Patents Assigned to The Forsyth Institute
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Patent number: 11471394Abstract: Described herein are oral care compositions comprising a deoxy sugar antimetabolite and methods of inhibiting microbial biofilm formation and/or degrading a microbial biofilm in a subject.Type: GrantFiled: May 27, 2020Date of Patent: October 18, 2022Assignees: COLGATE-PALMOLIVE COMPANY, THE FORSYTH INSTITUTEInventors: Lyndsay Schaeffer-Korbylo, Jorge Frias-Lopez
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Publication number: 20180110795Abstract: The invention features compositions comprising inhibitors of cobalamin biosynthesis, methods of detecting periodontal disease from a subject's subgingival plaque using a panel of biomarkers, and methods of treating periodontal disease using oral formulations.Type: ApplicationFiled: April 22, 2016Publication date: April 26, 2018Applicant: THE FORSYTH INSTITUTEInventor: JORGE FRIAS-LOPEZ
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Publication number: 20180078519Abstract: The invention provides methods for increasing plaque stabilization using LXA4, Resolvin E1, or analog thereof. Methods are also provided for treating or preventing arterial disorders that would benefit from increased plaque stabilization using LXA4, Resolvin E1, or analog thereof.Type: ApplicationFiled: March 18, 2016Publication date: March 22, 2018Applicant: The Forsyth InstituteInventors: Thomas E. Van Dyke, Hatice Hasturk, Alpdogan Kantarci, James A. Hamilton
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Publication number: 20160231334Abstract: The invention features panels of salivary biomarkers useful for identifying subjects having or at risk of developing a metabolic disease, such as Type 2 diabetes, and therapeutic methods for treating or preventing the onset of obesity and obesity-related disorders. Methods are also disclosed for identifying a subject, such as a non-obese adolescent, as having a propensity to develop inflammatory obesity.Type: ApplicationFiled: October 28, 2014Publication date: August 11, 2016Applicant: The Forsyth InstituteInventor: Max J. Goodson
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Publication number: 20150030989Abstract: The present invention relates to a handheld dental device that provides photodynamic therapy. The device of the present invention may have an elongated housing; an applicator tip extending from the distal end of the housing; wherein the applicator tip has a lumen defined by a wall; an optic fiber extending through the lumen of the applicator tip; at least one power source attached to or residing within the housing; at least one light source that provides light to the optic fiber and emits a wavelength that ranges from about 650 nm to about 1400 nm; and at least one oxygen source that provides oxygen to a passage that communicates with the oxygen source and the applicator tip. Oxygen and light may be provided at the applicator tip simultaneously. The device may be used to eliminate or reduce bacteria which cause oral disease or conditions, such as endodontic treatment failures.Type: ApplicationFiled: September 10, 2014Publication date: January 29, 2015Applicant: The Forsyth InstituteInventors: Nikolaos S. Soukos, Philip P. Stashenko
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Publication number: 20140315807Abstract: The invention provides new methods for inducing or promoting bone growth and/or for reducing or preventing bone deterioration in a mammal subject. The inventive methods generally comprise administering to the subject an effective amount of a resolving. In particular, the inventive methods may be useful for treating or preventing conditions associated with bone degradation, deterioration or degeneration such as periodontal disease, osteoarthritis, and metastatic bone disease and osteolytic bone disease. Pharmaceutical compositions and kits comprising at least one resolving are also provided that can be used to performed the inventive methods.Type: ApplicationFiled: December 19, 2013Publication date: October 23, 2014Applicant: The Forsyth InstituteInventor: Thomas E. Van Dyke
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Patent number: 8636986Abstract: The present invention provides new methods for inducing or promoting bone growth and/or for reducing or preventing bone deterioration in a mammal subject. The inventive methods generally comprise administering to the subject an effective amount of a resolvin. In particular, the inventive methods may be useful for treating or preventing conditions associated with bone degradation, deterioration or degeneration such as periodontal disease, osteoarthritis, and metastatic bone disease and osteolytic bone disease. Pharmaceutical compositions and kits comprising at least one resolvin are also provided that can be used to performed the inventive methods.Type: GrantFiled: November 17, 2006Date of Patent: January 28, 2014Assignee: The Forsyth InstituteInventor: Thomas E. Van Dyke
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Publication number: 20100306861Abstract: The invention provides apparatuses, systems, and methods for conducting assays in aquatic animals. The apparatuses, systems, and methods of the invention can be used to identify and/or characterize compounds that modulate morphological, anatomical, or behavioral characteristics. The apparatuses, systems, and methods of the invention can be used to identify and/or characterize compounds that modulate learning or memory.Type: ApplicationFiled: March 2, 2010Publication date: December 2, 2010Applicant: The Forsyth InstituteInventor: Michael Levin
