Patents Assigned to The Foundation for the Promotion of Industrial Science
  • Patent number: 11186860
    Abstract: A microchamber array device having built-in reaction microchambers, in which the dilution ratio can be greatly increased at the same time as dramatically raising cell recovery efficiency, and an inspection object analysis method using said device are provided. This microchamber array device is provided with: a microchamber array 1 for cell capture by electrophoresis comprising an arrangement of a substrate 2, electrodes 3 and photoresists 4; and a reaction microchamber array 6 which is separated from the capture microchamber array 1, and which is formed from reaction microchamber 8 comprising micro channels 7 arranged so as to be opposite of the aforementioned microchamber array 1.
    Type: Grant
    Filed: November 24, 2016
    Date of Patent: November 30, 2021
    Assignee: THE FOUNDATION FOR THE PROMOTION OF INDUSTRIAL SCIENCE
    Inventors: Teruo Fujii, Soo Hyeon Kim, Ken Ogata
  • Patent number: 11184978
    Abstract: An object to provide an electric device easy to manufacture, extensible and of high quality. The electric device comprises a plurality of module boards 51, the module boards 51 piled up on one another, each of the module boards 51 provided with an electrode 53 on its surface, the electrodes 53 on the piled-up module boards 51 generally positioned along a vertical straight line; and a connector 11 connecting the module boards 51, the connector 11 including a body portion 21, the body portion 21 electrically connecting the electrodes 53 positioned along the vertical straight line, and a holder 12 holding the body portion 21, the holder 12 including a board engagement portion and a holder connecting portion, the board engagement portion engaging with the module board 51 so that the connector 11 is mounted on the module board 51, and the holder connecting portion engaging with another holder connecting portion so that the connector 11 is coupled to another vertically adjacent connector 11.
    Type: Grant
    Filed: February 12, 2019
    Date of Patent: November 23, 2021
    Assignee: THE FOUNDATION FOR THE PROMOTION OF INDUSTRIAL SCIENCE
    Inventors: Takayasu Sakurai, Makoto Takamiya, Tokihiko Mori
  • Patent number: 11180797
    Abstract: An object is to provide a component for molecular Computing and a method of molecular Computing. A component for molecular Computing, the component comprising: a microsphere including pores, at least some of which are open on a surface of the microsphere, and a plurality of modules grafted on the microsphere wherein each of the modules is a continuous séquence of nucleic acid base.
    Type: Grant
    Filed: February 16, 2016
    Date of Patent: November 23, 2021
    Assignees: THE FOUNDATION FOR THE PROMOTION OF INDUSTRIAL SCIENCE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Guillaume Gines, Yannick Rondelez, Teruo Fujii
  • Publication number: 20210337668
    Abstract: An object to provide an electric device easy to manufacture, extensible and of high quality. The electric device comprises a plurality of module boards 51, the module boards 51 piled up on one another, each of the module boards 51 provided with an electrode 53 on its surface, the electrodes 53 on the piled-up module boards 51 generally positioned along a vertical straight line; and a connector 11 connecting the module boards 51, the connector 11 including a body portion 21, the body portion 21 electrically connecting the electrodes 53 positioned along the vertical straight line, and a holder 12 holding the body portion 21, the holder 12 including a board engagement portion and a holder connecting portion, the board engagement portion engaging with the module board 51 so that the connector 11 is mounted on the module board 51, and the holder connecting portion engaging with another holder connecting portion so that the connector 11 is coupled to another vertically adjacent connector 11.
    Type: Application
    Filed: February 12, 2019
    Publication date: October 28, 2021
    Applicant: THE FOUNDATION FOR THE PROMOTION OF INDUSTRIAL SCIENCE
    Inventors: TAKAYASU SAKURAI, MAKOTO TAKAMIYA, TOKIHIKO MORI
  • Patent number: 11111529
    Abstract: An object is to provide a method of eliminating background amplification in detection of rare nucleic acids based on isothermal amplification. The method comprising steps of: preparing a mixture including solution and enzymes, and adding a first and a second template into the mixture, wherein the first template is an amplification template, and the second template is a leak absorption template. Methods to use this approach for multiplexed, ultrasensitive and ultra-specific detection of nucleic acids are presented.
