSCIENCE AND MENTAL HEALTHInventors: Steve Cheung, Wah Chin Boon
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Patent number: 9791453Abstract: A mechanism is provided for utilizing a nanodevice to distinguish molecules with different structure. The molecules translocate through or across a nanochannel filled with a electrolyte solution. An electrical signal through the nanochannel is measured for every translocation event. Inner surfaces of the nanochannel include a functional layer, which is a coating to functionalize the nanochannel, in which the functional layer is configured to interact with predetermined ones of the molecules during translocation events. It is determined that a combination of at least two different molecules is formed based on predetermined ones of the molecules interacting with the functional layer to change the electrical signal and/or change a translocation time for the translocation event.Type: GrantFiled: December 26, 2012Date of Patent: October 17, 2017Assignees: INTERNATIONAL BUSINESS MACHINES CORPORATION, THE UNIVERSITY OF MELBOURNE, FLOREY INSTITUTE OF NEUROSCIENCE AND MENTAL HEALTHInventors: Matthew Downton, Natalie Gunn, Stefan Harrer, Priscilla Rogers, John Wagner, Ross Bathgate, Daniel Scott, Stan Skafidas
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Patent number: 9359422Abstract: The present invention relates to biologically active single chain relaxin polypeptides comprising a relaxin B chain derived from relaxin-3, the polypeptides being truncated by one or more amino acids at the C-terminus of the relaxin-3 B chain. Typically the single chain relaxin polypeptides are antagonists of the RXFP3 receptor, and in some embodiments are selective antagonists of the RXFP3 receptor.Type: GrantFiled: September 8, 2011Date of Patent: June 7, 2016Assignees: The University of Queensland, Howard Florey Institute of Experimental Physiology and MedicineInventors: Karl Johan Rosengren, Linda Maria Haugaard-Kedstrom, Ross Alexander David Bathgate, Mohammed Akhter Hossain, John Desmond Wade, Andrew Lawrence Gundlach, Andrew J. Lawrence
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Patent number: 9139879Abstract: Methods, compositions and kits based on TAM receptors, or TAM receptor ligands or agonists are for detection of neuropathological diseases or determination of their progression. The neural diseases include multiple sclerosis or other inflammatory neural disorders that are characterized by demyelination, oligodendrocyte cytotoxicity and microglial activation. These methods include screening cells of a subject where identification of an elevation of expression of a TAM receptor or a change in expression of a TAM receptor ligand indicates the presence of the disease presence or progression. In addition, subjects with such neuropathological diseases can be treated by administering TAM receptor ligands (such as GAS 6 or Protein S) or by administering agonists such as antibodies specific for the TAM receptors; Axl, Mer or Tyro3.Type: GrantFiled: August 19, 2011Date of Patent: September 22, 2015Assignee: HOWARD FLOREY INSTITUTEInventors: Victoria Mary Perreau, Judith Field, Michele D Binder, Trevor Kilpatrick
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Patent number: 9056922Abstract: Provided herein are modified relaxin polypeptides wherein the B chain comprises the core amino acid sequence CGR-XXX-R-XX-I/V-XX-CG (SEQ ID NO:1), where X is any amino acid. Also provided are modified relaxin polypeptides comprising at least an A and a B chain, wherein the A and B chains are derived from different naturally occurring relaxins and wherein the B chain comprises the core amino acid sequence CGR-XXX-R-XX-I/V-XX-CG (SEQ ID NO:1), where X is any amino acid.Type: GrantFiled: October 30, 2008Date of Patent: June 16, 2015Assignee: HOWARD FLOREY INSTITUTE OF EXPERIMENTAL PHYSIOLOGY AND MEDICINEInventors: Ross Alexander David Bathgate, Mohammed Akhter Hossain, Chrishan Surendran Samuel, John Desmond Wade, Geoffrey W Tregear
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Publication number: 20140323527Abstract: The present invention relates generally to the field of therapeutic treatment and compounds having utility therefor, in particular the therapy or management of conditions associated with excessive, unwanted or undesirable sodium ion passage through cellular membranes via voltage-gated sodium channels. In one embodiment the invention is concerned with the treatment of neuropathic pain. The invention contemplates to aryloxy-substituted amines, as sodium channel blockers or modulators. In further embodiments, the invention also relates to compounds which may advantageously have dual sodium channel blocker/modulating and antioxidative (free-radical scavenging) effects. Methods for their manufacture and compositions containing the compounds are also contemplated.Type: ApplicationFiled: March 24, 2014Publication date: October 30, 2014Applicant: HOWARD FLOREY INSTITUTEInventor: Bevyn JARROTT
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Patent number: 8841254Abstract: Human H3 preprorelaxin, human H3 prorelaxin, human H3 relaxin, human relaxin analogues having a modified A chain and/or a modified B chain are described. Also described are nucleic acid sequences encoded human H3 preprorelaxin, human H3 prorelaxin, human H3 relaxin, human relaxin analogues. Also described are methods for the treatment of conditions responsive to administration of H3 relaxin or analogues thereof.Type: GrantFiled: August 21, 2007Date of Patent: September 23, 2014Assignee: Howard Florey Institute of Experimental Physiology and MedicineInventors: Geoffrey Tregear, Ross Alexander David Bathgate, Chrishan Surendran Samuel, Tanya Christine Burazin, Andrew Lawrence Gundlach, John Desmond Wade
