Abstract: The present invention disclosed a medical use of cucurbitane triterpenoids represented by the following formula and isolated from Momordica charantia L. of Cucurbitaceae family in the preparation of medications for prevention and treatment of diabetes and obesity. The above cucurbitane triterpenoids may be acted as a glucose uptake stimulator, an agonist for the translocation of glucose transporter 4 (GLUT4) to the cell membrane, and an activator of adenosine monophosphate-activated protein kinase (AMPK). They may have potential for the prevention and treatment of diabetes and obesity.
Type:
Grant
Filed:
January 14, 2009
Date of Patent:
May 13, 2014
Assignees:
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, The Garvan Institute of Medical Research, Australia
Inventors:
Yang Ye, Minjia Tan, Changqiang Ke, Tong Chen, Xiqiang Li, Edward Kraegen, Jiming Ye, David James, Gregory Cooney
Abstract: The present invention disclosed a medical use of cucurbitane triterpenoids represented by the following formula and isolated from Momordica charantia L. of Cucurbitaceae family in the preparation of medications for prevention and treatment of diabetes and obesity. The above cucurbitane triterpenoids may be acted as a glucose uptake stimulator, an agonist for the translocation of glucose transporter 4(GLUT4) to the cell membrane, and an activator of adenosine monophosphate-activated protein kinase (AMPK). They may have potential for the prevention and treatment of diabetes and obesity.
Type:
Application
Filed:
January 14, 2009
Publication date:
June 23, 2011
Applicants:
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, The Garvan Institute of Medical Research, Australia
Inventors:
Yang Ye, David E. James, Minjia Tan, Gregory J. Cooney, Changqiang Ke, Edward W. Kraegen, Tong Chen, Jiming Ye, Xiqiang Li