    Type: Grant
    Filed: February 16, 2017
    Date of Patent: September 7, 2021
    Assignees: THE FOUNDATION FOR THE PROMOTION OF INDUSTRIAL SCIENCE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Yannick Rondelez, Guillaume Gines, Kevin Montagne, Teruo Fujii
  • Patent number: 11059207
    Abstract: Provided is a method for producing a composite member formed by bonding a base material and a resin member. The method includes: a surface treatment step of forming micro-order or nano-order asperities on a surface of a base material; and a bonding step of directly bonding, by injection molding, a resin member to the surface of the base material that has the asperities formed in the surface treatment step. In addition, the composite member includes: a base material having micro-order or nano-order asperities on a surface thereof; and a resin member that is in direct contact with the surface of the base material.
    Type: Grant
    Filed: February 17, 2016
    Date of Patent: July 13, 2021
    Assignees: The University of Tokyo, The Foundation for the Promotion of Industrial Science
    Inventors: Yusuke Kajihara, Fuminobu Kimura, Yuta Tamura, Naotake Nakura, Eiji Yamaguchi, Norihito Shibuya
  • Patent number: 10865372
    Abstract: An object is to provide a neuron cultivation device which promptly develops bundles of axons extending from neurons in vitro. A device for cultivating neuron with axon, the device comprising a cultivation plate and a plurality of modules arranged in the cultivation plate. Each of the modules includes at least one of first chambers receivable of cell bodies of neurons at least one of second chambers, and at least one of channels receivable of a bundle of axon extended from the cell bodies. The channels connect the first chambers and the second chambers. Bottom ends of the first chambers, the second chambers and the channels are closed and top ends of the first chambers and the second chambers are open.
    Type: Grant
    Filed: February 1, 2017
    Date of Patent: December 15, 2020
    Assignee: THE FOUNDATION FOR THE PROMOTION OF INDUSTRIAL SCIENCE
    Inventors: Teruo Fujii, Yoshiho Ikeuchi, Shohei Kaneda, Jiro Kawada
  • Patent number: 10845333
    Abstract: An object is to make a bridge of DNA expanding between a pair of electrodes, and to characterize the bridge of DNA, to thereby detect DNA easily and surely without employing any marker or labeling substances, such as fluorescent reagents. A method of detecting DNA using a detection device with at least a couple of electrodes, the method comprising immobilizing a primer on the electrodes; making a bridge of the DNA expanded between the electrodes, by immersing the electrodes in a solution including circular templates of single stranded DNA, annealing the circular templates, and generating single stranded DNA product utilizing RCA (Rolling Circle Amplification), with impressing a designated voltage between the electrodes; and characterizing the bridge of DNA which includes multiple single stranded DNA molecules between the electrodes.
    Type: Grant
    Filed: October 24, 2014
    Date of Patent: November 24, 2020
    Assignees: The Foundation for the Promotion of Industrial Science, Neuroindx, Inc., Centre National de la Recherche Scientifique (CNRS)
    Inventors: Hiroyuki Fujita, Stanislav L. Karsten, Dominique Collard, Momoko Kumemura
  • Publication number: 20200262157
    Abstract: A method of manufacturing a composite member including an aluminum member and a resin member bonded to each other, the method including: performing blasting on a surface of the aluminum member; modifying the surface of the aluminum member into aluminum hydroxide, the modifying including causing the surface of the aluminum member having undergone blasting to react with water by using at least one of heat and plasma; and directly bonding the resin member to the surface of the aluminum member modified to the aluminum hydroxide.
    Type: Application
    Filed: February 12, 2020
    Publication date: August 20, 2020
    Applicants: The University of Tokyo, The Foundation for the Promotion of Industrial Science
    Inventors: Nayuta HORIE, Eiji YAMAGUCHI, Yusuke KAJIHARA, Fuminobu KIMURA, Gota SUZUKI
  • Publication number: 20190249220
    Abstract: A microchamber array device having built-in reaction microchambers, in which the dilution ratio can be greatly increased at the same time as dramatically raising cell recovery efficiency, and an inspection object analysis method using said device are provided. This microchamber array device is provided with: a microchamber array 1 for cell capture by electrophoresis comprising an arrangement of a substrate 2, electrodes 3 and photoresists 4 and a reaction microchamber array 6 which is separated from the capture microchamber array 1, and which is formed from reaction microchamber 8 comprising micro channels 7 arranged so as to be opposite of the aforementioned microchamber array 1.
