Patents Assigned to The Florida State University Research Foundation, Inc.
  • Patent number: 10955300
    Abstract: The present invention includes scalable and cost-effective auxetic foam sensors (AFS) created through conformably coating a thin conductive nanomaterial-sensing layer on a porous substrate having a negative Poisson's ratio. In general, the auxetic foam sensors possess multimodal sensing capability, such as large deformation sensing, small pressure sensing, shear/torsion sensing and vibration sensing and excellent robustness in humidity environment.
    Type: Grant
    Filed: November 3, 2017
    Date of Patent: March 23, 2021
    Assignee: The Florida State University Research Foundation, Inc.
    Inventors: Changchun Zeng, Zhiyong Liang, Yan Li, Sida Luo, Tao Liu
  • Patent number: 10947119
    Abstract: Provided are organic metal halide crystals having a 1D nanotube structure. The metal halide crystals may have a unit cell that includes two or more face-sharing metal halide dimers. The metal halide crystals also may include organic cations. Methods of forming metal halide crystals having a 1D nanotube structure also are provided.
    Type: Grant
    Filed: October 9, 2018
    Date of Patent: March 16, 2021
    Assignee: Florida State University Research Foundation, Inc.
    Inventors: Biwu Ma, Haoran Lin
  • Patent number: 10940188
    Abstract: The present invention concerns the use of compounds for the treatment or prevention of Flavivirus infections, such as Zika virus infections. Aspects of the invention include methods for treating or preventing Flavivirus virus infection, such as Zika virus infection, by administering a compound or class of compound disclosed herein, such as a niclosamide compound, an emricasan compound, a cyclin-dependent kinase inhibitor, a proteasome inhibitor, or a combination of two or more of the foregoing, to a subject in need thereof; methods for inhibiting Flavivirus infections such as Zika virus infections in a cell in vitro or in vivo; pharmaceutical compositions; packaged dosage formulations; and kits for treating or preventing Flavivirus infections, such Zika virus infections.
    Type: Grant
    Filed: January 31, 2020
    Date of Patent: March 9, 2021
    Assignees: FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC., THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES, THE JOHNS HOPKINS UNIVERSITY
    Inventors: Hengli Tang, Emily M. Lee, Yichen Cheng, Yi Zhou, Wei Zheng, Ruili Huang, Miao Xu, Wenwei Huang, Menghang Xia, Hongjun Song, Guo-Li Ming, Zhexing Wen
  • Patent number: 10927045
    Abstract: Provided herein are methods of making composite materials. The methods may include infiltrating a carbon nanoscale fiber network with a ceramic precursor, curing the ceramic precursor, and/or pyrolyzing the ceramic precursor. The infiltrating, curing, and pyrolyzing steps may be repeated one or more times. Composite materials also are provided that include a ceramic material and carbon nanoscale fibers.
    Type: Grant
    Filed: January 10, 2019
    Date of Patent: February 23, 2021
    Assignee: Florida State University Research Foundation, Inc.
    Inventor: Chengying Xu
  • Patent number: 10919032
    Abstract: Compositions that include an ion exchange resin and a polyelectrolyte. The polyelectrolyte may be adsorbed to at least a portion of a surface of the ion exchange resin. Methods of treating a liquid with a composition, and methods of forming a composition that includes an ion exchange resin and a polyelectrolyte.
    Type: Grant
    Filed: January 19, 2019
    Date of Patent: February 16, 2021
    Assignee: Florida State University Research Foundation, Inc.
    Inventors: Joseph Schlenoff, Yara Ghoussoub
  • Patent number: 10920280
    Abstract: A MNase-Sequence Capture method, mTSS-seq, was developed herein to map genome-wide nucleosome distribution in cancer, for example primary human lung and colon adenocarcinoma tissue. Here, it was confirmed that nucleosome redistribution is an early, widespread event in lung adenocarcinoma (LAC) and colon adenocarcinoma (CRC). These altered nucleosome architectures are consistent between LAC and CRC patient samples indicating that they can serve as important early adenocarcinoma markers. As such, this consistency would be expected in other adenocarcinomas, as well as other carcinomas. It was demonstrated that the nucleosome alterations are driven by the underlying DNA sequence and potentiate transcription factor binding. DNA-directed nucleosome redistributions are widespread early in cancer progression, thus providing a methodology for early detection of cancer in grade one patients.
    Type: Grant
    Filed: December 13, 2017
    Date of Patent: February 16, 2021
    Assignee: The Florida State University Research Foundation, Inc.
    Inventor: Jonathan H. Dennis
  • Patent number: 10923707
    Abstract: A method of making an electrode for an electrochemical cell includes the step of providing an electrode composite comprising from 70-98% active material, from 0-10% conductive material additives, and from 2-20% polymer binder, based on the total weight of the electrode composite. The electrode composite is mixed and then compressed the electrode composite into an electrode composite sheet. The electrode composite sheet is applied to a current collector with pressure to form an electrode, wherein the electrode possesses positive characteristics for adhesion according to ASTM standard test D3359-09e2, entitled Standard Test Methods for Measuring Adhesion by Tape Test, and wherein the electrode composite sheet and the electrode possess positive characteristics for flexibility according to the Mandrel Test. The binder can be a single nonfluoropolymer binder. Dry process electrodes are also disclosed.