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Patent number: 8835362Abstract: A mechanism is provided for utilizing a nanodevice to distinguish molecules with different structure. The molecules translocate through or across a nanochannel filled with a electrolyte solution. An electrical signal through the nanochannel is measured for every translocation event. Inner surfaces of the nanochannel include a functional layer, which is a coating to functionalize the nanochannel, in which the functional layer is configured to interact with predetermined ones of the molecules during translocation events. It is determined that a combination of at least two different molecules is formed based on predetermined ones of the molecules interacting with the functional layer to change the electrical signal and/or change a translocation time for the translocation event.Type: GrantFiled: December 26, 2012Date of Patent: September 16, 2014Assignees: International Business Machines Corporation, The University of Melbourne, Florey Institute of Neuroscience and Mental HealthInventors: Matthew Downtown, Natalie Gunn, Stefan Harrer, Priscilla Rogers, John Wagner, Ross Bathgate, Daniel James Scott, Stan Skafidas
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Publication number: 20140193364Abstract: The present disclosure relates to the use of TAM receptor ligands, metabolites, precursor and binding partners thereof in the field of inflammatory neuropathology. This includes the early diagnosis and monitoring of an inflammatory neuropathology as well as screening for medicaments used in the treatment and prophylaxis of such a condition. The method comprises screening blood fluid from a subject for a TAM receptor ligand, or metabolite, or precursor thereof wherein an altered level of the ligand or its metabolite or precursor relative to a control is indicative of the presence of an inflammatory neuropathological disease or condition or a likelihood of developing the same. Diagnostic kits, high throughput screening assays and therapeutic compositions for inflammatory neuropathies are also taught herein.Type: ApplicationFiled: April 4, 2012Publication date: July 10, 2014Applicant: HOWARD FLOREY INSTITUTEInventors: Trevor Kilpatrick, Michele Denise Binder, Zhi-Ming Gerry Ma
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Publication number: 20140179541Abstract: A mechanism is provided for utilizing a nanodevice to distinguish molecules with different structure. The molecules translocate through or across a nanochannel filled with a electrolyte solution. An electrical signal through the nanochannel is measured for every translocation event. Inner surfaces of the nanochannel include a functional layer, which is a coating to functionalize the nanochannel, in which the functional layer is configured to interact with predetermined ones of the molecules during translocation events. It is determined that a combination of at least two different molecules is formed based on predetermined ones of the molecules interacting with the functional layer to change the electrical signal and/or change a translocation time for the translocation event.Type: ApplicationFiled: December 26, 2012Publication date: June 26, 2014Applicants: INTERNATIONAL BUSINESS MACHINES CORPORATION, FLOREY INSTITUTE OF NEUROSCIENCE & MENTAL HEALTH, THE UNIVERSITY OF MELBOURNEInventors: Matthew Downtown, Natalie Gunn, Stefan Harrer, Priscilla Rogers, John Wagner, Ross Bathgate, Daniel James Scott, Stan Skafidas
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Patent number: 8716528Abstract: The present invention relates generally to the field of therapeutic treatment and compounds having utility therefor, in particular the therapy or management of conditions associated with excessive, unwanted or undesirable sodium ion passage through cellular membranes via voltage-gated sodium channels. In one embodiment the invention is concerned with the treatment of neuropathic pain. The invention contemplates to aryloxy-substituted amines, as sodium channel blockers or modulators. In further embodiments, the invention also relates to compounds which may advantageously have dual sodium channel blocker/modulating and antioxidative (free-radical scavenging) effects. Methods for their manufacture and compositions containing the compounds are also contemplated.Type: GrantFiled: October 31, 2008Date of Patent: May 6, 2014Assignee: Howard Florey InstituteInventor: Bevyn Jarrott
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Publication number: 20140038895Abstract: The present invention relates to biologically active single chain relaxin polypeptides comprising a relaxin B chain derived from relaxin-3, the polypeptides being truncated by one or more amino acids at the C-terminus of the relaxin-3 B chain. Typically the single chain relaxin polypeptides are antagonists of the RXFP3 receptor, and in some embodiments are selective antagonists of the RXFP3 receptor.Type: ApplicationFiled: September 8, 2011Publication date: February 6, 2014Applicants: The University of Queensland, Howard Florey Institute of Experimental Physiology and MedicineInventors: Karl Johan Rosengren, Linda Maria Haugaard-Kedstrom, Ross Alexander David Bathgate, Mohammed Akhter Hossain, John Desmond Wade, Andrew Lawrence Gundlach, Andrew J. Lawrence
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Publication number: 20140024592Abstract: The present invention relates to biologically active relaxin polypeptides comprising a relaxin A chain and a B chain derived from a relaxin superfamily member, wherein the A chain comprises no intra-chain disulphide bonds. In particular embodiments the modified polypeptides comprise relaxin-3 derived A and B chains, and truncations of the A and/or B chains from the N-termini and/or C-termini. In particular embodiments the polypeptides of the invention are selective agonists or antagonists of the RXFP3 receptor.Type: ApplicationFiled: September 8, 2011Publication date: January 23, 2014Applicant: Howard Florey Institute of Experimental Physiology and MedicineInventors: Fazel Shabenpoor, Mohammed Akhter Hossain, Ross Alexander David Bathgate, John Desmond Wade, Andrew Lawrence Gundlach