    Type: Application
    Filed: November 24, 2016
    Publication date: August 15, 2019
    Applicant: THE FOUNDATION FOR THE PROMOTION OF INDUSTRIAL SCIENCE
    Inventors: TERUO FUJII, SOO HYEON KIM, KEN OGATA
  • Publication number: 20190127672
    Abstract: An object is to provide a neuron cultivation device which promptly develops bundles of axons extending from neurons in vitro. A device for cultivating neuron with axon, the device comprising a cultivation plate and a plurality of modules arranged in the cultivation plate. Each of the modules includes at least one of first chambers receivable of cell bodies of neurons at least one of second chambers, and at least one of channels receivable of a bundle of axon extended from the cell bodies. The channels connect the first chambers and the second chambers. Bottom ends of the first chambers, the second chambers and the channels are dosed and top ends of the first chambers and the second chambers are open.
    Type: Application
    Filed: February 1, 2017
    Publication date: May 2, 2019
    Applicant: THE FOUNDATION FOR THE PROMOTION OF INDUSTRIAL SCIENCE
    Inventors: TERUO FUJII, YOSHIHO IKEUCHI, SHOHEI KANEDA, JIRO KAWADA
  • Publication number: 20190054672
    Abstract: Provided is a method for producing a composite member formed by bonding a base material and a resin member. The method includes: a surface treatment step of forming micro-order or nano-order asperities on a surface of a base material; and a bonding step of directly bonding, by injection molding, a resin member to the surface of the base material that has the asperities formed in the surface treatment step. In addition, the composite member includes: a base material having micro-order or nano-order asperities on a surface thereof; and a resin member that is in direct contact with the surface of the base material.
    Type: Application
    Filed: February 17, 2016
    Publication date: February 21, 2019
    Applicants: The University of Tokyo, The Foundation for the Promotion of Industrial Science
    Inventors: Yusuke KAJIHARA, Fuminobu KIMURA, Yuta TAMURA, Naotake NAKURA, Eiji YAMAGUCHI, Norihito SHIBUYA
  • Patent number: 10184872
    Abstract: A viscosity/elasticity measurement device includes a container for containing a measurement target material for detection of viscosity/elasticity is contained, a floating rotor made of material including a conductor, formed in a plate and circular shape when seen in plan view, and configured to be floated on a surface of the measurement target material, a magnet applying a magnetic field to the floating rotor in a direction perpendicular to a surface of the measurement target material, a rotational magnetic field control unit driving the magnet to apply a rotational magnetic field to the floating rotor, inducing an induction current in the conductor, and applying rotational torque to the floating rotor to rotate by Lorentz interaction between the induction current and the magnetic field applied to the floating rotor, and a viscosity detection unit detecting the viscosity/elasticity of the measurement target material based on a rotation state of the floating rotor.
    Type: Grant
    Filed: May 11, 2012
    Date of Patent: January 22, 2019
    Assignee: THE FOUNDATION FOR THE PROMOTION OF INDUSTRIAL SCIENCE
    Inventor: Keiji Sakai
  • Patent number: 10031235
    Abstract: An object is to make it possible to determine and output an accurate current position reliably in a short time and at a low cost, even in environments where signals from positioning satellites are complicatedly affected by structures, geographical features, etc. Therefore, the present invention provides a position detection device comprising: a receiving unit receiving signals from a positioning satellite, and calculating a pseudo range to the positioning satellite based on the signals, and a positioning unit calculating an initial position based on the pseudo range calculated by the receiving unit, calculating the pseudo range to the positioning satellite at plural positions around the initial position using a three-dimensional map data and a ray-tracing method, selecting candidate positions from the plural positions based on the pseudo range, and deciding a current position based on the candidate positions within such a short distance from the initial position that predetermined conditions are satisfied.
    Type: Grant
    Filed: May 14, 2014
    Date of Patent: July 24, 2018
    Assignee: THE FOUNDATION FOR THE PROMOTION OF INDUSTRIAL SCIENCE
    Inventors: Shunsuke Kamijo, Shunsuke Miura
  • Patent number: 9746494
    Abstract: The present invention makes it possible to easily and efficiently observe a specimen contained in a fluid without using a filtration device separate from a scanning probe microscope by attaching a filter holding part holding a filter to a fluid cell of a specimen support. Therefore, a specimen support 10, for holding a specimen subject to observation by the scanning probe microscope, comprises a fluid cell 11, into which fluid including the specimen is introduced, and a filter unit including a filter 15, which allows the fluid passage and at least a part of the specimen is adhered to. The fluid cell 11 includes a fluid entrance, the filter unit includes a fluid exit opening, and the filter unit is attached to one side of the fluid cell 11.
