Abstract: A spot picker is comprised of a pipette and a disposable cutting tip. The pipette is comprised of a housing with a suction tube projecting from a lower end. An actuation button is positioned at the top end of the housing. The actuation button is connected to a piston inside the suction tube. A plunger attached to the piston has a lower end positioned outside the suction tube. The cutting tip is comprised of a hollow tube with an open proximal end attached to the suction tube. A compressible porous hydrophobic filter is securely but movably positioned within the hollow tube. The cutting tip cuts a gel spot when its open lower end is pushed into a sheet of gel. The plunger pushes the filter outward to discharge the gel spot from the cutting tip when the actuation button is fully depressed.