Abstract: The present disclosure provides a humanized anti-BASIGIN antibody or antigen binding fragment thereof, which comprises heavy chain variable region (VH) comprising an amino acid sequence of SEQ ID NO: 1; optionally further comprise light chain variable region (VL) comprising an amino acid sequence of SEQ ID NO: 2. The present disclosure also provides a composition comprising the humanized anti-BASIGIN antibody or antigen binding fragment thereof, an isolated nucleic acid sequence encoding the humanized anti-BASIGIN antibody or antigen binding fragment thereof, a vector comprising the nucleic acid, a host cell comprising the vector, and use of the humanized anti-BASIGIN antibody or antigen binding fragment thereof.

Abstract: A method for treating hypertrophic cardiomyopathy (HCM) utilizes an RF ablation electrode needle system that has an RF ablation generator, and an electrode needle. The distal end of the electrode needle is introduced to puncture within myocardium after piercing through epicardium and then advanced along an intramyocardial pathway between endocardia at two lateral sides of the interventricular septum to reach a hypertrophic area of an interventricular septum. The RF ablation generator is then turned on to implement single-point or multi-point ablation on the hypertrophic area of the interventricular septum, and then the RF electrode needle is withdrawn from the patient.

Abstract: The invention relates to a dentin collagen fibril demineralizing material, and a preparation method and application thereof. The invention relates to a conjugate of water-soluble chitosan and an aminocarboxylic acid metal chelating agent used for dental demineralization, preferably dentin demineralization. The invention also discloses a dentin collagen fibril demineralizing material and a preparation method and application thereof, wherein the material is prepared from 0.5-1 part by mass of water-soluble chitosan, 10-30 parts by mass of EDTA, and 0.8-1.5 parts by mass of cross-linking agent. The invention relates to a dental demineralization composition comprising a conjugate and a material of the invention. The conjugate, material and composition can be used for dentin demineralization treatment before dental bonding and restoration.

Abstract: A method for treating hypertrophic cardiomyopathy (HCM) utilizes an RF ablation electrode needle system that has an RF ablation generator, and an electrode needle. The distal end of the electrode needle is introduced to puncture within myocardium after piercing through epicardium and then advanced along an intramyocardial pathway between endocardia at two lateral sides of the interventricular septum to reach a hypertrophic area of an interventricular septum. The RF ablation generator is then turned on to implement single-point or multi-point ablation on the hypertrophic area of the interventricular septum, and then the RF electrode needle is withdrawn from the patient.

Abstract: A method for treating hypertrophic cardiomyopathy (HCM) utilizes an RF ablation electrode needle system that has an RF ablation generator, and an electrode needle. The electrode needle is introduced to puncture within myocardium and to reach the hypertrophic area of the interventricular septum. The RF ablation generator is then turned on to implement single-point or multi-point ablation on the hypertrophic area of the interventricular septum, and then the RF electrode needle is withdrawn from the patient.

Abstract: The invention provides a dual-purpose handle, comprising a body, wherein mounting holes are provided in the body and are used for connecting to functional members; the mounting holes are provided in the body in both an axial direction and a radial direction; axial and radial mounting holes provided in the body can enable the handle and the functional members to easily and quickly switch between two connection forms, i.e. straight and T-shaped; and torsional torques that are different in magnitude can be output by means of different connection manners under the action of the same operation force. Clamping devices fitted with the functional members are arranged in the mounting holes; and when the functional members are connected to the handle, the clamping devices can fix the functional members and prevent same from rotating in a cavity of the body of the handle.

Abstract: The present invention provides use of Tadalafil as a protein arginine methyltransferase 5 (PRMT5) inhibitor. The present invention finds out that Tadalafil is a PRMT5 inhibitor by virtually screening active compounds targeting PRMT5 based on crystal structure and information about active sites of PRMT5. The present invention not only confirms that Tadalafil can inhibit an enzymatic activity of PRMT5, but also confirms that Tadalafil alone can inhibit tumor growth in breast cancer and improve sensitivity to chemotherapy for breast cancer.

Abstract: The present invention provides a glycosylated CEA-specific single-chain antibody, and a chimeric antigen receptor (CAR) targeting a glycosylated CEA, which can be used in manufacture of an agent or a medicament for diagnosis or treatment of a tumor overexpressing glycosylated CEA.

Abstract: The invention provides a pair of dual-purpose forceps, comprising a first forceps body and a second forceps body. When the first forceps body is connected with the second forceps body by means of a first pressurizing connecting member and a second pressurizing connecting member, a first handheld member and a second handheld member move towards each other, and a first pressurizing functional member and a second pressurizing functional member also move towards each other to complete pressurizing; when the first forceps body is connected with the second forceps body by means of a first opening connecting member and a second opening connecting member, the first handheld member and the second handheld member move towards each other, and a first opening function member and a second opening function portion face away from each other to complete opening.

Abstract: The invention provides a pair of dual-purpose forceps, comprising a first forceps body and a second forceps body. When the first forceps body is connected with the second forceps body by means of a first pressurizing connecting member and a second pressurizing connecting member, a first handheld member and a second handheld member move towards each other, and a first pressurizing functional member and a second pressurizing functional member also move towards each other to complete pressurizing; when the first forceps body is connected with the second forceps body by means of a first opening connecting member and a second opening connecting member, the first handheld member and the second handheld member move towards each other, and a first opening function member and a second opening function portion face away from each other to complete opening.