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Patent number: 7700347Abstract: The invention provides apparatuses, systems, and methods for conducting assays in aquatic animals. The apparatuses, systems, and methods of the invention can be used to identify and/or characterize compounds that modulate morphological, anatomical, or behavioral characteristics. The apparatuses, systems, and methods of the invention can be used to identify and/or characterize compounds that modulate learning or memory.Type: GrantFiled: June 29, 2006Date of Patent: April 20, 2010Assignee: The Forsyth InstituteInventor: Michael Levin
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Publication number: 20080131920Abstract: The present invention provides methods for promoting dedifferentiation and/or regeneration by modulating membrane potential and/or intracellular pH in non-naturally regenerating cells.Type: ApplicationFiled: October 4, 2006Publication date: June 5, 2008Applicant: The Forsyth InstituteInventor: Michael Levin
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Patent number: 7326733Abstract: Methods and compounds for remodeling bone and treating osteopenic conditions are described. Methods and compounds for increasing bone mineral density by decreasing serotonin levels in osteoblasts are also described.Type: GrantFiled: June 2, 2003Date of Patent: February 5, 2008Assignee: The Forsyth InstituteInventors: Philip Stashenko, Richard Battaglino
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Patent number: 7323175Abstract: Immunogenic compositions and subunit vaccines for dental caries are described which comprise peptide subunits of glucan binding protein-B and peptide subunits of glucan binding protein-B in combination with peptide subunits of glucosyltransferase. Methods of provoking an immune response to S. mutans glucan binding protein-B or glucosyltransferase. Methods of immunizing a mammal against dental caries are also described, along with antibodies which bind particular epitopes of glucan binding protein-B or glucosyltransferase.Type: GrantFiled: March 7, 2003Date of Patent: January 29, 2008Assignee: The Forsyth InstituteInventors: Daniel J. Smith, Martin A. Taubman
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Publication number: 20070031962Abstract: The invention provides apparatuses, systems, and methods for conducting assays in aquatic animals. The apparatuses, systems, and methods of the invention can be used to identify and/or characterize compounds that modulate morphological, anatomical, or behavioral characteristics. The apparatuses, systems, and methods of the invention can be used to identify and/or characterize compounds that modulate learning or memory.Type: ApplicationFiled: June 29, 2006Publication date: February 8, 2007Applicant: The Forsyth InstituteInventor: Michael Levin
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Patent number: 7163682Abstract: Immunogenic compositions and subunit vaccines for dental caries are described which comprise peptide subunits of glucan binding protein-B and peptide subunits of glucan binding protein-B in combination with peptide subunits of glucosyltransferase. Methods of provoking an immune response to S. mutans glucan binding protein-B or glucosyltransferase. Methods of immunizing a mammal against dental caries are also described, along with antibodies which bind particular epitopes of glucan binding protein-B or glucosyltransferase.Type: GrantFiled: March 9, 2004Date of Patent: January 16, 2007Assignee: The Forsyth InstituteInventors: Daniel J. Smith, Martin A. Taubman
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Patent number: 7101562Abstract: The present invention provides glucan-based compositions and methods for stimulating an immune response against mutans streptococci components and vaccines and methods for the treatment and prevention of dental caries. In a preferred embodiment, a glucan polymer, preferably WSG, is covalently bound to one or more T cell-dependent antigens to form a conjugate vaccine. The T cell-dependent antigen preferably contains epitopes of one or more mutans streptococcal proteins, such as a glucosyltransferase. Moreover, one or more moieties, including haptens, may be conjugated to the glucan-T cell-dependent composition. In a preferred embodiment, these moieties are peptides which contain immunogenic epitopes corresponding to components of a mutans streptococcus.Type: GrantFiled: May 1, 2000Date of Patent: September 5, 2006Assignees: The Forsyth Institute, Henry M. Jackson Foundation for the Advancement of Military MedicineInventors: Andrew Lees, Martin A. Taubman, Daniel J. Smith
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Patent number: 7056517Abstract: Vaccine compositions and immunogenic compositions are described which are glucosyltransferase subunit vaccines for dental caries and which contain at least one peptide which corresponds to a sequence of glucosyltransferase containing aspartate 413, an equivalent of aspartate 413, aspartate 451, an equivalent of aspartate 451, aspartate 562, an equivalent of aspartate 562, aspartate 567, an equivalent of aspartate 567, histidine 561, an equivalent of histidine 561, tryptophan 491, an equivalent of tryptophan 491, glutamate 489, an equivalent of glutamate 489, arginine 449, an equivalent of arginine 449, or combinations thereof. These subunit vaccines elicit antibodies which protect an immunized mammal from dental caries. Methods of provoking an immune response to intact glucosyltransferase are also described.Type: GrantFiled: March 9, 2004Date of Patent: June 6, 2006Assignee: The Forsyth InstituteInventors: Daniel J. Smith, Martin A. Taubman