    Type: Grant
    Filed: June 27, 2016
    Date of Patent: February 16, 2021
    Assignee: FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC.
    Inventors: Jian-ping Zheng, Qiang Wu
  • Patent number: 10913789
    Abstract: A chimeric protein having deubiquitinase activity, methods of identifying anti-deubiquitinase compounds using chimeric proteins, and kits comprising chimeric proteins are described herein. In one aspect, a chimeric protein comprises a mammalian deubiquitinase catalytic domain, a linker domain, and a non-human deubiquitinase proteasome binding domain. In another aspect, a method of identifying a compound having deubiquitinase inhibition activity comprises a) providing an assay for identifying a compound having deubiquitinase inhibition activity, wherein the assay comprises one or more biological cells comprising a chimeric protein comprising a mammalian deubiquitinase catalytic domain, a linker domain, and a non-human deubiquitinase proteasome binding domain; b) screening the assay with at least one compound; and c) identifying a compound having deubiquitinase inhibition activity based on survival of the biological cell.
    Type: Grant
    Filed: April 29, 2020
    Date of Patent: February 9, 2021
    Assignee: The Florida State University Research Foundation, Inc.
    Inventor: Robert J. Tomko, Jr.
  • Patent number: 10916381
    Abstract: Forward and back electron transfer at molecule oxide interfaces are pivotal events in dye-sensitized solar cells, dye-sensitized photoelectrosynthesis cells and other applications. Disclosed herein are self-assembled multilayers as a strategy for manipulating electron transfer dynamics at these interfaces. The multilayer films are achieved by stepwise layering of bridging molecules, linking ions, and active molecule on an oxide surface. The formation of the proposed architecture is supported by ATR-IR and UV-Vis spectroscopy. Time-resolved emission and transient absorption establishes that the films exhibit an exponential decrease in electron transfer rate with increasing bridge length. The findings indicate that self-assembled multilayers offer a simple, straight forward and modular method for manipulating electron transfer dynamics at dye-oxide interfaces.
    Type: Grant
    Filed: July 14, 2015
    Date of Patent: February 9, 2021
    Assignee: The Florida State University Research Foundation. Inc.
    Inventors: Kenneth Hanson, Jamie Wang, Tanmay Banerjee, Omotola Ogunsolu
  • Patent number: 10916713
    Abstract: Wire-shaped perovskite devices and methods for manufacturing the same are provided. The perovskite devices have a uniform layer thickness of perovskite material on wire-shaped substrates of semi-conductor or carbon material. The method includes an electro-coating process, which advantageously allows for predictability and repeatability.
    Type: Grant
    Filed: January 17, 2020
    Date of Patent: February 9, 2021
    Assignee: The Florida State University Research Foundation, Inc.
    Inventors: Okenwa O. I. Okoli, Geoffrey R. Adams
  • Patent number: 10907220
    Abstract: Disclosed are non-naturally occurring zebrafish, such as transgenic zebrafish, which comprise a mutation in the rhodopsin (rho) gene. Also disclosed are methods of identifying compounds useful in treating retinal-specific defects and disorders, such as degeneration. Further disclosed are methods of identifying mutations in the rhodopsin gene that can cause retinal-specific defects.
    Type: Grant
    Filed: May 7, 2018
    Date of Patent: February 2, 2021
    Assignee: The Florida State University Research Foundation Inc.
    Inventor: James Fadool
  • Patent number: 10906813
    Abstract: Provided herein are methods off functionalizing a carbon nanotube, functionalized carbon nanotubes, methods of forming a suspension, and methods of forming a sensor. The methods may include contacting one or more carbon nanotubes with a dienophile in the presence of a supercritical fluid to form one or more functionalized carbon nanotubes. The one or more functionalized carbon nanotubes may have a degree of functionalization of about 1% to about 5%.
    Type: Grant
    Filed: September 27, 2018
    Date of Patent: February 2, 2021
    Assignee: Florida State University Research Foundation, Inc.
    Inventors: Changchun Zeng, Yan Li, Zhiyong Liang
  • Patent number: 10903441
    Abstract: Single-layer LEDs were developed using a composite thin film of organometal halide perovskite (Pero) and poly (ethylene oxide) (PEO). Single-layer Pero LEDs have a device structure that resembles “bottom electrode (ITO)/Pero-PEO/top electrode (In/Ga or Au)”. Green emission LEDs with methylammonium lead bromide (bromide-Pero) and PEO composite thin films exhibit a low turn-on voltage of about 2.8-3.1 V (defined at 1 cd m?2 luminance), a maximum luminance of 4064 cd m?2 and a moderate maximum current efficiency of about 0.24-0.74 cd A?1. Blue and red emission LEDs have also been fabricated using Cl/Br or Br/I alloyed Pero-PEO composite thin films.
    Type: Grant
    Filed: December 8, 2017
    Date of Patent: January 26, 2021
    Assignee: The Florida State University Research Foundation, Inc.