Abstract: The invention provides a dual-purpose handle, comprising a body, wherein mounting holes are provided in the body and are used for connecting to functional members; the mounting holes are provided in the body in both an axial direction and a radial direction; axial and radial mounting holes provided in the body can enable the handle and the functional members to easily and quickly switch between two connection forms, i.e. straight and T-shaped; and torsional torques that are different in magnitude can be output by means of different connection manners under the action of the same operation force. Clamping devices fitted with the functional members are arranged in the mounting holes; and when the functional members are connected to the handle, the clamping devices can fix the functional members and prevent same from rotating in a cavity of the body of the handle.

Abstract: A method for treating hypertrophic cardiomyopathy (HCM) utilizes an RF ablation electrode needle system that has an RF ablation generator, and an electrode needle. The electrode needle is introduced to puncture within myocardium and to reach the hypertrophic area of the interventricular septum. The RF ablation generator is then turned on to implement single-point or multi-point ablation on the hypertrophic area of the interventricular septum, and then the RF electrode needle is withdrawn from the patient.

Abstract: The present invention relates to the technical field of medicine, and specifically relates to a PUMA inhibitor, a method for preparation thereof, and a use thereof. The PUMA inhibitor is the compound as shown in (I) or a pharmaceutically acceptable salt thereof. The definitions of its substituent groups are as described in the description. The compound (I) or pharmaceutically acceptable salt thereof is capable of targeting a PUMA protein and has very good physicochemical properties, very good apoptosis resistance and radiation protection effects; it can selectively inhibit the competitive combined effect of a PUMA protein and a Bcl-2 apoptosis-resistant protein, block apoptosis, and effectively protects against bone marrow damage.

Abstract: A device for detecting electrical impedance by utilizing a theory of excitation and response signals and method thereof, wherein the excitation signal is a square wave excitation current signal (1), the response signal on a target is transformed to a square wave signal with appropriate amplitudes by buffering, amplifying, RC filtering and differential amplifying, then is transformed to a digital signal at a proper time by an analog-to-digital converter. The response signal is sampled once when at high level and once when at low level for every circle by the ADC, and a sample V1 and a sample V2 are obtained respectively, difference of the samples is taken as a detecting result for one circle. An average value of the detecting result from a plurality of circles is taken as a final result. Information of electrical impedance is illustrated by the final result because the excitation current signal is constant.

Abstract: The present disclosure relates to a nucleotide sequence comprising the sequence of SEQ ID NO: 5, and/or sequence of SEQ ID NO: 6, vector and host cell line comprising the nucleotide. The present disclosure also relates to an antibody that binds to extracellular region of human CD147, wherein the antibody comprises a heavy chain variable region having the amino acid sequence of SEQ ID NO: 2, and/or a light chain variable region having the amino acid sequence of SEQ ID NO: 1, and the antibody contains a glycoform lacking both fucose residues and xylose residues, pharmaceutical composition comprising the antibody or fragment thereof, the method of producing the antibody or fragment thereof, and use of the pharmaceutical composition in treatment of CD147 expression-related diseases.

Abstract: The present invention relates to a torsional vibration resonance frequency measuring method and a novel amplitude transformer for assessing the stability of dental implants. In one example, a torsional vibration resonance frequency measuring method includes installing an amplitude transformer on a dental implant, energizing a torsional vibration mode, gathering resonance signals, and analyzing a resonance frequency. In another example, an amplitude transformer for measuring torsional vibration resonance frequency in a dental implant, includes an anti-rotary horizontal double-winged component and a central bolt. The central bolt is configured to closely connect with the inner threads of the dental implant, such that the amplitude transformer can integrate with the dental implant sufficient to vibrate as an integral structure under energizing.

Abstract: A miniature portable multifunctional infusion device includes a liquid bottle (4) and a film box body (16) secured to a support frame (1). The film box body (16) is respectively provided with a directional input interface (17) and a directional output interface (14) in communication with the liquid bottle (4) and a needle via an infusion pipe. The film box body (16) is installed with an elastic film (27), and a transmission system (31) is arranged at a side of the elastic film (27). The transmission system (31) includes a miniature direct current motor (32) connected to a frequency modulating system (28). The miniature direct current motor (32) is connected to a spiral straightening device (34) via a speed reducer (33), and the spiral straightening device (34) is connected to a reciprocating film propping device (36) via a two-order shaft (43). A truncated cone (39) of the reciprocating film propping device (36) at a front end is in contact with the elastic film (27).

Abstract: The present invention provides a bufalin liposome comprising a liposome bilayer and bufalin. The liposome bilayer comprises phospholipid, sterol and polyethylene glycol (PEG)-derived compound. The liposome of the present invention can be used to treat cancer, especially a cancer chosen from liver cancer, lung cancer, ovarian cancer, prostate cancer, colon cancer, pancreas cancer, gastric cancer, and leukemia. The preparation method of the present invention is simple, and the bufalin liposome can increase an effect of antitumor, reduce a toxicity compared with bufalin monomer, and has wide applications.

Abstract: A multichannel UWB-based radar life detector includes a transmitting antenna and three receiving antennas for forming three radar echo signal channels.

Abstract: An electrical impedance detecting device of a portable electrical impedance imaging system by utilizing a theory of sending excitation signal and detecting response signal and a method thereof, wherein the excitation signal is a constant square wave excitation current signal, the response voltage signal on a target is transformed to a square wave signal with appropriate amplitudes by buffering, amplifying, RC filtering and differential amplifying circuits, and then is transformed to a digital signal at a proper time by an analog-to-digital converter. The response voltage signal is sampled once when at high level and once when at low level for every circle of the square wave signal by the ADC, and a sample V1 and a sample V2 are obtained respectively, difference of the sample V1 and the sample V2 is taken as a detecting result for one circle. An average value of the detecting result from a plurality of circles may be taken as a final result.