Abstract: The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein.
Type:
Grant
Filed:
January 20, 2010
Date of Patent:
October 18, 2011
Assignees:
The General Hosital Corporation, Cambridge Polymer Group, Inc.
Inventors:
Orhun K. Muratoglu, Stephen H. Spiegelberg
Abstract: The present invention relates to methods for making cross-linked oxidation-resistant polymeric materials and preventing or minimizing in vivo elution of antioxidant from the antioxidant-containing polymeric materials. The invention also provides methods of doping polymeric materials with a spatial control of cross-linking and antioxidant distribution, for example, vitamin E (?-Tocopherol), and methods for extraction/elution of antioxidants, for example, vitamin E (?-tocopherol), from surface regions of antioxidant-containing polymeric materials, and materials used therewith also are provided.
Type:
Application
Filed:
January 25, 2008
Publication date:
July 29, 2010
Applicants:
The General Hosital Corporation, Cambridge Polymer Group, Inc.
Inventors:
Orhun K. Muratoglu, Edward T. Kopesky, Ebru Oral