    Inventors: Zhibin Yu, Junqiang Li, Sri Ganesh Rohit Bade
  • Patent number: 10894854
    Abstract: An example of a bottlebrush polymer has a polymer backbone and a plurality of individual brush moieties bonded to the polymer backbone. The individual brush moieties respectively including a ketone, a hydrophilic segment, and a surface adhesive terminal group. The brush moieties can be functionalized and/or cross-linked.
    Type: Grant
    Filed: April 26, 2018
    Date of Patent: January 19, 2021
    Assignee: Florida State University Research Foundation, Inc.
    Inventor: Hoyong Chung
  • Patent number: 10865420
    Abstract: The subject invention concerns materials and methods for increasing and/or improving photosynthetic efficiency in plants, and in particular, C3 plants. In particular, the subject invention provides for means to increase the number of bundle sheath (BS) cells in plants, to improve the efficiency of photosynthesis in BS cells, and to increase channels between BS and mesophyll (M) cells. In one embodiment, a method of the invention concerns altering the expression level or pattern of one or more of SHR, SCR, and/or SCL23 in a plant. The subject invention also pertains to genetically modified plants, and in particular, C3 plants, that exhibit increased expression of one or more of SHR, SCR, and/or SCL23. Transformed and transgenic plants are contemplated within the scope of the invention.
    Type: Grant
    Filed: June 11, 2014
    Date of Patent: December 15, 2020
    Assignee: FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC.
    Inventors: Hongchang Cui, Danyu Kong, Yueling Hao
  • Publication number: 20200389343
    Abstract: A novel LPWAN technology includes a ZCNET node that transmit signals that occupy a very small fraction of the signal space, resulting in very low collision probabilities. ZCNET supports parallel root channels within a single frequency channel by using Zadoff-Chu (ZC) root sequences. The root channels do not severely interfere with each other, because the interference power is spread evenly over the entire signal space. ZCNET has its node randomly choose the transmission channel and range, while still achieving high packet receiving ratios such as 0.9 or above, because the load in each root channel is small.
    Type: Application
    Filed: June 8, 2020
    Publication date: December 10, 2020
    Applicant: The Florida State University Research Foundation, Inc.
    Inventor: Zhenghao ZHANG
  • Patent number: 10854740
    Abstract: Systems and methods for providing a phase modulator. The methods comprise creating a Field Effect Transistor (FET) by: placing a crystal structure displaying ambipolarity on a substrate comprising an oxide layer and a conductive silicon layer, the conductive silicon layer providing a gating electrical contact for the phase modulator, and forming source and drain electrical contacts on the crystal structure using e-beam lithography and an e-beam evaporator. The methods also comprising: annealing the FET to improve an interface between the crystal structure and the source and drain electrical contacts; and coating the FET with a dielectric layer to reduce or eliminate hysteresis so that a functionality of the phase modulator is improved.
    Type: Grant
    Filed: June 24, 2019
    Date of Patent: December 1, 2020
    Assignee: FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC.
    Inventors: Nihar R. Pradhan, Stephen A. Mcgill
  • Patent number: 10845211
    Abstract: Temperature sensors, pressure sensors, methods of making the same, and methods of detecting pressures and temperatures using the same are provided. In an embodiment, the temperature sensor includes a ceramic coil inductor having a first end plate and a second end plate, wherein the ceramic coil inductor is formed of a ceramic composite that comprises carbon nanotubes or, carbon nanofibers, or a combination of carbon nanotubes and carbon nanofibers thereof dispersed in a ceramic matrix; and a thin film polymer-derived ceramic (PDC) nanocomposite disposed between the first and the second end plates, wherein the thin film PDC nanocomposite has a dielectric constant that increases monotonically with temperature.
    Type: Grant
    Filed: January 5, 2018
    Date of Patent: November 24, 2020
    Assignee: Florida State University Research Foundation, Inc.
    Inventors: Chengying Xu, Amanda Schrand, Reamonn Soto
  • Patent number: 10844083
    Abstract: Provided herein are methods of making metal halide perovskites, including methods of making bulk crystals or micro crystals. The metal halide perovskites may be a light emitting material.
    Type: Grant
    Filed: January 4, 2018
    Date of Patent: November 24, 2020
    Assignee: Florida State University Research Foundation, Inc.
    Inventors: Biwu Ma, Chenkun Zhou, Zhao Yuan
  • Patent number: 10836135
    Abstract: Composite materials are provided which may include one or more sheets of carbon fibers woven in orthogonal direction bundles; carbon nanotubes embedded within pores between the bundles; and a matrix material in which the one or more sheets and the carbon nanotubes are embedded. In one case, the carbon fibers lie substantially in an x-direction and a y-direction and the carbon nanotubes are oriented substantially in a z-direction, which is substantially perpendicular to the x- and y-directions. Methods for making the composite materials are also provided.
    Type: Grant
    Filed: October 5, 2015
    Date of Patent: November 17, 2020
    Assignee: Florida State University Research Foundation, Inc.
    Inventor: Chengying Xu