    Type: Grant
    Filed: February 19, 2015
    Date of Patent: August 29, 2017
    Assignee: THE FOUNDATION FOR THE PROMOTION OF INDUSTRIAL SCIENCE
    Inventors: Shuhei Nishida, Teruo Fujii
  • Patent number: 9518908
    Abstract: An object is to measure a mechanical property of a fluid at a temporal resolution of at least 100 [?s]. Therefore, a method comprising: causing a droplet 21 to fly by ejecting a fluid to be measured from a nozzle 11a as the droplet 21; generating an electric field in a space around a flight path 22 of the droplet 21 by applying a voltage to an electrode arranged in the vicinity of the flight path 22; deforming the droplet 21 in a way of contactless deformation with a dielectric force induced by the electric field; and measuring a mechanical property of the fluid based on temporal variation of deformation state of the droplet 21 after deforming the droplet 21.
    Type: Grant
    Filed: March 5, 2013
    Date of Patent: December 13, 2016
    Assignee: THE FOUNDATION FOR THE PROMOTION OF INDUSTRIAL SCIENCE
    Inventors: Keiji Sakai, Tomoki Ishiwata
  • Patent number: 9455054
    Abstract: The present invention relates to a radioactive cesium adsorbent, a method for producing the same, and a method for decontaminating the environment from radioactive cesium with the adsorbent. The radioactive cesium adsorbent of the present invention includes a hydrophilic fiber substrate supporting a Prussian blue analog, in particular, Prussian blue, and the Prussian blue analog is immobilized in the inside of the fibers.
    Type: Grant
    Filed: August 16, 2012
    Date of Patent: September 27, 2016
    Assignee: The Foundation for the Promotion of Industrial Science
    Inventors: Kazuyuki Ishii, Masashi Obi, Kazuaki Kudo, Kengo Akagawa, Tetsu Tatsuma, Akiyoshi Sakoda
  • Publication number: 20160146945
    Abstract: An object is to make it possible to determine and output an accurate current position reliably in a short time and at a low cost, even in environments where signals from positioning satellites are complicatedly affected by structures, geographical features, etc. Therefore, the present invention provides a position detection device comprising: a receiving unit receiving signals from a positioning satellite, and calculating a pseudo range to the positioning satellite based on the signals, and a positioning unit calculating an initial position based on the pseudo range calculated by the receiving unit, calculating the pseudo range to the positioning satellite at plural positions around the initial position using a three-dimensional map data and a ray-tracing method, selecting candidate positions from the plural positions based on the pseudo range, and deciding a current position based on the candidate positions within such a short distance from the initial position that predetermined conditions are satisfied.
    Type: Application
    Filed: May 14, 2014
    Publication date: May 26, 2016
    Applicant: THE FOUNDATION FOR THE PROMOTION OF INDUSTRIAL SCIENCE
    Inventors: SHUNSUKE KAMIJO, SHUNSUKE MIURA
  • Publication number: 20150068290
    Abstract: An object is to measure a mechanical property of a fluid at a temporal resolution of at least 100 [?s]. Therefore, a method comprising: causing a droplet 21 to fly by ejecting a fluid to be measured from a nozzle 11a as the droplet 21; generating an electric field in a space around a flight path 22 of the droplet 21 by applying a voltage to an electrode arranged in the vicinity of the flight path 22; deforming the droplet 21 in a way of contactless deformation with a dielectric force induced by the electric field; and measuring a mechanical property of the fluid based on temporal variation of deformation state of the droplet 21 after deforming the droplet 21.
    Type: Application
    Filed: March 5, 2013
    Publication date: March 12, 2015
    Applicant: The Foundation for the Promotion of Industrial Science
    Inventors: Keiji Sakai, Tomoki Ishiwata
  • Publication number: 20140194665
    Abstract: The present invention relates to a radioactive cesium adsorbent, a method for producing the same, and a method for decontaminating the environment from radioactive cesium with the adsorbent. The radioactive cesium adsorbent of the present invention includes a hydrophilic fiber substrate supporting a Prussian blue analogue, in particular, Prussian blue, and the Prussian blue analogue is immobilized in the inside of the fibers.
    Type: Application
    Filed: August 16, 2012
    Publication date: July 10, 2014
    Applicant: The Foundation for the Promotion of Industrial Science
    Inventors: Kazuyuki Ishii, Masashi Obi, Kazuaki Kudo, Kengo Akagawa, Tetsu Tatsuma, Akiyoshi Sakoda