Patents Assigned to The Francis Crick Institute Limited
  • Analysis of HLA alleles in tumours and the uses thereof
    Patent number: 11634773
    Abstract: The present invention relates to a method for determining whether an HLA allele is lost in a tumour in a subject, wherein said method comprises the step of determining the specific copy number of said HLA allele in said tumour. The invention also relates to a method for treating cancer in a subject, comprising targeting a neoantigen which is predicted to be presented by an HLA molecule encoded by an HLA allele which has been determined not to have been lost in a tumour in said subject.
    Type: Grant
    Filed: July 13, 2018
    Date of Patent: April 25, 2023
    Assignees: THE FRANCIS CRICK INSTITUTE LIMITED, UNIVERSITY COLLEGE LONDON, CANCER RESEARCH TECHNOLOGY LIMITED
    Inventors: Charles Swanton, Nicholas McGranahan, Rachel Rosenthal
  • Visual implant
    Patent number: 11318299
    Abstract: A visual implant (2) comprises an array of micro-electrodes (4) including at least two stimulation micro-electrodes each comprising: a core (106) of conducting material; insulating material (108) surrounding the core; and a layer (112) of metal or metal oxide nano-structures deposited on tips of the micro-electrodes at a front end for interfacing with a target site for visual stimulation; and an integrated circuit (6) to control a pattern of stimulation current driven through the array of micro-electrodes.
    Type: Grant
    Filed: January 23, 2019
    Date of Patent: May 3, 2022
    Assignee: The Francis Crick Institute Limited
    Inventors: Romeo-Robert Racz, Gabriella Racz, Andreas Schaefer
  • Electrochemical probe
    Patent number: 10768139
    Abstract: An electrochemical probe comprises a wire bundle including two or more wire electrodes made of conducting material arranged alongside each other, and insulating material surrounding the electrodes. An impedance reducing layer of metal or metal oxide nano-structures is deposited on tips of the wire electrodes at a first end of the bundle. A functionalization layer is deposited on the impedance reducing layer at the first end of the bundle. Such a probe is particularly useful for electrochemical sensing applications such as neuronal scanning.
    Type: Grant
    Filed: September 8, 2016
    Date of Patent: September 8, 2020
    Assignee: The Francis Crick Institute Limited
    Inventors: Romeo-Robert Racz, Mihaly Kollo, Andreas Schaefer
  • Methods for detecting molecules in a sample
    Patent number: 10578620
    Abstract: The present invention relates to a method for detecting molecules.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: March 3, 2020
    Assignee: The Francis Crick Institute Limited
    Inventors: Banafshe Larijani, Peter Parker, Selvaraju Veeriah
  • Methods for detecting molecules in a sample
    Patent number: 10184944
    Abstract: The present invention relates to a method for detecting molecules.
    Type: Grant
    Filed: March 11, 2014
    Date of Patent: January 22, 2019
    Assignee: The Francis Crick Institute Limited
    Inventors: Banafshe Larijani, Peter Parker, Selvaraju Veeriah